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Links > Carcinoembryonic Antigen (CEA)

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CEA - Basic Q&A
What is CEA, How is it measured, what is the normal range for CEA blood values, what conditions can cause an elevated CEA, what are the limitations of CEA testing
http://www.medicinenet.com/Script/Main/Art.asp?li=DEP&ArticleKey=8832 		altman23
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CEA Surge in Metastatic Colorectal Cancer Patients Responding to Oxaliplatin Combination Chemotherapy: Implications for Tumor Ma
IJournal of Clinical Oncology, Vol 21, Issue 23 (December), 2003: 4466-4467 In general, a rise in carcinoembryonic antigen (CEA) level in patients with metastatic colorectal cancer means tumor progression. We have, however, observed in four patients a transient increase in CEA level despite objective response among patients receiving oxaliplatin combination chemotherapy for metastatic colorectal cancer. Such a surge phenomenon has not previously been described for patients with metastatic colorectal disease and has implications for tumor marker monitoring and guidelines
http://www.jco.org/cgi/content/full/21/23/4466 		altman23
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Carcinoembryonic Antigen
CEA stands for carcinoembryonic antigen. CEA is a type of protein molecule that can be found in many different cells of the body, but is typically associated with certain tumors and the developing fetus. The word "carcinoembryonic" reflects the fact that CEA is produced by some cancers ("carcino-") and by the developing fetus ("-embryonic").
http://www.medicinenet.com/Carcinoembryonic_Antigen/article.htm 		altman23
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Carcinoembryonic Antigen (CEA) test
What is it, and why is it done?
http://www.ahealthyme.com/topic/topic100586572 		altman23
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Distribution of CEA Values in Subjects by Diagnostic Group
CEA levels are elevated in smokers; patients with inflammation including infections, inflammatory bowel disease, and pancreatitis; some patients with hypothyroidism; cirrhosis; and in some patients with noncolorectal neoplasms especially gastric, pancreatic, breast, and ovarian.
http://www.labcorp.com/datasets/labcorp/html/chapter/mono/ri024300.htm 		altman23
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Elevated CEA in Asymptomatic Patient?
Medscape "Ask Experts" Question. A 41-year-old female was diagnosed with stage IV colon cancer with peritoneal seeding and metastases to the ovaries. Resection of the transverse colon and left oophorectomy with intraoperative radiotherapy was performed in 1998, and her postoperative CEA was 11.6. Chemotherapy of intraperitoneal 5-FU and IV leucovorin followed surgery, and her CEA dropped to 1.2.
http://www.medscape.com/viewarticle/420694 		altman23
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How Long for CEA to return to normal post surgery?
So, about three weeks to a month after all the cancer has been irradicated, the level should be nearly as low as it can get. Even so, the time to normalize can vary considerably.
http://www.oncolink.com/experts/article.cfm?c=3&s=15&ss=28&id=1384 		altman23
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The Carcinoembryonic Antigen (CEA): Past, Present, and Future
Full Text Paper
http://www.medicine.mcgill.ca/mjm/issues/v03n01/cea.html 		altman23
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