Please email Hawaii House Health Committee by 6 PM EST Tuesday re their
aspartame ban decision 4 PM EST Wednesday Feb. 13 re HB 2680 and SB2506 --
their MD chairman wanted more testimony from professionals: Murray
2008.02.09
http://rmforall.blogspot.com/2008_02_01_archive.htm
Saturday, February 9, 2008
http://groups.yahoo.com/group/aspartameNM/message/1515


Hello aspartame activists and professionals,

Stephen Fox on the phone here in Santa Fe 505-983-2002
stephen@... told me just now at 9:30 PM MST that at the
hearing this morning in Honolulu, a few anti-aspartame folks made oral
statements, while a few pro-aspartame people read their statements. The
Chair, Josh Green, M.D., an emergency room physician, deferred a decision
five days until Wednesday morning, as he felt there needed to be substantial
science-based professional testimony to support a State ban of a substance
that has federal FDA approval.

Especially if you are a professional, email research summaries, say, no more
than 3 pages, giving your credentials and full contact info,
starting the Subject line with:

House Bill 2680, Rm #329, 8 AM Wed. Feb. 13: aspartame ban evidence:
(detailed title of your evidence)

and start your email with your Title line, adding:

Honorable Rep. Josh Green, M.D., Chair,
and Honorable John Mizuno, Vice Chair:

Please copy as committee handout for this hearing.

and address to

repgreen@...; repmizuno@...;

and blind copy to the other 7 Health Committee members, plus Mele Carroll,
who initiated the House Bill,
and Senator David Y. Ige, Chair, and
Senator Carol Fukunaga, Vice-Chair,
Senate Committee on Health HTH, re SB2506.

repbelatti@...; repbertram@...;
repcabanilla@...; reprhoads@...;
reptokioka@...; repward@...;

repcarroll@...;
sendige@...; senfukunaga@...;
____________________________________________________


www.capitol.hawaii.gov/site1/docs/getstatus2.asp?billno=HB2680

Hawaii State Legislature
Bill Status
HB2680
Generated on 2/8/2008 6:29:20 PM
Measure Title: RELATING TO FOOD.
Report Title: Artificial Sweetener; Aspartame; Ban; Food
Description: Bans the use of the artificial sweetener aspartame in food
products.
Introducer(s): SAY (BR)
Current Referral: HLT, EDB/CPC [ HLT = Health Committee ]
Date Status Text
1/18/2008 H Pending introduction.
1/22/2008 H Introduced and Pass First Reading.
1/23/2008 H Referred to HLT, EDB/CPC, referral sheet 6
2/5/2008 H Bill scheduled to be heard by HLT on Friday, 02-08-08 at 8:00 am
in House conference room 329.
2/8/2008 H The committee(s) recommends that the measure be deferred until
02-13-08.
2/8/2008 H Bill scheduled for decision making on Wednesday, 02-13-08 at 8:00
am in conference room 329.

$ = Appropriation measure
ConAm = Constitutional Amendment

www.capitol.hawaii.gov/site1/house/comm/commHLT.asp
House Committee on Health HLT

Josh Green, M.D., Chair
6th Representative District
Hawaii State Capitol, Room 327
415 South Beretania Street
Honolulu, HI 96813
phone 808-586-9605; fax 808-586-9608
From the Big Island, toll free 974-4000 + 69605
E-mail repgreen@...;

John Mizuno, Vice-Chair
30th Representative District
Hawaii State Capitol, Room 436
415 South Beretania Street
Honolulu, HI 96813
phone 808-586-6050; fax 808-586-6051
E-mail repmizuno@...;

Karen Leinani Awana
44th Representative District
Hawaii State Capitol, Room 319
415 South Beretania Street
Honolulu, HI 96813
phone 808-586-8465; fax 808-586-8469
E-mail repawana@...;

Della Au Belatti
25th Representative District
Hawaii State Capitol, Room 331
415 South Beretania Street
Honolulu, HI 96813
Phone 808-586-9425; fax 808-586-9431
email repbelatti@...;

Joe Bertram, III
11th Representative District
Hawaii State Capitol, Room 311
415 South Beretania Street
Honolulu, HI 96813
phone 808-586-8525; fax 808-586-8529
From Maui, toll free 984-2400 + 68525
e-mail repbertram@...;

