I am reproducing below one article written by
Dr.Rangadhar Satapathy regarding Noni and diabetes
which may be of use to our group memebrs. Not
necessary one should drink Noni fruit juice. One can
eat Noni fruits if available easily.

DIABETES MELLITUS
By Dr.Rangadhar Satpathy

Diabetes Mellitus is a clinical syndrome characterized
by hyperglycemia (increase glucose level above normal
in blood) due to absolute or relative deficiency of
insulin caused by the degeneration or hypo activity of
the B-cells of the pancreas. That causes the following
metabolic disturbances.
•Depress the glycogenesis (formation of glycogen from
glucose) and increases glycogenolysis (convert of
glucose from glycogen). So glycogen contains from
liver and muscles low down and in blood the glucose
level raises.
•Glucose combustion (oxidation) is depressed in
absence of insulin. So extra cellular glucose level
rises
•The rate of gluconeogenesis (formation of glucose
from other than carbohydrates) increases. Thus glucose
level in blood rises.
•Depot fat mobilized and liver loaded with fats.
•Ketone bodies are produced at a faster rate and can
cause ketosis and diabetic coma.
Diabetic can classified primarily in two types

1) Type-1- insulin dependant diabetes mellitus (IDDM).

2) Type-2 – Non-insulin dependant diabetes mellitus
(NIDDM)

The cause of Type-1- IDDM is various. Those are

i) Genetic factor –HLA linked genetic predisposition.
ii) Some viruses like EMC virus, Mengo virus 2T that
destroys the
Pancreatic B-cells.

Pancreatic pathology: In type -1 – IDDM the islet of
langerhans is infiltrated with mononuclear cells like
activated macrophages, T lymphocytes, Natural killer
cells and B lymphocytes. That condition is called
‘insulitis’. It causes the destruction of more or less
all insulin secreting B-cells. So body produces little
or no insulin.

The cause of Type-2 – Non-insulin dependant diabetes
mellitus (NIDDM) are:
•Faulty life styles, over eating, obesity, lack of
exercise.
•Over weight predisposes the reaction in our liver and
peripheral fat stores lead to pro-inflammatory and
pro-Thrombotic (blood clotting) changes with elevated
C Reactive Proteins (CRP), interleukin -6(Il-6), and
fibrinogen (all made in the liver) plus platelet
activation. These lead to hardening of the arteries,
blood clots, HBP, heart attack, stroke and diabetes.
•Constant dwelling on severe stress full situation
causes diabetes. Stress elevates epinephrine,
nor-epinephrine, ACTH, cortisol and prolactin that
acts as an antagonist to insulin.
Pancreatic pathology – In Type-2-NIIDDM deposition of
amyloid on the islets tissues occur. But here very
less no. of B-cells are destroyed. So in this case
body produces enough insulin.
Here increased hepatic production of glucose and
resistance to the action of insulin are main cause of
NIDDM.
Insulin resistance may be due to
• An abnormal insulin molecule
• An excessive amount of circulating antagonist
• Target tissue defects.

ROLE OF NONI JUICE IN DIABETES
1.Xeronine in Noni juice helps to clear up the
resistance to the action of insulin by the following
way.
2.Xeronine combines with the inactive abnormal insulin
molecule and help modify its rigidity to make it
active.
3.Xeronine combining with insulin helps more glucose
combustion (oxidation) in peripheral tissues and also
helps to enhance the cellular permeability to glucose.
So that extra cellular glucose level falls.
4.The habit of overeating in human being is the cause
of obesity. The obese people generally feel hungry due
to low serotonin levels. Obesity also causes the
insulin resistance to glucose and hence the
predisposing factors of Type-2-NIDDM. Noni helps to
secrete more serotonin that eliminates the desire of
eating more. So it indirectly prevents obesity and
helps in preventing diabetes.
5.Noni helps to enhance the body immunity power by the
synergistic action of its all components in cellular
level. Thus by modulating the immunity power it may
help to correct the ‘insulitis’condition of pancreas
in Type-1-IDDM so that it prevents from destruction of
B-cells in pancreas and also activate the B-cells to
produce more insulin
6.Noni helps to reduce anxiety and lessens the stress
response to some extent by elevating the serotonin
level in blood.
7.Improves sleep.
Since the intake of sugar – even natural sugars – may
be important to track in a diabetic’s diet, it is good
to note that 4 ounces of Noni juice equals one fruit
exchange.
(Please Note: Type-1-IDDM should never substitute Noni
juice for insulin shot. This type of diabetes may be
able to reduce his or her insulin by using a natural
supplement such as Noni juice under the supervision of
a doctor).