well ive been busy the last few weeks moving into my brand new house...i never
thought i would get such a good deal until i found
http://nextplacetobe.info/jcqt .  they refied my old house  and gave        me
the money to buy another one

The Mitochondrial Disease Action Committee (MitoAction) is developing an
exciting new way to help mito families. Do you have any therapeutic or
adaptive equipment/toys that you no longer need or use? We would like to
create an inventory to post on www.mitoaction.org
<http://www.mitoaction.org/>  so that families can swap special needs
equipment. MitoAction will even pay for shipping if families need
assistance.

To get this project started, please email Millie Rodriguez
(nena1294@...
<http://us.f371.mail.yahoo.com/ym/Compose?To=nena1294@aol.com>  ) with a
description of your item(s), your state/town, and phone/email contact
info. We hope to have the list up on the web by March so please email
her ASAP!

Don't forget items like highchairs, bathseats, AFOs, augmentive
communication tools, swings, etc., in addition to durable medical
equipment like wheelchairs, walkers, etc.

Please Note: Mitochondrial Diseases are often mistaken for atypical
forms of conditions, including autism, autonomic dysfunction, cerebral
palsy, diabetes, fibromyalgia/CFS, seizure/stroke disorders, SIDS, and
gastrointestinal dysfunction, in babies, children and adults of all
ages.  For more information, go to www.mitoaction.org
<http://www.mitoaction.org/>  .

Suz MitoAction www.mitoaction.org <http://www.mitoaction.org/>  The
Mitochondrial Disease Action Committee

Get energized!



[Non-text portions of this message have been removed]

hey! check this out.. http://nestoverhere.info/yvjv ..basically it's saved me a
ton of money, you're placed up for auction       and financers outbid each other
on   getting you a better deal on your current home and repayments

Just got my BS and i wasnt even required to turn up! Just called these people
1 801 697-0461, filled out a few forms and a bit of paperwork and was accredited
within 3 weeks at an internationally recognised Uni! How good is that!

There is website about test for gluten intolerance. It is written that
people with GERD should have it done because they may have intolerance
or even celiac disease.
I was tested on celiac disease during first endo but it was negative.
Probably it did not developed yet or test was wrong. Because my ALCAT
test showed intolerance to gliadin (part of gluten) I may have it now.
If somebody was tested for celiac too?
www.Enterolab.com

Radio "waves" of death

It's been a while since I wrote about excessive water consumption.

If you've been a reader of mine for any length of time at all, you
know how I feel about the modern water craze. I think it's a
borderline-evil racket designed to do nothing more than sell over-
priced bottled water to naïve imbeciles.

It's the ultimate triumph of marketing over sense - almost free
water that you PAY to drink in needless, absurd quantities...

Don't believe me? Consider this: The H20 craze got started back in
the 1980s with a brand of water called Evian, remember?

Now think about it for a minute: What's "Evian" backward? Yep,
naïve.

So, why am I talking about water today, you're asking? Because once
again, excess water consumption is in the news - with deadly
results. Like the time I reported on the runners who routinely
suffer the sickening and deadly effects of too much short-term water
intake at races...

Or like the time I reported on the fraternity pledge who died from
drinking too much water as part of a fraternity hazing ritual...

Now I have the distinct displeasure (and disgust) of having to
report that yet another innocent, misguided person has been killed
by water intoxication. And all because of the mainstream's naiveté -
because of the notion that water is harmless. It isn't. People drown
in it. On dry land.

This latest victim was a contestant in a radio-show game. The point
of the game was to see how much water entrants could drink rapidly
before they went to the bathroom. The prize: A video game system.

According to the Associated Press and other sources, a 28-year-old
mother of three entered the contest - held at KNDN radio in
Sacramento, California - to win the coveted new-generation Nintendo
game for her kids. She didn't win.

And all she lost was her life. Keep reading...

****************************************************

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Would you believe that an extract from eggplant could cure -- that's
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cancers...usually in three months or less? This may seem like an
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results for over 20 years!

Keep reading to find out how a true cancer cure with a 100% success
rate - 80,000 success stories and a 26 year track record -- could
get COVERED UP?

http://www1.youreletters.com/t/483504/12608487/814704/59/

****************************************************
To start receiving your own copy of the Daily Dose, visit:
http://www.douglassreport.com/dailydose/freecopy.html Or forward
this e-mail to a friend so they can sign-up to receive their own
copy of the Daily Dose.
****************************************************

The last person to speak to the poor woman was one of the radio
station's staffers. She'd called the station on her way home, crying
and complaining of a massive headache...

Some hours later, she was found dead in her home.

The coroner's office that handled the case said that preliminary
indications were that the woman died of water intoxication. Later
investigations confirmed this finding.

As tragic as it is that this woman died of water over-consumption in
a quest for something that was only destined to rot her kids'
brains, what's even more tragic about her death is this: The woman
worked in a radiologist's office.

That means she probably had a medical background or education of
some kind - and that she probably thought she knew about the risks
of excessive consumption of everything under the sun (except
prescription drugs, of course): Alcohol, animal fats, tobacco
products...

Everything that's supposed to be bad for you, but isn't.

And what happens? She dies from consuming what everything thinks is
not only harmless, but HEALTHY.

Just to be crystal clear on the matter, there's not a shred of
scientific evidence I've ever seen that supports the notion that we
should drink any more water than what we have an occasional desire
to sip. Our bodies tell us when we need water...

Unfortunately, they don't tell us when we've had too much.

Never playing "games" about water's perils,

William Campbell Douglass II, M.D.

damn! these guys just fixed up my current house loan, consolidated all the old
ones, and im saving 600 bucks a month!! http://moveonover.info/gubl

THis thing is amazing, just graduated without even turning up   a single day.
Now
fully qualified in a BA and looking  to apply for a raise! I'll keep you guys
posted, but if      any of u interested in getting a BA or something as well
without having to actually go through  all the leg work i highly recommend these
ppl 801 697-0461

I am now to be referred      to as Dr. Jenkins haha ;) Took me about a month to
get
fully accredited, but after ringing these ppl 1-801 697 0461 they got me setup
at
an international uni and had me my BA in no time.

This four step guide will give you the foundation you always wanted. Learning
the basics in handling stocks.

