aspartame and sucrose each raise blood glucose in diabetes 2, Annie Ferland,
Paul Poirier, et al, talk 2005.05.13 Laval Hospital Research Center, Laval
University, Sainte-Foy, Canada: Murray 2007.01.11
http://groups.yahoo.com/group/aspartameNM/message/1401

[Rich Murray: I attempted to clarify their English computer translations of some
news articles in French. ]


http://www.scom.ulaval.ca/Au.fil.des.evenements/2005/05.26/aspartame.html

Annie Ferland was leader of a team of mainstream academic scientists:
Paul Poirier, Simone Lemieux, Jean Bergeron, Ginette Turbide, Lison Fournier and
Josée Bergeron.

Their study was the presented in a talk on May 13 2005 at a scientific workshop
of the Laval Hospital Research Centre, Lavel University, Sainte-Foy, Quebec,
Canada.

Virtual sugar

Aspartame produced the same effect as sugar in the diabetics who exercise

Jean Hamann fil@...,

Even if it is not a sugar, aspartame does not protect diabetics who exercise
from variations of the rate of blood glucose that can lead to hypoglycemia.

In fact, aspartame imitates table sugar so well that it not only fools the taste
buds, but also the system that controls the rate of blood glucose (glycemia).

Researchers have known for several years that, in diabetes 2, exercise after an
meal can cause stronger variations of glycemia than an exercise session carried
out on an empty stomach.

In the first two hours which follow a meal, glycemia of the diabetics rises --
especially if the consumed food is rich in sugars -- and then it goes down again
quickly if there is exercise.

“The more glycemia reaches a raised level, the more the subsequent risks of
hypoglycemia induced by the exercise increase”, explains Annie Ferland.

Does the food which contains synthetic sugar substitutes such as aspartame also
cause these glycemic Russian mountains?

To study this, the researchers tested ten subjects with diabetes 2 with an
exercise training session, 60 minutes on ergocycle.

This exercise session was on an empty stomach or two hours after a meal
sweetened with sucrose (table sugar) or aspartame.

Even if the caloric contents of the dish containing aspartame were 20% weaker
than that sweetened with the sucrose, the two meals caused a similar rise of
glycemia, followed by a fast fall coinciding with the beginning of the exercise
session.

On the other hand, the subjects on an empty stomach did not undergo significant
variations of glycemia.

'We were surprised by our own results, admits Annie Ferland.
As the aspartame is not a sugar, and the meal with aspartame had a lower
glycemic index, we did not expect a reaction similar to sucrose with our
subjects.”

The brain reacts to a meal containing aspartame as if it were sugar, Ferland, a
co-researcher, on the Faculty of Pharmacy, notes.

However, the aspartame is a small protein made up of two amino acids. One needs
from 160 to 220 times less aspartame than sugar to produce a taste sweetened
equivalent, so that the contribution of this sweetening substance to the
calories contained in drinks and food is about nil.

One of the nutritional recommendations made to diabetics precisely consists in
replacing sugar by a substitute like aspartame; approximately 65% of diabetics
respect this instruction.

Which lessons are necessarily drawn from this study?

Our results reaffirm the effectiveness of the regular practice of physical
activity as a method of control of glycemia, said Ferland.

They also show that the practice of physical activity on an empty stomach does
not pose a problem for the control of glycemia.

As regards exercise after a meal, diabetics must know that their glycemia is
likely to drop quickly, especially if it is high at the beginning, if the
exercise is vigorous and if the diabetes is severe.

The important thing is to anticipate what can occur and not to believe that the
aspartame can prevent important variations of glycemia.”

The researchers are unaware so far if other sugar substitutes produce the same
effect as aspartame for subjects with active diabetes.



http://www.passeportsante.net/fr/Actualites/Nouvelles/Fiche.aspx?doc=2005053101

aspartame can effect blood sugar changes in diabetics

June 2, 2005 -- Researchers of Laval University in Quebec were astonished to
note that the consumption of aspartame, a sweetening substance not containing
any sugar, could vary the rate of blood glucose change of people with diabetes
II who exercised after a meal.

Annie Ferland and her team of the Faculty of Pharmacy of Laval University
delivered their results of their study in a talk at the Scientific Workshop of
the Research Center of Laval Hospital, which was held on May 13 2005.

Their study used 10 subjects with type II diabetes who took 60 minute training
sessions on an ergocycle. These sessions proceeded either with an empty stomach,
or two hours after having eaten a meal sweetened with sucrose (table sugar) or
aspartame.

The two meals caused a similar rise of glycemia (sugar rate), followed by a
fast fall coinciding with the beginning of an exercise session.

On the other hand, the subjects with empty stomachs did not undergo significant
variations of their glycemia.

These results surprised the researchers.

“As aspartame is not a sugar, and as the glycemic index of the meal with
aspartame was lower, we did not think it would cause reaction similar to that of
sucrose with our subjects”, said Ferland. “The brain reacts to a meal containing
aspartame as if it was sugar”, she noted.

In traditional medicine, one usually recommends diabetics should replace sugar
by a substitute like aspartame.
It is estimated that approximately 65 % of diabetics respect this instruction.

According to Ferland, these results should encourage people with diabetes “not
to believe that the aspartame can protect them against the important variations
of glycemia”.

The researchers are unaware so far if the other sugar substitutes produce the
same effect as the aspartame on subjects with diabetic symptoms.

Pierre Lefrançois -- PasseportSanté.net
D’après Au fil des événements (Université Laval).



http://www.passeportsante.net/fr/Actualites/Dossiers/ArticleComplementaire.aspx?\
doc=edulcorant_gout_do

Danger from artificial sweeteners? Useful?

* A solution for diabetics?
* … and for those which want to get thinner?
* Two weights, two measurements?
* References

A solution for diabetics?

