-----Original Message-----
From: szukidavis@...
Sent: Sunday, February 22, 2009 2:16 PM
To: cancercure@yahoogroups.com, JohnnySeville69@..., dwiedershine@...,
MESAUG@...
Subject: [cancercure] LDN ARTICLE


> Immunomodulatory and Biochemical Effects of LDN
>
> LDN exerts its beneficial effects by reducing
> inflammation and oxidative stress, modulating the
> immune system, and inhibiting cancer cell
> proliferation.
> Naltrexone is an opiate antagonist that preferentially
> blocks the mu opiate receptor found on neuroendocrine
> and immune system cells. The consequences of this
> blockage depend on its duration. That is, naltrexone’s
> effects depend on how long the receptor is blocked.
> HDN vs. LDN
> High dose naltrexone (HDN) refers to naltrexone doses
> greater than 10 mg daily. Low dose naltrexone (LDN)
> refers to doses of naltrexone ranging from 1 to 10 mg
> daily.
> HDN blocks the opiate receptor continuously. This
> persistent blockade prevents opiates, both endogenous
> or naturally occurring opiate compounds and opiate
> drugs, from reacting with the opiate receptor.
> Consequently, opiate medications are prevented from
> causing biochemical effects.
> The endogenous opiate compounds, (the endorphins,
> dynorphins, and metenkephalins) are also prevented
> from causing their pleasurable effects. The natural
> increase in endorphins caused by exercise,
> acupuncture, chocolate, sunbathing, and lovemaking has
> no effect in someone on HDN.
> LDN blocks the opiate receptor for approximately 4
> hours. This intermittent blockade causes a rebound
> effect resulting in a dramatic increase in endogenous
> opiate production.
> LDN Dosage
> LDN is generally used in doses ranging from 3-10 mg
> daily depending on body weight, the patient’s
> condition, and individual response. For instance,
> patients with multiple sclerosis (MS) and muscle
> spasticity generally do better on a 3 mg dose than the
> standard 4.5 mg dose recommended for neurodegenerative
> disorders.
> The most common side effects of LDN are sleep
> disturbances and vivid dreams. These effects can be
> avoided by taking LDN in the morning. Although early
> reports suggested that LDN needed to be taken at
> night, studies have shown that LDN can be taken at any
> time. It is not necessary to take it at night.
>
> The Effects of LDN
> The Pennsylvania State University researcher, Dr. Ian
> Zagon, Ph.D. has been studying LDN for 25 years and
> reports that LDN’s most important effect is its
> ability to increase production of met-5-enkephalin,
> which he named opioid growth factor (OGF) for its
> functional properties. The endogenous opiates are
> neurotransmitters as well as cytokines, influencing
> the activities of immune system cells and having
> distinct biochemical effects (e.g. growth factors,
> neurotrophic factors, antiviral activity, anti-tumor
> activity, anti-inflammatory and pro-inflammatory
> effects).
>
> OGF forms a complex or system when it reacts with the
> OGF receptor, a receptor found on immune system cells
> and cancer cells. This system inhibits inflammation
> and cancer cell growth. This system also restores
> homeostasis, a natural process in which the body’s
> cells and systems work together to maintain health.
> Thus, LDN helps the body heal itself. In certain
> cancers, OGF is used in place of LDN.
> Dr. Jau-Shyong (John) Hong of the National Institute
> of Environmental Health Sciences (NIEHS) discovered
> that LDN also prevents microglial activation, the main
> cause of chronic brain inflammation. In addition, LDN
> has antioxidant properties that reduce the effects of
> free radicals throughout the body, thereby reducing
> chronic inflammation.
> LDN also causes changes that reduce neuronal
> degeneration. As a consequence, LDN offers protection
> against neurodegenerative diseases, such as
> Parkinson’s disease and MS. Chronic inflammation
> contributes to the persistence of autoimmune disorders
> and is an underlying cause of many conditions,
> including Crohn’s disease.
> By increasing endorphins, which are immunomodulators,
> LDN improves immune function. Immunomodulators
> stimulate antibody production in patients with
> immunodeficiency (HIV infection) and reduce antibody
> production in patients with excessive antibody
> production (autoimmune disorders, herpes, Lyme
> disease).
> The Common Link
> Doctors Zagon and Hong and other experts in the field
> reported that diseases which respond favorably to LDN
> are diseases that benefit from effects on cell
> proliferation (cancer inhibition) or from a reduction
> in inflammation (neurodegenerative and autoimmune
> disorders, fibromyalgia) or that benefit from the
> restoration of homeostasis and immunomodulation
> (virtually all disorders, including infectious
> diseases).
> Clinical Trials
> To date, LDN has been studied or is undergoing
> clinical trials for pancreatic and head and neck
> cancers, Crohn’s disease, HIV/AIDS, neuroblastoma,
> melanoma, autism, Parkinson’s disease, lymphoma,
> multiple sclerosis and fibromyalgia. There are also
> many anecdotal reports that suggest LDN offers
> benefits in a wide range of other autoimmune and
> neurodegenerative diseases and malignancies. Clinical
> trials are needed to confirm the anecdotal
> reports.♦
> Resources:
> Samantha Wilkinson, LDNers.org
> Private conversations with Doctors Ian Zagon, Jarred
> Younger, and John Hong, January, 2008.
>





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