  This guide will help anyone, interested in getting into the stocks game. Once
you follow through the guide, you will understand it's no rocket science. Only
thing is nobody ever try to explain it you from A to Z. Start now, just have a
look,

http://www.myjobhome.com/amex/

Step 1 - Basics
http://www.myjobhome.com/amex/Ameritrade-part1.htm

Step 2 - Initial Public Offerings
http://www.myjobhome.com/amex/Ameritrade-Part2.htm

Step 3 - Stock Market Players
http://www.myjobhome.com/amex/Ameritrade-Part3.htm

Step 4 - The Life of a Trade
http://www.myjobhome.com/amex/Ameritrade-Part4.htm





______________________________________________________________

If you think this email is spam
UNSUBSCRIBE - Please forward this email to deactivatenow@...

I have reached my Encyclopedia of Natural Medicine and red many
interesting things:

Decreased motility usually results from meal that is high in sugar.
When blood sugar level rises too rapidly a signal is sent to the
intestinal tract to slow down. Duodenum and jejunum become a topic
and stop to move chime through intestines via peristalsis.

For people who would like to try gastric acid supplementation there
is advice: Begin with taking one pill ( 10 grains or 600 mg) of
hydrochloric acid at the next large meal. If this not aggravate your
symptoms take one more pill at every next meal. When you reach 7
pill or when you will feel a warmth in your stomach. It is mean that
you should reduce your supplementation to one pill. Take less with
smaller meal. Later stomach will start to produce HCI itself and you
will feel warmth again. Cut down pills again.

In another book Alternative Cure I red that we can check stomach
acid by squeezing half of lemon into cup of warm water and drink it
with meal. If it improve digestion it `s sign that  you have an acid
deficiency. In this case take betaine hydrochloride before eating
from 300 mg and later you can increase dose. If you have burning
drink 12-16 ounces of water or water with baking soda to stop it.

Natural supplement MSM ( methylsulfonylmethane) strengthen the
lining of esophagus and protect from acid. Take 1-3 pills twice a
day with meals as long as you need it.

Surprisingly calcium is not problem with kidney stones. It is
binding the oxalate in the body which the reason for stones. You can
get calcium from many food like fish, and seafood, kelp, collard,
turnip greens, broccoli, cabbage, carrots, parsley, watercress,
romaine lettuce, summer squash, onions, pistachios, sesame seeds and
butter, out, buckwheat and brown rice as well as tofu, white beans,
pinto beans, chickpeas, dried figs. From supplements the best is
calcium chelated with magnesium up to 1000- 1500 mg a day but do not
use calcium lactate if you are sensitive to milk. It is good to take
magnesium and vitamin D and B 6 to reduce stones.

Vitamin C is recommended up to 1000 mg with meal in form of ascorbic
acid or any  other ascorbate form. It is good to take magnesium and
vitamin D and B 6 to reduce stones.

This four step guide will give you the foundation you always wanted. Learning
the basics in handling stocks.

  This guide will help anyone, interested in getting into the stocks game. Once
you follow through the guide, you will understand it's no rocket science. Only
thing is nobody ever try to explain it you from A to Z. Start now, just have a
look,

http://www.myjobhome.com/amex/

Step 1 - Basics
http://www.myjobhome.com/amex/Ameritrade-part1.htm

Step 2 - Initial Public Offerings
http://www.myjobhome.com/amex/Ameritrade-Part2.htm

Step 3 - Stock Market Players
http://www.myjobhome.com/amex/Ameritrade-Part3.htm

Step 4 - The Life of a Trade
http://www.myjobhome.com/amex/Ameritrade-Part4.htm





______________________________________________________________

If you think this email is spam
UNSUBSCRIBE - Please forward this email to deactivatenow@...

Hello, friends -- Some wonderful news to share with you today!!  As you
know, Cristy Balcells (RN MSN) has become MitoAction's new Executive
Director (please see her message to you below).  Already she has taken
us by storm, bringing us proactive changes, powerful programs, and a
desire to reach out to you all so that we can better help you and your
loved ones.  For this reason, she would like to meet you in person, on
Monday, January 22, at 1 PM in the Tufts-NEMC 3rd Floor Atrium.
Directions follow below after Cristy's message.

Please rest assured that we will plan one or two Meet and Greets via
conference call very soon, so that those of you in other parts of the
world can have a chance to chat informally with her.  We look forward to
meeting you either way!

Mitochondrial disorders are often mistaken for atypical forms of
diseases, such as autism, cerebral palsy, diabetes, fibromyalgia,
seizures, and gastrointestinal dysfunction, to name a few, in babies,
children and adults.  For more information about "Mito", please go to
www.mitoaction.org <http://www.mitoaction.org/>  .  Suz

Message from Cristy Balcells RN MSN

I wanted to take a moment to introduce myself as the new Executive
Director of MitoAction, the national Mitochondrial Disease Action
Committee ( www.mitoaction.org). I am so excited to be involved
with this wonderful non-profit group that was started by patients
and parents like you, as well as doctors and nurse practitioners who
all want to improve the daily quality of life for people affected by
mitochondrial disease.

I am a mom of three young children, including Eva who has Leigh's
disease. I earned a Master's in Community and Public Health Nursing
from the University of Virginia in 2002 and subsequently created a
community-based education program for new parents and their babies.
This program, "BabySense", has won a national nursing program award
and has been implemented in several community hospitals in the
Southeast. As my personal and professional interests evolved into
serving pediatric special needs populations and their families, I
began to develop program proposals for groups such as the
Mitochondrial Disease Action Committee as a way to reach and
serve this under-recognized medical population. I was thrilled to
accept the Executive Director position with MitoAction in November
of 2006, because I believe that through education, awareness and
advocacy, this growing non-profit organization can have a tremendous
impact on the quality of life for patients and families living with
mitochondrial disease. If you ever have a need for support or
questions/suggestions, please feel free to contact me at
director@... <mailto:director@...>  .

Looking forward to getting to know some of you better,
Cristy
--
Cristy Balcells RN MSN, Exec Director
Mitochondrial Disease Action Committee
www.mitoaction.org
"Get Energized!"

Directions to Tufts-NEMC :

Tufts-New England Medical Center is located in downtown Boston, next to
Chinatown and the Theater District and within walking distance of the
Boston Common, Downtown Crossing, and many hotels and restaurants.


The main entrance to Tufts-New England Medical Center for patients and
visitors is located at 800 Washington Street. This entrance has
connections to all other inpatient and outpatient buildings.