Rida T.R. Cabanilla
42nd Representative District
Hawaii State Capitol, Room 442
415 South Beretania Street
Honolulu, HI 96813
phone 808-586-6080; fax 808-586-6081
E-mail repcabanilla@...;

Karl Rhoads
28th Representive District
Hawaii State Capitol, Room 326
415 South Beretania Street
Honolulu, HI 96813
phone 808-586-6180; fax 808-586-6189
e-mail reprhoads@...;

James Kunane Tokioka
15th Representative District
Hawaii State Capitol, Room 322
415 South Beretania Street
Honolulu, HI 96813
phone 808-586-6270; fax 808-586-6271
From Kauai, toll free 274-3141 + 66270
e-mail reptokioka@...;

Gene Ward, Ph.D.
17th Representative District
Hawaii State Capitol, Room 318
415 South Beretania Street
Honolulu, HI 96813
phone 808-586-6420; fax 808-586-6421
E-mail repward@...;

Mele Carroll
13th Representative District
Hawaii State Capitol, Room 405
415 South Beretania Street
Honolulu, HI 96813
Phone 808-586-6790; fax 808-586-6779
From Maui, toll free 984-2400 + 66790
From Molokai and Lanai,
toll free 1-800-468-4644 + 66790
E-mail repcarroll@...;

www.capitol.hawaii.gov/site1/senate/comm/commHTH.asp
Senate Committee on Health HTH

Committee on Health -- The purview of this committee
includes those programs
relating to business regulation, professional and vocational licensing,
consumer protection, financial institutions, insurance
regulation; public utility regulation; and telecommunications
regulation; sustainability; housing development including affordable
housing, the landlord tenant code, condominium property regimes,
and leaseholds.

David Y. Ige, Chair
phone 808-586-6230; fax 808-586-6231
E-mail sendige@...;

Carol Fukunaga, Vice-Chair
phone 808-586-6890; fax 808-586-6899
e-mail: senfukunaga@...;
____________________________________________________


Three Testimonial Letters in Support of Hawaii Banning Aspartame

From Ralph Walton, M.D.
Subject: copy of letter I sent re Hawaii ban
Date: Thu, 7 Feb 2008 11:35:02 -0500

I would like to vigorously support the proposed ban on aspartame.

For the past 20 years I have written about the very significant health
hazards of this artificial sweetener. I am convinced that it can lower
seizure threshold, mimic or exacerbate multiple neuropsychiatric disorders,
contribute to the risk for certain cancers, and paradoxically increase
appetite and thus play a significant role in the worldwide epidemic of
obesity and type 2 diabetes.

The aspartame industry will undoubtedly cite the many studies attesting to
safety. It is important to recognize however that virtually all such
studies were funded by the industry. Nearly all independently funded
studies identify one or more problems.

Ralph G. Walton, M.D.
Former Professor and Chairman,
Department of Psychiatry
Northeastern Ohio Universities College of Medicine

Medical Director,
Safe Harbor Behavioral Health
1330 West 26th Street
Erie, PA 16508
www.safeharborbh.org
814.459.9300


Dear Chairman Dr. Green, Vice Chairman Mizuno, and members of the Hawaiian
House Health Committee:

As the documentary filmmaker behind the films, Sweet Misery and Sweet
Remedy, which both delve deeply into an analysis of aspartame -- its history
and chemical breakdown -- I am writing to commend you for seriously
considering the health of Hawaiians by bringing forward a bill to ban
aspartame. It is a truly admirable and courageous act, in the spirit of
positive community-based change. I, myself, am an aspartame survivor and
personally can attest to the physical horrors it can inflict. In 2002, I
was diagnosed with multiple sclerosis and shortly thereafter, was confined
to a wheelchair with double vision and slurred speech. As I began to
recover, I made the aforementioned aspartame documentaries, needing to alert
the public at large and to spare people from my personal traumas. I also
wanted to learn as much as I could during this film-making process about the
truth or fiction of the dangers of aspartame. Although I did not want to
believe that there was a problem with what had been my beverage of choice
for twenty years, I found that in aspartame's case at least, where there was
smoke, there was fire -- a raging inferno, in fact.

The largest tragedy in my own life was thinking that aspartame was not only
safe, but good for me. This same story has been repeated by countless
aspartame survivors who have contacted me as they regain their health. Many
other products have found to be toxic after entering the market place and
have subsequently been banned. Look at DDT in pesticides; lead in gasoline;
or even Red #1, #2 and #4 for use as food dyes.

