My name is Narice May and I am writing you to ask your consideration
of guidelines aimed at eliminating colon cancer by mandating
colonoscopy screening for all adults in the Commonwealth beginning
at age 18 NOT 50.
On December 5,2005 I lost my husband Phillip to colorectal cancer.
Phil was only 46. He NEVER was offered a colonoscopy despite the
fact his mother and grandmother died of Pancreatic and Uterine
cancer. These cancers are said to have some link to HEREDITARY colon
cancer. Even with this history Phil had no symptoms of cancer. He
was young, fit and appeared healthy so why would anyone even THINK
to test him?
BUT the same could be said about my 32 year old friend Amy Carter
who died of
Breast Cancer and had no history. The difference is that today Amy
and her
daughter would be checked for BREAST & CERVICAL cancer regardless of
age. Why
don't we do the same for colon cancer?
A colonoscopy can detect polyps and eradicate them BEFORE cancer
develops.
There is NO OTHER CANCER that has that claim. We have the ability to
PREVENT
and possibly totally ELIMINATE colon cancer and yet 50,000 plus
people will DIE
of this brutal disease this year.
A Colonoscopy is paid for IF an adult is 50 and over but 50
didn't save my
husband. You see, a good number of individuals are 40, 30, yes even
20 something,
when they are diagnosed with stage 4 cancer. Most are inoperable at
that point
meaning there is no cure just treatment to prolong life.
Treatment that costs hundreds of thousands of tax and/or state
insurance dollars.
Pennsylvania is paying out far too much in survivor benefits,
welfare, Medicaid and Disability.
Why? Because we have not demanded and mandated that we change the
guidelines
so that ALL adults can be tested every 3-5 years beginning at age
18. We spend
about 5-6,000 dollars every 3-5 years and we save taxpayers hundreds
of
thousands of dollars in lost wages, insurance, health care costs,
and priceless
loss of friends and family to this heartless killer.
Project March is a grassroots organization under the auspices of The
Colorectal Cancer Network an organization comprised of those whose
lives have been forever changed by this disease.
You can find their guidelines and suggestions at:
http://www.colorectal-cancer.net/projectmarch.htm
I urge you to read these guidelines and consider that the answer is
so very simple.
Screen everyone and no one should get colon cancer and the tiny
percent that is not caught can be easily treated.
Don't go with the flow on this one. You have the chance to be the
person or group who took the time to take a stand and make a
difference.
Those of you who work in Oncology, Surgery, and GI practices have
seen the devastation up close. Now's the time. Here is your chance
to make a difference!
Won't you please join me in ending Colon Cancer?
Thank you for your time and concern
Sincerely,
Narice May,
Project March PA State Coordinator
Erie, PA
END COLON CANCER!!
Colonoscpies for ALL PA Adults
Not just those over 50
pm_pastatecoordinator@...
---------------------------------------------------------------------
-----------
Country Interviews Online's 2006 Auction is under way! Money raised will go to
the Minnie Pearl Cancer Foundation! If you like country music, check it out!
www.countryinterviewsonline.net
Our Memorial is growing, slowly but surely. If you know someone who has also
suffered a loss, please let them know about the site.
--
Colon Cancer Victims Memorial http://www.coloncancermemorial.com
Get free web tools here
http://www.bravenet.com/webhosting/?csid=113&afilid=3133549479
[Non-text portions of this message have been removed]
Thank you to all who showed up for the march. Thank you to everyone who wrote
in to their legislators and who contacted the media in one way or another.
ProjectMARCH week turned out to be great.
Yes, unfortunately there were only a few of us there this year.
But we may have found a strong supporter in one of the representatives that we
visited - for screening at age 18.
And on Thursday, Louise and I attended a White House conference and the AMAZING
Louise actually got to talk - briefly - with President Bush about needing
screening at an earlier age. He was interested enough to take her card. And he
told her that no one had ever approached him about this.
Which demonstrates what I was saying awhile back. One letter to him doesn't
even reach him. It isn't even considered an issue. Ten letters to him will
start to make the letter openers remember that they've seen this issue before.
A thousand letters, phone calls, faxes and we get added to the possible issues
to be addressed list. And the next step after that...we get brought to his
attention or his top aides.
Folks, when we visited Rep. Chet Edwards of Texas we told his aide that what we
want is a bill introduced by next March that would mandate screening be made
available from age 18 up and a fund set up for those without insurance.
We have at least two sets of ears on the Hill listening. Now we need to
deliver. This time we had over 1200 petition signatures and the aides were
impressed. Before next March we need that many from every state.
So here's the plan.
Each state needs one state coordinator. And ideally, one coordinator for each
voting district (a coordinator can certainly take on multiple districts). Under
the state coordinators we need the following committees:
Media
Medical Community
Petition
Legislative
Medical Bills Posters
Community Groups Outreach
Each committee will need to meet at least once a month and be working hard to
accomplish its goals Each state coordinator needs to meet with the committee
leaders at least once a month and once a month meet with all the other state
coordinators.
All meetings can be done online.
So, step one, who can be the coordinator for their state. You must give us a
way to contact you that we can post online - phone and email ideally. No
address is needed. Your job will be to help; get those committees built for
your state and get them moving.
If you can't take on a state coordinator position then can you take on a
committee head? If you can't take on either coordinator roles choose a
committee to be on.
If we want this to happen, now that we have legislators that are interested, we
must deliver. They can't do this for us. They can write a bill and work on
getting co-sponsors, but WE have to demonstrate that the American public, the
voters, want this and will not accept anything less.
I have to tell you, finding one and even maybe two legislators that may support
us in this amazed me. That is a break-through that lights me up like I can't
begin to tell you. And icing the cake with Louise Bates getting the ear of the
President. We have a solid launching point. This is now within reach. If we
want it bad enough.
I hate the death toll of people I knew who lost their life to this cancer. I
hate that right now there is no way I can keep my kids from ending up where my
sister was - 44 and diagnosed with stage 2 colon cancer with no risk factors. I
hate the pain I see this cause. Life is tough enough to allow it to steal one
single person that we can prevent dying so simply. But for the first time since
I took up this fight, I have real hope that we can accomplish this. I knew it
was possible. But for so long I have felt like I was tilting at windmills.
Well, the windmill has fallen. This is our fight. Stand with me. Make
plans to be in DC next ProjectMARCH and work like crazy to meet the goals we
need to make this happen.
A suggestion was made that we move ProjectMARCH to the end of the month. It's a
good one. Better weather. MORE tourists in town. So it is officially moved to
the last monday in March - March 26th, 2007. Because that is right around the
Cherry Blossum festival you will need to plan to make your housing arrangements
6 months out. I'm hoping we can get someone to take on looking into housing
options and maybe the Network can swing the cost of a bus to bring people from
there into town.
Mark your calendars.
Any money spent is each individuals responsibility. CCNetwork is a 501c3 and so
cannot spend more than 4% of its budget on legislative items.
Priscilla A. Savary
Executive Director
Colorectal Cancer Network
PO Box 182, Kensington MD 20895
301-879-1500
psavary@...
www.colorectal-cancer.net
_________
Screening for All. Colon Cancer for None.
ProjectMARCH -- rarely in life do you get a chance to make major change or save
thousands of lives. March 6, 2006 you can.
http://www.colorectal-cancer.net/projectmarch.htm
[Non-text portions of this message have been removed]
Monday March 6, 2006 10:00 am
- 2:00 pm
This event does not repeat.
Event Location: Capitol Hill, Washington DC
Phone: 301-879-1500
Notes:
http://www.colorectal-cancer.net/projectmarch.htm
We have an opportunity to have a table at the BIO Conference (the assoc of
biotechnology pharmas) in Chicago. But we need volunteers to staff the table.
The goal will be to make the attendees aware of what we are doing and what are
position is about screening.
If you can help please let me know. There is also a complementary registration
to the conference that we can get if some of you want to attend and report back
to us on what you learn - new advances, etc. And there is a cocktail reception
on the 10th that is great personal time to meet these pharma reps.
Priscilla A. Savary
Executive Director
Colorectal Cancer Network
PO Box 182, Kensington MD 20895
301-879-1500
psavary@...
www.colorectal-cancer.net
_________
Screening for All. Colon Cancer for None.
ProjectMARCH -- rarely in life do you get a chance to make major change or save
thousands of lives. March 6, 2006 you can.
http://www.colorectal-cancer.net/projectmarch.htm
[Non-text portions of this message have been removed]
Monday March 6, 2006 10:00 am
- 2:00 pm
This event does not repeat.
The next reminder for this event will be sent in 4 days, 1 minute.
Event Location: Capitol Hill, Washington DC
Phone: 301-879-1500
Notes:
http://www.colorectal-cancer.net/projectmarch.htm
In a message dated 1/27/2006 9:00:06 P.M. Pacific Standard Time,
marc@... writes:
hi donna, hi everyone,
following your answer to dianne
i would like to tell you that i am currently managing my dad´s case.
he is 75 years old and has recently (august 2005) been detected metastases
at liver and lungs of an original colon cancer (resected in 1993)
since then we are doing oxaliplatin+ FU + leucovorin chemotherapy.
after 10sessions every 15 days and tumor has partailly shrunk (40%).. but
oxaliplatinum has reached its maximum toxicity in his body and it will be
deleted in future chemo sessions.
Marcelo:
What about Avastin? Why wasn't it used in combination with the
chemotherapy?
Patricia
[Non-text portions of this message have been removed]
Hi Marcelo .. so good to hear from you .. please know your dad will be in my
thoughts and prayers .. I'm also undergoing similar chemo ... to which the
Oncolyn only enhances and releaves side effects ..
did you use a search engine to find all the websites for Oncolyn .. there is
lots of sicentific data available. The same goes for the Papimi .. Dr Pappas in
Greece.. if you have trouble finding let me know and I will send you specific
paths ..