Parking is available in the Medical Center's garage at 274 Tremont
Street, next to the Wang Center. Parking tickets can be validated for
reduced parking rates.



For more info on driving directions go to www.tufts-nemc.org
<http://www.tufts-nemc.org/>



[Non-text portions of this message have been removed]

As I recall when I was on the Aciphex for a while, I started to have
the so-called panic attacks. I started to take the B vitamin-like
nutrient known as inositol in large multigram doses. I to this
day buy it in bulk powder and take in the form a heaping
teaspoonful as a preventative and if I feel like a panic
attack is near I take a heaping tablespoonful. For me it
is very very effective and no side effects. I dump the powder in
milk or juice or water it is sweet like sugar.

Thanks on the comments on the meds, I should take a hard look
at the mechanisms of the common medicines.

Dyspepsia leads to belching aka reflux and reflux can
cause heartburn. The reflux only has to be below 4.0
to cause trouble and that isn't very acidic at all.
And the reflux can be alkaline and/or bile loaded and
cause problems, also. The newest pH monitor checks the
pH in both directions below 4.0 and above 7.0 in the
esophageal lumen.

It was the dyspepsia the betaine HCL helped relieve.
I had gotten the inflammation under-control with the
PPI meds but the adverse effect from the meds had
gotten to be way bad. And I was sleeping on an incline.
I built myself adjustable tilt bed, I gave away my innerspring
mattress to the Good Will people as on an incline it hurt
my back, I got a foam mattress (really I just got a thick
sheet of soft deep foam), and
I started taking betaine HCL with one meal a day.
And I've pretty good ever since, true, there are things
that can tip the scales against me but I've learned
to pay attention and back off i.e. citrus and tomato
products. I still avoid coffee, chocolate, and like
things as well as really hard harsh foods. I eat
a high fiber, fruit and veggie rich diet with yogurt
and some meat. And I eat raw nuts.

I only know what helped me and I not sure it
will help others as people are different on
medical/biological level. Of course you know that.

Thanks .....and Get Well


--- In gerdrefluxdisease@yahoogroups.com, "imsinfo" <imsinfo@...>
wrote:
>
> I am agree that neurotransmitters and hormones played major part in
> GERD because why would Reglan helped to me at least in the past. It
> is connected to serotonin which is hormone to move gut in generally.
> Zelnorm for IBS work throught dopamine hormone and Motillium is
> connected to transmitters.
> Did you try to reduce anxiety with some medicine to reduce fear? Did
> you tried diet for that. Vata type diet is good for nerves but it is
> difficult to combine it with low-acid diet.
> I do not have fear now but in the past I have strong stress and it
> seems it is still effect me despite meditation and right life style.
> As far as I know TM meditation increase serotonin level. I am afrain
> taking hormones because the result could be bad given my hormone
> sensitivity or even allergy.
> I regard of acidity: I was taking Meralax – constipation treatment-
> for 2 days only and my acidity increased that I was afraid to llay
> down at night because of pain and belching. It is happen to be
> Propylen Glycol which increase lactose acid. Again I had to
> discontinue  it as many other meds and herbs.
> Is that mean that my symptoms are from high acidity not from
> dispepsia?Probably I do not need PH level exam because it is clearly
> high?
> Lazzat
>

I am agree that neurotransmitters and hormones played major part in
GERD because why would Reglan helped to me at least in the past. It
is connected to serotonin which is hormone to move gut in generally.
Zelnorm for IBS work throught dopamine hormone and Motillium is
connected to transmitters.
Did you try to reduce anxiety with some medicine to reduce fear? Did
you tried diet for that. Vata type diet is good for nerves but it is
difficult to combine it with low-acid diet.
I do not have fear now but in the past I have strong stress and it
seems it is still effect me despite meditation and right life style.
As far as I know TM meditation increase serotonin level. I am afrain
taking hormones because the result could be bad given my hormone
sensitivity or even allergy.
I regard of acidity: I was taking Meralax – constipation treatment-
for 2 days only and my acidity increased that I was afraid to llay
down at night because of pain and belching. It is happen to be
Propylen Glycol which increase lactose acid. Again I had to
discontinue  it as many other meds and herbs.
Is that mean that my symptoms are from high acidity not from
dispepsia?Probably I do not need PH level exam because it is clearly
high?
Lazzat

Am I "serious" you ask?  My response is that which I wrote is logical
to me. I am "serious" in that I am taking on regular or intermittent
basis  taking a number of chemicals/drugs/supplements/nutrients I
mention. Am I certain that all the things I do help with GERD? The
answer is No but often I see other possible benefits. What I do has
little downside FOR ME in comparison to suboptimal and toxic protocols
of standard medical care, IMO. The standard meds came have a nasty
sets of adverse effects and provided only partial relief for this
individual during the intervals of usuage.
More of my comments are sandwiched in between  the abstracts included
below. The abstracts are examples of the type of literature that is
suggestive to me of the concepts I suggest to be relevant.
Note the mechanism of action in the following.
----------------------------------------------------------------------

1: Scand J Gastroenterol. 2004 Jun;39(6):521-6.
Effect of sodium valproate on esophageal motility in healthy subjects
and patients with gastroesophageal reflux.
Tzovaras G, Tsiaoussis J, Athanasakis E, Zoras O, Xynos E, Chrysos E.
Laboratory of Gastrointestinal Motility, Dept. of General Surgery,
University Hospital of Heraklion, Crete, Greece.

BACKGROUND: There is experimental evidence to show that upper
gastrointestinal tract motility is influenced by a GABAergic
mechanism. Sodium valproate acts as a GABA agonist, and has been
proven to affect the human internal anal sphincter. The aim of this
study was to evaluate any possible effect of sodium valproate on
esophageal motility in healthy subjects and patients with
gastroesophageal reflux disease (GERD).

METHODS: Ten healthy volunteers (4 M, 6 F; age range: 20-61 years) and
12 patients (4 M, 8 F; age range: 25-70 years) with GERD were included
in the study. Standard esophageal manometry and ambulatory 24-h
esophageal pH monitoring were performed before and 5 days after oral
administration of sodium valproate (400 mg four times per day). Main
measurements included a) lower esophageal sphincter (LES) resting
pressure and amplitude and duration of peristalsis at 5, 10 and 15 cm
proximal to LES, and b) percentage of time with esophageal pH <4 and
number of reflux episodes.

