| Name |
Creator |
1 Block Center for Integrative Care
Block Center for Integrative Cancer Care. To my knowledge, this is the only US cancer center offering chronotherapy
http://www.blockmd.com/ |
altman23
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2 What is Chronotherapy?
from the Block center for Integrative Care
http://www.blockmd.com/unique/Chronotherapy.html |
altman23
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3 Keith Block--Integrating Diet, Fitness, and Psychological Support into an Oncology Practice
Chapter 17 from Michael Lerner's "Choices in Healing" online book free at http://www.commonweal.org/choicescontents.html
http://www.commonweal.org/choiceschap17.html |
altman23
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4 From circadian rhythms to cancer chronotherapeutics
PMID: 11962669 Chronobiol Int 2002 Jan;19(1):1-19 Clinical phase I and II trials have established the feasibility, the safety, and the activity of the chronotherapy schedules, so that this treatment method has undergone further evaluation in international multicenter phase III trials. Overall, more than 2,000 patients with metastatic disease have been registered in chronotherapy trials. Improved tolerability and/or better antitumor activity have been demonstrated in randomized multicenter studies involving large patient cohorts
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11962669&dopt=Abstract |
altman23
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5 Cancer chronotherapy: Principles, applications, and perspectives.
PMID: 12491517 Cancer 2003 Jan 1;97(1):155-69 RESULTS: In the current study, chronotherapeutic schedules were used to safely document activity of the combination of oxaliplatin, 5-fluorouracil, and leucovorin against metastatic colorectal carcinoma and to establish new medicosurgical management for this disease, and were reported to result in unprecedented long-term survival.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12491517&dopt=Abstract |
altman23
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6 Phase II Randomized Study of Chronomodulated Irinotecan
Fluorouracil, Leucovorin Calcium, and Oxaliplatin as First- or Second-Line Therapy in Patients With Locoregional or Metastatic Colorectal Cancer Protocol ID EORTC-05011
http://www.nci.nih.gov/clinicaltrials/view_clinicaltrials.aspx?version=healthprofessional&cdrid=69363 |
altman23
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A pilot study of chronomodulated infusional 5-fluorouracil chemoradiation for pancreatic cancer
PMID: 11432628 Ann Oncol 2001 May;12(5):681-4 CONCLUSIONS: Acute toxicity of 5-FU CIC (chemoradiation) appears to be less frequent and less severe than that reported with flat infusional or bolus 5-FU based chemoradiation used for adjuvant post-operative therapy for pancreatic cancer. This method may warrant further examination, as it may be attractive for the elderly or those who cannot tolerate the toxicity associated with standard post-operative treatment protocols.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11432628&dopt=Abstract |
altman23
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Chronomodulated chemotherapy and irradiation: an idea whose time has come?
PMID: 11962675 Chronobiol Int 2002 Jan;19(1):191-205 Since circadian variation exists in the proliferative activity of acute-reacting normal tissues like the gut and bone marrow, a potential therapeutic gain can be realized by the chronomodulated administration of S-phase chemotherapeutic agents at biological times when these normal tissues are in a different cell phase and thus relatively spared (chronotolerance).
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11962675&dopt=Abstract |
altman23
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Chronomodulated chemotherapy: clinical value and possibilities for dissemination in the United States.
PMID: 11962681 Chronobiol Int 2002 Jan;19(1):275-87 Despite the impressive body of evidence supporting the use of chronochemotherapy, with only a rare exception most oncology clinics in the United States lack the expertise and capability to implement it.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11962681&dopt=Abstract |
altman23
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Chronotherapy of colorectal cancer
PMID: 11962676 Chronobiol Int 2002 Jan;19(1):207-19 Phase I-III clinical trials show chronotherapy significantly increases tolerance to high doses of cancer drugs and improves antitumor activity in patients with metastatic colorectal cancer. These safe conditions of drug-delivery led to the first demonstration of the high activity of the 5-FU-leucovorin-L-OHP protocol. Chronotherapy with these three drugs also allows surgical removal of previously unresectable liver and lung metastases. This novel medico-surgical management provides hope for the cure of metastatic disease in patients with unresectable colorectal cancer metastases.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11962676&dopt=Abstract |
altman23
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Chronotherapy of colorectal cancer metastases
PMID: 11379299 Hepatogastroenterology 2001 Mar-Apr;48(38):320-2 High efficacy and good tolerability permitted secondary surgical resection of previously inoperable metastases, with apparent survival improvement (3-year survival > or = 20%) and cures in some patients. This strategy is currently undergoing further testing within the European Organization for Research and Treatment of Cancer. Nevertheless, combining chronotherapy with surgery of colorectal cancer metastases can be readily offered to patients as a safer therapeutic option for optimizing outcome.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11379299&dopt=Abstract |
altman23
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Dramatic tumor response of bulky liver metastases
following treatment with CPT-11 and a chronomodulated 4-day infusion of 5-fluorouracil, folinic acid and oxaliplatin every 2 weeks in a colorectal cancer patient. PMID: 10898541 Anticancer Drugs 2000 Apr;11(4):263-8
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10898541&dopt=Abstract |
altman23
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Marked 24-h rest/activity rhythms are associated with better quality of life, better response
and longer survival in patients with metastatic colorectal cancer and good performance status. PMID: 10955782 Clin Cancer Res 2000 Aug;6(8):3038-45 Patients with marked rest/activity rhythms also had better quality of life and reported significantly less fatigue. The individual rest/activity cycle provides a novel independent prognostic factor for cancer patients' survival and tumor response as well as a quantitative indicator for quality of life.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10955782&dopt=Abstract |
altman23
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Pharmaco-economic comparative evaluation of combination chronotherapy vs. standard chemotherapy for colorectal cancer
PMID: 11962682 Chronobiol Int 2002 Jan;19(1):289-97 Chrono-arm B was definitively more cost-effective than standard flat-arm A treatment since it made the outcome of treatment more effective; there was greater tumor response rate and longer time to progression with less treatment-associated toxicity
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11962682&dopt=Abstract |
altman23
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Phase II trial of chronomodulated infusion of high-dose 5-FU/LV in previously untreated patients with metastatic CC
PMID: 11870158 J Clin Oncol 2002 Mar 1;20(5):1175-81CONCLUSION: The Objective Response Rate achieved with intensified chronomodulated delivery of 5-FU/l-FA was nearly twice as high as that earlier obtained by our cooperative group using less intensive 5-FU/FA chronotherapy
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11870158&dopt=Abstract |
altman23
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