In 2004, the Canadian Diabetic Association published an important review of
studies, giving a progress report on the recourse to artificial sweeteners in
the management of diabetes. 1

Like more than one hundred nations in the world and the World Health
Organization (WHO), the CDA estimates that these products can prove to be useful
for people with diabetes
“to limit their glucose consumption, to control their glycemia and their weight
and to avoid dental decays”.

“It seems indeed that the daily consumption (up to the limit of the acceptable
daily intake)of aspartame, sucralose, saccharin, cyclamate
[...] does not have a significant effect on the glycemia or the blood
lipids of the people with diabetes”, states this review.

“These products are useful, yes, but that does not mean that one must use any,
as that remains a quite personal choice”, specifies Isabelle Galibois, Professor
of Nutrition at Laval University and a specialist in diabetes. She said that
many diabetics, in contrast to the popular belief, can indeed consume a certain
amount of “ordinary” sugar.

In fact, starches can affect much more glycemia more than added sugar. In
other words, the diabetic, by avoiding mashed potatoes, can generally allow a
little sugar in coffee.

Are artificial sweeteners useful for diabetics? Useful, but not necessary.

Deceive the brain with “imitation sugar”?

In 2005, preliminary research 2 carried out at the Laval University, in
Quebec, threw doubt on the utility of aspartame in the management of glycemia in
type 2 diabetes.

This study related the impact of substitution of sugar by aspartame in the same
meal, to its subsequent effects on the change of glycemia during an exercise
session.

In other words, is it to better to eat, or not, before exercising? An effort
was made to find by evidence the best energy composition of a meal before
exercise.

The participants with diabetes 2 had five exercise sessions, once on an empty
stomach and four other times after a meal.

The meals were identical visually: only the type of sweetening substance used
differed from one meal to another. However, contrary to the anticipated
results, the rise in glycemia after the ingestion
of the aspartame meal appeared similar to that of the sucrose meal!
How can we explain this?

A nutritionist and PhD student in the Faculty of Pharmacy, Annie Ferland, one of
the researchers, guesses that “one deceives the brain” by imitating the taste of
sugar. The simple fact “of tasting” sugar, even if the aspartame is
hypocaloric, could be enough to engage the glycemic response associated with
sucrose. However, hadn't science previously shown effectiveness of artificial
sweeteners in this matter?

“Many studies were carried out on the harmlessness of artificial sweeteners, but
few were interested in the glycemic process, explained Farland. Scientists
validated their use for long-term management of diabetes, but they knew little
about impacts studied soon after consumption, " added Ferland.

to make it clear

“That does not mean to say that they are dangerous!" Farland clarified. "The
problem quite simply is that diabetics do not know this, while it is something
which they should know to manage their glycemia.”

... and for those which want to get thinner?

The group of experts of the Canadian Diabetes Association which carried out a
review of studies claim that the sweetening substances can prove to be useful in
weight loss programs.
“The current studies indicate that the consumption of synthetic sweeteners,
added to multidisciplinary programs, can accelerate the loss of weight and
improve the control of weight by obese people”, indicated the experts.

Noting the key phrase “multidisciplinary program”: The few studies carried out
on this subject -- which were not all published in scientific journals --
evaluated the effectiveness of artificial sweeetners within the framework of a
more total program, i.e. that includes a restriction of food intake and an
increase in the energy expenditure (more exercise!) 3,4,5.

To lose weight, isn't it enough better to eat and move more?

“It is certain that studies do not show that only people who consume sucralose
are thinner than people who do not consume any!
One should not make a major life focus on aspartame or sucralose, but one can
use them as focused tools”, noted Isabelle Galibois, diabetes specialist.

Helene Baribeau, nutritionist, occasionally uses artificial products as “tools”
within the framework of her weight loss practice, in particular for women about
fifty who already shed an important amount of weight.
“It is necessary with them to go on a case-by-case basis and to consider where
this person comes from, she explains. If it is someone who eats a lot of sugar,
one can, as a first step, reduce sugar consumption by using substitutes. But,
in parallel, one must urge them to eat less sweetened food. Both tools should
be applied, not just one or the other.”

This is why the nutritionist recommends only sweetened products that offer food
value and that thus support the adoption of healthy food habits.
“I think of yogurts, especially, and some puddings with rice and tapioca, which
contain calcium, vitamin D and proteins. Even if there is a little sucralose, I
consider that these are relatively healthy products. It is not a question to
replace a piece of cake -- by a piece of cake with Splenda!”, stated Baribeau.

Two weights, two measurements?

Certain Web sites make promote artificial sweeteners by encouraging the
consumers to keep bad food habits. One of them even proposes a reducing diet
that allows the consumption of pie crusts, thanks to the use of their artificial
sweetener. Their argument is simple: by replacing “true” sugar by an artificial
sweetener, one reduces the daily caloric intake, which thus leaves us free to
eat pie crusts!

Do artificial sweeteners work towards the adoption of good food practices or do
they serve only the status quo, even dietary cheating?

The Canadian Diabetes Association, in its report on this study, recognizes this
risk.
“Artificial sweeteners are more advantageous when they are used to replace foods
with high energy content and low nutritive value, including sucrose, and less
advantageous when one uses them to replace food with high food value such as
milk, fruits and fruit juices.”

“If the substitute encourages you to eat food that takes the place of healthy
food, then there is a problem!”, Baribeau exclaims.

Another problem: the sweetening substance can systematically perpetuate the
practice of eating larger portions of cakes, biscuits or other starchy desserts
after meals. At best, the person will not have changed anything with such food
practices. In the worst case, the person will enter the vicious circle of
compensation.

