The effect of interaction between hepatitis C virus and cigarette smoking
on the

Short Communication



British Journal of Cancer (2006) 94, 737-739.
doi:10.1038/sj.bjc.6602981 Published online 7 February 2006

The effect of interaction between hepatitis C virus and cigarette smoking on
the risk of hepatocellular carcinoma

Y Fujita1, A Shibata1, I Ogimoto1, Y Kurozawa2, T Nose2, T Yoshimura3, H
Suzuki4, N Iwai5, R Sakata1, S Ichikawa1 and A Tamakoshi6 for the JACC Study
Group7

1Department of Public Health, Kurume University School of Medicine, Kurume
830-0011, Japan

2Department of Social Medicine, Division of Health Administration and
Promotion, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan

3Fukuoka Institute of Health and Environmental Sciences, Dazaihu 818-0135,
Japan

4Department of Public Health, Faculty of Medicine, Niigata University School
of Medicine, Niigata 951-8510, Japan

5Chugoku Occupational Health Association, Tottori 680-0942, Japan

6Department of Preventive Medicine/Biostatistics and Medical decision
Making, Nagoya University Graduate School of Medicine, Nagoya 466-8550,
Japan



Correspondence to: Dr Y Fujita, E-mail: yf123@...

7Study group members are listed in Appendix A.

Received 25 October 2005; revised 9 December 2005; accepted 16 January 2006;
published online 7 February 2006



We evaluated the interaction between hepatitis C virus (HCV) and cigarette
smoking on death from hepatocellular cancer in The Japan Collaborative
Cohort Study. The odds ratio of death from HCC for smoking was 9.60
(1.50-61.35) and 1.71(0.58-5.08) among anti-HCV positive and negative
individuals, respectively.







[Non-text portions of this message have been removed]