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Adoptive Transfer
One 16-year-old patient had a tumour that started on his knee and spread throughout his body despite treatment. He developed a volleyball-sized tumour in his pelvis and was on round-the-clock narcotics, Rosenberg said.
http://groups.yahoo.com/group/experimentalandunconventional/message/688 		altman23
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Experimental therapy uses immune cells to beat cancer
American doctors say they've successfully treated seriously ill melanoma patients with a new therapy that shrank the tumours. The experimental treatment was used on 13 patients; six of them saw their tumours shrink by half, the researchers said. Some of the patients probably only had months to live. Doctors knocked out the patients' immune system with high dose chemotherapy to make way for billions of new immune system cells, called T-cells, that fight disease. T-cells were prepared in the lab and then injected into patients, where the cells multiplied further. Of the 13 patients: 6 clearly got better 4 had mixed responses 3 saw no benefit
http://www.cbc.ca/stories/2002/09/19/cancer_tcells020919 		altman23
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New Approach to Replacing Immune Cells Shrinks Tumors in Patients with Melanoma
A new approach to cancer treatment that replaces a patient's immune system with cancer-fighting cells can lead to tumor shrinkage, researchers report today in the journal Science*. The study demonstrates that immune cells, activated in the laboratory against patients' tumors and then administered to those patients, can attack cancer cells in the body. The experimental technique, known as adoptive transfer, has shown promising results in patients with metastatic melanoma who have not responded to standard treatment. With further research, scientists hope this approach may have applications to many cancer types, as well as infectious diseases such as AIDS.
http://www.cancer.gov/newscenter/melanomavaccine 		altman23
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Researcher summarizes the promise of dendritic cells
Baylor Institute for Immunology Research scientists, Banchereau, Joseph Fay, MD, and Karolina Palucka, MD, PhD, are aggressively developing Food and Drug Administration-approved clinical trials and actively enrolling patients, with a current emphasis on metastatic melanoma, a deadly skin cancer. Other trials under way include B cell lymphoma and prostate and colon cancer. When injected into patients, the antigen-loaded dendritic cells are expected to ramp up patients' immune responses against their own tumors, thereby killing the cancer.
http://groups.yahoo.com/group/experimentalandunconventional/message/823 		altman23
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T-cell clones shrink tumors
The study, conducted by Dr. Cassian Yee, a researcher at the Fred Hutchinson Cancer Research Center, involved 10 people diagnosed with advanced melanoma. For each patient immune system cells able to identify and target melanoma were extracted and cloned. The cloned cells were expanded in the lab and reinjected into the patient. The results of the study showed that in five patients tumors stopped growing for up to one year and in three of the patients the tumors appeared to shrink.
http://groups.yahoo.com/group/experimentalandunconventional/message/820 		altman23
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