“The artificially sweetened products never taste like the original version. One
wants a genuine chocolate cake, but one takes a small biscuit with aspartame.
Later, you take your real chocolate cake. And you take some twice more! I
prefer people take the naturally sweetened products, one at a time, rather than
seek satiety through all these artificial products”, explained Baribeau.

Taste of sugar

The basic problem, which animates many discussions between nutritionists of
various opinions, is that of the taste of sugar.
“The true problem raised by the use of artificial sweeteners thus would not be
one of harmlessness nor of effectiveness for the control of glycemia or weight.
But it would be rather related to the fact that artificial sweeteners cultivate
the taste of sugar.

“The human being is physiologically programmed to seek a sweet taste. Can one
repress this need, this innate taste? Perhaps, but for me, I am not certain of
that. I think that the artificial sweeteners can offer good options for people
who, especially should do without this sweetened taste, in particular type 1
diabetics.”

Isabelle Galibois [photo]

“We have many taste buds to detect sugar. It is not proven scientifically, but
according to Eastern wisdom, it important that we taste a little of each type,
[sweet, bitter, salty and sour, Umami (savory)] in a meal. If your meal is
rather salted, it is normal to afterwards to crave a sweet taste. If it is a
small quantity, there is no problem. The goal is not to cut sugar out
completely.”

Helene Baribeau [ photo]

research and writing: Julie Calvé On October 16, 2006

References

Note: the hypertext links for other sites are not updated continuously. It is
possible that a link becomes untraceable. Then please use search engines to find
desired information.

Bibliography

Interview with Isabelle Galibois, Professor, Department of Food Sciences, Laval
University, on September 6, 2006.

Interview with Annie Ferland, nutritionist, Laval Hospital Research Center, on
September 7, 2006.

Interview with Helene Baribeau, nutritionist, on September 19, 2006.

Notes

1. Gougeon, Spidel, et al, Canadian Diabetes Association Nutrition Committee
Technical Review: Non-nutritive Intense Sweeteners in Diabetes Management,
Canadian Newspaper of Diabetes, December 2004.

2. The article reporting this research was reviewed by Diabetes Care. For more
on the work of this group of researchers, see in particular:
Ferland A, Poirier P, et al,
Elevated peak exercise systolic blood pressure is not associated with reduced
exercise capacity in subjects with Type 2 diabetes.
J Appl Physiol. 2006 Sep; 101 (3): 893-7. Epub 2006 May 25.

3. Kanders BS, Lavin PT, Kowalchuk MB, Greenberg I, Blackburn GL.
An evaluation of the effect of aspartame on weight loss.
Appetite. 1988;11 Suppl 1:73-84. PMID: 3190220

4. SJ Rodearmel, et al,
Effectiveness for Families on the Move! In Family-Based Approach for Preventing
Excessive Weight Gain in Children,
McNeil Nutritionals/Splenda, 2006.

5. Scientific Studies Show Aspartame is Beneficial in Weight Control, The
Benefits,
Aspartame Center Information. www.aspartame.org

Reproduction and royalty © 1998-2006 Totalmédia Inc.

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Peter Bogaty, MD, Quebec Heart Institute/Laval Hospital,
2725 Chemin Ste-Foy, Ste-Foy, Quebec, Canada G1V 4G5.
peter.Bogaty@...,


http://www.lipidologie.qc.ca/Membres_FRM.html

Mme Annie Desmeules (Membre régulier)
Profession:
Poste académique:
Je suis étudiant au MSc
Centre de Recherche du CHUL
Centre Hospitalier de L'Université Laval
Endocrinologie moléculaire et oncologie
2705 boul Laurier T3-67
St-Foy, Québec, Québec Canada G1V 4G2
(418) 654-2296 Télécopieur: (418) 654-2761
annie.desmeules@...,
Date de mise à jour: 2006/02/03

http://www.lipidologie.qc.ca/comite.asp
Secretaire
Dr Jean Bergeron , MD, FRCP(C)
Téléphone: (418) 654-2106 Télécopieur: (418) 654-2277
Courriel: jean.bergeron@...,
CHUQ CHUL CRML, service de Biochimie
Local S-102 2705 boul. Laurier
Sainte-Foy, Québec, Canada G1V 4G2

Patrice Brassard,
Annie Ferland,
Valérie Gaudreault, Gaudreault, Valérie Dre valou@...,
Nadine Bonneville, Bonneville, Nadine Mme nadine.bonneville@...,
Jean Jobin, and
Paul Poirier paul.poirier@...,


http://www.sciencepresse.qc.ca/kiosque/recherche/sante_et_medecine?page=15

* Health and medicine

Aspartame can affect the sugar levels of diabetics

Researchers of Laval University of Quebec were astonished to note that the
consumption of aspartame, a sweetening substance not containing any sugar, could
vary the of blood glucose levels of diabetics who exercised.
Annie Ferland and her team of the Faculty of Pharmacy of the Laval University
delivered the results of this test within the framework of the Scientific
Workshop of the Laval Hospital Research Centre, which was held on May 13. The
researchers are so far unaware if other artificial sweeteners produce the same
effect as aspartame with type 2 diabetics.

* Protéus network
* 2005-06-02


http://www.diabetesport.org/Actuel/Aspartame.php?MU=F@@1@@4

aspartame and exercise

A study presented last on May 13 at the Hospital Laval (Canada) revealed
astonishing effects by aspartame in relation to exercise in diabetes. 2

It is well known that in type 2 diabetes, exercise after an meal lowers glycemia
more than exercising on an empty stomach. If part of glucids [ Glucids (sugars,
sucrose, glucose, fructose) ] of the meal is replaced by aspartame, will the
reduction in the glycemia be less important?

For research, the researchers invited diabetic subjects to an exercise training
session for 60 minutes on an empty stomach or two hours after a meal sweetened
with table sugar or aspartame.

