Oxaliplatin-Based Regimen Prolongs Survival After Colorectal Cancer Surgery The chemotherapy combination known as FOLFOX – oxaliplatin, 5-fluorouracil (5-FU), and leucovorin – significantly improved disease-free survival compared to 5-FU and leucovorin when used as adjuvant therapy (after surgery) in patients with stage II and stage III colorectal cancer. http://www.cancer.gov/clinicaltrials/results/mosaic-trial0601