May God Bless and guide you to the information you require .. d
[Non-text portions of this message have been removed]
hi donna, hi everyone,
following your answer to dianne
i would like to tell you that i am currently managing my dad´s case.
he is 75 years old and has recently (august 2005) been detected metastases
at liver and lungs of an original colon cancer (resected in 1993)
since then we are doing oxaliplatin+ FU + leucovorin chemotherapy.
after 10sessions every 15 days and tumor has partailly shrunk (40%).. but
oxaliplatinum has reached its maximum toxicity in his body and it will be
deleted in future chemo sessions.
i am always thinking of adding other things.... that is why i joined some
forums.
but.. i would like to propose therapies that have some scientific
background.
i read about your experience with oncolyn and papimi therapy and i would
like to ask you if you can send me links to scientific data on these or
other therapies.
i would like to ask everyone if you can guide me with aditional therapies
that have scientific background and donot collide with traditional
chemotherapy.
with best regards
marcelo
Uruguay
----- Original Message -----
From: <experimentalandunconventional@yahoogroups.com>
To: <experimentalandunconventional@yahoogroups.com>
Sent: Friday, January 27, 2006 4:02 PM
Subject: [Experimental and Unconventional] Digest Number 475
> There are 5 messages in this issue.
>
> Topics in this digest:
>
> 1. My Brothers Wife
> From: "dianevespa" <dianevespa@...>
> 2. Re: My Brothers Wife
> From: Mel <>
> 3. Re: My Brothers Wife
> From: Mel <meldonna@...>
> 4. Re: My Brothers Wife
> From: "James Glass" <jglass@...>
> 5. Re: My Brothers Wife
> From: "Diane Vespa" <dianevespa@...>
>
>
> ________________________________________________________________________
> ________________________________________________________________________
>
> Message: 1
> Date: Fri, 27 Jan 2006 03:07:27 -0000
> From: "dianevespa" <dianevespa@...>
> Subject: My Brothers Wife
>
> Hello everyone,
>
> I am joining this group on behalf of my Dear Sister-in-Law, wife of
> my baby brother, and Mom to two adorable kids. Her name is Debbie.
> Two weeks ago she went in to see her Doctor because of a "flu" that
> didn't seem to go away, and swellings in her abdomen. A mere three
> days later, she was post surgery, with half of her colon removed,
> and a diagnosis of Stage 4 colon cancer mestasized to the liver.
> Needless to say, we are all in shock and a state of disbelief. She
> is 48 years old. I am coming to this board looking for
> advice/suggestions/support/hope really anything that we can turn in
> to hope for Debbie. She lives close to and is being treated in
> Elgin, IL. I am trying to encourage my Brother to take her to a
> larger clinic but he seems satisfied with the protocol prescribed by
> the smaller hospital. (Sherman) Apparently they confer with the
> larger hospitals. She will be getting chemotherapy the traditional
> way. They cannot inject it directly in to her liver because the
> cancer is too advanced. If we are overlooking anything or if I am
> missing "a big picture" please enlighten me. Thank you for reading
> and caring and on behalf of Debbie and Steve we look forward to any
> help.
>
> Diane Vespa
>
>
>
>
>
> ________________________________________________________________________
> ________________________________________________________________________
>
> Message: 2
> Date: Fri, 27 Jan 2006 07:41:56 -0600
> From: Mel <meldonna@...>
> Subject: Re: My Brothers Wife
>
> Hello Diane .. first off please know Debbie will be in my prayers .. I
> understand she has had surgery and now the big concern is the cancer that
> has taken up residence in her liver ... I'm sure the chemo is the route to
> take now .... The chemo though can be enhanced as well as side effects
> reduced with certain alternative cancer treatments ..
> the cancer can be chased away and killed with cancer herbs and Papimi
> therapy .. I have was diagnosed with stage 3 colin cancer in July .. My
> Surgeon and My Endoscopic Dr were having a disagrement as what route to
> take as to best get this under control and cure ... surgery vs chemo and
> radiation prior to sugery .. I live in Canada .. and since there was an
> argument going on as to my treatment .. My hubby took me to Rocester Mn to
> the Mayo Clinic ... I spent $18,000.. but found out that Mayo would treat
> the tumor prior to surgery ...( this I know is not an option now for
> Debbie since she has had surgery ... what needs to happen now is to shrink
> .. steralize and destroy the liver tumor.
>
> I was introduced to Papimi therapy in July and had 30 treatments ... I
> know It shrunk the tumor .. no doubt in my mind .. I was also introduced
> to a cancer herb called Oncolyn ..and started taking it in Aug . I take 6
> caplets daily .. 2 -3X daily .. and know with out a doubt the Oncolyn has
> helped me stay strong and healthy by enhancing the chemo and reducing the
> side effects .. I did have surgery Dec 8 /05 .. the tumor was gone
> completely .. I saw with my own eyes during colonoscopy the day prior to
> .. the biopsy of the tumor site also revealed cancer free ... My sugeon
> removed all of the lympth nodes in the groin area at the same time .. 11
> in all .. one of which showed signs of cancer .. so now I'm having chemo
> again .. 5 days on ... 3 weeks off .. I will admit to a loss of appetite
> somewhat .. mainly because the taster isn't working .. and that I'm more
> tired than usual .. I also must say .. these side effects do not last long
> .. just a couple of days .. then daily I become stronger and healthier ...
> I will have my second week of chemo starting Feb 6 and would not ever
> think of not taking my Oncolyn .. check this cancer product out it has
> several patents in the US was discovered by Dr D'jang of New York .. it
> should be at your finger tips .. My supplier lives in Edmonton Alberta
> Canada .. Daryl Robinson..web site address www.inukshuk.com
> inukshuk means not to worry others have been there before ...
> Daryl is my rock .. he was diagnosed with terminal lung cancer that began
> in his testicles ... His story and the stories of others that he has
> helped will give Debbie hope and knowledge ... Daryl is a man of God and
> I'm sure God works through him to heal all the people he can ..
> Again please let Debbie know there is hope .. Believe in God ..
> investigate the therapies and herb treatments that have worked for me and
> many others .. stay positive .. refuse to think negative thoughts ..
> surround herself with positive people ... and have faith .. I will most
> certainly be praying for her to give her the strength she requires to get
> through this health bump ... this adventure in life .. she will one day be
> helping others do the same ..
> May God Bless you and yours as well ... You are a wonderful sister in law
> Diane .. God is proud of you for taking on the role of lets get active and
> research what is out there ... God expects us to use our noodles to help
> in our own recovery .. he will guide the people to us that we need .. then
> it is up to us to get in charge of our recovery ... there is no doubt in
> my mind that God led me to Daryl Robinson and Oncolyn as well as to the
> Papimi therapy clinic in my town ... If I can help in any way please know
> I'm here ... at the other end of the keyboard. or phone if requied ..
> Sent with love .. Donna T, Saskatchewan, Canada
>
> ---- Original Message -----
> From: dianevespa
> To: experimentalandunconventional@yahoogroups.com
> Sent: Thursday, January 26, 2006 9:07 PM
> Subject: [Experimental and Unconventional] My Brothers Wife
>
>
> Hello everyone,
>
> I am joining this group on behalf of my Dear Sister-in-Law, wife of
> my baby brother, and Mom to two adorable kids. Her name is Debbie.
> Two weeks ago she went in to see her Doctor because of a "flu" that
> didn't seem to go away, and swellings in her abdomen. A mere three
> days later, she was post surgery, with half of her colon removed,
> and a diagnosis of Stage 4 colon cancer mestasized to the liver.
> Needless to say, we are all in shock and a state of disbelief. She
> is 48 years old. I am coming to this board looking for
> advice/suggestions/support/hope really anything that we can turn in
> to hope for Debbie. She lives close to and is being treated in
> Elgin, IL. I am trying to encourage my Brother to take her to a
> larger clinic but he seems satisfied with the protocol prescribed by
> the smaller hospital. (Sherman) Apparently they confer with the
> larger hospitals. She will be getting chemotherapy the traditional
> way. They cannot inject it directly in to her liver because the
> cancer is too advanced. If we are overlooking anything or if I am
> missing "a big picture" please enlighten me. Thank you for reading
> and caring and on behalf of Debbie and Steve we look forward to any
> help.
>
> Diane Vespa
>
>
>
>
>
> SPONSORED LINKS Colon cancer treatments Colon cancer alternative
> treatment Colon cancer
> Colon cancer prevention Colon cancer surgery Colon cancer
> diagnosis
>
>
> ------------------------------------------------------------------------------
> YAHOO! GROUPS LINKS
>
> a.. Visit your group "experimentalandunconventional" on the web.
>
> b.. To unsubscribe from this group, send an email to:
> experimentalandunconventional-unsubscribe@yahoogroups.com
>
> c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of
> Service.
>
>
> ------------------------------------------------------------------------------
>
>
>
> [Non-text portions of this message have been removed]
>
>
>
> ________________________________________________________________________
> ________________________________________________________________________
>
> Message: 3
> Date: Fri, 27 Jan 2006 08:03:42 -0600
> From: Mel <meldonna@...>
> Subject: Re: My Brothers Wife
>
> I wonder why this comes back to me and not to Diane ... tell me what I
> have done wrong .. d
> ----- Original Message -----
> From: Mel
> To: experimentalandunconventional@yahoogroups.com
> Sent: Friday, January 27, 2006 7:41 AM
> Subject: Re: [Experimental and Unconventional] My Brothers Wife
>
>
> Hello Diane .. first off please know Debbie will be in my prayers .. I
> understand she has had surgery and now the big concern is the cancer that
> has taken up residence in her liver ... I'm sure the chemo is the route to
> take now .... The chemo though can be enhanced as well as side effects
> reduced with certain alternative cancer treatments ..
> the cancer can be chased away and killed with cancer herbs and Papimi
> therapy .. I have was diagnosed with stage 3 colin cancer in July .. My
> Surgeon and My Endoscopic Dr were having a disagrement as what route to
> take as to best get this under control and cure ... surgery vs chemo and
> radiation prior to sugery .. I live in Canada .. and since there was an
> argument going on as to my treatment .. My hubby took me to Rocester Mn to
> the Mayo Clinic ... I spent $18,000.. but found out that Mayo would treat
> the tumor prior to surgery ...( this I know is not an option now for
> Debbie since she has had surgery ... what needs to happen now is to shrink
> .. steralize and destroy the liver tumor.