Result: Both type of meal caused a similar rise of glycemia, followed by a fast
fall coinciding with the beginning of the meeting of exercises. The subjects
with empty stomachs did not undergo significant variations of glycemia.

Astonished by this report, Annie Ferland, one of the authors of the study,
underlines: “The brain reacts to a meal containing aspartame as if it were
sugar! Our results reaffirm the effectiveness of the practice of the physical
exercise as a method of control of glycemia. After a meal, the diabetics must
know that their glycemia is likely to drop quickly. The important thing is to
anticipate what can occur and not to believe that the aspartame can prevent
important variations of glycemia”.

Source: http://www.scom.ulaval.ca


http://asso.objectif-sciences.com/L-aspartame-produit-le-meme-effet.html

L’aspartame produit le meme effet que le sucre chez les diabetiques qui
s’adonnent a une activite physique


Contacts:
annie.ferland.1@...,
Sources :
Jean Hamann - Au fil des evenements, 26/05/2005 - Universite Laval
[ Scientific Information Officer Phone (Bus): (418)656-2131 Ext 4691 (Fax):
(418)656-2809
Address: 3577 Pavillon Alphonse-Desjardins, Cite Universitaire, Quebec, PQ G1K
7P4
Evening/Weekend Phone: (418)254-3141 Web Site: www.ulaval.ca ]
Redacteur : Nicolas Vaslier, MONTREAL, nicolas.vaslier@...,


1: Metabolism. 2006 Nov; 55(11): 1532-7.
Influence of glycemic control on pulmonary function and heart rate in response
to exercise in subjects with type 2 diabetes mellitus.
Brassard P, M. Patrice Brassard Ste-Foy, Québec, Canada
Brassard, Patrice M. patrice.brassard@...,
Ferland A,
Bogaty P,
Desmeules M,
Jobin J,
Poirier P.
Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de
Pneumologie, Universite Laval, Ste-Foy, Quebec, Canada G1V 4G5.

Conflicting results exist regarding the impact of glycemic control on peak
oxygen uptake (VO2peak) in subjects with type 2 diabetes mellitus.
The influence of glycemic control on submaximal oxygen uptake (VO2) in these
subjects is unknown.
The aim of this study was to evaluate the impact of fasting blood glucose (FBG)
(short-term glycemic control) and glycated hemoglobin (HbA1c) (long-term
glycemic control) on submaximal VO2 and VO2peak during exercise in subjects with
type 2 diabetes mellitus without cardiovascular disease.
FBG and HbA1c levels and exercise tolerance in 30 sedentary men with type 2
diabetes mellitus treated with oral hypoglycemic agents and/or diet were
evaluated. VO2, carbon dioxide production (VCO2), heart rate, pulmonary
ventilation (VE), and the respiratory exchange ratio (RER) were measured
throughout the exercise protocol.
Subjects were separated into 2 groups of the same age, weight, and body mass
index according to median FBG and HbA1c levels (6.5 mmol/L and 6.1%,
respectively).
Per protocol design, there was a significant difference in FBG and HbA1c levels
(P < .001), but not for age, weight, or body mass index.
There was no significant difference in peak exercise parameters between the 2
groups according to median FBG or median HbA1c levels.
However, the subjects with elevated HbA1c level had lower submaximal V e
throughout the exercise protocol (P < .03), and the subjects with elevated FBG
concentration had a blunted heart rate pattern during submaximal exercise (P <
.03).
Although relatively small abnormalities in the control of glycemia do not affect
VO2peak in subjects with type 2 diabetes mellitus without cardiovascular
disease, they may influence pulmonary function and the chronotropic response
during submaximal exercise in these subjects. PMID: 17046557


http://www.exrx.net/Store/HK/AdvancingFrontCardiopulReh.html

Advancing the Frontiers of Cardiopulmonary Rehabilitation

Advancing the Frontiers of Cardiopulmonary Rehabilitation
Jean Jobin, Francois Maltais, Paul Poirier, Clermont Simard, Pierre LeBlanc
2002 US Price: $39 272 pages 9780736042161

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Advancing the Frontiers of Cardiopulmonary Rehabilitation is an essential
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Jean Jobin, PhD, professor of medicine at Laval University in Québec, is
director of the Cardiopulmonary Rehabilitation Research Laboratory at the
Institut de cardiologie et de pneumologie de l'Université Laval at Laval
Hospital. Dr. Jobin is a certified program director of the American College of
Sports Medicine's (ACSM) Certification for Exercise Specialists in French at
Laval University. He is a fellow of the ACSM and of the American Association of
Cardiovascular and Pulmonary Rehabilitation and a member of the Canadian
Association of Cardiac Rehabilitation and the Canadian Cardiovascular Society.
He was president of the scientific committee of the Québec International
Symposium on Cardiopulmonary Rehabilitation in 1999 and 2001. He was an editor
for the book Advances in Cardiopulmonary Rehabilitation. Dr. Jobin enjoys
jogging, alpine skiing, and carpentry. He, his wife, and children live in
Cap-Rouge, Québec. Jean.Jobin@...,

François Maltais, MD, is a respirologist at the Pneumology Center at Laval
Hospital in Québec. He is adjunct professor of medicine at Laval University and
medical director of the Pulmonary Rehabilitation Program at Laval Hospital. A
member of the Québec, Canadian, and American Thoracic Societies, Dr. Maltais is
certified in internal medicine and in pulmonary medicine. He has been awarded
numerous research grants from private and public foundations, including the
Medical Research Council of Canada (MRC), to investigate such topics as
peripheral muscle dysfunction, strength training, and exercise training in COPD,
among many others. Having completed a two-year research training program in
respiratory physiology, Dr. Maltais is devoted to the study of exercise and
muscle physiology in chronic lung diseases. He was vice president of the
scientific committee of the Québec International Symposium on Cardiopulmonary
Rehabilitation in 1999 and 2001. He was an editor for the book Advances i
n Cardiopulmonary Rehabilitation. Dr. Maltais enjoys mountain biking, downhill
skiing, and golfing. He lives with his wife and children in L'Ancienne-Lorette,
Québec. francois.maltais@...,

