WC Monte gives 1917 rabbit study that shows blood vessel thickening by
formic acid, made by ADH in many tissues from methanol -- sources are canned
fruits, wood & tobacco smoke, alcohol drinks, aspartame: Rich Murray
2010.07.04
http://rmforall.blogspot.com/2010_07_01_archive.htm
Sunday, July 4, 2010
[at end of each long page, click on Older Posts]
http://groups.yahoo.com/group/aspartameNM/message/1608
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Rich,

Yes there is a lot of thickening of connective tissue lining the vessels of
individuals poisoned with methanol who live long enough for the changes to
occur. This is to be expected since the layers of the veins and arteries
that contain ADH are indeed the the ones that are involved in thickening.
I have attached an article from 1917 -- take a look at page 770.

Woody 2010.07.03 12:36 PM MST


"My impression is that the apparent increase of the connective tissue is due
not only to the fact that the parenchyma cells have disappeared, but to the
actual proliferation of the fixed tissue cells, as seen by the very marked
thickening of the adventitia and the media of the blood-vessels."

'In cases of long standing, in addition to the above general appearance
there is also a marked increase of the connective tissue, especially around
the blood-vessels."

http://whilesciencesleeps.com/references

589 references -- click on each title for free full pdf

15 Eisenberg AA.; 1917. "Visceral Changes in Wood Alcohol Poisoning by
Inhalation", American Journal of Public Health 7:765

http://whilesciencesleeps.com/references/pdf/15 7 pages

[ This is the time before Roe when it was unknown that humans were many
times more sensitive to methanol than any other animal.

Keen eyes, a century ago, noted a progression of horrors in a variety of
tissues -- worth quoting at length. ]

Arthur Alexander Eisenberg, BA, MD
Director, Pathological Laboratories, St. Vincent's Charity Hospital,
Cleveland.

"But Pohl (8) observed experimentally that while no bad effects followed
immediately after the administration to an animal of a small dose of methyl
alcohol, very serious results were noticeable a few days later, the
experiment in many instances terminating fatally. If a small non-lethal
dose be repeated a few times, fatal issue occurs invariably, while ethyl
alcohol, similarly administered, produces no such effects.

How are we to explain such paradoxical phenomenon? Why does a substance,
non-lethal in a single dose, become lethal after a few repeated doses, and
vice versa? The explanation as given by Pohl is as follows: Ethyl alcohol
is very rapidly oxidized in the animal body, in fact so rapidly that over 90
per cent. of it is converted to carbon dioxide and water, whereas methyl
alcohol is oxidized very slowly, with the formation of formaldehyde and then
formic acid.

It is formic acid and its cumulative action that is responsible for the
untoward effects of methyl alcohol, the variability of individual results
depending on the individual power of oxidation, the action of wood alcohol
thus becoming especially dangerous in those who are ill nourished...

The histo-chemical investigations of Placet (9) show that the power of
fixing methyl alcohol varies with the different tissues, the following
organs being given in the order of their affinity: brain, liver, kidney and
muscles. This statement of Placet finds abundant confirmation in the
results of my experiments...

The most striking observation was the uniformity of lesions (practically in
every case the same organs, and those only, were involved), the extent of
lesions varying with the duration of time exposure, thus the fatty
degeneration of the cardiac muscle or destruction of the perenchyma cells of
the cerebrum being more extensive in the rabbit which had been exposed for
6 months than in the one which had inhaled wood alcohol or Columbian
spirits [ more refined] for but 2 months...

...the central nervous system -- notably the cerebrum -- appears to bear the
brunt of the attack, it being together with the optic nerve the most
frequently as well as the most extensively involved organ. Next in
frequency, but not necessarily in extent, of involvement are the kidneys,
the liver, and the muscle -- the latter again showing a very marked
inequality of involvement, the cardiac muscle being affected in every case
while the striated and the smooth muscle were involved but in 10 per cent.
of the cases...no difference between the effects of wood alcohol when
imbided and when inhaled.

The lesions found in the various parts of the cerebrum, the cerebellum, the
medulla and the pons consisted of different degrees of inflammatory and
degenerative processes. Macroscopically the tissues appear yellowish,
glistening; the line of demarcation between the grey and the white matter is
not as sharp as in the control animals, in the more prolonged cases the gray
matter appearing quite thinned -- the entire picture being one of a
nonspecific atrophy.

Microscopically, the neurocytes are diminished, assuming a spindle-like
shape, Nissl's granules also are diminished, with brownish pigment scattered
here and there.