>
> I was introduced to Papimi therapy in July and had 30 treatments ... I
> know It shrunk the tumor .. no doubt in my mind .. I was also introduced
> to a cancer herb called Oncolyn ..and started taking it in Aug . I take 6
> caplets daily .. 2 -3X daily .. and know with out a doubt the Oncolyn has
> helped me stay strong and healthy by enhancing the chemo and reducing the
> side effects .. I did have surgery Dec 8 /05 .. the tumor was gone
> completely .. I saw with my own eyes during colonoscopy the day prior to
> .. the biopsy of the tumor site also revealed cancer free ... My sugeon
> removed all of the lympth nodes in the groin area at the same time .. 11
> in all .. one of which showed signs of cancer .. so now I'm having chemo
> again .. 5 days on ... 3 weeks off .. I will admit to a loss of appetite
> somewhat .. mainly because the taster isn't working .. and that I'm more
> tired than usual .. I also must say .. these side effects do not last long
> .. just a couple of days .. then daily I inukshuk means not to worry
> others have been there before ...
> Daryl is my rock .. he was diagnosed with terminal lung cancer that began
> in his testicles ... His story and the stories of others that he has
> helped will give Debbie hope and knowledge ... Daryl is a man of God and
> I'm sure God works through him to heal all the people he can ..
> Again please let Debbie know there is hope .. Believe in God ..
> investigate the therapies and herb treatments that have worked for me and
> many others .. stay positive .. refuse to think negative thoughts ..
> surround herself with positive people ... and have faith .. I will most
> certainly be praying for her to give her the strength she requires to get
> through this health bump ... this adventure in life .. she will one day be
> helping others do the same ..
> May God Bless you and yours as well ... You are a wonderful sister in law
> Diane .. God is proud of you for taking on the role of lets get active and
> research what is out there ... God expects us to use our noodles to help
> in our own recovery .. he will guide the people to us that we need .. then
> it is up to us to get in charge of our recovery ... there is no doubt in
> my mind that God led me to Daryl Robinson and Oncolyn as well as to the
> Papimi therapy clinic in my town ... If I can help in any way please know
> I'm here ... at the other end of the keyboard. or phone if requied ..
> Sent with love .. Donna T, Saskatchewan, Canada
>
> ---- Original Message -----
> From: dianevespa
> To: experimentalandunconventional@yahoogroups.com
> Sent: Thursday, January 26, 2006 9:07 PM
> Subject: [Experimental and Unconventional] My Brothers Wife
>
>
> Hello everyone,
>
> I am joining this group on behalf of my Dear Sister-in-Law, wife of
> my baby brother, and Mom to two adorable kids. Her name is Debbie.
> Two weeks ago she went in to see her Doctor because of a "flu" that
> didn't seem to go away, and swellings in her abdomen. A mere three
> days later, she was post surgery, with half of her colon removed,
> and a diagnosis of Stage 4 colon cancer mestasized to the liver.
> Needless to say, we are all in shock and a state of disbelief. She
> is 48 years old. I am coming to this board looking for
> advice/suggestions/support/hope really anything that we can turn in
> to hope for Debbie. She lives close to and is being treated in
> Elgin, IL. I am trying to encourage my Brother to take her to a
> larger clinic but he seems satisfied with the protocol prescribed by
> the smaller hospital. (Sherman) Apparently they confer with the
> larger hospitals. She will be getting chemotherapy the traditional
> way. They cannot inject it directly in to her liver because the
> cancer is too advanced. If we are overlooking anything or if I am
> missing "a big picture" please enlighten me. Thank you for reading
> and caring and on behalf of Debbie and Steve we look forward to any
> help.
>
> Diane Vespa
>
>
>
>
>
> SPONSORED LINKS Colon cancer treatments Colon cancer alternative
> treatment Colon cancer
> Colon cancer prevention Colon cancer surgery Colon cancer
> diagnosis
>
>
>
------------------------------------------------------------------------------
> YAHOO! GROUPS LINKS
>
> a.. Visit your group "experimentalandunconventional" on the web.
>
> b.. To unsubscribe from this group, send an email to:
> experimentalandunconventional-unsubscribe@yahoogroups.com
>
> c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of
> Service.
>
>
>
------------------------------------------------------------------------------
>
>
>
> [Non-text portions of this message have been removed]
>
>
>
> SPONSORED LINKS Colon cancer treatments Colon cancer alternative
> treatment Colon cancer
> Colon cancer prevention Colon cancer surgery Colon cancer
> diagnosis
>
>
> ------------------------------------------------------------------------------
> YAHOO! GROUPS LINKS
>
> a.. Visit your group "experimentalandunconventional" on the web.
>
> b.. To unsubscribe from this group, send an email to:
> experimentalandunconventional-unsubscribe@yahoogroups.com
>
> c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of
> Service.
>
>
> ------------------------------------------------------------------------------
>
>
>
> [Non-text portions of this message have been removed]
>
>
>
> ________________________________________________________________________
> ________________________________________________________________________
>
> Message: 4
> Date: Fri, 27 Jan 2006 09:04:52 -0500
> From: "James Glass" <jglass@...>
> Subject: Re: My Brothers Wife
>
> Johns Hopkins is the place to consult for liver cancer
>
>>>> meldonna@... 01/27/06 8:41 AM >>>
>
>
>
> ________________________________________________________________________
> ________________________________________________________________________
>
> Message: 5
> Date: Fri, 27 Jan 2006 08:24:59 -0600
> From: "Diane Vespa" <dianevespa@...>
> Subject: Re: My Brothers Wife
>
> Thank you Donna, for your suggestions and support. I am passing all the
> imparted pearls of wisdom on to my Brother and Sister in Law. Appreciate
> your help!
> Diane
> ----- Original Message -----
> From: Mel
> To: experimentalandunconventional@yahoogroups.com
> Sent: Friday, January 27, 2006 8:03 AM
> Subject: Re: [Experimental and Unconventional] My Brothers Wife
>
>
> I wonder why this comes back to me and not to Diane ... tell me what I
> have done wrong .. d
> ----- Original Message -----
> From: Mel
> To: experimentalandunconventional@yahoogroups.com
> Sent: Friday, January 27, 2006 7:41 AM
> Subject: Re: [Experimental and Unconventional] My Brothers Wife
>
>
> Hello Diane .. first off please know Debbie will be in my prayers .. I
> understand she has had surgery and now the big concern is the cancer that
> has taken up residence in her liver ... I'm sure the chemo is the route to
> take now .... The chemo though can be enhanced as well as side effects
> reduced with certain alternative cancer treatments ..
> the cancer can be chased away and killed with cancer herbs and Papimi
> therapy .. I have was diagnosed with stage 3 colin cancer in July .. My
> Surgeon and My Endoscopic Dr were having a disagrement as what route to
> take as to best get this under control and cure ... surgery vs chemo and
> radiation prior to sugery .. I live in Canada .. and since there was an
> argument going on as to my treatment .. My hubby took me to Rocester Mn to
> the Mayo Clinic ... I spent $18,000.. but found out that Mayo would treat
> the tumor prior to surgery ...( this I know is not an option now for
> Debbie since she has had surgery ... what needs to happen now is to shrink
> .. steralize and destroy the liver tumor.
>
> I was introduced to Papimi therapy in July and had 30 treatments ... I
> know It shrunk the tumor .. no doubt in my mind .. I was also introduced
> to a cancer herb called Oncolyn ..and started taking it in Aug . I take 6
> caplets daily .. 2 -3X daily .. and know with out a doubt the Oncolyn has
> helped me stay strong and healthy by enhancing the chemo and reducing the
> side effects .. I did have surgery Dec 8 /05 .. the tumor was gone
> completely .. I saw with my own eyes during colonoscopy the day prior to
> .. the biopsy of the tumor site also revealed cancer free ... My sugeon
> removed all of the lympth nodes in the groin area at the same time .. 11
> in all .. one of which showed signs of cancer .. so now I'm having chemo
> again .. 5 days on ... 3 weeks off .. I will admit to a loss of appetite
> somewhat .. mainly because the taster isn't working .. and that I'm more
> tired than usual .. I also must say .. these side effects do not last long
> .. just a couple of days .. then daily I inukshuk means not to worry
> others have been there before ...
> Daryl is my rock .. he was diagnosed with terminal lung cancer that
> began in his testicles ... His story and the stories of others that he has
> helped will give Debbie hope and knowledge ... Daryl is a man of God and
> I'm sure God works through him to heal all the people he can ..
> Again please let Debbie know there is hope .. Believe in God ..
> investigate the therapies and herb treatments that have worked for me and
> many others .. stay positive .. refuse to think negative thoughts ..
> surround herself with positive people ... and have faith .. I will most
> certainly be praying for her to give her the strength she requires to get
> through this health bump ... this adventure in life .. she will one day be
> helping others do the same ..
> May God Bless you and yours as well ... You are a wonderful sister in
> law Diane .. God is proud of you for taking on the role of lets get active
> and research what is out there ... God expects us to use our noodles to
> help in our own recovery .. he will guide the people to us that we need ..
> then it is up to us to get in charge of our recovery ... there is no doubt
> in my mind that God led me to Daryl Robinson and Oncolyn as well as to the
> Papimi therapy clinic in my town ... If I can help in any way please know
> I'm here ... at the other end of the keyboard. or phone if requied ..
> Sent with love .. Donna T, Saskatchewan, Canada
>
> ---- Original Message -----
> From: dianevespa
> To: experimentalandunconventional@yahoogroups.com
> Sent: Thursday, January 26, 2006 9:07 PM
> Subject: [Experimental and Unconventional] My Brothers Wife
>
>
> Hello everyone,
>
> I am joining this group on behalf of my Dear Sister-in-Law, wife of
> my baby brother, and Mom to two adorable kids. Her name is Debbie.
> Two weeks ago she went in to see her Doctor because of a "flu" that
> didn't seem to go away, and swellings in her abdomen. A mere three
> days later, she was post surgery, with half of her colon removed,
> and a diagnosis of Stage 4 colon cancer mestasized to the liver.