Paul Poirier, MD, is a cardiologist at Laval Hospital in Québec. He holds
certifications from both the American College of Cardiology and the Royal
College of Physicians and Surgeons of Canada. He is program director of the
cardiac rehabilitation program of the Québec Heart Institute. A member of the
American College of Sports Medicine, Dr. Poirier is widely known and well
published. His is first author of a chapter about the heart and obesity in the
cardiology textbook The Heart, and he authored an article about exercise in the
management of obesity in Cardiology Clinics (2001). In his spare time, Dr.
Poirier enjoys reading, being active outdoors, and spending time with his
family. He makes his home in Ste-Foy, Québec.

Pierre LeBlanc, MD, is clinical professor in the department of medicine at Laval
University, where he is in charge of teaching respiratory physiology. He is a
member of the American Thoracic Society and the Canadian Thoracic Society. Dr.
LeBlanc has published highly significant and often quoted research concerning
mechanisms of breathlessness during exercise in cardiorespiratory patients. He
was an editor for the book Advances in Cardiopulmonary Rehabilitation. Dr.
LeBlanc is an avid cyclist and enjoys cross-country skiing. From 1975 to 1976,
he was a member of the Canadian track and field team. He, his wife, and children
live in Cap-Rouge, Québec.

Clermont Simard, PhD, is professor of physical education and special populations
at Laval University. He founded the International Federation for Adapted
Physical Activity in 1976, for which he was specially honored by Spain's
University of Lleida in 1999. Dr. Simard is a fellow of the ACSM, was president
of the Québec International Symposium on Cardiopulmonary Rehabilitation in May
1999, was president of the Motor Adaptation Foundation, and is president for the
Rehabilitation International 21st World Congress in 2008. His many years of
research have focused on adapting physical activity to populations with special
needs, the impact of disuse on muscular metabolism and function, the aging
process and physical activity as they affect quality of life, and helping older
adults live more autonomous lives. He was an editor for the book Advances in
Cardiopulmonary Rehabilitation. Dr. Simard and his wife make their home in
St.-Nicolas, Québec.Advancing the Frontiers of Cardiopulmonary Reh
abilitation fam@...,


http://www.lipidologie.qc.ca/CGI/LDist.asp?act=lst&sel=etud

Ferland, Annie Mme, annie.ferland@..., annie.ferland.1@...,

http://www.lipidologie.qc.ca/CGI/LDist.asp?act=lst&sel=regu emails

Poirier, Paul Dr paul.poirier@...,
Lemieux , Simone Dre simone.lemieux@...,
Bergeron , Jean Dr jean.bergeron@...,
Turbide, Ginette Mme ginette.turbide@...,
Fournier, Lison Mme lison.fournier@...,
Bergeron, Josée Mme josee.bergeron@...,

Mme Annie Ferland (Étudiant)
Profession: Diététiste
Poste académique: Doctorat en pharmacie
Je suis étudiant au PhD
Hôpital Laval
Centre de recherche clinique
Pavillon U-2
2725 chemin Ste-Foy
Ste-Foy, Québec, Canada G1V 4G5
Téléphone: (418) 656-8711 poste 2626 Télécopieur: (418) 876-2528
annie.ferland@...
Date de mise à jour: 2006/11/28



http://www.prnewswire.co.uk/cgi/news/release?id=186746

News Release
Thursday 14 December 2006, 17:15 GMT

Thursday 14 December 2006 Date
HEALTH topic
International Chair on Cardiometabolic Risk company

The Prestigious Scientific Journal Nature Recognizes the Scientific Work Carried
Out With the Research Centre of Hospital Laval and at the University Laval

QUEBEC, Canada, December 14 /PRNewswire/ --

- Measuring Waist Circumference is Key to Assessing Cardiometabolic Risk

Today's issue of Nature (Vol # 444) summarizes in an article, signed by both
Professor Jean-Pierre Despres and Doctor Isabelle Lemieux from the University of
Laval, the current issues and status of abdominal obesity and the Metabolic
Syndrome. Given the announced pandemic for this syndrome - 300 million people
will be diagnosed with diabetes between now and year 2025[1], cardiovascular
diseases will have become the world's leading cause of death by 2010[2], already
over one billion people, mainly among the poor in developed nations, are
overweight[3] -, health policies can no longer ignore the importance of global
Cardiometabolic Risk. This term describes a cluster of metabolic abnormalities
associated with cardiovascular disease and diabetes type 2 and, in particular,
abdominal obesity, whose importance as a risk factor has simply been
underestimated for far too long. Yet, measuring it is easy, quick and
inexpensive. Any doctor can do it. All they need to do is remember to wrap an
ordinary tape measure around the waist of their patients at risk.

For the past 20 years now, Professor Jean-Pierre Despres, [
Jean-Pierre.Despres@... ] Director of Research in Cardiology at the
Laval Hospital Research Centre, Scientific Director of the International Chair
on Cardiometabolic Risk and Professor at the Faculty of Medicine of the
University of Laval, has conducted numerous studies with his team on this
subject. For him, abdominal obesity is a major risk factor for diabetes type 2
and cardiovascular disease. "In light of the alarming increase of these
diseases, we need to do everything we can to help doctors who treat such
patients change their habits and start integrating, in a more systematic manner,
measurements of waist circumference in their daily practice". For Professor
Despres and his team, waist circumference is as vital a sign as hypertension,
smoking and cholesterol for estimating cardiovascular risk. Indeed, their work
has allowed them to show that it can help determine levels of abdominal
adiposity, now recognized as key contributor to several cardiometabolic
dysfunctions.

