Mon Dec 31, 2007 4:41 am (PST)
J Med Virol. 2008 Feb;80(2):268-76.
Epidemiological and clinical evaluation of hepatitis B, hepatitis C, and delta
hepatitis viruses in Tajikistan.
Khan A, Kurbanov F, Tanaka Y, Elkady A, Sugiyama M, Dustov A, Mizokami M.
Department of Clinical Molecular Informative Medicine, Nagoya City University
Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, Japan.
The implication of genotypes is recognized increasingly in the clinical course
of hepatitis B virus (HBV) and in response to anti-viral drugs of hepatitis C
virus (HCV). Genotypic prevalence of both etiological agents varies
geographically and no data are available for Tajikistan. To investigate the
epidemiology and clinical significance of HBV and HCV genotypes in chronic
hepatitis (group 1) and liver cirrhosis/hepatocellular carcinoma (HCC) (group 2)
patients in Tajikistan, 124 patients with chronic liver disease (group 1 = 84
and group 2 = 40) were enrolled. Genotypes of HBV, HCV, and delta hepatitis
virus (HDV) were determined by sequencing. The overall prevalence of anti-HCV,
HCV core antigen (HCVcAg) and HBsAg was 46% (57/124) and 41.1% (51/124),
respectively. Coinfection of HCV/HBV, HBV/HDV, and HCV/HBV/HDV was found in 4.8%
(6/124), 11.2% (12/124), and 0.8% (1/124) of cases, respectively. HDV genotype 1
was found in 19.6% (10/51) of HBsAg-positive patients. The
HBV/HDV coinfection was relatively high in group 2 compared to group 1 (15% vs.
7.1%). HCV/1b detected in 84.6% (44/52) of HCV RNA-positive patients, followed
by 3a (7.6%), 2a (5.7%), and 2c (1.9%). HBV/D was detected in 94.1% (48/51) of
HBsAg-positive patients, followed by HBV/A [5.8% (3/51)]. T1762/A1764 double
mutation was associated with liver cirrhosis/HCC in HBV-infected patients (P =
0.0004). This is the first study on the molecular epidemiology of hepatitis
viruses among chronic liver diseases patients in Tajikistan. Among HBV-infected
patients, the T1762/A1764 mutation was associated with liver cirrhosis/HCC. J.
Med. Virol. 80:268-276, 2008. (c) 2007 Wiley-Liss, Inc.
PMID: 18098133 [PubMed - in process]



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