> Needless to say, we are all in shock and a state of disbelief. She
> is 48 years old. I am coming to this board looking for
> advice/suggestions/support/hope really anything that we can turn in
> to hope for Debbie. She lives close to and is being treated in
> Elgin, IL. I am trying to encourage my Brother to take her to a
> larger clinic but he seems satisfied with the protocol prescribed by
> the smaller hospital. (Sherman) Apparently they confer with the
> larger hospitals. She will be getting chemotherapy the traditional
> way. They cannot inject it directly in to her liver because the
> cancer is too advanced. If we are overlooking anything or if I am
> missing "a big picture" please enlighten me. Thank you for reading
> and caring and on behalf of Debbie and Steve we look forward to any
> help.
>
> Diane Vespa
>
>
>
>
>
> SPONSORED LINKS Colon cancer treatments Colon cancer alternative
> treatment Colon cancer
> Colon cancer prevention Colon cancer surgery Colon cancer
> diagnosis
>
>
>
------------------------------------------------------------------------------
> YAHOO! GROUPS LINKS
>
> a.. Visit your group "experimentalandunconventional" on the web.
>
> b.. To unsubscribe from this group, send an email to:
> experimentalandunconventional-unsubscribe@yahoogroups.com
>
> c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of
> Service.
>
>
>
------------------------------------------------------------------------------
>
>
>
> [Non-text portions of this message have been removed]
>
>
>
> SPONSORED LINKS Colon cancer treatments Colon cancer alternative
> treatment Colon cancer
> Colon cancer prevention Colon cancer surgery Colon cancer
> diagnosis
>
>
>
------------------------------------------------------------------------------
> YAHOO! GROUPS LINKS
>
> a.. Visit your group "experimentalandunconventional" on the web.
>
> b.. To unsubscribe from this group, send an email to:
> experimentalandunconventional-unsubscribe@yahoogroups.com
>
> c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of
> Service.
>
>
>
------------------------------------------------------------------------------
>
>
>
> [Non-text portions of this message have been removed]
>
>
>
> SPONSORED LINKS Colon cancer treatments Colon cancer alternative
> treatment Colon cancer
> Colon cancer prevention Colon cancer surgery Colon cancer
> diagnosis
>
>
> ------------------------------------------------------------------------------
> YAHOO! GROUPS LINKS
>
> a.. Visit your group "experimentalandunconventional" on the web.
>
> b.. To unsubscribe from this group, send an email to:
> experimentalandunconventional-unsubscribe@yahoogroups.com
>
> c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of
> Service.
>
>
> ------------------------------------------------------------------------------
>
>
>
> [Non-text portions of this message have been removed]
>
>
>
> ________________________________________________________________________
> ________________________________________________________________________
>
>
>
> ------------------------------------------------------------------------
> Yahoo! Groups Links
>
>
>
>
> ------------------------------------------------------------------------
>
>
>
>
>
>
>
Thank you Donna, for your suggestions and support. I am passing all the imparted
pearls of wisdom on to my Brother and Sister in Law. Appreciate your help!
Diane
----- Original Message -----
From: Mel
To: experimentalandunconventional@yahoogroups.com
Sent: Friday, January 27, 2006 8:03 AM
Subject: Re: [Experimental and Unconventional] My Brothers Wife
I wonder why this comes back to me and not to Diane ... tell me what I have
done wrong .. d
----- Original Message -----
From: Mel
To: experimentalandunconventional@yahoogroups.com
Sent: Friday, January 27, 2006 7:41 AM
Subject: Re: [Experimental and Unconventional] My Brothers Wife
Hello Diane .. first off please know Debbie will be in my prayers .. I
understand she has had surgery and now the big concern is the cancer that has
taken up residence in her liver ... I'm sure the chemo is the route to take now
.... The chemo though can be enhanced as well as side effects reduced with
certain alternative cancer treatments ..
the cancer can be chased away and killed with cancer herbs and Papimi
therapy .. I have was diagnosed with stage 3 colin cancer in July .. My Surgeon
and My Endoscopic Dr were having a disagrement as what route to take as to best
get this under control and cure ... surgery vs chemo and radiation prior to
sugery .. I live in Canada .. and since there was an argument going on as to my
treatment .. My hubby took me to Rocester Mn to the Mayo Clinic ... I spent
$18,000.. but found out that Mayo would treat the tumor prior to surgery ...(
this I know is not an option now for Debbie since she has had surgery ... what
needs to happen now is to shrink .. steralize and destroy the liver tumor.
I was introduced to Papimi therapy in July and had 30 treatments ... I know
It shrunk the tumor .. no doubt in my mind .. I was also introduced to a cancer
herb called Oncolyn ..and started taking it in Aug . I take 6 caplets daily .. 2
-3X daily .. and know with out a doubt the Oncolyn has helped me stay strong and
healthy by enhancing the chemo and reducing the side effects .. I did have
surgery Dec 8 /05 .. the tumor was gone completely .. I saw with my own eyes
during colonoscopy the day prior to .. the biopsy of the tumor site also
revealed cancer free ... My sugeon removed all of the lympth nodes in the groin
area at the same time .. 11 in all .. one of which showed signs of cancer .. so
now I'm having chemo again .. 5 days on ... 3 weeks off .. I will admit to a
loss of appetite somewhat .. mainly because the taster isn't working .. and that
I'm more tired than usual .. I also must say .. these side effects do not last
long .. just a couple of days .. then daily I inukshuk means not to worry others
have been there before ...
Daryl is my rock .. he was diagnosed with terminal lung cancer that began in
his testicles ... His story and the stories of others that he has helped will
give Debbie hope and knowledge ... Daryl is a man of God and I'm sure God works
through him to heal all the people he can ..
Again please let Debbie know there is hope .. Believe in God .. investigate
the therapies and herb treatments that have worked for me and many others ..
stay positive .. refuse to think negative thoughts .. surround herself with
positive people ... and have faith .. I will most certainly be praying for her
to give her the strength she requires to get through this health bump ... this
adventure in life .. she will one day be helping others do the same ..
May God Bless you and yours as well ... You are a wonderful sister in law
Diane .. God is proud of you for taking on the role of lets get active and
research what is out there ... God expects us to use our noodles to help in our
own recovery .. he will guide the people to us that we need .. then it is up to
us to get in charge of our recovery ... there is no doubt in my mind that God
led me to Daryl Robinson and Oncolyn as well as to the Papimi therapy clinic in
my town ... If I can help in any way please know I'm here ... at the other end
of the keyboard. or phone if requied ..
Sent with love .. Donna T, Saskatchewan, Canada
---- Original Message -----
From: dianevespa
To: experimentalandunconventional@yahoogroups.com
Sent: Thursday, January 26, 2006 9:07 PM
Subject: [Experimental and Unconventional] My Brothers Wife
Hello everyone,
I am joining this group on behalf of my Dear Sister-in-Law, wife of
my baby brother, and Mom to two adorable kids. Her name is Debbie.
Two weeks ago she went in to see her Doctor because of a "flu" that
didn't seem to go away, and swellings in her abdomen. A mere three
days later, she was post surgery, with half of her colon removed,
and a diagnosis of Stage 4 colon cancer mestasized to the liver.
Needless to say, we are all in shock and a state of disbelief. She
is 48 years old. I am coming to this board looking for
advice/suggestions/support/hope really anything that we can turn in
to hope for Debbie. She lives close to and is being treated in
Elgin, IL. I am trying to encourage my Brother to take her to a
larger clinic but he seems satisfied with the protocol prescribed by
the smaller hospital. (Sherman) Apparently they confer with the
larger hospitals. She will be getting chemotherapy the traditional
way. They cannot inject it directly in to her liver because the
cancer is too advanced. If we are overlooking anything or if I am
missing "a big picture" please enlighten me. Thank you for reading
and caring and on behalf of Debbie and Steve we look forward to any
help.
Diane Vespa
SPONSORED LINKS Colon cancer treatments Colon cancer alternative
treatment Colon cancer
Colon cancer prevention Colon cancer surgery Colon cancer
diagnosis
------------------------------------------------------------------------------
YAHOO! GROUPS LINKS
a.. Visit your group "experimentalandunconventional" on the web.
b.. To unsubscribe from this group, send an email to:
experimentalandunconventional-unsubscribe@yahoogroups.com
c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of
Service.
------------------------------------------------------------------------------
[Non-text portions of this message have been removed]
SPONSORED LINKS Colon cancer treatments Colon cancer alternative treatment
Colon cancer
Colon cancer prevention Colon cancer surgery Colon cancer diagnosis
------------------------------------------------------------------------------
YAHOO! GROUPS LINKS
a.. Visit your group "experimentalandunconventional" on the web.
b.. To unsubscribe from this group, send an email to:
experimentalandunconventional-unsubscribe@yahoogroups.com
c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of Service.
------------------------------------------------------------------------------
[Non-text portions of this message have been removed]
SPONSORED LINKS Colon cancer treatments Colon cancer alternative treatment
Colon cancer
Colon cancer prevention Colon cancer surgery Colon cancer diagnosis
------------------------------------------------------------------------------
YAHOO! GROUPS LINKS
a.. Visit your group "experimentalandunconventional" on the web.
b.. To unsubscribe from this group, send an email to:
experimentalandunconventional-unsubscribe@yahoogroups.com
c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of Service.
------------------------------------------------------------------------------
[Non-text portions of this message have been removed]
I wonder why this comes back to me and not to Diane ... tell me what I have done
wrong .. d
----- Original Message -----
From: Mel
To: experimentalandunconventional@yahoogroups.com
Sent: Friday, January 27, 2006 7:41 AM
Subject: Re: [Experimental and Unconventional] My Brothers Wife
Hello Diane .. first off please know Debbie will be in my prayers .. I
understand she has had surgery and now the big concern is the cancer that has
taken up residence in her liver ... I'm sure the chemo is the route to take now
.... The chemo though can be enhanced as well as side effects reduced with
certain alternative cancer treatments ..
the cancer can be chased away and killed with cancer herbs and Papimi therapy
.. I have was diagnosed with stage 3 colin cancer in July .. My Surgeon and My
Endoscopic Dr were having a disagrement as what route to take as to best get
this under control and cure ... surgery vs chemo and radiation prior to sugery
.. I live in Canada .. and since there was an argument going on as to my
treatment .. My hubby took me to Rocester Mn to the Mayo Clinic ... I spent
$18,000.. but found out that Mayo would treat the tumor prior to surgery ...(
this I know is not an option now for Debbie since she has had surgery ... what
needs to happen now is to shrink .. steralize and destroy the liver tumor.