RESULTS: Sodium valproate (i) significantly increased LES resting
pressure in both groups (P<0.05), without affecting either the LES
postdeglutition relaxation or any of the parameters of the esophageal
peristaltic activity, (ii) significantly reduced the number of reflux
episodes at the postprandial period in both healthy subjects (P=0.02)
and reflux patients without hiatal hernia (P=0.04) and (iii) the time
percentage with esophageal pH <4 at the postprandial period in reflux
patients (P=0.01).
CONCLUSIONS: Sodium valproate increases normal and reduced tonic
activity of the human LES and reduces the number of reflux episodes in
health and GERD. This action could be attributed to a central
GABAergic mechanism.
PMID: 15223674 [PubMed - indexed for MEDLINE]
-----------------------------------------------------------
GABA is a neurotransmitter that exerts influence of both the CNS and
PNS. It has complex interactions with many other hormones. And clearly
GABA improves the tone of the LES.
-----------------------------------------------------------
1: Am J Gastroenterol. 2003 Oct;98(10):2139-45.
Belching: dyspepsia or gastroesophageal reflux disease?
Lin M, Triadafilopoulos G. Gastroenterology Section, Veterans Affairs
Medical Center Palo Alto, and Division of Gastroenterology and
Hepatology, Stanford University, Stanford, California 94304, USA.

OBJECTIVES: Eructation (belching) is a common symptom seen in clinical
practice. Because either belching or heartburn may result from
transient lower esophageal sphincter relaxations, it has been proposed
that belching may be a manifestation of gastroesophageal reflux
disease (GERD). In this retrospective study we evaluated the
prevalence of belching in dyspepsia and GERD and the relation of
belching to acid reflux events documented by pH monitoring.

METHODS: We examined the prevalence, frequency, and severity of
belching and other GERD symptoms by use of standardized questionnaires
in 180 GERD patients (group A) and 78 dyspeptic controls (group B)
referred for evaluation at our institution. GERD was defined as either
endoscopic esophagitis (or Barrett's esophagus) or positive DeMeester
score (>14.2) on pH monitoring or both. Dyspeptic patients had normal
endoscopy and pH studies. We also analyzed the relationship of
belching to acid reflux events during the 24-h period of pH studies.

RESULTS: Of 180 GERD patients, 132 (70%) reported belching during pH
monitoring, versus 63 of 78 dyspeptic patients (80%) (p = ns).
Similarly, 163 of 180 GERD patients (90%) reported heartburn versus 64
of 78 of dyspeptic patients (82%) (p = ns). Review of symptom
questionnaires revealed no significant difference in belching severity
between groups. However, heartburn and acid regurgitation were
significantly more severe among GERD patients. There was a
significantly higher correlation of both heartburn and belching with
acid events in patients with GERD compared with patients with
dyspepsia. In addition, although both belching and heartburn were
significantly improved in patients with GERD, belching scores remained
unchanged after proton pump inhibitor (PPI) therapy in patients with
dyspepsia.

CONCLUSIONS: Belching is as common and as severe in patients with
dyspepsia as it is in patients with GERD. Belching and heartburn in
GERD patients are more likely correlated with episodes of pathological
acid reflux. Because belching cannot be clinically used as a
discriminatory symptom, ambulatory pH monitoring should be considered
to elucidate the relationship of belching to acid reflux in patients
with dyspepsia or GERD.
PMID: 14572558 [PubMed - indexed for MEDLINE]++++1:

Am J Gastroenterol. 2003 Oct;98(10):2139-45.
Belching: dyspepsia or gastroesophageal reflux disease?

Lin M, Triadafilopoulos G. Gastroenterology Section, Veterans Affairs
Medical Center Palo Alto, and Division of Gastroenterology and
Hepatology, Stanford University, Stanford, California 94304, USA.

OBJECTIVES: Eructation (belching) is a common symptom seen in clinical
practice. Because either belching or heartburn may result from
transient lower esophageal sphincter relaxations, it has been proposed
that belching may be a manifestation of gastroesophageal reflux
disease (GERD). In this retrospective study we evaluated the
prevalence of belching in dyspepsia and GERD and the relation of
belching to acid reflux events documented by pH monitoring.

METHODS: We examined the prevalence, frequency, and severity of
belching and other GERD symptoms by use of standardized questionnaires
in 180 GERD patients (group A) and 78 dyspeptic controls (group B)
referred for evaluation at our institution. GERD was defined as either
endoscopic esophagitis (or Barrett's esophagus) or positive DeMeester
score (>14.2) on pH monitoring or both. Dyspeptic patients had normal
endoscopy and pH studies. We also analyzed the relationship of
belching to acid reflux events during the 24-h period of pH studies.

RESULTS: Of 180 GERD patients, 132 (70%) reported belching during pH
monitoring, versus 63 of 78 dyspeptic patients (80%) (p = ns).
Similarly, 163 of 180 GERD patients (90%) reported heartburn versus 64
of 78 of dyspeptic patients (82%) (p = ns). Review of symptom
questionnaires revealed no significant difference in belching severity
between groups. However, heartburn and acid regurgitation were
significantly more severe among GERD patients. There was a
significantly higher correlation of both heartburn and belching with
acid events in patients with GERD compared with patients with
dyspepsia. In addition, although both belching and heartburn were
significantly improved in patients with GERD, belching scores remained
unchanged after proton pump inhibitor (PPI) therapy in patients with
dyspepsia.

CONCLUSIONS: Belching is as common and as severe in patients with
dyspepsia as it is in patients with GERD. Belching and heartburn in
GERD patients are more likely correlated with episodes of pathological
acid reflux. Because belching cannot be clinically used as a
discriminatory symptom, ambulatory pH monitoring should be considered
to elucidate the relationship of belching to acid reflux in patients
with dyspepsia or GERD.
PMID: 14572558 [PubMed - indexed for MEDLINE]
--------------------------------------------------------
Belching was a problem for me until I began the use of betaine HCL. I
suspect betaine base may also have the same effect even though most in
alternative medicine providers focus use the betaine HCL for it acidic
properties. I've yet to experiment with this idea as I've only
recently purchase some betaine base also known as trimethylgylcine.
This is a chemical/nutrient found in high concentrations in beets.
And I have other reasons for using trimethylgylcine (in either form)
as it lowers homocysteine levels, should help stablize the genome, be
choline sparing, increases levels of SAMe, and reduce the toxicity of
high dose niacin and niacinamide. Understand for these the reasons I
list have evidence of various levels backing them. Is it enough? That
is a judgement call and a risk versus rewards question.
----------------------------------------------------
1: Gut. 2003 Apr;52(4):464-70.
Effect of acute and chronic administration of the GABA B agonist
baclofen on 24 hour pH metry and symptoms in control subjects and in
patients with gastro-oesophageal reflux disease.

