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Links > Genetics Research and Resources

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A Molecular Basis for Estrogen-Induced Cryptorchidism: Review (2000)
From the Our Stolen Future website, this is an overview of a study published by S. Nef, T Shipman and LF Parada in 2000 in the journal Developmental Biology.
http://www.ourstolenfuture.org/NewScience/reproduction/cryptorchidism/2000nefetal.htm
skerlin2000
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Anomalies of human sexual development: clinical aspects and genetic analysis (2002, abstract)
Abstract of a study by E Vilain published in the January 2002 issue of the journal Novartis Foundation Symposium.
http://highwire.stanford.edu/cgi/medline/pmid;11990797
skerlin2000
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DNA Methylation and Male Infertility (2004, abstract)
Abstract of a study by FJ Cisneros published in the May 2004 issue of the journal Frontiers in Bioscience.
http://highwire.stanford.edu/cgi/medline/pmid;14977536
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Developmental Diethylstilbestrol Exposure Alters Genetic Pathways of Uterine Cytodifferentiation (2005, abst)
Abstract of a study by Wei-Wei Huang, et al. published in the March 2005 issue of the journal Molecular Endocrinology.
http://mend.endojournals.org/cgi/content/abstract/19/3/669
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Diethylstilbestrol exposure in utero: A paradigm for mechanisms leading to adult disease (2005, abstract)
Abstract of a study by Mathias Mericskay, Luca Carta, and David Sassoon published March 2005 in the journal Birth Defects Research Part A: Clinical and Molecular Teratology.
http://www3.interscience.wiley.com/cgi-bin/abstract/109933346/ABSTRACT
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Effect of neonatal exposure to diethylstilbestrol on testicular gene expression in adult mouse: comprehensive... (2004, abst)
Absract of a study by Yoshiharu Matsuno et al. published in the April 2004 issue of the International Journal of Andrology.
http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0105-6263&date=2004&volume=27&issue=2&spage=115
skerlin2000
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Endotext: Sexual Differentiation (2003 update)
This chapter excerpted from the online Endotext (www.endotext.org) includes in-depth discussion of the genetic factors associated with sexual differentiation in humans.
http://www.endotext.org/pediatrics/pediatrics7/pediatrics7.htm
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Environmental Exposure, DNA Methylation, and Gene Regulation: Lessons from Diethylstilbestrol-Induced Cancers (2003)
Full text of a review/article by SHUANFANG LI, STEPHEN D. HURSTING, BARBARA J. DAVIS, JOHN A. McLACHLAN and J. CARL BARRETT published in the March 2003 issue of the Annals of the New York Academy of Sciences.
http://www.annalsnyas.org/cgi/content/full/983/1/161?
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Environmental Signaling: What Embryos and Evolution Teach Us About Endocrine Disrupting Chemicals, by John McLachlan (2001)
Full text article by DES research specialist and Professor John McLachlan, published in the journal Endocrine Reviews, Vol. 3, 2001, and providing a wealth of research on the impact (including genetic) of DES and other endocrine disrupting chemicals.
http://edrv.endojournals.org/cgi/content/full/22/3/319
skerlin2000
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Exposure of Neonatal Rats to Diethylstilbestrol Affects the Expression of Genes Involved in Ovarian Differentiation (2003, abst)
Abstract of a Japanese study by A Nagai, Y Ikeda, T Aso, K Eto, and MA Ikeda published in the March 2003 Journal of Medical and Dental Sciences.
http://highwire.stanford.edu/cgi/medline/pmid;12715917?
skerlin2000
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From Malformations to Molecular Mechanisms in the Male: Three Decades of Research on Endocrine Disrupters (2001, abstract)
Abstract of a study which includes central focus on DES research by JA McLachlan, RR Newbold, ME Burow, and SF Li published in the April 2001 issue of the journal APMIS.
http://highwire.stanford.edu/cgi/medline/pmid;11469497?
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Gene Imprinting in Developmental Toxicology: A Possible Interface Between Physiology and Pathology (2001, abstract)
Abstract of a study of DES by JA McLachlan, M Burow, TC Chiang, and SF Li published in the March 2001 issue of the journal Toxicology Letters.
http://highwire.stanford.edu/cgi/medline/pmid;11323173?
skerlin2000
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Gene-Teratogen Interactions in Chemically Induced Congenital Malformations (2004, abstract)
Abstract of Italian study by Erminio Giavini and Elena Menegola published in the January 2004 issue of the journal Biology of the Neonate.
http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=BON2004085002073
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Gestational and Lactational Exposure of Male Mice to Diethylstilbestrol Causes Long-Term Effects on the Testis... (2002, abst)
Abstract of a study which includes effects of DES on testicular gene expression, published by Mark R. Fielden et al. in the August 2002 issue of the journal Endocrinology.
http://endo.endojournals.org/cgi/content/abstract/143/8/3044
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In Utero Diethylstilbestrol (DES) Exposure alters Hox Gene Expression in the Developing Müllerian System (2000)
Full text of an article published in the June 2000 issue of the FASEB Journal by Karen Block et al., examining the impact of prenatal DES exposure on gene expression in exposed females.
