533 mostly negative reports on sucralose in 2 1/2 years (many GI symptoms) Mark
J & Cherie Yannone, Phoenix, AZ www.FoodAndDiet.com: GI stimulation, M Kidd et
al, Yale U, AJPGLP 2008.06.12: Rich Murray 2008.07.29
http://rmforall.blogspot.com/2008_07_01_archive.htm
Tuesday, July 29, 2008
http://groups.yahoo.com/group/aspartameNM/message/1555
___________________________________________________


http://www.foodanddiet.com/splenda/symptom-list.html

Food and Diet, Mark J. and Cherie Yannone
1421 E Charleston Ave
Phoenix AZ 85022
Phone 602-569-9632 foodanddiet@...;
Site designed and maintained by webDedication webDesign Studios
© 2002-2007 webDedication webDesign Studios and Cherie Yannone.
All rights reserved

All of the symptoms listed on this page may be caused by something other than
sucralose consumption. Be certain to speak with your physician to discuss your
symptoms and to get treatment for allergies, illnesses, diseases, or conditions
that require medical attention.

Having clarified that, based upon the more than 500 stories received from our
visitors, we have compiled a list of the most frequently reported symptoms
resulting from the use of sucralose (Splenda). The list, expanding almost
monthly, may not contain your particular symptom. That does not mean you aren't
suffering side effects from Splenda consumption, but may mean that the side
effect has not been reported often enough for us to add it to the list (yet).

* bloating
* abdominal pain
* gas, sometimes painful
* nausea
* heartburn
* diarrhea
* headaches
* migraines (severe headaches)
* heart palpitations (fluttering, irregular heartbeats)
* shortness of breath
* depression
* anxiety and panic attacks
* spaced-out or drugged sensation
* joint pain, especially in the knees
* dizziness

http://www.foodanddiet.com/splenda/story-index.html
Index 7 -- 18, from 2005.04.26 to 2006.06.21

Each of the following links will take you to an individual index containing 25
stories from Splenda users.
Some stories are positive, as indicated by a bright yellow happy face.
Some stories are negative, as indicated by a sickly green unhappy face.
Note that the indices start at Index 7.
Previous indices are found on our main website.

In addition, the following side effects are being reported more often, although
not with the same degree of frequency as those above:

* lone atrial fibrillation
* extreme fatigue
* muscle weakness
* tingling mouth or tongue
* tingling in fingers and hands
* numbness in the lips and tongue
* swollen lips or tongue
* swollen face
* redness or welts on face
* mouth sores
* blurred vision

If you believe you are suffering ill effects after consuming Splenda, we
strongly suggest you conduct the two-week test:

For two weeks, double-check every package label (from bottled waters to OTC
medications) to ensure you consume absolutely nothing with Splenda (sucralose).
Not every product containing sucralose will display the now-familiar Splenda
logo, so read every label.
If, during the two-week period your symptoms stop and don't return, try
consuming something with Splenda as you did previously.
If the symptoms return, you've likely discovered the source of your illness.
If the symptoms don't abate, worsen, or do not return with a return to Splenda
consumption, you may have another illness or problem.
In either case, be certain to speak with your physician and discuss your
suspicions about sucralose as it relates to your condition.

[ The last four stories, after which no more stories are collected, are:

http://www.foodanddiet.com/splenda/stories-500-599/splenda-story533.html

On 18 June 2006, we received this note from E.L. concerning their use of
sucralose.

"Approximately one month ago, I drank a diet lemonade. It must have had Splenda
in it because one day later I had severe cramping and diarrhea. It lasted for
two days. At first, I thought I had a bug.

A few days ago, I drank another lemonade drink (only about 2 ounces this time).
It was so sweet and so awful I threw most of it away. One night later, I had
severe stomach cramps and diarrhea. It took two days to get over it. I almost
went to the ER I was so sick.

Now that I know it's the Splenda, I will watch what I drink.

My friend ate one piece of dietetic chocolate candy. She had diarrhea before she
could get home! She knew exactly what caused it. She didn't even get home before
it hit her!

I will not touch that stuff any more."

Thank you E.L. for sharing your story with our visitors.

If you have experienced any side effects, whether you are sure it is Splenda or
not, be sure to speak with your physician and discuss all possibilities.

You can also use the search function at the bottom of the page to find stories
based solely on a particular side effect or symptom.

http://www.foodanddiet.com/splenda/stories-500-599/splenda-story534.html

On 19 June 2006, we received this note from L. concerning their use of
sucralose.