Ciccaglione AF, Marzio L. University G d' Annunzio, Chieti-Pescara,
Italy.

  BACKGROUND AND AIMS: The gamma-aminobutyric acid (GABA(B)) agonist
baclofen has been shown to reduce reflux episodes during the first
three postprandial hours in patients with gastro-oesophageal reflux
disease (GORD) and in normal controls. The aim of the study was to
assess the effect of acute (one day) and chronic (four weeks)
administration of baclofen on 24 hour pH metry and symptoms in GORD
patients and normal controls.

PATIENTS AND METHODS: Acute study: 28 patients with GORD with none or
mild oesophagitis at endoscopy and 15 controls underwent oesophageal
and gastric 48 hour pH metry in which baclofen or placebo was given
for 24 hours in a double blinded manner. Chronic study: 16 GORD
patients received baclofen (10 mg four times daily) or placebo for
four weeks. Twenty four hour oesophageal pH metry and reflux symptom
scores were evaluated before and at the end of treatment.

RESULTS: Acute study: the number of reflux episodes and per cent time
with pH <4 was significantly lower after baclofen in GORD patients and
controls (p<0.003; p<0.0007). Gastric pH increased significantly in
GORD patients and controls (p<0.001; p<0.05). Chronic study: four
weeks after initial administration of baclofen, the number of reflux
episodes and percentage of time with pH <4 significantly decreased in
all GORD patients (p<0.003; p<0.02). Symptom scores significantly
improved after treatment with baclofen (p<0.0007).

CONCLUSIONS: The GABA(B) agonist baclofen reduces 24 hour gastro-
oesophageal reflux and increases gastric pH in GORD patients and
controls. When given for one month to GORD patients, baclofen reduces
oesophageal acid refluxes and significantly improves symptoms.
Baclofen may be useful in the therapy of GORD. PMID: 12631652 [PubMed
- indexed for MEDLINE]
------------------------------------------------------------
The issue for me is whether the use of the GABA agonist is simply
clumsy replacement for GABA. And perhaps direct use of GABA would
result in the same benefits minus the balcofen adverse effect profile.
An it is appropriate to recall at this point the melatonin potentiates
the actions of GABA. And further I'll ask you to recall that melatonin
is synthesized from the amino acid l-tryptophan which explains why the
AA has been used as a sleep aid in the past.
  ---------------------------------------------------------
: Aliment Pharmacol Ther. 2003 Oct 1;18(7):699-704.
Effect of non-selective gamma-aminobutyric acid receptor stimulation
on motor function of the lower oesophageal sphincter and gastro-
oesophageal reflux in healthy human subjects.
Cantu P, Carmagnola S, Savojardo D, Allocca M, Penagini R. Cattedra di
Gastroenterologia, Dipartimento di Scienze Mediche, University of
Milan, IRCCS Ospedale Maggiore, Milan, Italy.

BACKGROUND: Transient lower oesophageal sphincter relaxation and low
lower oesophageal sphincter pressure are the main mechanisms of
reflux. It has recently been shown that the stimulation of gamma-
aminobutyric acid type B (GABAB) receptors by baclofen decreases the
rate of transient lower oesophageal sphincter relaxation and increases
the lower oesophageal sphincter pressure in healthy humans. Valproic
acid increases synaptosomal GABA concentrations, thus affecting all
types of GABA receptors.

AIM: To evaluate the effect of valproic acid on transient lower
oesophageal sphincter relaxation, lower oesophageal sphincter pressure
and gastro-oesophageal reflux.

METHODS: Thirteen healthy subjects underwent 2-h post-prandial
oesophageal motility and pH monitoring on two separate occasions after
the oral administration of 1 g valproic acid or placebo.

RESULTS: Valproic acid increased the lower oesophageal sphincter
pressure by 41% (14.0 +/- 2.1 mmHg vs. 9.9 +/- 2.0 mmHg after placebo,
P<0.02), but did not affect the rate of transient lower oesophageal
sphincter relaxation (7.9 +/- 1.0/h vs. 8.2 +/- 0.9/h after placebo),
the number of reflux episodes or gastro-oesophageal reflux.

CONCLUSIONS: Non-selective GABA receptor stimulation may be beneficial
to reflux patients with low lower oesophageal sphincter pressure, but
exerts a different modulation of transient lower oesophageal sphincter
relaxation than the selective stimulation of GABAB receptors. PMID:
14510743 [PubMed - indexed for MEDLINE]

-----------------------------------------------------------
In the following paper. I don't believe the mechanism they used to
explain the effect as the primary force but I do credit the effect as
likely  being real. I believe the mechanism of action is in part
potentiatation of GABA by melatonin and possibly some actions from
betaine on bile production and GI tract hormones. I suspect other the
vitamins and AA are minor players in this formulation.
-----------------------------------------------------------
1: J Pineal Res. 2006 Oct;41(3):195-200.
Regression of gastroesophageal reflux disease symptoms using dietary
supplementation with melatonin, vitamins and aminoacids: comparison
with omeprazole.

Pereira Rde S. Depto. de Farmacia-Universidade Estadual da Paraiba, Av
das Baraunas, 351/Campus Universitario, Bodocongo/Campina Grande-PB-
Brazil-CEP 58109-753, Brazil. ricardodesouzapereira@...

The prevalence of gastroesophageal reflux disease (GERD) is
increasing. GERD is a chronic disease and its treatment is
problematic. It may present with various symptoms including heartburn,
regurgitation, dysphagia, coughing, hoarseness or chest pain. The aim
of this study was to investigate if a dietary supplementation
containing: melatonin, l-tryptophan, vitamin B6, folic acid, vitamin
B12, methionine and betaine would help patients with GERD, and to
compare the preparation with 20 mg omeprazole. Melatonin has known
inhibitory activities on gastric acid secretion and nitric oxide
biosynthesis. Nitric oxide has an important role in the transient
lower esophageal sphincter relaxation (TLESR), which is a major
mechanism of reflux in patients with GERD. Others biocompounds of the
formula display anti-inflammatory and analgesic effects. A single
blind randomized study was performed in which 176 patients underwent
treatment using the supplement cited above (group A) and 175 received
treatment of 20 mg omeprazole (group B). Symptoms were recorded in a
diary and changes in severity of symptoms noted. All patients of the
group A (100%) reported a complete regression of symptoms after 40
days of treatment. On the other hand, 115 subjects (65.7%) of the
omeprazole reported regression of symptoms in the same period. There
was statiscally significant difference between the groups (P < 0.05).
This formulation promotes regression of GERD symptoms with no
significant side effects.
PMID: 16948779 [PubMed - indexed for MEDLINE]
-------------------------------------------------------------
Of course, you can wait until current standard paradigm for the
treatment of GERD is left behind by the medical/pharmacy establishment
  ;-) ....... that will be a long wait.

