The most promising alternative route of insulin administration seems to be pulmonary delivery by inhalation. For a maximal rate of absorption insulin must be...
The lung has inherent advantages for insulin administration. These include: a vast (in humans 50-140 m2, ~500 millions of alveoli) and well-perfused absorptive...
Insulin in a given aerosol (independent from powder or liquid) is unevenly distributed among particles with various sizes and deposition properties. Thus, the...
It was the invention of modern handheld inhalers, allowing the generation of an aerosol with an adequate particle size distribution, some 15 years ago, which...
The published data about the results of the phase III trials with Exubera indicate that the metabolic control achieved is superior compared to oral agents and...
Patients with stable cardiac symptoms do not need to have coronary revascularization before vascular surgery, according to the results of a large, randomized...
Patients at increased risk for perioperative events can be identified on the basis of clinical markers such as angina pectoris, previous MI or heart failure,...
In patients who undergo coronary artery stenting, diabetes has a greater impact on major adverse cardiac events in women than in men, physicians in Germany...
Investigators are encouraged by the improved response of baboons to hearts transplanted from pigs. The swine hearts were from animals in which a single epitope...
Supplemental carnitine can improve pain associated with chronic diabetic peripheral neuropathy (DPN), as well as vibratory perception and nerve regeneration,...
QT interval abnormalities, present at the time of diabetes diagnosis, appear to be better predictors of cardiac death than are ankle brachial pressure index...
Retinopathy is an independent risk factor for congestive heart failure (CHF), even in the absence of preexisting heart disease, hypertension or diabetes,...
A "hybrid" approach consisting of percutaneous revascularization followed by valve surgery is effective in patients with complex coronary artery and valve...
Compared with ventricular pacing, dual-chamber pacing is cost- effective for sinus node dysfunction, according to a report in the January 18, 2005 issue of...
Use of clozapine and olanzapine is associated with a significantly higher risk of developing insulin resistance than is use of risperidone, according to the...
In patients who undergo coronary artery stenting, diabetes has a greater impact on major adverse cardiac events in women than in men, physicians in Germany...
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In a new study, a 12-week lifestyle intervention helped an ethnically diverse group of adults with hypertension, hyperlipidemia, and hyperglycemia reach their...
A paclitaxel-eluting stent made by Boston Scientific and a sirolimus- eluting stent made by Cordis Corp. appear to equally effective in patients undergoing...
Clinicians rarely discuss deactivating implantable cardioverter defibrillators (ICDs) with their patients, and when they do, it is less planned and more likely...
The combination of low HDL cholesterol and high triglycerides is associated with coronary artery disease (CAD) in patients with type 2 diabetes, according to a...
Treatment with beta-lactam antibiotics protects neurons from injury in vitro and improves motor function and survival in animal model of amyotrophic lateral...
Patients who have undergone successful deep brain stimulation (DBS) as treatment for movement disorders appear to be at increased risk of suicide, Swiss...
In selected cardiac patients, stress testing can be performed safely in the first 2 to 3 days after admission for unstable angina or non- ST elevation...
The results of a study published in the January issue of Diabetes Care suggest that periodontal disease is strongly predictive of mortality from ischemic heart...
Regardless of cardiovascular risk, losartan-based therapy is better than conventional therapy with atenolol at preventing strokes in hypertensive patients with...
The combination of low HDL cholesterol and high triglycerides is associated with coronary artery disease (CAD) in patients with type 2 diabetes, according to a...
The results of new study confirm ties between migraine and other headaches, especially with aura, and chest pain but not coronary heart disease (CHD). Dr....