"I have been using Splenda for probably two years. I have always loved it
because it didn't leave an aftertaste. But it seemed every month before my
menstrual cycle my breasts would become extremely tender, so much that it was
almost unbearable. I knew that caffeine could cause this, but I was drinking
half-caf coffee and really didn't feel like I was drinking too much to cause the
breast tenderness.

I decided to experiment a little. I stopped using Splenda in my coffee about a
month ago and started using saccharin to sweeten my coffee. I just started my
cycle today. It totally caught me off-guard because before I knew when I was
going to start my cycle because of the breast tenderness. I had NO breast
tenderness at all this month!!!

I am totally shocked.

I have also been having headaches a lot in the past. So I will see if stopping
the Splenda will help that as well. Just thought I should share my story.

Thanks so much for your website!"

http://www.foodanddiet.com/splenda/stories-500-599/splenda-story535.html

On 20 June 2006, we received this note from B. concerning their use of
sucralose.

"I was searching for a website about sucralose and found your site.

I have problems with this sucralose that are among your list. I have experienced
bloating, abdominal pain (real bad), redness on my face, swollen itchy bumps on
my face, and diarrhea. I have also had a symptom that is not on your list:
clumsiness. It's like my feet don't go where they are supposed to go. I trip and
stumble.

I know these problems are caused by the sucralose because I tested myself. The
days I drank flavored water with sucralose, I had the symptoms. A couple of days
without sucralose and the symptoms disappeared. I tried the drinks a week later,
and the symptoms reoccurred.

I'm really disappointed because I hate the taste of regular water, but it seems
everything now has sucralose in it. When Fruit 2-0 first came out, I
experienced the above symptoms. I called the company to ask if Splenda could be
causing it or if they had any complaints of side effects. I was told there had
been no adverse effects at all. BULL!

It's like I now haven't any choie except to be very careful of what I eat and
drink. I read every word on labels. What ever happened to just plain sugar?!
Doesn't anyone care what this stuff is doing to people?!

Thank you for your website."

http://www.foodanddiet.com/splenda/stories-500-599/splenda-story536.html

On 21 June 2006, we received this note from N.H. in Northern California
concerning their use of sucralose.

"Quite a few years ago, I was diagnosed by my physician as having reactive
hypoglycemia. My blood sugar dropped to 43 during the testing. I struggled with
that off and on over the years depending on how careful I was about what I ate.

About three years ago, I was diagnosed as hypothyroid. I was avoiding caffeine
and taking Synthroid (50, the white ones). I was actually feeling better than I
had in a long time. I don't remember when I first tried Splenda, but I didn't
like it because it seemed to cause my blood sugar to shoot up and then crash so
I could barely stay awake. I didn't buy anything with it, but I may have had
some occasionally at a restaurant or at someone's house.

Last Thanksgiving, I bought some flavored instant decaf coffee. When I was
drinking that I was not having the sleepy crash so I didn't suspect the Splenda.
But I was not feeling well. I was anxious and depressed, especially in the
mornings. The coffee was the only thing I was eating or drinking that was
different. When I stopped drinking the coffee, I felt much better. I didn't
associate the problem with the Splenda, though, and thought it may have been
related to the process of removing the caffeine.

Since then, I occasionally had soda with Splenda and didn't seem to be bothered,
although as I look back, my hypoglycemia seemed worse at times and I had
symptoms with lower amounts of carbs. Last month, at the end of the school year
(I am a teacher), when I was under more stress than usual to get everything
done, I bought some sugar-free ice cream with Splenda. The stress and the
Splenda together caused real problems. I felt terrible. I was nervous and
depressed, especially in the mornings. I could feel my heart beat and my
thyroid started working overtime, so I had to stop taking my thyroid medication.
After less than a week without Splenda, I was feeling much better, and after a
week the symptoms were gone.

I think, in my case, the Splenda aggravated the hypoglycemia. I'm not sure why
it made my thyroid work overtime, but it certainly seems that it did." ]

http://www.foodanddiet.com/NewFiles/splenda.html
Index 1 -- 6, from 2003.12.28 to 2005.04.16
___________________________________________________


http://ajpgi.physiology.org/cgi/content/abstract/00056.2008v1

"Mechanisms by which gut luminal content regulates secretion and motility is
ill-understood.
... the artificial sweetener, sucralose, stimulated (EC50 = 9.2nM and 0.38nM)."