In the December 14th issue of Nature, Professor Despres and his colleague Doctor
Isabelle Lemieux, [ isabelle.lemieux@... ] have summarized the
current state of knowledge regarding abdominal obesity as a Cardiometabolic Risk
factor. According to Professor Despres: "There is still quite a lot of
controversy around the Metabolic Syndrome and it is precisely this controversial
context that has led Nature to ask us to present key elements of on-going
international debates while putting into perspective the specific areas of our
research. He added: "Our position is quite simple, abdominal obesity is by far,
for reasons shared in the article itself, the most widespread form of the
Metabolic Syndrome." "Nevertheless, this should not prevent doctors from also
focussing their attention on more classical risk factors including age, gender,
good and bad cholesterol, high blood pressure, history of tobacco and diabetes,
to evaluate cardiovascular risk in a more holistic manner, or more precisely
Cardiometabolic Risk".

This publication in Nature underscores the expertise and leadership of the Laval
Hospital Research Centre and University of Laval in this area", mentioned Dr.
Raymond Leblanc, [ Raymond.leblanc@... ] Deputy Provost of Research at
University of Laval. "Professor Despres and his colleagues, scientists,
cardiologists and heart surgeons were not only pioneers of these important
discoveries on the role of abdominal obesity, but will be increasing their
efforts in this area in order to significantly improve worldwide patient
management added Dr. Denis Richard, Director of the Laval Hospital Research
Centre. According to him, "The new challenge for our center and our university
lies now in our ability to provide adequate lab facilities, equipment and
resources for all our physicians, scientists and research assistants".

Keeping in mind these constraints, Dr. Francois Philippon, [
francois.pholippon@... ] Director of the Multidisciplinary Department
of Cardiology at Laval Hospital stated that "The work of Dr. Despres and his
team is a key component of our research activities in cardiology, metabolism and
cardiovascular risk factors. Our team's research and clinical expertise in
preventive cardiology has now achieved international recognition". Dr. Paul
Poirier, Medical Director of the Pavilion for the prevention of cardiovascular
disease at Laval Hospital commented that "So far, we can be proud of what we
have achieved with limited resources which cannot be compared to those of the
major American research centres working in the same area". "However, given that
our environment requires so much research and training of qualified personnel,
we need important funding, especially if we want to continue to remain on the
forefront of knowledge in this field, as is the case today", he concluded.

Professor Despres, who has personally been funded by the Canadian Institutes of
Health Research during most of his career, emphasizes the need to support the
establishment and its young research scientists in Quebec and Canada. "Knowledge
development through research will not only allow us to provide better health
care to patients, but also to adapt and implement preventive care strategies
that will have been scientifically proven".

About the International Chair on Cardiometabolic Risk

Founded in 2005 at University of Laval, the International Chair on
Cardiometabolic Risk is made up of 25 world-renowned international scientists.
Their goals are to develop awareness and knowledge around the Cardiometabolic
Risk factor in order to improve international patient management. Each year,
this group organizes a series of conferences and debates. Starting 2007, they
will be providing physicians and patients with various educational materials.

About the Laval Hospital

Founded in 1918, Laval Hospital, the heart and lung institute of University
Laval includes cardiology, pneumology, and the surgical management of obesity
departments. The Hospital's expertise includes ambulatory and hospital care,
teaching, research, and the evaluation of health technologies.

About the Laval Hospital Research Centre

The main goal of the Laval Hospital Research Centre is to slow the obesity
epidemic and the progression of cardiac and pulmonary disease through research
and prevention. The Laval Hospital Research Centre has focused its development
around this vision and aims to become the leading North American research centre
in cardiology, pneumology, and obesity.

For further information or requests, please contact:
Jean-Claude Coubard
Executive Director International Chair on Cardiometabolic Risk
Telephone: +1-(418)-656-8711 extension 3183
Cell phone: +33-63-334-7813
E-mail : chair.cardiometabolic-risk@...,
Web Site: www.HopitalLaval.qc.ca

Linda Pavy
Burson-Marsteller Agency
Telephone : +33-14186-7626
E-mail : linda_pavy@...,

References :

[1] http://www.emro.who.int/ncd/news-diabetes0504-rdaddress.htm - last accessed
on December 11, 2006

[2] http://www.inserm.fr/fr/recherches/pnr/pnrc.html - last accessed on December
11, 2006

[3] http://www.rfi.fr/fichiers/mfi/sante/744.asp - last accessed on December 11,
2006

Distributed by PR Newswire on behalf of International Chair on Cardiometabolic
Risk

http://jap.physiology.org/cgi/content/abstract/101/3/893

Journal of Applied Physiology
101: 893-897, 2006. First published May 25, 2006;
doi:10.1152/japplphysiol.00260.2006
8750-7587/06 $8.00

Elevated peak exercise systolic blood pressure is not associated with reduced
exercise capacity in subjects with Type 2 diabetes
Patrice Brassard, Annie Ferland, Valérie Gaudreault, Nadine Bonneville, Jean
Jobin, and Paul Poirier
Institut Universitaire de Cardiologie et de Pneumologie, Centre de Recherche de
l'Hôpital Laval, Université Laval, Québec, Canada G1V 4G5.
Submitted 28 February 2006 ; accepted in final form 24 May 2006
Laval Hospital Research Centre, Lavel University

Subjects with Type 2 diabetes without cardiovascular disease have a reduced
exercise capacity compared with nondiabetic subjects.

However, the mechanisms responsible for this phenomenon are unknown.