You do what you do and I'll do what I do.  And always remember I sleep
on a incline steeper than commonly suggested and I credit that with
the larger share of my improvement.

Learn how to use Pubmed.

There maybe other avenues by which nutrients, neurotransmitters,
hormones and GERD are related. One posting can only hint
at the scope.

Before you do anything let your Doctor tell you not to.







--- In gerdrefluxdisease@yahoogroups.com, "nkliphuis" <skinty78@...>
wrote:
>
> --- In gerdrefluxdisease@yahoogroups.com, "betaine_hcl"
> <betaine_hcl@> wrote:
> > The fear and restless mind suggests a possible
> > neurotransmitter imbalance and I believe there
> > is evidence that a weak LES is the result of
> > some sort of neurotransmitter imbalance. Understand
> > this idea is beyond the scope of most Docs medical
> > understanding and is only a theory/hypothesis on
> > my part and perhaps a few advanced Docs and a few drug
> > companies egg heads.
>
> Are you serious? Where can I find more info about this? I have a lot
of
> problems with nerves so would like to read more about this.
>

There is info about new surgery for GERD in Europe

http://www.comcast.net/data/news/photoshow/html/news/416120.html
http://www.comcast.net/news/health/index.jsp?
cat=HEALTHWELLNESS&fn=/2006/06/18/416120.html

I had pain in my stomach similar to ulcels but on
endoscopy there is nothing in the stomach. It was
probably spasp or pain from acids there but now it is
gone. I do not think GERD it pre-existing for ulcels.
You should talk to high managers in the insurance
company if you really want to have endo done.They
mistaken very often and you should fight for your
rights. Ask them provide you any prooffs for such
statement.


--- nkliphuis <skinty78@...> wrote:

> I think I might have an ulcer. My insurance won't
> pay for an endoscopy
> because my GERD counts as a pre-existing condition.
> Do you think a
> doctor can make a diagnosis and give me medication
> without doing a
> (very costly) endoscopy?
>
>

I do not remember where I got this site but I red it few months ago
and I have done test and treatment for Candida but gave up because I
was not able to keep it for a long time. Now when I know exactly
that I have it from ALCAT I will try more hard.

Another idea hit me that I may have Candida Esophagitis which case
of my pain and difficulty of swallowing. If so I know the major
reason for my reflux too and I can manage it with doctor.

I would recommend everybody to read about simple test for candida
here and to find if you have it. After 4 days on diet I have flat
stomach and no gas. I use some supplement from these site and other
but I think diet is the most important. Keep in mind that I did not
have all the symptoms of candida and did not believed I have it. My
test was questanable too. So it is better to check with lab test
that relay on self-test.


Good luck!
http://yeastinfectionadvisor.com/yeastinfectionquestionnaire.html

There is info about Candida esophagitis

http://www.nlm.nih.gov/medlineplus/ency/article/000643.htm

--- In gerdrefluxdisease@yahoogroups.com, "betaine_hcl"
<betaine_hcl@...> wrote:
> The fear and restless mind suggests a possible
> neurotransmitter imbalance and I believe there
> is evidence that a weak LES is the result of
> some sort of neurotransmitter imbalance. Understand
> this idea is beyond the scope of most Docs medical
> understanding and is only a theory/hypothesis on
> my part and perhaps a few advanced Docs and a few drug
> companies egg heads.

Are you serious? Where can I find more info about this? I have a lot of
problems with nerves so would like to read more about this.

--- In gerdrefluxdisease@yahoogroups.com, "betaine_hcl"
<betaine_hcl@...> wrote:
>
> I don't think they used a nasal passage on me.
> Understand it was 1996 though I did watch the procedure
> in person in 2001 at least in part but I can not
> recall what I saw. As to the use
> of an anaesthetic or not, it seems like they gave me
> two shots of something that pretty well knocked me
> out such that I have no memory of the
> event. They put in an IV needle with a port
> and the shots went into that as I very dimly recall.

Thanks. It seems they do a general anaesthetic here. Interesting...

--- In gerdrefluxdisease@yahoogroups.com, IMS Info <imsinfo@...> wrote:
>
> You can ask for endo without anestesia too but they
> use spreay to relax muscles. The tube will go to the
> troat but if you will breath through mouth you will be
> OK

Yes, that is how I remember it from having it last time (9 yrs ago)
Thank you!

It is hard to know. Consider your docs
are having a hard time and they are there
on the ground with you so to speak.

I'll suggest that GERD and reflux has much more
to do a relaxed lower esophageal sphincter than
it does with excess acid to most people.

While spices foods are on all the lists of No No food for
GERD sufferer, personally I NEVER found this to be
true even on my worsen days. Perhaps your
"spicy" foods are in fact fatty foods?

Your upper back pain may in fact be upper back pain.
You may for example need a new mattress? Or
since I don't know if you are sleep on an incline or not,
it may matter what type of mattress you sleep on
in an inclined position. I don't know your age or
gender. It could be arthritis, osteoporosis, an old
injury, a bone spur, a bad disk, etc.

Any chance of a hiatal hernia?

The fear and restless mind suggests a possible
neurotransmitter imbalance and I believe there
is evidence that a weak LES is the result of
some sort of neurotransmitter imbalance. Understand
this idea is beyond the scope of most Docs medical
understanding and is only a theory/hypothesis on
my part and perhaps a few advanced Docs and a few drug
companies egg heads.

In short, I've no idea about your problems
only endless possibilities.