Am J Physiol Gastrointest Liver Physiol. 2008 Jun 12. [Epub ahead of print]
The luminal regulation of normal and neoplastic human EC cell serotonin release
is mediated by bile salts, amines, tastants and olfactants.
Kidd M, Modlin IM, Gustafsson BI, Drozdov I, Hauso O, Pfragner R.
Surgery, Yale University School of Medicine, New Haven, Connecticut, United
States.

Introduction:
Mechanisms by which gut luminal content regulates secretion and motility is
ill-understood.

We evaluated whether neuroendocrine enterochromaffin (EC) cells act as
luminal-sensors for a wide variety of nutrients and defined the secretory
mechanisms of this process.

Methods and Results:
Pure (98-99%) FACS-sorted human EC cells and neoplastic EC cells (KRJ-I) were
studied.

RT-PCR identified transcripts for T2R1 (bitter), OR1G1 (class II olfactory) and
trace amine (TAR1) GPCRs, and transporters for glutamine (SNAT1/2), glucose
(GLUT1/3/SGLT1) and bile salts (ABST).

Glutamine and sodium deoxycholate stimulated 5HT release (EC50 =
0.002-0.2microM; 2-fold release) but were 10-100x more potent in neoplastic EC
cells which also secreted 6-13x more 5HT.

Tastants (caffeine, tyramine, octopamine) and olfactants (thymol/eugenol), also
stimulated normal and neoplastic EC cell 5HT secretion (EC50 = 1.2nM-2.1microM
and 0.05nM-0.1microM release, respectively) while 2-deoxyglucose and the
artificial sweetener, sucralose, stimulated (EC50 = 9.2nM and 0.38nM).

5HT release was associated with ERK phosphorylation (1.5-fold, p<0.02) and could
be inhibited by a somatostatin analogue (IC50: 10(-12)M).

Eleven secretory associated genes including the vesicle docking inhibitor,
STXBP3, were up-regulated in response to glutamine and bile salt stimulation in
neoplastic EC cells.

Targeting STXBP3 expression using antisense knockdown significantly (p<0.05)
reduced 5HT secretion.

Conclusions:
EC cells express GPRCs and transporters for luminal tastants, olfactants,
glutamine, glucose and bile salts.

Activation includes a panel of secretory genes, ERK phosphorylation and 5HT
secretion.

Luminal EC cell regulation is likely to be as important as the G cell regulation
in gastric acid secretion; development of agents to target EC cell function is a
critical therapeutic goal.

Key words: gastrointestinal, luminal, neuroendocrine, secretion, tastant.
PMID: 18556422

Mark S. Kidd 1, mark.kidd@...;
Irvin M. Modlin 2*, imodlin@...; Telephone: +1-203-7855429 Fax:
+1-203-7374067
Bjorn I Gustafsson 3, bjorn.gustafsson@...;
Ignat Drozdov 1, ignat.drozdov@...;
Oyvind Hauso 4, oyvind.hauso@...;
and Roswitha Pfragner 5 roswitha.pfragner@...;

1 Surgery, Yale University School of Medicine, New Haven, Connecticut, United
States
2 Surgery, Yale University School of Medicine, New Haven, Connecticut, United
States; United States
3 Surgery, Yale University School of Medicine, New Haven, Connecticut, United
States; Internal Medicine, Gastroenterology, St Olavs University Hospital HF,
Trondheim, Norway
4 Molecular Biology and Cancer Research, NTNU, Trondheim, Norway
5 Institute of Pathophysiology, Centre for Molecular Medicine, Medical
University of Graz, Graz, Austria; Institute of Pathophysiology and Immunology,
Centre for Molecular Medicine, Medical University of Graz, Graz, Austria
* To whom correspondence should be addressed. E-mail: imodlin@...;
___________________________________________________


http://en.wikipedia.org/wiki/Sucralose

http://groups.yahoo.com/group/aspartameNM/message/1481
Australia official report 2001.12.10 finds arsenic impurity in sucralose
at 15 % of USA EPA adult ADI limits for daily drinking water, also 67 %
of child lead alarm limits -- evidence for claims by D.L. Dewey and G.N.
Ferebee petition (some typos): Murray 2007.10.25

http://groups.yahoo.com/group/aspartameNM/message/1413
sucralose, aspartame, sugar legal melee, How Sweet It Isn't, Avery
Johnson, Wall Street Journal: Murray 2007.04.06