Aspartame is a very sneaky, cumulative toxin accompanied by a smiley face.
This is very dangerous. As more knowledge comes to light, it has become
your responsibility and high honor to react to this new understanding. I ask
you to give your bill a do pass in your Health Committee.

Thank you truly for your time and consideration.

Sincerely,

Cori Brackett
Sound and Fury Productions
2301 East Broadway
Tucson, AZ 85719
(520) 884-4346 (Direct line)
www.sweetremedy.tv


HESH GOLDSTEIN, MScNutr
"Health Talk" Moderator K-108 Radio
P.O. Box 240783
Honolulu, Hawaii 96824-0783
Tel: (808) 258-1177 / Fax: (808) 848-8640
heshgoldstein@...;

TESTIMONY IN SUPPORT OF HB2680: TO BAN THE USE OF ASPARTAME

For Hearing in Room #329, 8 A.M., Friday 2/8/08

PLEASE COPY AS COMMITTEE HANDOUT FOR THIS HEARING

TO: CHAIR JOSH GREEN M.D., VICE CHAIR JOHN MIZUNO, MEMBERS OF THE COMMITTEE

No doubt you will be lobbied by companies like Ajinomoto, Coca Cola, Pepsi
and others to not ban Aspartame. You must not lose sight of the fact that
their sole motivation for you to not ban Aspartame is money and profits and
most definitely not the health of the people. We, the people of Hawaii, can
only hope and pray that you will focus on our health and not corporate
profits.

Aspartame is marketed as a "diet aid". The reality is that Aspartame causes
the brain to stop producing serotonin, which results in feeling as though
you haven't had enough to eat even when you are full.

75% of ALL recorded complaints received by the FDA were concerning
Aspartame. Those symptoms complained about included headache, nausea,
vertigo, insomnia, loss of control of limbs, blurred vision, blindness,
memory loss, slurred speech, depression, hyperactivity, gastronomical
disorders, seizures, skin lesions, rashes, anxiety attacks, muscle and joint
pain, numbness, mood changes, menstrual cramps out of cycle, hearing loss or
ringing in the ears, and heart palpitations.

Aspartame has three components: phenylalanine (50%), aspartic acid (40%),
and methanol, aka wood alcohol (10%). But, their breakdowns present an even
greater cause for concern. Phenylalanine decomposes into diketopiperazine
(DKP), a known carcinogen when exposed to warm temperatures or prolonged
storage. At 84 degrees F, the wood alcohol converts to formaldehyde. The
body's temperature is 98.6 degrees F. Talk about
"Night of the Living Dead"!

Infants are four more times sensitive to excitotoxins, which is what
Aspartame is classified as, than adults. FDA refused to approve Aspartame
16 straight times. It was specifically rejected in 1974 because it was shown
to cause brain tumors in rats.

Pages S5507 -- S5511 of the Congressional Record dated May 7, 1985 showed
convincing evidence that G.D. Searle and Company, the manufacturer of
Aspartame which is now owned by Monsanto, manipulated its tests to get
approval.

If you follow the money trail you will find that Monsanto has a billion
dollars in sales annually from the sale of Aspartame, the media has tens of
billions of dollars invested in advertisements for over 5,000 products, the
medical system makes hundreds of billions in expensive but useless tests
that cannot pinpoint patients' problems with certainty, and there is the
pharmaceutical industry pushing expensive drugs that don't work

What's interesting is that the herb stevia, which is completely safe, is a
natural sweetener that does not contribute to weight gain, yet the FDA has
made it illegal for stevia's manufacturers to state that it is a sugar
substitute.

Please, please put health first and not corporate profits.

Aloha! Hesh Goldstein

[ Rich Murray note: Heat does not cause methanol to turn into formaldehyde.
Ingested or inhaled methanol from any source is quickly made into
formaldehyde, and thence largely into formic acid --both multipotent toxins
at very small levels.

Fully 11 % of aspartame is methanol -- 1,120 mg aspartame
in 2 L diet soda, almost six 12-oz cans, gives 123 mg methanol
(wood alcohol). The methanol is immediately released
into the body after drinking .
Within hours, the liver turns much of the methanol into formaldehyde,
and then much of that into formic acid, both of which in time
are partially eliminated as carbon dioxide and water.