The purpose of this study was to evaluate the impact of exercise systolic blood
pressure (SBP) response on diverse exercise tolerance parameters in Type 2
diabetic subjects.

Twenty-eight sedentary men with Type 2 diabetes were recruited for this study.

Subjects were treated with oral hypoglycemic agents and/or diet.

Evaluation of glycemic control and peak exercise capacity were performed for
each subject.

The subjects were divided into two groups according to the median value of peak
SBP (210 mmHg) measured in each subject.

We observed a 13, 13, and 16% reduction in the relative peak oxygen uptake (VO2
peak), absolute VO2 peak, and peak work rate
in the low- compared with the high-peak SBP group
[26.95 (SD 5.35) vs. 30.96 (SD 3.61) ml·kg–1·min–1,
2.5 (SD 0.4) vs. 2.8 (SD 0.6) l/min, and
169 (SD 34) vs. 202 (SD 32) W; all P < 0.05].

After adjusting for age, relative VO2 peak was still significantly different (P
< 0.05).

There were similar peak respiratory exchange ratio (RER)
[1.20 (SD 0.08) vs. 1.16 (SD 0.07); P = 0.24] and
peak heart rate [160 (SD 20) vs. 169 (SD 15) beats/min; P = 0.18] between the
low- compared with the high-SBP group.

No difference in glycemic control was observed between the two groups.

The results reported in this study suggest that in subjects with Type 2 diabetes
without cardiovascular disease, an elevated exercise SBP is not associated with
reduced exercise capacity and its modulation is probably not related to glycemic
control. PMID: 16728521

peak oxygen uptake; Type 2 diabetic patients; high blood pressure response

Address for reprint requests and other correspondence: P. Poirier, Institut
Universitaire de Cardiologie et de Pneumologie, Centre de Recherche
Clinique/Hôpital Laval, 2725 Chemin Ste-Foy, Sainte-Foy, Québec, Canada G1V 4G5
(e-mail: paul.poirier@... )

Dre Valérie Gaudreault (Étudiant)
Profession: Medecin résident medecine interne
Poste académique:
Je suis étudiant au MSc
Université Laval
966-2 avenue Marguerite Bourgeoys, Québec, Québec Canada G1S 3X7
Téléphone: (418) 683-8229
valou@...
Date de mise à jour: 2006/04/09

Bonneville N,
Mme Nadine Bonneville (Étudiant)
Profession: nutritionniste
Poste académique: étudiante maîtrise pharmacie
Je suis étudiant au MSc
Hôpital Laval
Centre de recherche clinique
Pavillon U-1
2725, chemin Ste-Foy
Sainte-Foy, Québec
Canada
G1V 4G5
Téléphone: (418) 656-8711 poste 3026 Télécopieur: (418) 000-0000
nadine.bonneville@...
Date de mise à jour: 2006/12/04

Jobin J,
Poirier P.
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http://groups.yahoo.com/group/aspartameNM/message/1379
short aspartame (methanol, formaldehyde) toxicity research summary:
Murray 2007.01.11

"Of course, everyone chooses, as a natural priority,
to actively find, quickly share, and positively act upon the facts
about healthy and safe food, drink, and environment."

Rich Murray, MA Room For All rmforall@...
505-501-2298 1943 Otowi Road Santa Fe, New Mexico 87505

http://groups.yahoo.com/group/aspartameNM/messages
group with 76 members, 1,401 posts in a public, searchable archive
http://RMForAll.blogspot.com

http://groups.yahoo.com/group/aspartameNM/message/1340
aspartame groups and books: updated research review of 2004.07.16:
Murray 2006.05.11


http://groups.yahoo.com/group/aspartameNM/message/1395
Aspartame Controversy, in Wikipedia democratic encyclopedia, 72
references (including AspartameNM # 864 and 1173 by Murray), brief
fair summary of much more research: Murray 2007.01.01


http://groups.yahoo.com/group/aspartameNM/message/1385
Coca-Cola carcinogenicity in rats, Ramazzini Foundation, F Belpoggi, M
Soffritti, Annals NY Academy Sciences 2006 Sept, parts of 17 pages:
Murray 2006.12.02

http://groups.yahoo.com/group/aspartameNM/message/1382
Fiorella Belpoggi & Morando Soffritti of Ramazzini Foundation prove
lifetime carcinogenicity of Coca-Cola, aspartame, and arsenic, Annals
of the NY Academy of Sciences: Murray 2006.11.28

http://groups.yahoo.com/group/aspartameNM/message/1383 aspartame

http://groups.yahoo.com/group/aspartameNM/message/1384 arsenic


http://groups.yahoo.com/group/aspartameNM/message/1376
soft drinks and adolescent hyperactivity, mental distress, conduct
problems, Lars Lien, Nanna Lien, Sonja Heyerdahl, Mayne Thoresen, Espen
Bjertness 2006 Oct., A J Pub Health: Murray 2006.10.21

http://groups.yahoo.com/group/aspartameNM/message/1375
healthy diet, vitamins, and fish oil help reduce depression and
violence, studies by Joseph Hibbeln, Bernard Gesch, and Stephen
Schoenthaler, articles by Felicity Lawrence in UK Guardian Unlimited
and Pat Thomas in The Ecologist: Murray 2006.10.21


http://groups.yahoo.com/group/aspartameNM/message/1378
11 members of New Mexico legislature sign letter to ban aspartame as a
source of toxic methanol and formaldehyde, Stephen Fox, NM Senator
Gerald Ortiz y Pino: Murray 2006.10.22

http://groups.yahoo.com/group/aspartameNM/message/1374
47 UK Members of Parliament now support aspartame ban initiative of
Roger Williams, MP: Murray 2006.10.16