--- In gerdrefluxdisease@yahoogroups.com, "parsar67" <parsar67@...>
wrote:
>
> I am facing the following problems:
> High acidity
> burning sensation in the chest after eating spicy foods and some
> time in sitting in a particular position.
> Upper Back pain
> Always in fear & restless mind.
> uneasiness in the left chest.
>
> I have undergone all tests including chest x-ray, endoscopy, echo-
> cardiography, stress test, sonography & CT Scan etc. and found
> nothing.  Almost all doctors are saying it is because of acidity.
>
> I am facing this problem for the past 2 years.
>
> Can anybody tell about the exact problem.
>
>
>
>
>
>
>
>
>
>
>
>
> --- In gerdrefluxdisease@yahoogroups.com, "betaine_hcl"
> <betaine_hcl@> wrote:
> >
> > I don't think they used a nasal passage on me.
> > Understand it was 1996 though I did watch the procedure
> > in person in 2001 at least in part but I can not
> > recall what I saw. As to the use
> > of an anaesthetic or not, it seems like they gave me
> > two shots of something that pretty well knocked me
> > out such that I have no memory of the
> > event. They put in an IV needle with a port
> > and the shots went into that as I very dimly recall.
> >
> > --- In gerdrefluxdisease@yahoogroups.com, "nkliphuis" <skinty78@>
> > wrote:
> > >
> > > --- In gerdrefluxdisease@yahoogroups.com, "betaine_hcl"
> > > <betaine_hcl@> wrote:
> > > >
> > > > Endoscopy is no big deal in my one experience with it.
> > > > I did have someone else drive as they did sedate me.
> > >
> > > Can you tell me how they did it? I had an endoscopy ten yrs ago
> in my
> > > native country of the Netherlands, and I only got a local
> > anaesthetic.
> > > They put the camera in through my mouth. Is it true that in the
> > States
> > > they insert it through the nose?
> > >
> >
>

I am facing the following problems:
High acidity
burning sensation in the chest after eating spicy foods and some
time in sitting in a particular position.
Upper Back pain
Always in fear & restless mind.
uneasiness in the left chest.

I have undergone all tests including chest x-ray, endoscopy, echo-
cardiography, stress test, sonography & CT Scan etc. and found
nothing.  Almost all doctors are saying it is because of acidity.

I am facing this problem for the past 2 years.

Can anybody tell about the exact problem.












--- In gerdrefluxdisease@yahoogroups.com, "betaine_hcl"
<betaine_hcl@...> wrote:
>
> I don't think they used a nasal passage on me.
> Understand it was 1996 though I did watch the procedure
> in person in 2001 at least in part but I can not
> recall what I saw. As to the use
> of an anaesthetic or not, it seems like they gave me
> two shots of something that pretty well knocked me
> out such that I have no memory of the
> event. They put in an IV needle with a port
> and the shots went into that as I very dimly recall.
>
> --- In gerdrefluxdisease@yahoogroups.com, "nkliphuis" <skinty78@>
> wrote:
> >
> > --- In gerdrefluxdisease@yahoogroups.com, "betaine_hcl"
> > <betaine_hcl@> wrote:
> > >
> > > Endoscopy is no big deal in my one experience with it.
> > > I did have someone else drive as they did sedate me.
> >
> > Can you tell me how they did it? I had an endoscopy ten yrs ago
in my
> > native country of the Netherlands, and I only got a local
> anaesthetic.
> > They put the camera in through my mouth. Is it true that in the
> States
> > they insert it through the nose?
> >
>

A cure by conventional medicine, I say is highly
unlikely. First the ailment is a golden goose/cash cow
for the Drug companies who fund most research.
When most or all the PPI class drug patents
all pass into history I expect that the new improved
GABA agonists class meds will become the new wonder
med for GERD. "Research" the off label treatment of
GERD with balcofen (generic name).

I suggest you research the use of betaine HCL, betaine base,
melatonin, and GABA in connection with reflux. The first
item is highly acidic so if you are inflamed in the esophagus
or if you have an ulcer it may not be an ideal agent.
Understand these are things not available in every nation
and are either considered very experimental or very alternative.
And they certainly would not be in the range of standard
medical care protocols. Nor am I saying they work, I
am saying each separately is an item of interest and
worthy of an aggressive information search on your part.
Currently I use two of these things and am experimenting
on myself with the other two. I don't know if
I dare try sleeping on the level again as that is
what helped me to get long way toward better.
I sleep with the head of my bed raised my 18 inches
not the commonly suggested 6 inches which in my
opinion is too little and hence guarantees most
people to misery and failure and a
lifetime of visits to their medical
care providers and endless med use.
Currently I am in remission from GERD and I don't
use the Doc PPI meds anymore as they have became much
too toxic for me. I've not taken a PPI med
or an H-2 blocker in two and half years.

Then again I maybe completely wrong, talk to your
Doc ;-)

I didn't address the various operations and possible
medical devices that might be developed.


--- In gerdrefluxdisease@yahoogroups.com, "karnaranjanium"
<karnaranjanium@...> wrote:
>
> Hi People
>            howz the research on GERD going on .Could we expect a
> permanent cure for this condition in the near future./??
>

You'll very likely be quite safe. The only persons
that need to worry are those with bad livers and hence
prone to esophageal varices and the resultant bleeding
as I recall. If you are prone to panic attack the
Doc can provide an SSRI med to suppress this feeling.
I take a heaping teaspoonful of inositol powder
every day to prevent panic attacks and if I feel
one is near I take a heaping tablespoon of the same.
Understand this is either alternative or experimental
medicine but it works for me. Your Doc likely won't know
about inositol but he will know how to hand out a SSRI
prescription. Anyway I have no idea whether the inositol
would work for you.....disclaimer.

Understand I suspect that GERD has a basis in
some neurotransmitter shortage or imbalance such
that the LES receive too little stimulation to keep its
tone. And hence it leaks and permits reflux.