However, about 30 % of the methanol remains in the body
as cumulative durable toxic metabolites of formaldehyde
and formic acid -- 37 mg daily,
a gram every month, accumulating in and affecting every tissue.

The 1999 FDA alarm limit for formaldehyde in daily drinking water is only 2
mg for 2 L. ]
____________________________________________________


www.capitol.hawaii.gov/session2008/bills/HB2680_.htm

Report Title: Artificial Sweetener; Aspartame; Ban; Food
Description: Bans the use of the artificial sweetener aspartame in food
products.

HOUSE OF REPRESENTATIVES H.B. NO. 2680
TWENTY-FOURTH LEGISLATURE, 2008
STATE OF HAWAII

A BILL FOR AN ACT relating to food.
[ identical to SB2506, text in full, below in this post ] ]

reps@...;sens@...;

Hawaii State Legislature
Hawaii State Capitol
415 South Beretania Street
Honolulu, Hawaii 96813
www.capitol.hawaii.gov/site1/info/direct/sendir.asp all Senators
www.capitol.hawaii.gov/site1/info/direct/repdir.asp all Representatives

www.capitol.hawaii.gov/site1/search/billsearch.asp?query=aspartame&currpage=1

www.capitol.hawaii.gov/site1/docs/getstatus2.asp?billno=HB2680
____________________________________________________


metabolic syndrome is tied to diet soda,
PL Lutsey, LM Steffen, J Stevens, Circulation 2008.01.22:
role of formaldehyde and formic acid from methanol
in wines, liquors, or aspartame?: Murray 2008.02.07
http://rmforall.blogspot.com/2008_02_01_archive.htm
Thursday, February 7, 2008
http://groups.yahoo.com/group/aspartameNM/message/1513

"But the one-third who ate the most fried food
increased their risk by 25 percent,
compared with the one-third who ate the least,
and surprisingly, the risk of developing metabolic syndrome
was 34 percent higher among
those who drank one can of diet soda a day
compared with those who drank none.

"This is interesting," said Lyn M. Steffen,
an associate professor of epidemiology
at the University of Minnesota and a co-author
of the paper, which was posted online in the journal
Circulation on Jan. 22. "Why is it happening?
Is it some kind of chemical in the diet soda,
or something about the behavior of diet soda drinkers?""

"The diet soda association was not hypothesized
and deserves further study."

vinyl acetate, ethyl alcohol, or aspartame in womb increases
later cancers in adults with lifetime exposure in many studies,
M Soffritti et al, Ramazzini Foundation,
Basic Clin. Pharm. Toxicol. 2008 Feb.:
Rich Murray 2008.02.07
http://rmforall.blogspot.com/2008_02_01_archive.htm
Thursday, February 7, 2008
http://groups.yahoo.com/group/aspartameNM/message/1511

need to find safe levels for aspartame
(methanol, formaldehyde, formic acid) via rapid, safe,
low-cost, highly accurate and sensitive modern breath
gas analysis: Claire Turner et al,
Foundation for Innovative New Diagnostics:
Rich Murray 2008.02.07
http://rmforall.blogspot.com/2008_02_01_archive.htm
Thursday, February 7, 2008
http://groups.yahoo.com/group/aspartameNM/message/1512

folic acid prevents neurotoxicity from formic acid, made by
body from methanol impurity in alcohol drinks
[ also 11 % of aspartame ], BM Kapur, PL Carlen,
DC Lehotay, AC Vandenbroucke, Y Adamchik,
U. of Toronto, 2007 Dec., Alcoholism Cl. Exp. Res.:
Murray 2007.11.27
http://rmforall.blogspot.com/2007_11_01_archive.htm
Wednesday, November 27, 2007
http://groups.yahoo.com/group/aspartameNM/message/1495


www.nytimes.com/2008/02/05/health/nutrition/05symp.html?ref=health

Fitness & Science
Vital Signs

Symptoms: Metabolic Syndrome Is Tied to Diet Soda
By Nicholas Bakalar
Published February 5, 2008

Researchers have found a correlation between drinking diet soda
and metabolic syndrome -- ­ the collection of risk factors for
cardiovascular disease and diabetes that include abdominal obesity,
high cholesterol and blood glucose levels,
and elevated blood pressure.

The scientists gathered dietary information
on more than 9,500 men
and women ages 45 to 64
and tracked their health for nine years.

