*******************************************************

http://groups.yahoo.com/group/aspartameNM/message/1317
neotame safety must be assessed by independent, long-term studies with
high doses with vulnerable groups of humans, with likely co-factors
included: DA Mayhew, NutraSweet Co.: Rich Murray 2006.03.07

March 7, 2006 Dear Dale A. Mayhew, NutraSweet Co.,

Naturally, as a conscientious layman reviewer of mainstream research
on aspartame toxicity for seven years, I am concerned that only two
studies, both by NutraSweet staff, are in PubMed, in 2003, that give
direct experimental findings about neotame safety in rats, mice, and dogs.

Logically, if the evidence for human safety of neotame was robust, then
the industry would be highly motivated to have independently funded
teams publish thorough, definitive studies in mainstream, peer-reviewed
journals, after over two decades of development.

Since neotame is forty times sweeter than aspartame, then the dose is
forty times less, justifying a preliminary appraisal that toxicity might
also be forty times lower.

However, it is mandatory that safety be proved by long-term studies on
large groups of vulnerable humans with high doses,
with interactions with common co-factors included,
and that these studies, matters of life and death, be available forever and
for free on the Net, along with perpetual, archived public forums for
discussion of the research.

In addition, proactive effort must welcome all critical feedback by users
and professionals, and made instantly and permanently available to
everyone via the Net.

Certainly, it is obvious that individual volunteers in the last decade are
competently meeting some of these needs. It is striking to observe that
capitalism has overlooked this huge, obvious business opportunity.

To put a product on the mass market without full adherence to the
precautionary principle is to endanger the public and therefore the future
of your firm.

The sharply increasing pace of evolution of toxicology in all its aspects
and levels, coupled with instantaneous mobilization of world public
consensus, has created a new environment to which all firms have to
willingly and rapidly adapt, if they are to survive as profitable service
institutions that best meet the many levels of needs of the peoples
of our world.

In mutual service, Rich Murray
*******************************************************


http://groups.yahoo.com/group/aspartameNM/message/1315
49% consumers want their local store to stock foods free of artificial
sweeteners, Steve French, The Natural Marketing Institute,
NMIsolutions.com: NaturalProductsInsider.com: Murray 2006.03.07

" And consumers are more than eager to support alternative sugar
substitutes, evidenced by the fact that over half of U.S. adults
(58 percent) indicate using artificial sweeteners over the past year,
a steady 25 percent increase in usage since 2002....

However, even with such high usage, half of consumers (55 percent)
are concerned about the negative side effects of artificial sweeteners.
About half of consumers (49 percent) even want their local store to
stock foods that are free from artificial sweeteners,
and a quarter (23 percent) prefer not to serve their family anything
with artificial sweeteners.
Such dichotomies create challenges for companies
throughout the supply chain.
Certain segments of consumers show even stronger conflicting
attitudes, creating even greater challenges for the food and
sweetener industries.

For instance, over three-quarters (78 percent) of consumers who use
organic foods/beverages on a daily basis are concerned about the
negative side effects of artificial sweeteners,
while just under three-quarters (73 percent) also desire foods
with no sugar added.
While 73 percent of diabetics use artificial sweeteners for a diabetic diet,
half (49 percent) are indeed concerned about the negative side effects.
So what's a consumer to do? "

http://www.naturalproductsinsider.com/articles/631feat05.html

Copyright © 2006 by Virgo Publishing. Posted : 03/06/2006

Divergent Sweetener Attitudes Highlight Emerging Opportunities
by Steve French


http://groups.yahoo.com/group/aspartameNM/message/1312
the beginning of the end? USA diet soda volume sales up only 0.4%
last 52 weeks, after years of big jumps -- awareness of aspartame as
toxic methanol, formaldehyde, formic acid source?:
Melanie Warner, New York Times: Murray 2006.03.03


"After milk, eggs, bread and bananas, soda is the highest-volume item in
grocery stores. In recent years, sales of regular soda have been
declining, while sales of diet soda have boomed.
But even more recently, diet soda sales have tapered off,
with unit volumes up just 0.4 percent for the 52 weeks
that ended Jan. 28, according to ACNielsen."
*******************************************************