In the more severe cases the parenchyma cells are greatly reduced in numbers
as well as in size. Thus, for example, the brain of the rabbit which had
been exposed to the inhalation of Columbian Spirits showed practically
nothing but neuroglia cells, and no trace of parenchyma cells, the latter
being represented by masses of granular debris and fat droplets, partly
taken up by the so-called contractile cells, i.e. leucocytes, lymphocytes,
and according to Birch-Hirschfield, endothelial cells.

The different states of parenchymatous degeneration depend, of course, on
the length of the exposure to which the animal has been subjected, the
nuclear changes varying from the wandering of the nucleus to the periphery
of the cell to the total karyolysis.

My impression is that the apparent increase of the connective tissue is due
not only to the fact that the parenchyma cells have disappeared, but to the
actual proliferation of the fixed tissue cells, as seen by the very marked
thickening of the adventitia and the media of the blood-vessels.

The entire microscopical picture corresponds very closely to Adami's
"exhaustion" condition, which is "anatomically recognized by the
disappearance of cells and fibres and the secondary overgrowth of glial
tissue filling in the space."

The lesions of the liver and the kidney present, both macroscopically and
microscopically, the typical characteristic of albuminous degeneration
(cloudy swelling) and fatty degeneration -- the increased size of the organ,
softened consistence, the tissue being almost friable (etat crible),
glistening yellowish color, the protoplasm being uniformly dull-grey, the
outline of the cells in most cases being altered or lost. The nuclei are
much smaller than they normally are, lost in many cases, and appearing as
vague, shadowy structures in others. The cell bodies are filled with
granular, dust-like masses.

In cases of long standing, in addition to the above general appearance there
is also a marked increase of the connective tissue, especially around the
blood-vessels.

The muscle cells, especially the heart, present an appearance very similar
to that of the liver and the kidney, as well as both fragmentation and
segmentation, in some of the cases.

The lung shows in many cases patches of broncho-pneumonia, which, however,
are not uniform, either in distribution or in extent."


Woodrow C Monte, PhD, Emiritus Prof. Nutrition gives many PDFs of reseach --
methanol (11% of aspartame) puts formaldehyde into brain and body --
multiple sclerosis, Alzheimer's, cancers, birth defects, headaches: Rich
Murray 2010.05.13
http://rmforall.blogspot.com/2010_05_01_archive.htm
Thursday, May 13, 2010
http://groups.yahoo.com/group/aspartameNM/message/1601


[ Other formaldehyde sources include alcohol drinks and
tobacco and wood smoke,
while adequate folic acid levels protect most people,
but not for brain and retina harm.

http://whilesciencesleeps.com/montediet

Methanol: Where Is It Found? How Can It Be Avoided?

AVOID the following, ranked in order of greatest danger:

1. Cigarettes.
2. Diet foods and drinks with aspartame.
3. Fruit and vegetable products and their juices in bottles,
cans, or pouches.
4. Jellies, jams, and marmalades not made fresh and kept
refrigerated.
5. Black currant and tomato juice products, fresh or
processed.
6. Tomato sauces, unless first simmered at least 3 hours
with an open lid.
7. Smoked food of any kind, particularly fish and meat.
8. Sugar-free chewing gum.
9. Slivovitz: You can consume one alcoholic drink a day
on this diet -- no more! [ no fruit brandies ]
10. Overly ripe or near rotting fruits or vegetables.


http://whilesciencesleeps.com/references

589 references -- click on each title for free full pdf

Article 2 http://www.thetruthaboutstuff.com/review2.html

Selection from Article 2, Fitness Life, December 2007, and
well discussed in the DVD video:

"Identical Symptoms of MS, Methanol Poisoning
and Aspartame Toxicity

The symptoms of multiple sclerosis (44, 83, 85, 169), chronic
and acute methanol poisoning (13, 144, 189), and Aspartame
toxicity (54, 58, 93, 181), are in all ways identical.

There is nothing that happens to the human body from the toxic
effect of methanol that has not been expressed during the
course of MS... nothing (143, 144).

This generalization extends even to the remarkable
opthomological conditions common to both: transitory optic
neuritis and retrolaminar demyelinating optic neuropathy with
scotoma of the central visual field (which occasionally
manifests as unilateral temporary blindness (85, 138, 163).

In fact, these opthomological symptoms have been thought of
for years in their respective literatures to be "tell tale"
indications for the differential diagnosis for each of these
maladies independently (85, 138, 148, 163, 169).