Over all, a Western dietary pattern ­--
high intakes of refined grains,
fried foods and red meat -- was associated with an
18 percent increased risk for metabolic syndrome,
while a "prudent" diet dominated by
fruits, vegetables, fish and poultry correlated with
neither an increased nor a decreased risk.

But the one-third who ate the most fried food
increased their risk by 25 percent,
compared with the one-third who ate the least,
and surprisingly, the risk of developing metabolic syndrome
was 34 percent higher among
those who drank one can of diet soda a day
compared with those who drank none.

"This is interesting," said Lyn M. Steffen,
an associate professor of epidemiology
at the University of Minnesota and a co-author
of the paper, which was posted online in the journal
Circulation on Jan. 22. "Why is it happening?
Is it some kind of chemical in the diet soda,
or something about the behavior of diet soda drinkers?"

Copyright 2008 The New York Times Company
____________________________________________________


Published Online on January 22, 2008

Circulation. 2008
Published online before print January 22, 2008, doi:
10.1161/CIRCULATIONAHA.107.716159
Submitted on May 18, 2007
Accepted on December 7, 2007

Dietary Intake and the Development of the Metabolic Syndrome.
The Atherosclerosis Risk in Communities Study
Pamela L. Lutsey MPH, lutsey@...;
Lyn M. Steffen PhD, MPH, RD*, steffen@...;
and June Stevens PhD, MS, RD june_stevens@...;

From the Division of Epidemiology and Community Health,
University of Minnesota, School of Public Health,
Minneapolis (P.L.L., L.M.S.),
and Department of Nutrition,
University of North Carolina, Chapel Hill (J.S.).

Division of Epidemiology and Community Health,
University of Minnesota,
1300 South Second Street, Suite 300,
Minneapolis, MN 55454, USA.
lutsey@...;

* To whom correspondence should be addressed.
E-mail: steffen@...;

Background
The role of diet in the origin of metabolic syndrome
(MetSyn) is not well understood;

thus, we sought to evaluate the relationship
between incident MetSyn and dietary intake
using prospective data from 9514 participants
(age, 45 to 64 years) enrolled in
the Atherosclerosis Risk in Communities (ARIC) study.

Methods and Results
Dietary intake was assessed at baseline
via a 66-item food frequency questionnaire.

We used principal-components analysis to derive
"Western" and "prudent"
dietary patterns from 32 food groups
and evaluated 10 food groups used in previous studies
of the ARIC cohort.

MetSyn was defined by American Heart Association guidelines.

Proportional-hazards regression was used.

Over 9 years of follow-up,
3782 incident cases of MetSyn were identified.

After adjustment for
demographic factors, smoking, physical activity, and
energy intake,
consumption of a Western dietary pattern (Ptrend = 0.03)
was adversely associated with incident MetSyn.

After further adjustment for intake of
meat, dairy, fruits and vegetables,
refined grains, and whole grains,
analysis of individual food groups revealed that
meat (Ptrend under 0.001),
fried foods (Ptrend = 0.02),
and diet soda (Ptrend under 0.001)
also were adversely associated with incident MetSyn,
whereas dairy consumption (Ptrend = 0.006) was beneficial.

No associations were observed between incident MetSyn
and a prudent dietary pattern
or intakes of whole grains, refined grains,
fruits and vegetables, nuts,
coffee, or sweetened beverages.

Conclusions
These prospective findings suggest that consumption
of a Western dietary pattern, meat, and fried foods
promotes the incidence of MetSyn, whereas
dairy consumption provides some protection.

The diet soda association was not hypothesized
and deserves further study. PMID: 18212291

Key words:
dairy products, diet, food habits, meat, metabolic syndrome X
____________________________________________________


"The results, reported in table 6, show that aspartame
causes a significant, dose-related increase
of lymphomas/leukaemias
and malignant tumours of the renal pelvis and ureter in females
and malignant tumours of peripheral nerves in males.

These results demonstrate for the first time that aspartame is a
carcinogenic agent, capable of inducing malignancies
at various dose levels,
including those lower than the current acceptable daily intake
for humans (50 mg/kg of body weight in the USA,
40 mg/kg of body weight in the European Union)."

"Based on the results of long-term carcinogenicity bio-assays testing
chemical and physical agents using rodents, there is ample evidence
demonstrating that developmental, in conjunction with adult exposure
to carcinogenic risks, produces an overall increase in the incidence of
malignant tumours and an increased incidence of
specific neoplasms related to exposures to specific carcinogens.