I was introduced to Papimi therapy in July and had 30 treatments ... I know
It shrunk the tumor .. no doubt in my mind .. I was also introduced to a cancer
herb called Oncolyn ..and started taking it in Aug . I take 6 caplets daily .. 2
-3X daily .. and know with out a doubt the Oncolyn has helped me stay strong and
healthy by enhancing the chemo and reducing the side effects .. I did have
surgery Dec 8 /05 .. the tumor was gone completely .. I saw with my own eyes
during colonoscopy the day prior to .. the biopsy of the tumor site also
revealed cancer free ... My sugeon removed all of the lympth nodes in the groin
area at the same time .. 11 in all .. one of which showed signs of cancer .. so
now I'm having chemo again .. 5 days on ... 3 weeks off .. I will admit to a
loss of appetite somewhat .. mainly because the taster isn't working .. and that
I'm more tired than usual .. I also must say .. these side effects do not last
long .. just a couple of days .. then daily I inukshuk means not to worry others
have been there before ...
Daryl is my rock .. he was diagnosed with terminal lung cancer that began in
his testicles ... His story and the stories of others that he has helped will
give Debbie hope and knowledge ... Daryl is a man of God and I'm sure God works
through him to heal all the people he can ..
Again please let Debbie know there is hope .. Believe in God .. investigate
the therapies and herb treatments that have worked for me and many others ..
stay positive .. refuse to think negative thoughts .. surround herself with
positive people ... and have faith .. I will most certainly be praying for her
to give her the strength she requires to get through this health bump ... this
adventure in life .. she will one day be helping others do the same ..
May God Bless you and yours as well ... You are a wonderful sister in law
Diane .. God is proud of you for taking on the role of lets get active and
research what is out there ... God expects us to use our noodles to help in our
own recovery .. he will guide the people to us that we need .. then it is up to
us to get in charge of our recovery ... there is no doubt in my mind that God
led me to Daryl Robinson and Oncolyn as well as to the Papimi therapy clinic in
my town ... If I can help in any way please know I'm here ... at the other end
of the keyboard. or phone if requied ..
Sent with love .. Donna T, Saskatchewan, Canada
---- Original Message -----
From: dianevespa
To: experimentalandunconventional@yahoogroups.com
Sent: Thursday, January 26, 2006 9:07 PM
Subject: [Experimental and Unconventional] My Brothers Wife
Hello everyone,
I am joining this group on behalf of my Dear Sister-in-Law, wife of
my baby brother, and Mom to two adorable kids. Her name is Debbie.
Two weeks ago she went in to see her Doctor because of a "flu" that
didn't seem to go away, and swellings in her abdomen. A mere three
days later, she was post surgery, with half of her colon removed,
and a diagnosis of Stage 4 colon cancer mestasized to the liver.
Needless to say, we are all in shock and a state of disbelief. She
is 48 years old. I am coming to this board looking for
advice/suggestions/support/hope really anything that we can turn in
to hope for Debbie. She lives close to and is being treated in
Elgin, IL. I am trying to encourage my Brother to take her to a
larger clinic but he seems satisfied with the protocol prescribed by
the smaller hospital. (Sherman) Apparently they confer with the
larger hospitals. She will be getting chemotherapy the traditional
way. They cannot inject it directly in to her liver because the
cancer is too advanced. If we are overlooking anything or if I am
missing "a big picture" please enlighten me. Thank you for reading
and caring and on behalf of Debbie and Steve we look forward to any
help.
Diane Vespa
SPONSORED LINKS Colon cancer treatments Colon cancer alternative treatment
Colon cancer
Colon cancer prevention Colon cancer surgery Colon cancer diagnosis
------------------------------------------------------------------------------
YAHOO! GROUPS LINKS
a.. Visit your group "experimentalandunconventional" on the web.
b.. To unsubscribe from this group, send an email to:
experimentalandunconventional-unsubscribe@yahoogroups.com
c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of Service.
------------------------------------------------------------------------------
[Non-text portions of this message have been removed]
SPONSORED LINKS Colon cancer treatments Colon cancer alternative treatment
Colon cancer
Colon cancer prevention Colon cancer surgery Colon cancer diagnosis
------------------------------------------------------------------------------
YAHOO! GROUPS LINKS
a.. Visit your group "experimentalandunconventional" on the web.
b.. To unsubscribe from this group, send an email to:
experimentalandunconventional-unsubscribe@yahoogroups.com
c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of Service.
------------------------------------------------------------------------------
[Non-text portions of this message have been removed]
Hello Diane .. first off please know Debbie will be in my prayers .. I
understand she has had surgery and now the big concern is the cancer that has
taken up residence in her liver ... I'm sure the chemo is the route to take now
.... The chemo though can be enhanced as well as side effects reduced with
certain alternative cancer treatments ..
the cancer can be chased away and killed with cancer herbs and Papimi therapy
.. I have was diagnosed with stage 3 colin cancer in July .. My Surgeon and My
Endoscopic Dr were having a disagrement as what route to take as to best get
this under control and cure ... surgery vs chemo and radiation prior to sugery
.. I live in Canada .. and since there was an argument going on as to my
treatment .. My hubby took me to Rocester Mn to the Mayo Clinic ... I spent
$18,000.. but found out that Mayo would treat the tumor prior to surgery ...(
this I know is not an option now for Debbie since she has had surgery ... what
needs to happen now is to shrink .. steralize and destroy the liver tumor.
I was introduced to Papimi therapy in July and had 30 treatments ... I know It
shrunk the tumor .. no doubt in my mind .. I was also introduced to a cancer
herb called Oncolyn ..and started taking it in Aug . I take 6 caplets daily .. 2
-3X daily .. and know with out a doubt the Oncolyn has helped me stay strong and
healthy by enhancing the chemo and reducing the side effects .. I did have
surgery Dec 8 /05 .. the tumor was gone completely .. I saw with my own eyes
during colonoscopy the day prior to .. the biopsy of the tumor site also
revealed cancer free ... My sugeon removed all of the lympth nodes in the groin
area at the same time .. 11 in all .. one of which showed signs of cancer .. so
now I'm having chemo again .. 5 days on ... 3 weeks off .. I will admit to a
loss of appetite somewhat .. mainly because the taster isn't working .. and that
I'm more tired than usual .. I also must say .. these side effects do not last
long .. just a couple of days .. then daily I become stronger and healthier ...
I will have my second week of chemo starting Feb 6 and would not ever think of
not taking my Oncolyn .. check this cancer product out it has several patents in
the US was discovered by Dr D'jang of New York .. it should be at your finger
tips .. My supplier lives in Edmonton Alberta Canada .. Daryl Robinson..web site
address www.inukshuk.com
inukshuk means not to worry others have been there before ...
Daryl is my rock .. he was diagnosed with terminal lung cancer that began in his
testicles ... His story and the stories of others that he has helped will give
Debbie hope and knowledge ... Daryl is a man of God and I'm sure God works
through him to heal all the people he can ..
Again please let Debbie know there is hope .. Believe in God .. investigate the
therapies and herb treatments that have worked for me and many others .. stay
positive .. refuse to think negative thoughts .. surround herself with positive
people ... and have faith .. I will most certainly be praying for her to give
her the strength she requires to get through this health bump ... this adventure
in life .. she will one day be helping others do the same ..
May God Bless you and yours as well ... You are a wonderful sister in law Diane
.. God is proud of you for taking on the role of lets get active and research
what is out there ... God expects us to use our noodles to help in our own
recovery .. he will guide the people to us that we need .. then it is up to us
to get in charge of our recovery ... there is no doubt in my mind that God led
me to Daryl Robinson and Oncolyn as well as to the Papimi therapy clinic in my
town ... If I can help in any way please know I'm here ... at the other end of
the keyboard. or phone if requied ..
Sent with love .. Donna T, Saskatchewan, Canada
---- Original Message -----
From: dianevespa
To: experimentalandunconventional@yahoogroups.com
Sent: Thursday, January 26, 2006 9:07 PM
Subject: [Experimental and Unconventional] My Brothers Wife
Hello everyone,
I am joining this group on behalf of my Dear Sister-in-Law, wife of
my baby brother, and Mom to two adorable kids. Her name is Debbie.
Two weeks ago she went in to see her Doctor because of a "flu" that
didn't seem to go away, and swellings in her abdomen. A mere three
days later, she was post surgery, with half of her colon removed,
and a diagnosis of Stage 4 colon cancer mestasized to the liver.
Needless to say, we are all in shock and a state of disbelief. She
is 48 years old. I am coming to this board looking for
advice/suggestions/support/hope really anything that we can turn in
to hope for Debbie. She lives close to and is being treated in
Elgin, IL. I am trying to encourage my Brother to take her to a
larger clinic but he seems satisfied with the protocol prescribed by
the smaller hospital. (Sherman) Apparently they confer with the
larger hospitals. She will be getting chemotherapy the traditional
way. They cannot inject it directly in to her liver because the
cancer is too advanced. If we are overlooking anything or if I am
missing "a big picture" please enlighten me. Thank you for reading
and caring and on behalf of Debbie and Steve we look forward to any
help.
Diane Vespa
SPONSORED LINKS Colon cancer treatments Colon cancer alternative treatment
Colon cancer
Colon cancer prevention Colon cancer surgery Colon cancer diagnosis
------------------------------------------------------------------------------
YAHOO! GROUPS LINKS
a.. Visit your group "experimentalandunconventional" on the web.
b.. To unsubscribe from this group, send an email to:
experimentalandunconventional-unsubscribe@yahoogroups.com
c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of Service.