The common symptoms of
headache (13, 83, 181, 189),
nervousness (13, 83, 181),
depression (58, 83, 189, 181),
memory loss (18, 147, 85, 169, 181),
tingling sensations (13, 85, 168, 138, 169),
pain in the extremities (13, 85, 169),
optic neuritis (85, 138, 148, 163, 169),
bright lights in the visual field (139, 83),
seizures (21, 83, 160),
inability to urinate or to keep from urinating (139, 146, 167)
are all shared by each of these conditions and shared yet again
by complaints from aspartame poisoning (54, 58, 93, 181).

I take these strikingly similar symptom patterns as evidence
that these disorders act on identical components of the central
nervous system and in the same way.

The "Miracle" that MS shares with Methanol poisoning

In the early stages of MS, or when a non-lethal dose of
methanol has been administered, complete recovery is a
possibility.

The only two afflictions for which such dramatic "remissions"
are reported from identical neuromuscular and opthomological
damage, even "blindness" is relapsing-remitting multiple
sclerosis (85) and methyl alcohol poisoning (138, 163).

The pathology of the two maladies is in may ways identical,
particularly when it comes to destruction of the myelin sheath
with no harm to the axon itself (18, 148, 176).

Sex Ratios for MS and Aspartame Reactions

Women bear the brunt of multiple sclerosis (91a-c) and lupus
(SLE)(73) with fully three-fold representations in infliction
numbers over men for both diseases.

This is exactly the proportion represented by adverse reactors
to Aspartame reported by the US Center for Disease Control
in their study of 1984(58).

The Center found three women to every man whose
Aspartame consumption complaints were serious enough to
warrant investigation (93).

Although the female/male ratio for those stricken with MS has
always been high, recent estimates place it at over 3 to 1
(91, 91a, 91c).

What might account for the difference across sexes in
incidence?

A study published in the New England Journal of Medicine
(94) reports biopsies of the gastric lining of men and women.

A result was that the concentration of ADH in the gastric lining
of men was much higher than for woman.

Men have the advantage of removing methanol from the
bloodstream four times faster on an equal-body-size basis
than women.

Thus, for men, methanol is more likely to be removed from the
blood before it reaches the brain.

The brain is spared but the methanol removed would still be
metabolized to formaldehyde in the gut where it would reap its
havoc on a more forgiving organ.

This may help explain why men have more gastrointestinal
complaints from both methanol and Aspartame consumption
(93, 99).

On the other hand, women's complaints from both more
frequently involve serious neurological complications."

role of formaldehyde, made by body from methanol from
foods and aspartame, in steep increases in fetal alcohol
syndrome, autism, multiple sclerosis, lupus, teen suicide,
breast cancer, Nutrition Prof. Woodrow C. Monte, retired,
Arizona State U., two reviews, 190 references supplied,
Fitness Life, New Zealand 2007 Nov, Dec:
Murray 2007.12.26
http://groups.yahoo.com/group/aspartameNM/message/1498

Monte WC., Is your Diet Sweetener killing you?
Fitness Life. 2007 Nov; 33: 31-33.
Monte WC., A Deadly Experiment.
Fitness Life. 2007 Dec; 34: 38-42.
Monte WC., Bittersweet: Aspartame Breast Cancer Link.
Fitness Life. 2008 Feb; 34: 21-22.

Article 1 http://www.thetruthaboutstuff.com/review1.html
Article 2 http://www.thetruthaboutstuff.com/review2.html
Article 3 http://www.thetruthaboutstuff.com/review3.html

http://www.thetruthaboutstuff.com/articles.html
223 references with abstracts or full and partial texts


methanol (11% of aspartame), made by body into
formaldehyde in many vulnerable tissues, causes modern
diseases of civilization, summary of a century of research,
Woodrow C Monte PhD, Medical Hypotheses journal:
Rich Murray 2009.11.15
http://rmforall.blogspot.com/2009_11_01_archive.htm
Sunday, November 15, 2009
http://groups.yahoo.com/group/aspartameNM/message/1589

Methanol: A Chemical Trojan Horse as the Root of the
Inscrutable U, Prepublication Copy; Medical Hypotheses
-- 06 November 2009 (10.1016/j.mehy.2009.09.059)
http://www.medical-hypotheses.com/article/S0306-9877(09)00693-8/abstract
Woodrow C. Monte PhD
Professor of Food Science (retired)
Arizona State University
corresponding author : Woodrow C. Monte PhD
470 South Rainbow Drive
Page, Arizona 86040
Key Words:
food epidemiology; diseases of civilization; methanol;
formaldehyde; aspartame; autism; multiple sclerosis; Alzheimer's;
U-shaped curve.

