HCV and HIV co-infection in pregnant women attending St. Camille
Medical
Centre in Ouagadougou (Burkina Faso).

Simpore J, Ilboudo D, Samandoulougou A, Guardo P, Castronovo P,
Musumeci S.

Laboratoire Saint Camille de Ouagadougou, Burkina Faso, Unite de
Formation
et de Recherche/SVT, Universite de Ouagadougou, Ouagadougou, Burkina
Faso.

Five hundred and forty-seven pregnant women with less than 32 weeks of
amenorrhoea, attending an antenatal clinic of St. Camille Medical
Centre
(SCMC) of Ouagadougou were enrolled for a hepatitis C virus (HCV) and
HIV
co-infection study. Fifty-eight (10.6%) were HIV positive and 18 (3.3%)
were
anti-HCV positive. Only seven pregnant women (i.e., 1.3%) had a
documented
HIV and HCV co-infection. HCV-RNA was found in 5 out of 18 (27.8%)
patients,
who had anti-HCV antibodies. The genotype analysis of these five
patients
showed that two were of 1b whereas three were of 2a genotype.
Mother-to-infant transmission of the same HCV genotype (2a) was
documented
in only one case. High 1b prevalence has been reported in other parts
of
Africa, while 2a is the prevalent genotype (60%) in Burkina Faso. This
genotype has a higher response rate to treatment. Serum transaminases
were
normal, also in presence of HCV-RNA. The higher than expected rate of
co-infection in Burkina Faso seems to demonstrate a correlation between
these two infections, which could influence the evolution of HIV and
HCV
diseases. J. Med. Virol. 75:209-212, 2005. (c) 2004 Wiley-Liss, Inc.

PMID: 15602740




Sandra Tara Balduf (Ane)

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