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Date: Mon, 6 Jul 2009 12:56:43 -0700 (PDT)
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From: Gabriela DeVelbiss <gabrieladevelbiss@...>
Subject: Autism May Be Linked to Mom's Autoimmune Disease
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http://www.forbes.com/feeds/hscout/2009/07/06/hscout628750.html
=A0
Possible causes of disorder should now include celiac disease, study sugges=
ts
MONDAY, July 6 (HealthDay News) -- Children of mothers who have autoimmune =
diseases such as type 1 diabetes, rheumatoid arthritis and celiac disease h=
ave up to a three times greater risk for autism, a new study finds.=20
Although the association between autism and a maternal history of type 1 di=
abetes and rheumatoid arthritis had been found in earlier research, the res=
earchers behind the new study say that theirs is the first to find a link b=
etween autism and celiac disease. People with celiac disease cannot tolerat=
e gluten, a protein in wheat, rye and barley.
"This finding reinforces the suggestion that autoimmune processes are conne=
cted somehow with the cause of autism and autism spectrum disorder," said r=
esearcher William W. Eaton, chairman of the Department of Mental Health at =
the Bloomberg School of Public Health at Johns Hopkins University. "This fi=
nding is on the pathway of finding the cause of autism."
Eaton noted that there is no clinical significance to the finding but that =
it could guide future research as scientists try to pin down the cause or c=
auses of autism.
One reason autoimmune diseases might have a role in autism is genetic, Eato=
n said. Children who are born underweight or premature are at higher risk f=
or autism, and both of these obstetric problems are associated with celiac =
disease, he added.
"There may be an overlap in the genetics of some of the autoimmune diseases=
and autism that would not be trivial," he said. "Autism is strongly inheri=
ted, but we don't have the faintest idea where. But this may point a flashl=
ight to areas of the genome that connect to autism."
In addition, there might also be environmental triggers that affect the fet=
us, he said.
The report is published in the July 6 online edition of Pediatrics.
For the study, Eaton's team collected data on 3,325 Danish children diagnos=
ed with autism spectrum disorder, including 1,089 diagnosed with infantile =
autism. The children were born between 1993 and 2004, and their data was pa=
rt of the Danish National Psychiatric Registry. Data on family members with=
autoimmune diseases came from the Danish National Hospital Register.
The researchers found that children whose mothers had autoimmune disease we=
re at a higher risk of developing autism spectrum disorder than children of=
mothers who did not have these conditions. In addition, the risk of infant=
ile autism was increased in children with a family history of type 1 diabet=
es.
The increased risk that autoimmune diseases contribute to autism is not hug=
e, Eaton said.
"The increased risk for type 1 diabetes is a little less than two times, fo=
r rheumatoid arthritis it's about 1.5 times and for celiac disease it's mor=
e than three times," Eaton said. "That's enough to impress an epidemiologis=
t, but not enough to make anybody in the general population start changing =
their behavior."
Dr. Hjordis O. Atladottir, from the Institute of Public Health at the Unive=
rsity of Aarhus in Denmark and the study's lead researcher, said that the f=
indings are important because they support the theory that autism is someho=
w associated with disturbances in the immune system.
"It is important to emphasize that these results should not cause worry or =
be unsettling for parents or future parents with any of the above-mentioned=
diseases," Atladottir said. "The large majority of people affected by an a=
utoimmune disease do not have children with autism."
Autism expert Dr. Jeffrey Brosco, a professor of clinical pediatrics at the=
University of Miami Miller School of Medicine, said the study reinforces t=
he association between autism and a mother's autoimmune disease or, in the =
cases of type 1 diabetes, a mother's or father's condition.
"This study confirms that we still don't know what's going on in autism but=
suggests there is something interesting about autoimmune diseases in paren=
ts of children with autism," Brosco said.
Though there seems to be a connection between autism and some parental auto=
immune diseases, he said, the mechanism of that interaction is not known. I=
t could be associated with the diseases themselves, it could be that the ge=
nes associated with autoimmune diseases and autism are located near each ot=
her or it could be that an autoimmune disease changes the quality of a preg=
nancy, which results in circumstances that increase the risk for autism, Br=
osco explained.
"These findings are not going to change anything anyone does," Brosco said.=
"You are not going to treat any patients differently. There is no strong e=
vidence for changing clinical practice, but it does help scientists who are=
interested in autism understand what are the next questions to ask."
Geraldine Dawson, chief science officer for Autism Speaks, said that eviden=
ce is increasing that the immune system might have a role in autism.
"One of the things we are realizing about autism is that it is not one dise=
ase but rather many different diseases or conditions that has many differen=
t etiologies," Dawson said. "This may be one cause or one risk factor, and =
if it interacts with a genetic vulnerability, it can increase the risk for =
autism," she said.
More information=20
The U.S. National Institute of Child Health and Human Development has more =
on autism.
