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Links > Fluorouracil (5-FU)

Name Creator
60-day, all-cause mortality rates
ASCO Abstract 515 (2002)
http://www.asco.org/asco/ascoMainConstructor/1,1003,_12-002324-00_29-00A-00_18-002002-00_19-00515,00.asp 		altman23
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Cardiotoxicity of the antiproliferative compound fluorouracil
PMID: 10235688 Drugs 1999 Apr;57(4):475-84. Estimates of the overall incidence of fluorouracil cardiotoxicity have varied widely from 1.2 to 18% of patients. Patients may present with angina-like chest pain, cardiac arrhythmias or myocardial infarction. There is no unequivocally effective prophylaxis or treatment in this syndrome. Once fluorouracil administration is discontinued symptoms are usually reversible, although fatal events have been described. The overall mortality rate has been estimated to be between 2.2 and 13.3%. There is a high risk of relapse when patients are re-exposed to this drug following previous cardiac incidents
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10235688&dopt=Abstract 		altman23
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Severe cardiotoxicity during 5-fluorouracil chemotherapy: a case and literature report
PMID: 10521060 Am J Clin Oncol 1999 Oct;22(5):466-70 The chemotherapeutic agent 5-fluorouracil (5-FU) is a widely accepted part of many cancer treatment protocols. Its cardiotoxic potential is known, but considered uncommon and usually not life threatening, although some cases of severe cardiotoxicity related to 5-FU have been reported
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10521060&dopt=Abstract 		altman23
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Symptomatic cardiotoxicity associated with 5-fluorouracil
PMID: 9250550 Pharmacotherapy 1997 Jul-Aug;17(4):729-36 A sample of 483 patients [197 (41%) women, overall average age +/- SD 60.9 +/- 11.9 yrs] were followed for one cycle of 5-FU infusion. Thirty-eight (7.9%) patients had abrupt termination of the infusion. There were 9 (1.9%) cases of suspected or documented cardiotoxic events. Cardiotoxicity occurred in 7 (3.35%) of 209 patients receiving their first course of 5-FU and in 2 (0.73%) other patients (p=0.044).
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9250550&dopt=Abstract 		altman23
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