------------------------------------------------------------------------------
[Non-text portions of this message have been removed]
Hello everyone,
I am joining this group on behalf of my Dear Sister-in-Law, wife of
my baby brother, and Mom to two adorable kids. Her name is Debbie.
Two weeks ago she went in to see her Doctor because of a "flu" that
didn't seem to go away, and swellings in her abdomen. A mere three
days later, she was post surgery, with half of her colon removed,
and a diagnosis of Stage 4 colon cancer mestasized to the liver.
Needless to say, we are all in shock and a state of disbelief. She
is 48 years old. I am coming to this board looking for
advice/suggestions/support/hope really anything that we can turn in
to hope for Debbie. She lives close to and is being treated in
Elgin, IL. I am trying to encourage my Brother to take her to a
larger clinic but he seems satisfied with the protocol prescribed by
the smaller hospital. (Sherman) Apparently they confer with the
larger hospitals. She will be getting chemotherapy the traditional
way. They cannot inject it directly in to her liver because the
cancer is too advanced. If we are overlooking anything or if I am
missing "a big picture" please enlighten me. Thank you for reading
and caring and on behalf of Debbie and Steve we look forward to any
help.
Diane Vespa
Last Updated: January 19, 2006
NEW YORK (Reuters Health) - Adjuvant chemotherapy regimens involving
fluorouracil in combination with leucovorin, with or without
levamisole, appear to achieve similar survival in patients with high-
risk colon cancer, according to long-term findings from a randomized
trial.
In the December issue of the Journal of Clinical Oncology, Dr. Daniel
G. Haller of the University of Pennsylvania, Philadelphia and
colleagues note that the study, begun in 1988, involves the single
largest population of patients with high-risk colon cancer.
Following surgery, almost 3800 patients were randomized to
fluorouracil in combination with high or low-dose leucovorin or low-
dose leucovorin along with levamisole for up to 32 weeks. Controls
were given fluorouracil with levamisole for 1 year.
After a median follow-up of 10 years, 47% of patients had died. Of
these, 13% died without evidence of recurrence. Some 37% experienced
recurrence and 10% of these patients are still alive. Overall, 48% of
patients were alive and disease free.
The researchers observe that interim analyses suggested survival
advantages with certain regimens. This is no longer the case and
there are no significant differences apparent among treatments. The
researchers also note that hospital volume was not associated with
survival as has been documented in other studies.
Finally, they conclude that although therapy containing leucovorin
and levamisole was significantly more toxic than that containing
leucovorin without levamisole, there were no significant differences
across groups in deaths potentially attributable to treatment.
Last Updated: January 19, 2006
NEW YORK (Reuters Health) - A new method of isolating colonocytes
from naturally evacuated feces may form the basis for early detection
of colorectal cancer, according to Japanese researchers.
Investigator Dr. Yasuhiro Matsumura told Reuters Health that in
envisioning the technique "we predicted that normal mucous cells
would die and be exfoliated during turnover and that the cancer cells
would likely survive for a long time in feces."
In the December issue of Gastroenterology, Dr. Matsumura of the
National Cancer Center Hospital East, Kashiwa City and colleagues
note that they tested the feasibility of this approach by analyzing
feces from 116 patients with colorectal cancer and from 83 healthy
volunteers.
The new method involved a funnel-shaped filtration system that was
capable of filtrating the entire stool suspension without filter
clogging, the authors write. They then used magnetic beads coated
with mouse antibodies specific for a membrane antigen epressed on
most normal and neoplastic human epithelial tissues to separate cell
populations.
The researchers used both cytological and DNA techniques to examine
retrieved cells. Cytology showed atypical cells in 28% of the cancer
patients and none of the volunteers.
Genetic alterations were seen in 82 of the cancer patients, giving a
sensitivity of 71%. However, alterations were also seen in 10 of the
volunteers, yielding a specificity of 88%.
When the analysis was limited to cases in which genetic alterations
were present in cancer tissue, the detection rate for such
alterations using these methods was 86%.
Given these encouraging findings, Dr. Matsumura concluded that "we
are now planning a prospective randomized study to compare our new
method with the hemoccult test to determine the actual specificity
and sensitivity in a real screening population and to verify its
clinical usefulness and medical economics."
----------------------------------------------------------------------
----------
Last Updated: December 22, 2005
NEW YORK (Reuters Health) - The presence in colorectal cancers of a
recently characterized immune cell population -- effector memory T
cells -- has a major impact on tumor evolution, according to European
investigators who have shown that these cells prevent colorectal
cancer dissemination and distant metastases and are associated with
prolonged survival.
Until now, the role of tumor-infiltrating immune cells in the early
metastatic invasion of colorectal cancer was largely unknown. "Our
data suggest that the tumor microenvironment and the host's immune
response are of major importance in tumor progression," the study
team concludes in their paper in the December 22nd issue of The New
England Journal of Medicine.
In their analysis of 959 resected colorectal tumor specimens, early
conventional pathological tumor-node-metastasis stage and the absence
of early metastatic invasion -- venous emboli, lymphatic invasion,
and perineural invasion, collectively termed VELIPI -- were
independently associated with increased survival.
Moreover, according to Dr. Jerome Galon, a research scientist at
INSERM, the French National Institute of Health and Medical Research
in Paris, "a high-density of intratumoral effector memory T cells
significantly correlated with VELIPI-negative tumors. In contrast, a
low-density of intratumoral effector-memory T cells significantly
correlated with tumor dissemination (VELIPI-positive), lymph-node
metastasis, distant metastasis, and shorter survival."
It may be possible, Dr. Galon said, to classify tumors based on the
density of these immune cells "with better predictive value than the
gold-standard histo-prognostic classification, which is based on
tumor criteria only. This will allow us to define patient groups with
high-risk of relapse justifying adjuvant therapy."
In addition, the amplification or stimulation of these effector
memory cells could be used as a novel immunotherapy for the treatment
of colorectal cancer and possibly other cancers as well, Dr. Galon
noted.
Dr. Giorgio Parmiani from the National Tumor Institute in Milan notes
in an editorial that these data provide "strong but indirect evidence
of immune-mediated control of the growth of colorectal cancer."
"What we lack are functional studies showing an ongoing, tumor-
specific immune response mediated by T cells in untreated patients
with colorectal cancer," the researcher notes.
Nonetheless, there is "convincing evidence," Dr. Parmiani notes, of
an association between a favorable prognosis and the infiltration by
cytotoxic cytokine-releasing effector memory CD8+ T cells into
melanoma, ovarian cancer, non-Hodgkin's lymphoma, and now colorectal
cancer.
There is good data on mushroom extract for colon cancer. We are trying
to use Lin-zhi, a potent(likely the most potent) activator of
dendritic cells, T reg, NK cellls, along with chemotherapy and
monoclonal antobodies, to treat advanced as well as high risk colon
cancers. Our theory is that chemo(not all chemo) is immunogenic, and
Linzhi will amplify the response. This theory is supported by many lab
and clinical studies.
Any body interested in our approach(physicians, or patients),please
email me, or visit my website www.cure4cancer.com
Merry Xmas!
www.cure4cancer.com
Cancer's road map to metastasis revealed
Last Updated: December 07, 2005
LONDON (Reuters) - Scientists have discovered how cancer spreads from
a primary site to other places in the body in a finding that could
open doors for new ways of treating and preventing advanced disease.
Instead of a cell just breaking off from a tumour and travelling
through the bloodstream to another organ where it forms a secondary
tumour, or metastasis, researchers in the United States have shown
that the cancer sends out envoys to prepare the new site.
Intercepting those envoys, or blocking their action with drugs, might
help to prevent the spread of cancer or to treat patients in whom
metastasis has already occurred.
"We are basically looking at all the earlier steps that are involved
in metastasis that we weren't previously aware of. It is complex but
we are opening the door to all these things that occur before the
tumour cell implants itself," said Dr. David Lyden of Cornell
University in New York. "It is a map to where the metastasis will
occur," he added in an interview.
LANDING SITE FOR CANCER CELLS
Cancer's ability to colonise other organs is what makes the disease
so deadly. Once the cancer has spread beyond its original site it is
much more difficult to treat.
In research reported in the journal Nature, Lyden and his colleagues
describe what happens before the arrival of the cancerous cells at
the new site.
"The authors show that tumour cells can mobilise normal bone marrow
cells, causing them to migrate to particular regions and change the
local environment so as to attract and support a developing
metastasis," Dr. Patricia Steeg, of the National Cancer Institute in
Bethesda, Maryland, said in a commentary.
Cells at the site of the metastasis multiply and produce a protein
called fibronectin, which acts like a glue to attract and trap the
bone marrow cells to create a landing pad or nest for the cancer
cells.
"These nests provide attachment factors for the tumour cells to
implant and nurture them. It causes them not only to bind, but to
proliferate. Once that all takes place we have a fully formed
metastatic site or secondary tumour," said Lyden.
"This is the first time anyone has discovered what we call the pre-
metastatic niche."
Without the landing pad, the cancerous cell cannot colonise the organ.
In animal and laboratory studies, the scientists looked at how
breast, lung and oesophageal cancer spread. The envoys from the
tumour determine the site of the secondary site.
Lyden said measuring the number of special bone marrow cells
circulating in the body could help to determine whether a cancer is
likely to spread.
"This opens up the door to new concepts of how metastasis is taking
place. If we can understand all these multiple processes we can
develop new drugs that block each step. That way we have a much
better future than just trying to treat the tumour cell, which is
almost like a last step in this process," he added.
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Last Updated: November 29, 2005
CHICAGO (Reuters Health) - Magnetic resonance-guided laser-induced
thermotherapy (LITT) for treatment of both primary and metastatic
liver tumors improves survival with less morbidity compared to
standard surgical resection, researchers reported Tuesday at the
annual meeting of the Radiological Society of North America.
Dr. Martin Mack, associate professor of diagnostic and interventional
radiology at the University of Frankfort, Germany reported results
from a series of 839 patients, mean age 62, who underwent LITT over a
12-year period.