Moreover, when comparing prenatal and postnatal exposure,
the development of certain tumours may appear earlier in life.

We must take into serious consideration the warnings provided by
long-term carcinogenicity studies and take adequate action today.

Based on the evidence presented, increased attention must be given
to developmental exposures to diffuse carcinogens.

It is only in this way that in the future we can hope to avoid a passive
registration of a worsening epidemiological situation."


www.blackwell-synergy.com/action/showFullText?submitFullText=Full+Text+HTML&doi=\
10.1111%2Fj.1742-7843.2007.00200.x
free full text

Basic & Clinical Pharmacology & Toxicology
Volume 102 Issue 2 Page 118-124, February 2008

To cite this article:
Morando Soffritti, Fiorella Belpoggi, Davide Degli Esposti,
Laura Falcioni, Luciano Bua (2008)
Consequences of Exposure to Carcinogens
Beginning During Developmental Life
Basic & Clinical Pharmacology & Toxicology 102 (2), 118-124.
doi:10.1111/j.1742-7843.2007.00200.x

Free Content
Full Text

MiniReview

Consequences of Exposure to Carcinogens
Beginning During Developmental Life
Morando Soffritti,
Fiorella Belpoggi,
Davide Degli Esposti,
Laura Falcioni and
Luciano Bua
Cesare Maltoni Cancer Research Center,
European Ramazzini Foundation of Oncology and Environmental Sciences,
Bologna, Italy

Author for correspondence: Morando Soffritti,
Cesare Maltoni Cancer Research Center,
European Ramazzini Foundation of Oncology and Environmental Sciences,
Castello di Bentivoglio, Via Saliceto 3,
40010 Bentivoglio, Bologna, Italy
fax +39 051 6640223, e-mail crcfr@...

Abstract:

The increased incidence of cancer over the last 50-60 years
may be largely attributed to two factors:
the ageing of the population
and the diffusion of agents and situations
presenting carcinogenic risks.

Today, we have entered into a new era in which populations are
ever-increasingly exposed to diffuse carcinogenic risks,
present not only in the occupational,
but also in the general environment.

We must now also consider an additional factor in the carcinogenic process,
that is, the age in which exposure to carcinogenic risks begins.

Apart from the paradigmatic cases of diethylstilboestrol and ionizing
radiation, the available epidemiological data concerning the adult
consequences of developmental exposure to carcinogens
is very limited.

However, important data have been provided by long-term
experimental carcinogenicity bioassays conducted using rodents.

This paper reports a selection of studies conducted in the
laboratories of the Cesare Maltoni Cancer Research Center
of the European Ramazzini Foundation
in which exposure to the chemical agents vinyl acetate monomer,
ethyl alcohol and aspartame was started
during developmental life and continued into adulthood.

The results of these studies provide supporting evidence that
lifespan exposure to carcinogenic agents
beginning during developmental life produces
an overall increase in the carcinogenic effects observed.

Moreover, when comparing prenatal and postnatal exposure,
the data demonstrate that the development of cancers
may appear earlier in life.

Cancer represents one of the most important issues
in public health today,
both in the industrialized and developing worlds.

The epidemiological dimension of the disease is epidemic,
with one out of two males and one out of three females
destined to become ill with cancer during their lifetimes [1].

Above all, cancer affects the oldest segment of the population,
from 60-84 years of age.

Data from the Nominative Mortality Register
of European Ramazzini Foundation
from the period 1982-2002 show that more than 30%
of the mortality in the province of Bologna, Italy, is cancer-related.

Of these deaths, 80% occurred after the age of 60-65 years [2].

If we consider the estimates that in 25 years,
the number of persons over
than the age of 70 years will have doubled,
it is necessary to prepare for a
dramatic increase in the number of tumours.

In the USA alone, it is predicted that the number of cancers
will indeed double by 2050 [1].

Although the scientific effort and economic resources
dedicated to cancer
have increased over the last 30 years
(directed especially towards the
discovery of effective cancer drug therapies),
in the USA, the 5-year relative survival rates
based on patient follow-up from 1976-2000 have not
substantially improved (table 1),
with the exception of female breast,
prostate and colon-rectal cancer,
for which early diagnosis has certainly played an important role.

Other exceptions are cancers of the lung and bronchus in males
that reflects the decrease in smoking more than the past 30 years.