Abstract:

Until 200 years ago, methanol was an extremely rare
component of the human diet and is still rarely consumed in
contemporary hunter and gatherer cultures.
With the invention of canning in the 1800s, canned and
bottled fruits and vegetables, whose methanol content greatly
exceeds that of' their fresh counterparts, became far more
prevalent.
The recent dietary introduction of aspartame, an artificial
sweetener, 11% methanol by weight, has also greatly
increased methanol consumption.
Moreover, methanol is a major component of cigarette
smoke, known to be a causative agent of many diseases of
civilization (DOC).
Conversion to formaldehyde in organs other than the liver is
the principal means by which methanol may cause disease.
The known sites of class I alcohol dehydrogenase (ADH I),
the only human enzyme capable of metabolizing methanol to
formaldehyde, correspond to the sites of origin for many DOC.
Variability in sensitivity to exogenous methanol consumption
may be accounted for in part by the presence of aldehyde
dehydrogenase sufficient to reduce the toxic effect of
formaldehyde production in tissue through its conversion to
the much less toxic formic acid.
The consumption or endogenous production of small amounts
of ethanol, which acts as a competitive inhibitor of methanol's
conversion to formaldehyde by ADH I, may afford some
individuals protection from DOC.


old tiger roars -- Woodrow C Monte, PhD -- aspartame
causes many breast cancers, as ADH enzyme in breasts
makes methanol from diet soda into carcinogenic
formaldehyde -- same in dark wines and liquors,
Fitness Life 2008 Jan.: Murray 2008.02.11
http://rmforall.blogspot.com/2008_02_01_archive.htm
Monday, February 11, 2008
http://groups.yahoo.com/group/aspartameNM/message/1517


http://groups.yahoo.com/group/aspartameNM/message/870
Aspartame: Methanol and the Public Interest 1984: Monte:
Murray 2002.09.23

Dr. Woodrow C. Monte
Aspartame: methanol, and the public health.
Journal of Applied Nutrition 1984; 36 (1): 42-54.
(62 references) Professsor of Food Science [retired 1992]
Arizona State University, Tempe, Arizona 85287
woodymonte@...; woodymonte@...;
The methanol from 2 L of diet soda, 5.6 12-oz cans,
20 mg/can, is 112 mg, 11% of the aspartame.
The EPA limit for water is 7.8 mg daily for methanol
(wood alcohol), a deadly cumulative poison.
Many users drink 1-2 L daily.
The reported symptoms are entirely consistent with chronic
methanol toxicity. (Fresh orange juice has 34 mg/L, but,
like all juices, has 16 times more ethanol, which strongly
protects against methanol.)

"The greater toxicity of methanol to man is deeply rooted in
the limited biochemical pathways available to humans for
detoxification.
The loss of uricase (EC 1.7.3.3.),
formyl-tetrahydrofolate synthetase (EC 6.3.4.3.) (42)
and other enzymes (18) during evolution sets man apart from
all laboratory animals including the monkey (42).

There is no generally accepted animal model
for methanol toxicity (42, 59).

Humans suffer "toxic syndrome" (54) at a minimum lethal
dose of <1 gm/kg, much less than that of monkeys,
3-6 g/kg (42, 59).

The minimum lethal dose of methanol
in the rat, rabbit, and dog is 9.5, 7.0 , and 8.0 g/kg,
respectively (43);
ethyl alcohol is more toxic than methanol to these
test animals (43)."
_______________________________________________


"Label present in liver, plasma and kidney was in the range
of 1-2 % of total radioactivity administered per g or mL,
changing little with time.
Other organs (brown and white adipose tissues, muscle, brain,
cornea and retina) contained levels of label
in the range of 1/12th to 1/10th of that of liver.
In all, the rats retained, 6 hours after administration,
about 5 % of the label, half of it in the liver."

7 Trocho C. Pardo R. Fafecas I. Virgili J. Remesar X. Fernandez-Lopez. J;
"A.1988. Formaldehyde derived from dietary aspartame binds to tissue
components in vivo", Life Sci 63: 337

http://whilesciencesleeps.com/references/pdf/7 13 pages

Abstract:

Adult male rats were given an oral dose of 10 mg/kg aspartame,
14C-labeled in the methanol carbon.
At timed intervals of up to 6 hours, the radioactivity in plasma
and several organs was investigated.
Most of the radioactivity found (>98 % in plasma, >75 % in liver)
was bound to protein.
Label present in liver, plasma and kidney was in the range
of 1-2 % of total radioactivity administered per g or mL,
changing little with time.
Other organs (brown and white adipose tissues, muscle, brain,
cornea and retina) contained levels of label
in the range of 1/12th to 1/10th of that of liver.
In all, the rats retained, 6 hours after administration,
about 5 % of the label, half of it in the liver.