http://groups.yahoo.com/group/aspartameNM/message/1366
toxicity in rat brains from aspartame, Vences-Mejia A, Espinosa-Aguirre
JJ et al 2006 Aug: Murray 2006.09.06

http://groups.yahoo.com/group/aspartameNM/message/1373
aspartame rat brain toxicity re cytochrome P450 enzymes, expecially
CYP2E1, Vences-Mejia A, Espinosa-Aguirre JJ et al, 2006 Aug,
Hum Exp Toxicol: relevant abstracts re formaldehyde from methanol
in alcohol drinks: Murray 2006.09.29


http://groups.yahoo.com/group/aspartameNM/message/1271
combining aspartame and quinoline yellow, or MSG and brilliant blue,
harms nerve cells, eminent C. Vyvyan Howard et al, 2005
education.guardian.co.uk, Felicity Lawrence: Murray 2005.12.21

http://groups.yahoo.com/group/aspartameNM/message/1277
50% UK baby food is now organic -- aspartame or MSG
with food dyes harm nerve cells, CV Howard 3 year study
funded by Lizzy Vann, CEO, Organix Brands,
Children's Food Advisory Service: Murray 2006.01.13

http://groups.yahoo.com/group/aspartameNM/message/1279
all three aspartame metabolites harm human erythrocyte [red blood cell]
membrane enzyme activity, KH Schulpis et al, two studies in 2005,
Athens, Greece, 2005.12.14: 2004 research review, RL Blaylock:
Murray 2006.01.14

http://groups.yahoo.com/group/aspartameNM/message/1369
Bristol, Connecticut, schools join state program to limit artificial
sweeteners, sugar, fats for 8800 students, Johnny J Burnham, The
Bristol Press: Murray 2006.09.22

http://groups.yahoo.com/group/aspartameNM/message/1341
Connecticut bans artificial sweeteners in schools, Nancy Barnes,
New Milford Times: Murray 2006.05.25

http://groups.yahoo.com/group/aspartameNM/message/1353
carcinogenic effect of inhaled formaldehyde, Federal Institute of Risk
Assessment, Germany -- same safe level as for Canada:
Murray 2006.06.02

http://groups.yahoo.com/group/aspartameNM/message/1352
Home sickness -- indoor air often worse, as our homes seal in
pollutants
[one is formaldehyde, also from the 11% methanol part of aspartame],
Megan Gillis, WinnipegSun.com: Murray 2006.06.01


http://groups.yahoo.com/group/aspartameNM/message/1349
NIH NLM ToxNet HSDB Hazardous Substances Data Bank
inadequate re aspartame (methanol, formaldehyde, formic acid):
Murray 2006.08.19

http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~HwoSfJ:1
HSDB Hazardous Substances Data Bank: Aspartame

ASPARTAME CASRN: 22839-47-0
METHANOL CASRN: 67-56-1
FORMALDEHYDE CASRN: 50-00-0
FORMIC ACID CASRN: 64-18-6


http://groups.yahoo.com/group/aspartameNM/message/1052
DMDC: Dimethyl dicarbonate 200mg/L in drinks adds methanol 98 mg/L
( becomes formaldehyde in body ): EU Scientific Committee on Foods
2001.07.12: Murray 2004.01.22


http://www.HolisticMed.com/aspartame mgold@...
Aspartame Toxicity Information Center Mark D. Gold
12 East Side Drive #2-18 Concord, NH 03301 603-225-2100

http://www.holisticmed.com/aspartame/abuse/methanol.html
"Scientific Abuse in Aspartame Research"

http://groups.yahoo.com/group/aspartameNM/message/957
safety of aspartame Part 1/2 12.4.2: EC HCPD-G SCF:
Murray 2003.01.12 rmforall EU Scientific Committee on Food,
a whitewash

http://groups.yahoo.com/group/aspartameNM/message/1045
http://www.holisticmed.com/aspartame/scf2002-response.htm
Mark Gold exhaustively critiques European Commission Scientific
Committee on Food re aspartame ( 2002.12.04 ):
59 pages, 230 references

http://groups.yahoo.com/group/aspartameNM/message/1371
Russell L. Blaylock, MD discusses MSG, aspartame, excitotoxins
with Mike Adams: Murray 2006.09.27

http://groups.yahoo.com/group/aspartameNM/message/1372
Mike Adams interviews Randall Fitzgerald on "The Hundred Year Lie:
How Food and Medicine are Destroying Your Health" 2006.06.21:
Murray 2006.09.28
*******************************************************


http://groups.yahoo.com/group/aspartameNM/message/782
RTM: Smith, Terpening, Schmidt, Gums:
full text: aspartame, MSG, fibromyalgia 2002.01.17
Jerry D Smith, Chris M Terpening,
Siegfried OF Schmidt, and John G Gums
Relief of Fibromyalgia Symptoms Following
Discontinuation of Dietary Excitotoxins.
The Annals of Pharmacotherapy 2001; 35(6): 702-706.
Malcolm Randall Veterans Affairs Medical Center,
Gainesville, FL, USA.
BACKGROUND: Fibromyalgia is a common rheumatologic
disorder that is often difficult to treat effectively.
CASE SUMMARY: Four patients diagnosed with fibromyalgia
syndrome for two to 17 years are described.
All had undergone multiple treatment modalities with limited success.
All had complete, or nearly complete,
resolution of their symptoms within months after eliminating
monosodium glutamate (MSG) or MSG plus aspartame from their diet.
All patients were women with multiple comorbidities
prior to elimination of MSG.
All have had recurrence of symptoms whenever MSG is ingested.

Siegfried O. Schmidt, MD Asst. Clinical Prof. siggy@...
Community Health and Family Medicine, U. Florida, Gainesville, FL
Shands Hospital West Oak Clinic Gainesville, FL 32608-3629
352-376-5071
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