Modafinil's Use in Combating Interferon-Induced Fatigue Tue Apr 3, 2007 4:23
am (PST) Dig Dis Sci. 2007 Apr;52(4):893- 6. Epub 2007 Feb 21.

Modafinil's Use in Combating Interferon-Induced Fatigue.

Martin KA, Krahn LE, Balan V, Rosati MJ.

Department of Psychiatry and Psychology, Mayo Clinic Arizona, 13400 East
Shea Boulevard, Scottsdale, Arizona, 85259, USA, martin.kariann@ mayo.edu.

Interferon (IFN) is an effective agent in the treatment of chronic viral
hepatitis C. A variety of adverse neuropsychiatric effects including
anxiety, depression, delirium, psychoses, and mania complicates its usage.
IFN-alpha-induced depression is presumed to be composed of two overlapping
syndromes: a depression-specific syndrome characterized by depressed mood,
anxiety, and cognitive complaints, and a neurovegetative syndrome consisting
of fatigue, anorexia, somatic pain complaints, and psychomotor retardation
[1]. Our results show that depression-specific symptoms peak at 12 weeks of
IFN therapy and respond well to serotoninergic antidepressants [2]. We
conclude that neurovegetative symptoms are relatively treatment refractory
to antidepressants, occur early in the course of treatment, and tend to
persist for the duration of therapy [1].

PMID: 17318387 [PubMed - in process]





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