The specific radioactivity of tissue protein, RNA and DNA
was quite uniform.
The protein label was concentrated in amino acids,
different from methionine, and largely coincident
with the result of protein exposure to labeled formaldehyde.
DNA radioactivity was essentially in a single different adduct base,
different from the normal bases present in DNA.
The nature of the tissue label accumulated was, thus,
a direct consequence of formaldehyde binding to tissue structures.

The administration of labeled aspartame to a group of cirrhotic rats
resulted in comparable label retention by tissue components,
which suggests that liver function (or its defect) has little effect
on formaldehyde formation from aspartame
and binding to biological components.

The chronic treatment of a series of rats with 200 mg/kg of
non-labeled aspartame during 10 days results in the accumulation
of even more label when given the radioactive bolus,
suggesting that the amount of formaldehyde adducts
coming from aspartame in tissue proteins and nucleic acids
may be cumulative.

It is concluded that aspartame consumption may constitute
a hazard because of its contribution
to the formation of formaldehyde adducts. PMID: 9714421


-----Original Message-----
From: Rich Murray [mailto:rmforall@...]
Sent: Friday, July 02, 2010 8:06 PM
To: Woodrow Monte
Cc: Rich Murray; RichMurray.rmforall@...
Subject: neck vein narrowing & MS -- any methanol connection? Monte: Murray
2010.07.02

neck vein narrowing & MS -- any methanol connection? Monte: Murray
2010.07.02

http://www.nytimes.com/2010/06/29/health/29vein.html

http://www.nytimes.com/2010/06/29/health/29vein.html?pagewanted=print

June 28, 2010
From M.S. Patients, Outcry for Unproved Treatment
By DENISE GRADY

For her first appointment with Dr. Daniel Simon, Neelima Raval showed up
with a rolling file cabinet full of documents. She had downloaded every word
written by or about Dr. Paolo Zamboni, a vascular surgeon from Italy with a
most unorthodox theory about multiple sclerosis.

Dr. Zamboni believes that the disease, which damages the nervous system, may
be caused by narrowed veins in the neck and chest that block the drainage of
blood from the brain. He has reported in medical journals that opening those
veins with the kind of balloons used to treat blocked heart arteries-an
experimental treatment he calls the "liberation procedure" -- can relieve
symptoms....

She has a degree in toxicology and works for a drug company...

Dr. Zamboni, 53, (no relation to the inventor of the ice-rink machine) began
studying the medical literature on multiple sclerosis in 1995 when his wife
learned she had the disease.

"What I found was like a detective story," he said.

He discovered reports of vein abnormalities and of brain lesions forming
around veins. But the research had been abandoned. Vein disorders are his
specialty; he has been studying them for 25 years. He began using ultrasound
and other imaging techniques to examine veins, and found narrowings in the
neck and chest veins in people with the disease, but not in healthy ones. He
suspected that abnormal blood flow and pressure in the veins -- not just
narrowing alone -- might cause minute amounts of bleeding in the brain,
leading to an immune reaction and inflammation that damaged myelin and
nerves. Iron deposits could also form, and add to the damage. He wondered if
opening the narrowed areas might help.
In 2006 he began using balloons to treat patients, including his wife, whose
symptoms went away and, he says, have not come back....


Int Angiol. 2010 Apr;29(2):140-8.
CSF dynamics and brain volume in multiple sclerosis are associated with
extracranial venous flow anomalies: a pilot study.
Zamboni P, Menegatti E, Weinstock-Guttman B, Schirda C, Cox JL, Malagoni AM,
Hojnacki D, Kennedy C, Carl E, Dwyer MG, Bergsland N, Galeotti R, Hussein S,
Bartolomei I, Salvi F, Ramanathan M, Zivadinov R.
Vascular Diseases Center, University of Ferrara-Bellaria Neurosciences,
Ferrara and Bologna, Italy.
Paolo Zamboni <zmp@...>;
_______________________________________________


Rich Murray, MA
Boston University Graduate School 1967 psychology,
BS MIT 1964, history and physics,
1943 Otowi Road, Santa Fe, New Mexico 87505
505-501-2298 rmforall@...

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