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Love, Gabby. :0)
http://stemcellforautism.blogspot.com/
=A0
"I know of nobody who is purely Autistic or purely neurotypical. Even God h=
ad some Autistic moments, which is why the planets all spin." ~ Jerry Newpo=
rt=20
=A0
=A0
=20=20=20=20=20=20
--0-249527909-1246910203=:96167
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<table cellspacing=3D"0" cellpadding=3D"0" border=3D"0" ><tr><td valign=3D"=
top" style=3D"font: inherit;"><DIV><A href=3D"http://www.forbes.com/feeds/h=
scout/2009/07/06/hscout628750.html"><FONT size=3D3>http://www.forbes.com/fe=
eds/hscout/2009/07/06/hscout628750.html</FONT></A></DIV>
<DIV><FONT size=3D3></FONT> </DIV>
<H1><FONT size=3D3>Possible causes of disorder should now include celiac di=
sease, study suggests</FONT></H1>
<SCRIPT src=3D"http://images.forbes.com/scripts/jquery/jquery.js" type=3Dte=
xt/javascript></SCRIPT>
<SCRIPT src=3D"http://images.forbes.com/scripts/jquery/jquery.dimensions.js=
" type=3Dtext/javascript></SCRIPT>
<SCRIPT src=3D"http://images.forbes.com/scripts/jquery/ui.core.js" type=3Dt=
ext/javascript></SCRIPT>
<SCRIPT src=3D"http://images.forbes.com/scripts/jquery/ui/ui.tabs.js" type=
=3Dtext/javascript></SCRIPT>
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ext/javascript></SCRIPT>
<DIV class=3Dlingo_region id=3Dlingo_span><BR>
<DIV><FONT size=3D3>MONDAY, July 6 (HealthDay News) -- Children of mothers =
who have autoimmune diseases such as type 1 diabetes, rheumatoid arthritis =
and celiac disease have up to a three times greater risk for autism, a new =
study finds. </FONT>
<DIV><FONT size=3D3>Although the association between autism and a maternal =
history of type 1 diabetes and rheumatoid arthritis had been found in earli=
er research, the researchers behind the new study say that theirs is the fi=
rst to find a link between autism and celiac disease. People with celiac di=
sease cannot tolerate gluten, a protein in wheat, rye and barley.</FONT></D=
IV>
<DIV><FONT size=3D3>"This finding reinforces the suggestion that autoimmune=
processes are connected somehow with the cause of autism and autism spectr=
um disorder," said researcher William W. Eaton, chairman of the Department =
of Mental Health at the Bloomberg School of Public Health at </FONT><A styl=
e=3D"DISPLAY: inline; FONT-WEIGHT: 400; FONT-SIZE: 14px; CURSOR: pointer; C=
OLOR: #003399; BORDER-BOTTOM: 1px dotted; FONT-STYLE: normal; FONT-FAMILY: =
Arial,Helvetica,sans-serif; TEXT-DECORATION: none" href=3D"http://topics.fo=
rbes.com/Johns%20Hopkins%20University" rel=3Dnofollow _old_href=3D"http%3A%=
2F%2Ftopics.forbes.com%2FJohns%2520Hopkins%2520University"><FONT size=3D3>J=
ohns Hopkins University</FONT></A><FONT size=3D3>. "This finding is on the =
pathway of finding the cause of autism."</FONT></DIV>
<DIV><FONT size=3D3>Eaton noted that there is no clinical significance to t=
he finding but that it could guide future research as scientists try to pin=
down the cause or causes of autism.</FONT></DIV>
<DIV><FONT size=3D3>One reason autoimmune diseases might have a role in aut=
ism is genetic, Eaton said. Children who are born underweight or premature =
are at higher risk for autism, and both of these obstetric problems are ass=
ociated with celiac disease, he added.</FONT></DIV>
<DIV><FONT size=3D3>"There may be an overlap in the genetics of some of the=
autoimmune diseases and autism that would not be trivial," he said. "Autis=
m is strongly inherited, but we don't have the faintest idea where. But thi=
s may point a flashlight to areas of the genome that connect to autism."</F=
ONT></DIV>
<DIV><FONT size=3D3>In addition, there might also be environmental triggers=
that affect the fetus, he said.</FONT></DIV>
<DIV><FONT size=3D3>The report is published in the July 6 online edition of=
<I>Pediatrics</I>.</FONT></DIV>
<DIV><FONT size=3D3>For the study, Eaton's team collected data on 3,325 Dan=
ish children diagnosed with autism spectrum disorder, including 1,089 diagn=
osed with infantile autism. The children were born between 1993 and 2004, a=
nd their data was part of the Danish National Psychiatric Registry. Data on=
family members with autoimmune diseases came from the Danish National Hosp=
ital Register.</FONT></DIV>
<DIV><FONT size=3D3>The researchers found that children whose mothers had a=
utoimmune disease were at a higher risk of developing autism spectrum disor=
der than children of mothers who did not have these conditions. In addition=
, the risk of infantile autism was increased in children with a family hist=
ory of type 1 diabetes.</FONT></DIV>
<DIV><FONT size=3D3>The increased risk that autoimmune diseases contribute =
to autism is not huge, Eaton said.</FONT></DIV>