The increased incidence of cancer over the last 50-60 years may be
attributed to two increasing trends:
(i) the increase in life expectancy (about 10 years for males
and 15 years for females);
and (ii) the increase in the diffusion of agents and situations
presenting carcinogenic risks in both the occupational and general
environment.
A third factor in the carcinogenetic process is genetic predisposition;
however, it is unlikely that this factor has changed significantly
over the last decades.

In addition, a fourth factor must also be considered; that is,
the age in which exposure to carcinogenic risks begins.

In this context, the present epidemiological dimension of cancer
is undoubtedly a sign of the previous era in which the majority of the
population had been exposed to carcinogenic risks
either in the occupational environment as adolescents or adults.

Today, however, we are facing an era characterized
by two new trends:
(i) lifetime exposure to carcinogenic risks beginning during
developmental life (prenatally or postnatally).

This exposure during early development, when cell mutiplication and
differentiation make an organism more vulnerable,
may cause an increase in carcinogenic effects later in life;

and (ii) exposure to 'diffuse carcinogenic risks'.
This term is used to describe carcinogenic risks of low potency,
but to which almost the entire population of the planet
may be exposed.

Examples of diffuse carcinogenic risks include:
(i) agents that are slightly carcinogenic at any dose;
(ii) low or extremely low doses of strong carcinogenic agents;
or (iii) mixtures of small doses of any carcinogenic agent [3].

Apart from the paradigmatic cases of diethylstilboestrol and ionizing
radiation, the available epidemiological data concerning the adult
consequences of developmental exposure to carcinogenic agents
are very limited.

We now know much more about the effects
of this early exposure thanks to
experimental long-term bioassays.

If adequately designed and conducted,
these bioassays can produce data that
can be effectively used to identify/predict carcinogenic risks and,
consequently, to make decisions to protect public health.

Numerous long-term carcinogenicity studies have been conducted
at the Cesare Maltoni Cancer Research Center
of the European Ramazzini Foundation (CMCRC/ERF)
that demonstrate the life-time consequences of chemical/physical
exposures beginning during developmental life and lasting for life.

This paper presents a selection of these exemplary cases
including vinyl acetate, ethyl alcohol and aspartame.
____________________________________________________


possible neurologic effects of aspartame, TJ Maher, RJ Wurtman,
Environ. Health Persp. 1987 Nov, full text: other seizure reports re
aspartame, methanol, formaldehyde, formic acid:
Murray 2008.01.10
http://rmforall.blogspot.com/2008_01_01_archive.htm
Thursday, January 10, 2008
http://groups.yahoo.com/group/aspartameNM/message/1501


Seizures and hyponatremia after excessive intake of diet coke, LJ
Mortelmans, M Van Loo, HG De Cauwer, K Merlevede, Klina
General Hospital, Brasschaat, Belgium, EJEM 2008 Feb:
Mark D. Gold critique: Murray 2008.01.10
http://rmforall.blogspot.com/2008_01_01_archive.htm
Thursday, January 10, 2008
http://groups.yahoo.com/group/aspartameNM/message/1502

Eur J Emerg Med. 2008 Feb; 15(1): 51.
Seizures and hyponatremia after excessive intake of diet coke.
Mortelmans LJ, Luc.mortelmans@...,
Van Loo M,
De Cauwer HG, haralddecauwer@...,
Merlevede K. Karen.Merlevede@...,
Departments of
a Emergency Medicine
b Neurology,
Klina General Hospital, Brasschaat, Belgium.

We describe a case of epileptic seizures after a massive intake of
diet coke.

Apart from the hyponatremia due to water intoxication the
convulsions can be potentiated by the high dose of caffeine and
aspartame from the diet coke.

To our knowledge this is the first report of seizures due to
excessive diet coke intake. PMID: 18180668


Methyl alcohol ingestion as a model etiologic agent in multiple
sclerosis, WC Monte, D Glanzman, C Johnston;
Methanol induced neuropathology in the mammalian central
nervous system, Woodrow C. Monte, Renee Ann Zeising,
both reports 1989.12.04: Murray 2007.12.28
http://rmforall.blogspot.com/2007_12_01_archive.htm
Friday, December 28 2007
http://groups.yahoo.com/group/aspartameNM/message/1499