The operative mortality rate was just 0.2% for the LITT patients
compared with an historical mortality rate of 3%-4% for patients who
undergo open-surgical resections, Dr. Mack said. Likewise, post-
procedural complications were much lower: 2% among LITT patients
versus 30% in historical controls.
"Those who undergo surgery have a median survival of 3.4 to 4.5
years, but patients who undergo ablation treatment have a median
survival of around 5 years," reported Dr. Mack in a press briefing.
He said that LITT can also be repeated several times in the event of
recurrences.
The LITT procedure involves MRI to precisely locate a tumor and then
guide a laser probe into the tumor. Laser energy destroys the lesion.
Dr. Mack said the procedure is equally effective for primary liver
tumors or metastases.
LITT is, however, limited by both the number of lesions and the size
of the tumors. Ideally patients should have no more than five
lesions, each 5 cm or less. For patients with larger tumors or more
lesions, he recommended staging with chemotherapy or
chemoembolization prior to LITT.
Unlike surgical resection, which can require a week or more hospital
stay, LITT patients are typically discharged within 6 hours. "It can
be performed on an outpatient basis," Dr. Mack said.
Cost comparisons also favor LITT, "with each ablation costing about
$5,000-$6,000 versus $30,000 for surgery and chemotherapy averaging
$3,000 to $5,000 a month with treatment continuing over several
months," he said.
----------------------------------------------------------------------
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www.asco.org c Copyright 2002 American Society of Clinical Oncology
All rights reserved worldwide.
Thanks for the tip. Please let me know if there is a way my website can be
beneficial to you, too.
--
Colon Cancer Victims Memorial www.coloncancermemorial.com
-------------- Original message --------------
THIS IS VERY IMPORTANT! We have an opportunity to be heard nationwide. I will
be calling in and talking about ProjectMARCH and why we are gathering to demand
screening for all adults starting at age 18 and regardless of insurance or not.
Please call in. Let your voice be heard. The only way colon cancer issues
will ever rise to the top is if we seize opportunity when it arrives. Do you
want to continue to just hear about other cancers most of the time? Do you want
to stand up for those here who were diagnosed under the age of 60? (Because if
you were diagnosed in your 50s it was too late - you needed to be screened
before age 50 to NOT get this cancer.)
Will you make the call?
Priscilla A. Savary
Executive Director
Colorectal Cancer Network
PO Box 182, Kensington MD 20895
301-879-1500
psavary@...
www.colorectal-cancer.net
_________
Screening for All. Colon Cancer for None.
ProjectMARCH -- rarely in life do you get a chance to make major change or save
thousands of lives. March 6, 2006 you can.
http://www.colorectal-cancer.net/projectmarch.htm
________________________________________________________________________________\
_____
Dear Colorectal Cancer Advocates,
On Sunday, October 23rd, The Group Room radio program will be devoted to a
discussion of colorectal cancer. Joining us in-studio will be Dr. Heinz-Josef
Lenz, Associate Professor of Medicine, Director, GI Oncology Program, Scientific
Director, Cancer Genetics, USC Keck School of Medicine, USC/Norris Comprehensive
Cancer Center. Calling into the show from Massachusetts General Hospital will
be David P. Ryan MD, Clinical Director, Tucker Gosnell Center for
Gastrointestinal Cancers Massachusetts General Hospital Cancer Center, Assistant
in Medicine, Massachusetts General Hospital and Assistant Professor of Medicine,
Harvard Medical School.
I am writing to let you know that we have highlighted your organization on our
web page (www.vitaloptions.org) in the Advocacy In Action section for this
program. We gladly promote your organizations and your events on both our radio
show and our website because you have your fingers on the pulse of the issues
colorectal cancer patients. I am urging you to promote this show to your
members. We hope you will consider a reciprocal link on your web site as well.
By linking to our web site, those visiting your web site will find the radio
stations in your area with which to listen to the Colorectal Cancer Awareness
show. We are also broadcast live on XM Satellite Radio on the ASK channel, as
well as streaming live via internet. In addition, we also archive all shows on
the website fro future reference.
More important, this is really an opportunity for you and your constituents to
call in and be sure that we are addressing those issues that really matter to
colorectal and other cancer patients and survivors. We want to involve you and
your members to the fullest degree in this nationwide dialogue; this is a
valuable forum that we hope you will take advantage of.
Your cooperation will be truly appreciated!
Thank you,
Felice
_____________________________________________
_____________________________________________
Felice Bachrach
Vital Options International and The Group Room
To Facilitate a Global Cancer Dialogue
Advocacy Relations Manager
4419 Coldwater Canyon Ave.
Studio City, Ca 91604
U.S.A.
Ph: 1-818-508-5657
Email: fbachrach@...
Website: www.vitaloptions.org
[Non-text portions of this message have been removed]
Below is a letter I just sent to the Community Director at one of NBC's offices.
If you want this to happen....if you want colon cancer to be made a line in a
history book....you must take action. Call write or email every media person
you can. Make sure all local papers, tv anchors and reporters, local magazines,
and radio stations have this letter or rather one in your words from you. There
is an easy email option on the Association of Community Cancer Centers website.
Will you do this? Choose your town, your county, or your state. Just don't sit
by. We all are suffering enough. It is time that we used the hard won right of
demanding action to end this cancer. Those of us who are Americans know that
we have a long history of standing up and demanding what we want. What we know
is right.
Those here who are not in the United States - shouldn't you be demanding the
same in your own country. It isn't enough to end this here in the States. Any
disease that can be eradicated, must be eradicated for all. On March 6 - stand
in solidarity with us. And while you are at it, send a letter to our President.
It might wake him up to hear that people around the world are expecting him to
do the right thing.
I am pushing. I am demanding. I can't stand to see another Joe lost to a
cancer that should never have been.
If not now, when? If not you, then who?
Priscilla A. Savary
Executive Director
Colorectal Cancer Network
PO Box 182, Kensington MD 20895
301-879-1500
psavary@...
www.colorectal-cancer.net
_________
Screening for All. Colon Cancer for None.
ProjectMARCH -- rarely in life do you get a chance to make major change or save
thousands of lives. March 6, 2006 you can.
http://www.colorectal-cancer.net/projectmarch.htm
----- Original Message -----
From: Priscilla Savary
To: jean.nemeti@...
Cc: Priscilla Savary
Sent: Monday, October 17, 2005 4:18 PM
Subject: ProjectMARCH - The End of Colon Cancer is in Sight
Once in a lifetime you might get an opportunity to save a live. Few of us do.
Once in a century there might be an opportunity to save thousands of lives.
NOT try. NOT help in raising funds to fight diseases we don't know how to stop.
An TRUE opportunity to save a life...or rather, 56,000 lives. The building is
burning - will you help free the victims from the fire?
Colon cancer is the fire. 56,000 deaths annually for as long as its been
measured is the cost. And you have the power to help force this cancer into
oblivion.
Reporting on the press releases from the pharmaceuticals when a new drug is
marketed that will only prolong life for a little while - that isn't the path.
As a journalist, you either love writing, love knowing the inside story, or
maybe, just maybe, you got into this career because you wanted to uncover the
scandels; ensure freedom of speech; protect the People's right to know; and to
make sure that we all know what we need to know about our country and our lives.
Colon cancer can be stopped. Today. Without another research dollar. Without
new tools or new drugs. And if you are not reporting that side of the story,
shouldn't you ask yourself why not.
Remember this date. Make sure your readers know that for the first time ever
action is being taken by the People of this country that can result in ending
the very first cancer to become eradicated.
March 6, 2006
Gathering in Washington DC will be survivors, caregivers and many others who are
coming to demand screening for all starting at age 18.
Since President Nixon the United States continues to state that it is at war
with cancer. Are we really? If we are doesn't that mean that when we can win
the battle against one of the cancers that we should and must take those actions
to do so? Of course it does. Yet we have ignored for more than a decade that
we can NOW end colon cancer before it starts. No magic pills. No high-tech
expensive equipment. Just a simple colonoscopy every 5 years starting at age 18
and colon cancer would quickly become a distant memory.
Yet we continue to ignore this. Only in recent years has there even been any
effort on the part of major health and cancer organizations to promote screening
for this cancer at all.
What has happened to us? We used to be a country of action. When we could do
something we did.
Polio is a perfect example. At its highest it did not kill nor maim as many
people as colon cancer continues to do annually. If eradicating polio was left
in the same hands (as those who are sort-of, kind-of getting serious about doing
well, at least some colon cancer screening...maybe) polio would still be
devastating the lives of so many of us. Instead, once a vaccine for polio was
developed we put it into use. Were mistakes made? Yes. But rapidly a safe
vaccine was developed and now nearly all children in the United States are given
this vaccine.
We have that "vaccine" for colon cancer. And have had it for decades. It
isn't a shot. (Yet, anyway.) It's a colonoscopy. Not a flexible
sigmoidoscopy which if used to its best ability can't catch any more than 40% of
colon cancers - and never comes close to that number in practice.
Research demonstrating the effectiveness of colonoscopies, however, has shown
that even at its worst showing we can expect 80+% pickup rates. And more often
it picks up well into the 90+$ of colon cancer cases.
So, we know that colon cancer CAN happen at any age. Even kids can get colon
cancer - but nearly all of them, if not all, fall into the hereditary cases and
there is a huge family history already so they are watched like a hawk. Still,
in the nine years that I have been doing this I have come across an 8 year old
and an 11 year old who both died of colon cancer.
We know that diabetes and obesity have some link to colon cancer risk. We know
that these both are on the rise in the under 50 population. We therefore are
fore-armed with the knowledge that if the link is real then the incidence level
in the under 50 population is going to start rising rapidly too. And maybe
already has.
We have the weapon (colonoscopies). We have the ability (screening starting at
age 18). We certainly have the reason (56,000 dead every year, 130,000 -
168,000 newly diagnosed every year).
Are we at war or not?
Are you going to do real journalism and ask these questions or not?
You will be touched by colon cancer. You have already even if that person isn't
telling anyone yet. I in 18 Americans get this.