http://www.fasebj.org/cgi/content/full/14/9/1101
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Lessons Learned from Perinatal Exposure to Diethylstilbestrol (2004, abstract)
Article by DES researcher Retha Newbold published in the September 2004 issue of the journal Toxicology and Applied Pharmacology.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids==15313586
skerlin2000
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Minireview: Sexual Differentiation (2001, abstract)
Abstract of a comprehensive article by Ieuen Hughes which includes discussion of genetic aspects of sexual differentiation, published in the August 2001 issue of the journal Endocrinology.
http://endo.endojournals.org/cgi/content/abstract/142/8/3281
skerlin2000
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Modus Operandi of an Infamous Drug: Diethylstilbestrol (1999)
An article originally from Science News Online in 1999, this full-text reproduction discusses the genetic impact of DES.
http://www.sciencenews.org/sn_arc99/2_20_99/bob2.htm
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Molecular Effects of the Herbal Compound PC-SPES: Identification of Activity Pathways in Prostate Carcinoma (2002, abstract)
Abstract of a study involving DES published by Michael Bonham, Hugh Arnold, Bruce Montgomery and Peter S. Nelson in the July 15, 2002 issue of the journal Cancer Research.
http://cancerres.aacrjournals.org/cgi/content/abstract/62/14/3920
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Persistent Gene Expression in Mouse Vagina Exposed Neonatally to Diethylstilbestrol (2004, abstract)
Abstract of a study by S Miyagawa published in the June 2004 issue of the Journal of Molecular Endocrinology.
http://journals.endocrinology.org/jme/032/jme0320663.htm
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Perspective: Reproductive Tract Development—New Discoveries and Future Directions (2001)
Full-text edition of a comprehensive study including discussion of genetic factors published by David T. MacLaughlin, Jose Teixeira and Patricia K. Donahoe in the June 2001 issue of the journal Endocrinology. Includes significant discussion of the effects of DES on reproductive development and gene expression.
http://endo.endojournals.org/cgi/content/full/142/6/2167
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Rediscovering Biology: Expert Interview Transcripts--Biology of Sex and Gender
This resource is excerpted from an online reference guide to "Rediscovering Biology", featuring an interview with UCLA Assistant Professor Eric Vilain, MD, PhD, an expert in human genetics.
http://www.learner.org/channel/courses/biology/units/gender/experts/vilain.html
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Regulation of Sexual Dimorphism in Mammals (1998)
Full text of a comprehensive article by CHRISTOPHER M. HAQQ AND PATRICIA K. DONAHOE published in the January 1998 issue of the journal Physiological Reviews.
http://physrev.physiology.org/cgi/content/full/78/1/1
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Sex Determination and Differentiation (2004, selection)
Selected portion of full-text article by David T. MacLaughlin and Patricia K. Donahoe published in the January 22, 2004 issue of the New England Journal of Medicine, including some discussion of DES.
http://content.nejm.org/cgi/content/extract/350/4/367?
skerlin2000
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Sex with Two SOX on: SRY and SOX9 in Testis Development (2002, abstract)
Abstract of an important study of sexual differentiation by MJ Clarkson and VR Harley published in the April 2002 issue of the journal Trends in Endocrinology & Metabolism.
http://highwire.stanford.edu/cgi/medline/pmid;11893523
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The Emergence of Molecular Gynecology: Homeobox and Wnt Genes in the Female Reproductive Tract (2000, abstract)
Abstract of a study of genes targeted by DES, authored by J. Kitajewski & D. Sassoon published in the October 2000 issue of the journal Bioessays.
http://highwire.stanford.edu/cgi/medline/pmid;10984716?
skerlin2000
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The Genetics of Male Undermasculinization (2002, abstract)
Abstract of a study by SF Ahmed and IA Hughes published in the January 2002 issue of the journal Clinical Endocrinology (Oxford).
http://highwire.stanford.edu/cgi/medline/pmid;11849240
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The Inhibition of DNA Repair Capacity by Stilbene Estrogen in Leydig Cells... (2001, abstract)
Abstract of a study of DES by JW DuMond and D Roy published in the November 2001 issue of the journal Mutations Research.
http://highwire.stanford.edu/cgi/medline/pmid;11600129?
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The Wnt Gene Home Page (2004 update)
Wnt genes are among those investigated in contemporary DES research, and this website provides substantial overview of the scope of recent Wnt genes research.
http://www.stanford.edu/~rnusse/wntwindow.html
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Toxicogenomic difference between diethylstilbestrol and 17-estradiol and in mouse testicular gene expression... (2003, abstract
Abstract of a study by Tetsuya Adachi et al. published in the November 2003 issue of the journal Molecular Reproduction and Development.
http://www3.interscience.wiley.com/cgi-bin/abstract/106566811/ABSTRACT
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Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans
A study from the University of California, discussing the WNT-4 gene and it's relationship to sexual differentiation in humans.
http://www.journals.uchicago.edu/AJHG/journal/issues/v68n5/012731/012731.html
starlite_2200
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WNT Signalling Pathway, from the Japanese National Cancer Center
A brief summary of the WNT signalling pathway, which appears to be a primary target of DES based on experimental studies.
http://www.ncc.go.jp/en/nccri/divisions/13gent/13gent02.html
skerlin2000
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Wnt7a Is a Suppressor of Cell Death in the Female Reproductive Tract and Is Required for Postnatal and Estrogen... (2004, abst)
Abstract of a study by Luca Carta and David Sassoon published in the May 2004 issue of the journal Biology of Reproduction.
http://www.biolreprod.org/cgi/content/abstract/biolreprod.103.026534v1
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