<DIV><FONT size=3D3>"The increased risk for type 1 diabetes is a little les=
s than two times, for rheumatoid arthritis it's about 1.5 times and for cel=
iac disease it's more than three times," Eaton said. "That's enough to impr=
ess an epidemiologist, but not enough to make anybody in the general popula=
tion start changing their behavior."</FONT></DIV>
<DIV><FONT size=3D3>Dr. Hjordis O. Atladottir, from the Institute of Public=
Health at the </FONT><A style=3D"DISPLAY: inline; FONT-WEIGHT: 400; FONT-S=
IZE: 14px; CURSOR: pointer; COLOR: #003399; BORDER-BOTTOM: 1px dotted; FONT=
-STYLE: normal; FONT-FAMILY: Arial,Helvetica,sans-serif; TEXT-DECORATION: n=
one" href=3D"http://topics.forbes.com/University%20of%20Aarhus" rel=3Dnofol=
low _old_href=3D"http%3A%2F%2Ftopics.forbes.com%2FUniversity%2520of%2520Aar=
hus"><FONT size=3D3>University of Aarhus</FONT></A><FONT size=3D3> in Denma=
rk and the study's lead researcher, said that the findings are important be=
cause they support the theory that autism is somehow associated with distur=
bances in the immune system.</FONT></DIV>
<DIV><FONT size=3D3>"It is important to emphasize that these results should=
not cause worry or be unsettling for parents or future parents with any of=
the above-mentioned diseases," Atladottir said. "The large majority of peo=
ple affected by an autoimmune disease do not have children with autism."</F=
ONT></DIV>
<DIV><FONT size=3D3>Autism expert Dr. Jeffrey Brosco, a professor of clinic=
al pediatrics at the University of Miami Miller School of Medicine, said th=
e study reinforces the association between autism and a mother's autoimmune=
disease or, in the cases of type 1 diabetes, a mother's or father's condit=
ion.</FONT></DIV>
<DIV><FONT size=3D3>"This study confirms that we still don't know what's go=
ing on in autism but suggests there is something interesting about autoimmu=
ne diseases in parents of children with autism," Brosco said.</FONT></DIV>
<DIV><FONT size=3D3>Though there seems to be a connection between autism an=
d some parental autoimmune diseases, he said, the mechanism of that interac=
tion is not known. It could be associated with the diseases themselves, it =
could be that the genes associated with autoimmune diseases and autism are =
located near each other or it could be that an autoimmune disease changes t=
he quality of a pregnancy, which results in circumstances that increase the=
risk for autism, Brosco explained.</FONT></DIV>
<DIV><FONT size=3D3>"These findings are not going to change anything anyone=
does," Brosco said. "You are not going to treat any patients differently. =
There is no strong evidence for changing clinical practice, but it does hel=
p scientists who are interested in autism understand what are the next ques=
tions to ask."</FONT></DIV>
<DIV><FONT size=3D3>Geraldine Dawson, chief science officer for Autism Spea=
ks, said that evidence is increasing that the immune system might have a ro=
le in autism.</FONT></DIV>
<DIV><FONT size=3D3>"One of the things we are realizing about autism is tha=
t it is not one disease but rather many different diseases or conditions th=
at has many different etiologies," Dawson said. "This may be one cause or o=
ne risk factor, and if it interacts with a genetic vulnerability, it can in=
crease the risk for autism," she said.</FONT></DIV>
<DIV><FONT size=3D3><B>More information</B> </FONT></DIV>
<DIV><FONT size=3D3>The U.S. National Institute of Child Health and Human D=
evelopment has more on </FONT><A href=3D"http://www.nichd.nih.gov/health/to=
pics/asd.cfm" target=3D_new><FONT color=3D#003399 size=3D3>autism</FONT></A=
><FONT size=3D3>.</FONT></DIV>
<DIV></DIV>
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<DIV><FONT face=3D"comic sans ms" size=3D3>Love, Gabby. :<STRONG><FONT colo=
r=3D#ff0000>0</FONT></STRONG><EM>)</EM></FONT></DIV>
<DIV><A href=3D"http://stemcellforautism.blogspot.com/" target=3D_blank rel=
=3Dnofollow><SPAN class=3Dyshortcuts id=3Dlw_1213563087_0><FONT face=3D"com=
ic sans ms" color=3D#007f40 size=3D3><STRONG>http://stemcellforautism.blogs=
pot.com/</STRONG></FONT></SPAN></A></DIV>
<DIV> </DIV>
<DIV><FONT size=3D3><FONT color=3D#7792ac><FONT face=3D"comic sans ms"><SPA=
N style=3D"FONT-WEIGHT: bold; FONT-STYLE: italic">"I know of nobody who is =
purely Autistic or purely neurotypical. Even God had some Autistic moments,=
which is why the planets all spin." </SPAN><SPAN style=3D"FONT-STYLE: ital=
ic">~ Jerry Newport</SPAN></FONT></FONT></FONT> </DIV>
<DIV> </DIV>
<DIV><FONT face=3D"Lucida Sans Typewriter"></FONT> </DIV></td></tr></t=
able><br>
=20=20=20=20=20=20
--0-249527909-1246910203=:96167--
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Gabriela DeVelbiss <gabrieladevelbiss@...>
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