Keith:m But what do you think of its use in stage 3 patients?--- In
experimentalandunconventional@yahoogroups.com, altman23
<no_reply@y...> wrote:
> Hi All,
>
> Was looking thru recent Abstracts of Journal Articles.
>
> This one is the result of clinical trials comparing FOLFOX
> (Oxaliplatin.5-FU/LV) to IROX (irinotecan and oxaliplatin) to IFL
> (Irinotecan/5-FU/LV). "Irinotecan" is the SAME drug as "Camptosar".
>
> http://tinyurl.com/2v528
>
> The article says there is NO DISADVANTAGE efficacywise to using
> FOLFOX as a first line therapy, and in fact the SIDE EFFECTS seem
> BETTER when one does so!
>
> Nothing "new" here (if you've been following a few of my recent
posts
> about FOLFOX!), but I thought worthwhile to remind "newbies" of
this
> topic!
>
> THE KEY RESULTS ARE:
>
> [snip]
> A total of 795 patients were randomly assigned between May
> 1999 and April 2001. A median time to progression of 8.7 months,
> response rate of 45%, and median survival time of 19.5 months were
> observed for FOLFOX. These results were significantly superior to
> those observed for IFL for all end points (6.9 months, 31%, and
15.0
> months, respectively) or for IROX (6.5 months, 35%, and 17.4
months,
> respectively) for time to progression and response. The FOLFOX
> regimen had significantly lower rates of severe nausea, vomiting,
> diarrhea, febrile neutropenia, and dehydration. Sensory neuropathy
> and neutropenia were more common with the regimens containing
> oxaliplatin. CONCLUSION The FOLFOX regimen of oxaliplatin and
infused
> fluorouracil plus leucovorin was active and comparatively safe. It
> should be considered as a standard therapy for patients with
advanced
> colorectal cancer.
>
> Best Wishes,
>
> Keith