J Infect Dis. 2007 Jan 15;195(2):230- 5. Epub 2006 Dec 11.

Mortality in Siblings of Patients Coinfected with HIV and Hepatitis C Virus.

Hansen AB, Gerstoft J, Kronborg G, Pedersen C, Sorensen HT, Obel N.

Department of Infectious Diseases, Odense University Hospital, DK-5000
Odense C, Denmark. ann-brit.eg. hansen@rh. hosp.dk.

Background. Coinfection with hepatitis C virus (HCV) is a poor prognostic
factor for human immunodeficiency virus (HIV)-infected patients. We examined
whether the increased mortality in these patients is partly explained by a
familial excess risk of death.Methods. Danish HIV-infected patients who had
had at least 1 HCV test were included (n=3531). In addition, 336,652
population control subjects matched for sex, age, and residency were
identified from the Danish Civil Registration System. For both HIV-infected
patients and population control subjects, we identified all siblings born
after 1951, with dates of death or emigration. Siblings of HIV-infected
patients were classified according to the patients' HCV serostatus. Survival
after age 20 years was compared among the groups of siblings.Results. We
identified 437 siblings of HIV/HCV-coinfected patients, 1856 siblings of
HIV-monoinfected patients, and 285,509 siblings of population control
subjects. Mortality was substantially higher in siblings of
HIV/HCV-coinfected patients than in either siblings of HIV-monoinfected
patients (mortality rate ratio [MRR], 2.97 [95% confidence interval {CI},
1.98-4.45]) or siblings of control subjects (MRR, 4.23 [95% CI, 3.09-5.79]).
Siblings of HIV-monoinfected patients had slightly higher mortality (MRR,
1.43 [95% CI, 1.10-1.85]) than siblings of control subjects.Conclusion s. HCV
infection is a marker of familial factors that affect the survival of
HIV-infected patients independently of the pathogenicity of HCV.

PMID: 17191168 [PubMed - in process]




Sandra Tara Balduf (Ane)

Support for patients and educational materials

regarding all forms of liver disease.

http://frontline-hepatitis-awareness.com

509-888-0587






[Non-text portions of this message have been removed]