[ These seminal 1989 studies by Prof. Woodrow C. Monte are
also given in this previous post, along his two recent comprehensive
reviews:

role of formaldehyde, made by body from methanol from foods and
aspartame, in steep increases in fetal alcohol syndrome, autism,
multiple sclerosis, lupus, teen suicide, breast cancer, Nutrition
Prof. Woodrow C. Monte, retired, Arizona State U., two reviews,
190 references supplied, Fitness Life, New Zealand
2007 Nov, Dec: Murray 2007.12.26
http://rmforall.blogspot.com/2007_12_01_archive.htm
Wednesday, December 26 2007
http://groups.yahoo.com/group/aspartameNM/message/1498 ]


formaldehyde in FEMA trailers and other sources (aspartame,
dark wines and liquors, tobacco smoke): Murray 2008.01.30
http://rmforall.blogspot.com/2008_01_01_archive.htm
Wednesday, January 30, 2008
http://groups.yahoo.com/group/aspartameNM/message/1508


details on 6 epidemiological studies since 2004 on diet soda (mainly
aspartame) correlations, as well as 14 other mainstream studies on
aspartame toxicity since summer 2005: Murray 2007.11.27
http://rmforall.blogspot.com/2007_11_01_archive.htm
Wednesday, November 14, 2007
http://groups.yahoo.com/group/aspartameNM/message/1490


http://groups.yahoo.com/group/aspartameNM/message/1340
aspartame groups and books: updated research review of
2004.07.16: Murray 2006.05.11

http://groups.yahoo.com/group/aspartameNM/message/1453
Souring on fake sugar (aspartame), Jennifer Couzin,
Science 2007.07.06: 4 page letter to FDA from 12 eminent
USA toxicologists re two Ramazzini Foundation
cancer studies 2007.06.25: Murray 2007.07.18

http://groups.yahoo.com/group/aspartameNM/message/1426
ASDA (unit of Wal-Mart Stores WMT.N) and Marks & Spencer
will join Tesco and also Sainsbury to ban and limit
aspartame, MSG, artificial flavors dyes preservatives additives,
trans fats, salt "nasties" to protect kids from ADHD:
leading UK media: Murray 2007.05.15

http://groups.yahoo.com/group/aspartameNMmessage/1451
Artificial sweeteners (aspartame, sucralose) and coloring
agents will be banned from use in newly-born and baby foods,
the European Parliament decided: Latvia ban in schools 2006:
Murray 2007.07.12

http://groups.yahoo.com/group/aspartameNM/message/1341
Connecticut bans artificial sweeteners in schools, Nancy Barnes,
New Milford Times: Murray 2006.05.25

http://groups.yahoo.com/group/aspartameNM/message/1369
Bristol, Connecticut, schools join state program to limit artificial
sweeteners, sugar, fats for 8800 students, Johnny J Burnham,
The Bristol Press: Murray 2006.09.22

Devra Lee Davis, U. Pittsburgh Cancer Institute, rejects
aspartame -- Luke Ravenstahl, Mayor,
drinks 12 cans Diet Pepsi daily:
accurate warning by Ronald K. Frazer: Murray 2008.01.13
http://rmforall.blogspot.com/2008_01_01_archive.htm
Sunday, January 13, 2008
http://groups.yahoo.com/group/aspartameNM/message/1503

http://groups.yahoo.com/group/aspartameNM/message/1141
Nurses Health Study can quickly reveal the
extent of aspartame
(methanol, formaldehyde, formic acid) toxicity:
Murray 2004.11.21

The Nurses Health Study is a bonanza of information about the
health of probably hundreds of nurses who use 6 or more cans daily
of diet soft drinks -- they have also stored
blood and tissue samples from their immense pool of subjects.

http://en.wikipedia.org/wiki/Aspartame_controversy
____________________________________________________


"Of course, everyone chooses, as a natural priority, to enjoy peace,
joy, and love by helping to find, quickly share, and positively act
upon evidence about healthy and safe food, drink, and environment."

Rich Murray, MA Room For All rmforall@...
505-501-2298 1943 Otowi Road, Santa Fe, New Mexico 87505

http://groups.yahoo.com/group/aspartameNM/message/1469
highly toxic formaldehyde, the cause of alcohol hangovers, is made by
the body from 100 mg doses of methanol from dark wines and liquors, dimethyl
dicarbonate, and aspartame: Murray 2007.08.31

http://RMForAll.blogspot.com new primary archive

http://groups.yahoo.com/group/aspartameNM/messages
group with 120 members, 1,515 posts in a public archive
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