http://groups.yahoo.com/group/aspartameNM/message/1412
sucralose (an earnest effort at a neutral summary of both sides of the
Splenda toxicity debate), Wikipedia 2007.03.26: Murray 2007.03.29

adroit PR firm Qorvis Communications, hired by Sugar Association, coyly
sets up Citizens For Health front to attack sucralose (Splenda):
Murray 2007.03.22
http://groups.yahoo.com/group/aspartameNM/message/1411

http://groups.yahoo.com/group/aspartameNM/message/1328
Migraine from sucralose, Bigal ME & Krymchantowski AV,
Headache 2006 March; formaldehyde from 11% methanol part of
aspartame or from red wine causes same toxicity (hangover) harm:
Murray 2006.04.24

http://groups.yahoo.com/group/aspartameNM/message/1257
Comet assay tests groups of 4 mice to show sucralose genotoxicity
in stomach, colon, lung, Yu F Sasaki et al, Mutation Research 2002,
full plain text: Murray 2005.11.22

http://groups.yahoo.com/group/aspartameNM/message/1152
reply to Ferne Hudson, Tate & Lyle PLC, re Splenda (sucralose) policy:
Murray 2005.02.08
"This weekend I found a large, competent website by Mr. Mark J. Yannone, a
programmer, who in email on 2001.01.22 reported that his seizures were cured
by giving up aspartame. Aspartame and sucralose are only a small fraction
of the issues listed on his voluminous site.

http://www.foodanddiet.com/ foodanddiet@... Mark J. & Cherie Yannone
1421 E Charleston Ave, Phoenix AZ 85022
Phone 602-569-9632 Fax 602-569-9635

http://www.foodanddiet.com/NewFiles/splenda-story-list.html lists an
ever-growing archive, now 236 reports in a year, of posts about symptoms from
sucralose -- about 10% of the posts said they had no problems. The
sophistication, size, organization, and clarity of this site far exceeds what
aspartame activists offered six years ago, as does the amount of user
information.

Here are the first titles:

"I woke up with my very first migraine ever...
There has never been any negative side effect...
I have been headache free for two weeks now...
Using Splenda for a year now with no problem...
Uncontrollable bouts with gas...
I'll continue with the Splenda...
Hot and cold flashes, but also depressed for no reason...
I plan to throw out the entire box...
It IS the sucralose making me ill...
At no point would I have ever put two-and-two together...
We recently changed our way of eating...
I can relate to the symptoms I have read...
I know I feel better now, and I know how I was feeling then...
Splenda was like a kick in the stomach...
I felt so terrible I was not even able to go to work...
My focus seems to be returning...
I'm still in awe of my experience...
I have had a whopping headache for hours now...
I had one encounter with the use of Splenda...
Splenda is not so splendid...
I truly cannot attribute negative side effects to the sweetener...
I can't believe that I have been poisoning myself ...
I also stopped losing weight after adding sucralose...
I found myself spinning into a dark depression...
I started feeling "not myself"...
I have only used Splenda a few times...
I noticed incredible fatigue and sleepiness...
I am not happy with the results...
I didn't even realize it might be the Splenda ...
I had the worst feeling...
Two weeks ago, my wife decided to use Splenda ...
What a terrible mistake!...
I have had no side effects at all...
I decided to try Splenda again...
I wanted to pass along my story about sucralose...
I started using Splenda in small doses..."

"Based upon information supplied to us by our visitors, we note the
following possible side effects from consumption of sucralose:

bloating
abdominal pain
gas
nausea
diarrhea
headaches
migraines (severe headaches)
heart palpitations (fluttering)
shortness of breath
depression or overwhelming anxiety
spaced-out or drugged sensation
joint pain
dizziness"

I notice that these are also common symptoms reported by aspartame reactors."
___________________________________________________


"Of course, everyone chooses, as a natural priority, to enjoy peace,
joy, and love by helping to find, quickly share, and positively act
upon evidence about healthy and safe food, drink, and environment."

Rich Murray, MA Room For All rmforall@...
505-501-2298 1943 Otowi Road, Santa Fe, New Mexico 87505

http://RMForAll.blogspot.com new primary archive

http://groups.yahoo.com/group/aspartameNM/messages
group with 126 members, 1,555 posts in a public archive

http://groups.yahoo.com/group/aspartame/messages
group with 1,126 members, 22,843 posts in public archive
___________________________________________________