Whether you report this side of the story because it is news, or whether you do
it because you have the power to help stop the first cancer ever - the reason
doesn't matter. But the result will matter to the 56,000 who are dying this
year. And those who will guaranteed, die next year, and all the years after
that.
Well?
Attached is our proprietary document that backsup what we are saying. Check it
out. You'll see that the best research minds in the world have done the
research that can end this cancer. Then call me. And report on this. Your
readers have a right to know that they are being kept from preventing this
disease. They have a right to know that they have an opportunity to rise up
and demand screening for all. Because here in America, though we rarely
exercise it, we have the right to demand the changes that we want. Don't you
have a responsibility to your readers and listeners to tell the other side of
the story.
And by the way, if you haven't been screened, go schedule a colonoscopy for
yourself. Regardless of your age. You deserve it. We all do.
Peace and good health,
Priscilla A. Savary
Executive Director
Colorectal Cancer Network
PO Box 182, Kensington MD 20895
301-879-1500
psavary@...
www.colorectal-cancer.net
_________
Screening for All. Colon Cancer for None.
ProjectMARCH -- rarely in life do you get a chance to make major change or save
thousands of lives. March 6, 2006 you can.
http://www.colorectal-cancer.net/projectmarch.htm
[Non-text portions of this message have been removed]
THIS IS VERY IMPORTANT! We have an opportunity to be heard nationwide. I will
be calling in and talking about ProjectMARCH and why we are gathering to demand
screening for all adults starting at age 18 and regardless of insurance or not.
Please call in. Let your voice be heard. The only way colon cancer issues
will ever rise to the top is if we seize opportunity when it arrives. Do you
want to continue to just hear about other cancers most of the time? Do you want
to stand up for those here who were diagnosed under the age of 60? (Because if
you were diagnosed in your 50s it was too late - you needed to be screened
before age 50 to NOT get this cancer.)
Will you make the call?
Priscilla A. Savary
Executive Director
Colorectal Cancer Network
PO Box 182, Kensington MD 20895
301-879-1500
psavary@...
www.colorectal-cancer.net
_________
Screening for All. Colon Cancer for None.
ProjectMARCH -- rarely in life do you get a chance to make major change or save
thousands of lives. March 6, 2006 you can.
http://www.colorectal-cancer.net/projectmarch.htm
________________________________________________________________________________\
_____
Dear Colorectal Cancer Advocates,
On Sunday, October 23rd, The Group Room radio program will be devoted to a
discussion of colorectal cancer. Joining us in-studio will be Dr. Heinz-Josef
Lenz, Associate Professor of Medicine, Director, GI Oncology Program, Scientific
Director, Cancer Genetics, USC Keck School of Medicine, USC/Norris Comprehensive
Cancer Center. Calling into the show from Massachusetts General Hospital will
be David P. Ryan MD, Clinical Director, Tucker Gosnell Center for
Gastrointestinal Cancers Massachusetts General Hospital Cancer Center, Assistant
in Medicine, Massachusetts General Hospital and Assistant Professor of Medicine,
Harvard Medical School.
I am writing to let you know that we have highlighted your organization on our
web page (www.vitaloptions.org) in the Advocacy In Action section for this
program. We gladly promote your organizations and your events on both our radio
show and our website because you have your fingers on the pulse of the issues
colorectal cancer patients. I am urging you to promote this show to your
members. We hope you will consider a reciprocal link on your web site as well.
By linking to our web site, those visiting your web site will find the radio
stations in your area with which to listen to the Colorectal Cancer Awareness
show. We are also broadcast live on XM Satellite Radio on the ASK channel, as
well as streaming live via internet. In addition, we also archive all shows on
the website fro future reference.
More important, this is really an opportunity for you and your constituents to
call in and be sure that we are addressing those issues that really matter to
colorectal and other cancer patients and survivors. We want to involve you and
your members to the fullest degree in this nationwide dialogue; this is a
valuable forum that we hope you will take advantage of.
Your cooperation will be truly appreciated!
Thank you,
Felice
_____________________________________________
_____________________________________________
Felice Bachrach
Vital Options International and The Group Room
To Facilitate a Global Cancer Dialogue
Advocacy Relations Manager
4419 Coldwater Canyon Ave.
Studio City, Ca 91604
U.S.A.
Ph: 1-818-508-5657
Email: fbachrach@...
Website: www.vitaloptions.org
[Non-text portions of this message have been removed]
(Loss of DNA repair capacity due to inactivation of a specific gene
is one of the characteristics of cancer, and can already be detected
in normal appearing tissues away from the from the cancer)
Contact: Sarah L. Zielinski
jncimedia@...
301-841-1287
Journal of the National Cancer Institute
Change in gene may be underlying molecular defect in some colorectal
cancers, study suggests
Inactivation of a DNA repair gene may be an early step in the
development of sporadic colorectal tumors, and detection of the
molecular basis for this inactivation may ultimately be useful in
risk assessment for colorectal cancer, according to a new study in
the September 21 issue of the Journal of the National Cancer
Institute.
Cancers can arise from a region of cells with a "field defect", cells
that appear normal but that have an underlying molecular defect. The
molecular basis for the field defect is easy to understand when
tumors develop from cells that all have similar genetic
abnormalities, such as those that occur in patients who are
genetically predisposed to a cancer or those who undergo an exposure
to a carcinogen such as tobacco smoke. However, how the field defect
may arise in most sporadic cancers in unclear.
In colorectal cancer, the DNA repair gene O6-methylguanine-DNA
methyltransferase (MGMT) is often methylated--that is, the gene's
promoter region has methyl groups added to it, which inactivate the
gene. Jean-Pierre J. Issa, M.D., of the University of Texas M. D.
Anderson Cancer Center in Houston, and colleagues hypothesized that
MGMT promoter methylation could be one of the characteristics of the
field defect in colorectal cancer, so they studied MGMT promoter
methylation in the tumor, adjacent mucosa, and nonadjacent mucosa of
95 colorectal cancer patients and in the colon mucosa of 33 subjects
without cancer.
MGMT promoter methylation was found in 50% to 94% of colorectal
tumors, depending on the method of detection, and normal-appearing
colon mucosa up to 10 cm away from the tumor had detectable MGMT
methylation. In addition, the authors detected MGMT methylation in
the normal colon mucosa of several subjects who did not have cancer.
"Because a loss of MGMT protein function is a plausible predisposing
factor for cancer through the increased occurrence of mutations…, our
data indicate that MGMT promoter methylation may qualify as a marker
of the field defect in colorectal cancer," the authors write. In
addition, "given the high lifetime risk of colorectal tumor
development in the U.S. population, it is reasonable to propose
testing to determine whether healthy persons with MGMT promoter
methylation in normal colorectal mucosa are at higher risk of
developing a colon tumor than those without such methylation."
In an editorial, Edward Giovannucci, M.D., Sc.D., of the Harvard
School of Public Health, and Shuji Ogino, of Brigham and Women's
Hospital, both in Boston, review the concept of the field defect
(also called the field effect or field cancerization). They also
raise several questions about how these findings may affect related
areas of research, such as approaches to chemoprevention and "whether
the reversal of DNA methylation in precancerous cells may prevent the
development of new primary cancers in the same organ," they write.
###
Contacts:
Article: Laura Sussman, Communications Office, M. D. Anderson Cancer
Center, 713-745-2457, lsussman@...
Editorial: Edward Giovannucci, Harvard School of Public Health,
egiovann@...
Citations:
Article: Shen L, Kondo Y, Rosner GL, Xiao L, Hernandez NS, Vilaythong
J, et al. MGMT Promoter Methylation and Field Defect in Sporadic
Colorectal Cancer. J Natl Cancer Inst 2005;97:1330–8.
Citation: Giovannucci E, Ogino S. DNA Methylation, Field Effects, and
Colorectal Cancer. J Natl Cancer Inst 2005;97:1317–9.
Note: The Journal of the National Cancer Institute is published by
Oxford University Press and is not affiliated with the National
Cancer Institute. Attribution to the Journal of the National Cancer
Institute is requested in all news coverage. Visit the Journal online
at http://jncicancerspectrum.oxfordjournals.org/.
Walking exercise improves bowel prep for colonoscopy
Last Updated: September 27, 2005
NEW YORK (Reuters Health) - Adding walking exercise to the bowel
cleansing procedure results in better colonic cleansing without
increasing patient discomfort and should be recommended as part of
routine colonoscopic bowel preparation in ambulatory outpatients,
physicians in South Korea report.
"Adequate bowel preparation is one of the most difficult aspects of
colonoscopy," Dr. Hyun Soo Kim and colleagues note in their report in
the American Journal of Gastroenterology for September 5. A key
barrier to successful colonoscopy is inadequate bowel cleansing, with
poor preparation increasing the risk of missed lesions, complications
and a prolonged procedure time.
Based on animal studies showing that exercise improved defecation,
Dr. Kim, from Yonsei University Wonju College of Medicine in Seoul,
and colleagues theorized that walking exercise would improve colonic
cleansing.
For their prospective study, they randomly assigned patients to
walking exercise (n = 182) or to a nonexercise group (n = 174), with
both groups drinking 2.5 to 3 L of polyethylene glycol solution (PEG).
Those randomized to the walking exercise group were instructed to
drink 250 mL of PEG and then walk at least 5 minutes at intervals of
10 minutes until they had finished consuming the PEG. Those in the
nonexercise group drank 250 mL of PEG every 10 minutes, resting in
between.
Significantly more patients in the exercise group had excellent or
good preparations (40.7% versus 25.3% in the nonexercise group.
Multivariate analysis also showed that walking improved the
proportion of satisfactory colonic cleansing (odds ratio 2.06; p =
0.003), regardless of the presence of constipation.
Subgroup analysis showed walking to be of additional benefit in
patients younger than 65 years old and in patients without obesity or
a past history of abdominal or gynecologic surgery. Therefore, the
authors advise, "walking exercise for colonoscopic bowel preparation
should be recommended primarily for younger nonobese ambulatory
patients without a history of abdominal or gynecological surgery."
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