--- In gerdrefluxdisease@yahoogroups.com, Kim Harcarik
<imhere228@...> wrote:
>
> I do have panic attacks, but havent had one in a long time. If i
get really scared about something being done to me like surgery or
that thing down my throat I get a little panicy. Its probably nerves
as well.
>   I do have a phobia of getting sick,so I am specialy causious
durning the year, was my hands severly times a day,etc.
>
>
>
> betaine_hcl <betaine_hcl@...> wrote:
>           Endoscopy is no big deal in my one experience with it.
> I did have someone else drive as they did sedate me.
>
> Are you nervous or are you having "panic attacks"?
> I suspect for many GERD is some sort of neurotransmitter
> problem that leads to a relaxed lower esophageal sphincter
> and the same problem may make one more prone to panic attacks and
> perhaps even OCD?
> Then the acid suppression therapy impairs stomach motility in
> some such that they end up also motility meds.
> Both ideas are hypotheses or at best strong theories.
>
> --- In gerdrefluxdisease@yahoogroups.com, Kim Harcarik
> <imhere228@> wrote:
> >
> > Hi Lauren,
> >
> > I'm recently joined this group. I am having a Endoscopy done on
> the 29th of this month. I am so nervious I can't stand it! My
Doctor
> has said that I have GERD and she wanted me to do that test. Have
you
> ever had that done? I am talking Prevacid but sometimes tend to
> forget to take it,which really upsets me,because I do want to feel
> better.
> >
> > Take Care,
> >
> > Kim
> >
>
>
>
>
>
>
> Kim
>
>
> ---------------------------------
> Need a quick answer? Get one in minutes from people who know. Ask
your question on Yahoo! Answers.
>
> [Non-text portions of this message have been removed]
>

I don't think they used a nasal passage on me.
Understand it was 1996 though I did watch the procedure
in person in 2001 at least in part but I can not
recall what I saw. As to the use
of an anaesthetic or not, it seems like they gave me
two shots of something that pretty well knocked me
out such that I have no memory of the
event. They put in an IV needle with a port
and the shots went into that as I very dimly recall.

--- In gerdrefluxdisease@yahoogroups.com, "nkliphuis" <skinty78@...>
wrote:
>
> --- In gerdrefluxdisease@yahoogroups.com, "betaine_hcl"
> <betaine_hcl@> wrote:
> >
> > Endoscopy is no big deal in my one experience with it.
> > I did have someone else drive as they did sedate me.
>
> Can you tell me how they did it? I had an endoscopy ten yrs ago in my
> native country of the Netherlands, and I only got a local
anaesthetic.
> They put the camera in through my mouth. Is it true that in the
States
> they insert it through the nose?
>

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Check Domperidone on-line it is available from Canada
or Europe. It is safe but did not helped me. I had to
try it from 1/4 because of headaxches but gladually
used to it. Some people take doble dose and it worked.


--- Kim Harcarik <imhere228@...> wrote:

> Okay,goody! I hope to get this done and over with so
> they can see what the heck is going on! Thanks
> Lauren! Have a good day
>
> Lauren Luisi <l.luisi@...> wrote:          I
> havein had 2 endoscopies. The test itself is
> nothing. They put you out and you wake up fine and
> can't believe it is over. For me it is the anxiety
> of what they are going to find. I can't take the PPI
> (like prevacid) drugs. They don't do anything for
> me. I take reglan morning and at night and I take
> 150mg of zantac am and 1 before bed. I have been
> quite under control for awhile. I don't generally
> eat after dinner and still watch what I eat.
>
> Good luck
>
> Lauren
> ----- Original Message -----
> From: Kim Harcarik
> To: gerdrefluxdisease@yahoogroups.com
> Sent: Wednesday, January 10, 2007 3:27 PM
> Subject: Re: [GERD reflux disease] Domberidone,
> Reglan, or Zelnorm?
>
> Hi Lauren,
>
> I'm recently joined this group. I am having a
> Endoscopy done on the 29th of this month. I am so
> nervious I can't stand it! My Doctor has said that I
> have GERD and she wanted me to do that test. Have
> you ever had that done? I am talking Prevacid but
> sometimes tend to forget to take it,which really
> upsets me,because I do want to feel better.
>
> Take Care,
>
> Kim
>
> Lauren Luisi <l.luisi@...> wrote:
> I take reglan according to my dr in very small doses
> where side effects are not see. However it might be
> very different in children. I take 10 mg in am and
> 10mg in pm. I, however, am taking it for Gerd. It
> has helped a lot.
>
> Lauren
> ----- Original Message -----
> From: francescainboston
> To: gerdrefluxdisease@yahoogroups.com
> Sent: Wednesday, January 10, 2007 1:10 PM
> Subject: [GERD reflux disease] Domberidone, Reglan,
> or Zelnorm?
>
> Hi, everyone,
>
> My daughter is 7 and has Mitochondrial Disease.
> Since GI issues are a
> very common feature, her mito docs requested a
> gastric emptying study to
> be done (she also had symptoms). The results
> revealed that she had
> emptied only 30% (as opposed to the 50% norm) after
> one hour.
>
> Her GI doc at Mass General feels she would benefit
> from medicine. The Q
> is, which one? He has told us about three: Reglan,
> which can have
> significant CNS side effects; Domberidone, which is
> unavailable through
> regular pharmacies in this country (was pulled off
> US market due to
> cardiac conduction issues, so he requests regular
> EKGs w/this one); and
> Zelnorm, which is more for the adult population and
> also for bowel
> (intestinal) moreso than for stomach emptying.
>
> I would welcome your suggestions on these. Thank you
> in advance.
>
> Susan Zelenko www.mitoaction.org
> <http://www.mitoaction.org>
>
> www.umdf.org <http://www.umdf.org> and
> www.mdausa.org
> <http://www.mdausa.org>
>
> [Non-text portions of this message have been
> removed]
>
> [Non-text portions of this message have been
> removed]
>
> Kim
>
> __________________________________________________
> Do You Yahoo!?
> Tired of spam? Yahoo! Mail has the best spam
> protection around
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>
> [Non-text portions of this message have been
> removed]
>
> [Non-text portions of this message have been
> removed]
>
>
>
>
>
>
> Kim
>
>
> ---------------------------------
> Check out the all-new Yahoo! Mail beta - Fire up a
> more powerful email and get things done faster.
>
> [Non-text portions of this message have been
> removed]
>
>

You can ask for endo without anestesia too but they
use spreay to relax muscles. The tube will go to the
troat but if you will breath through mouth you will be
OK

--- nkliphuis <skinty78@...> wrote:

> --- In gerdrefluxdisease@yahoogroups.com,
> "betaine_hcl"
> <betaine_hcl@...> wrote:
> >
> > Endoscopy is no big deal in my one experience with
> it.
> > I did have someone else drive as they did sedate
> me.
>
> Can you tell me how they did it? I had an endoscopy
> ten yrs ago in my
> native country of the Netherlands, and I only got a
> local anaesthetic.
> They put the camera in through my mouth. Is it true
> that in the States
> they insert it through the nose?
>
>