Regul Toxicol Pharmacol. 2003 Oct; 38(2): 124-43.
Food consumption and body weight changes with neotame, a new
sweetener with intense taste: differentiating effects of palatability from
toxicity in dietary safety studies.
Mayhew DA, Comer CP, Stargel WW.
Regulatory Affairs, The NutraSweet Company,
1801 Maple Street, Evanston, IL 60201, USA.
dale.a.mayhew@... PMID: 14550755

Regul Toxicol Pharmacol. 2003 Oct; 38(2): 144-56.
Long-term food consumption and body weight changes in neotame
safety studies are consistent with the allometric relationship observed for
other sweeteners and during dietary restrictions.
Flamm WG, Blackburn GL, Comer CP, Mayhew DA, Stargel WW.
AAC Consulting Group, Vero Beach, FL, USA PMID: 14550756
Regul Toxicol Pharmacol. 2003 Oct; 38(2): 124-43.

[ http://www.aacgroup.com/

You probably know that AAC has been providing consulting, auditing,
training support and assistance to the industries regulated by the FDA
and similar agencies since 1960. We're staffed with a uniquely qualified
team of former high level FDA officials and industry experts.

But did you know that AAC is now part of Kendle, a leading global
clinical research organization?


Corporate Headquarters Rockville Office
Kendle Kendle / AAC
1200 Carew Tower 7361 Calhoun Place
441 Vine Street Suite 500
Cincinnati, OH 45202 Rockville, MD 20855
Tel: 1-800-733-1572 (in U.S. only) Tel:+1-301-838-3120
Tel: +1-513-381-5550 Fax:+1-301-838-3182
Fax: +1-513-381-5870 isd@...
info@... ]


http://groups.yahoo.com/group/aspartameNM/message/911
RTP ties to industry criticized by CSPI: Murray: 2002.12.09
*******************************************************

http://groups.yahoo.com/group/aspartameNM/message/1018
aspartame toxicity coverup increases danger of corporate meltdown:
Michael C. Carakostas of Coca-Cola: Murray 2003.08.11 rmforall
http://www.isrtp.org/new_members/members1.htm
The International Society of Regulatory Toxicology and Pharmacology
Carakostas, Michael C., DVM, PhD Director/Scientific & Regulatory
Affairs The Coca-Cola Company PO Drawer 1734 Atlanta, GA 30301
404/676-4234 F. 404/676-7166 mcarakostas@...
http://www2.coca-cola.com/ourcompany/columns_aspartame.html
[photo] Aspartame: The world agrees it's safe By Michael Carakostas,
DVM, PhD Director, Scientific and Regulatory Affairs, Coca-Cola

It is commendable that Carakostas mentions the core problem, albeit
disparagingly, and overlaid with multiple untruths: "During digestion,
aspartame yields a very small amount of methanol -- as do many other
food substances. The body converts this methanol to formaldehyde,
which is instantly converted to formate.
Formate is quickly eliminated as carbon dioxide and water."

Carakostas deceptively make claims, unsupported by research, that the
amount of methanol from aspartame is "very small", and that little of the
inevitable formaldehyde or formic acid toxic products accumulate in
body tissues. This executive, with a PhD in veterinary science,
is deceiving people about very serious multiple toxicities.

Thus, there is evidence here cited from 1973 to 2004 that research and
reviews by immense vested interests about aspartame must be
scrutinized with the greatest skepticism.
The greatest Internet myth about aspartame is this:
"Aspartame is the most thoroughly tested food additive in history."

http://groups.yahoo.com/group/aspartameNM/message/857
www.dorway.com: original documents and long reviews of flaws in
aspartame toxicity research: Murray 2002.07.31

http://groups.yahoo.com/group/aspartameNM/message/858
Samuels: Strong: Roberts: Gold: flaws in double-blind studies re
aspartame and MSG toxicity: Murray 2002.08.01

"Survey of aspartame studies: correlation of outcome and funding
sources," 1998, unpublished: http://www.dorway.com/peerrev.html
Walton found 166 separate published studies in the peer reviewed
medical literature, which had relevance for questions of human safety.
The 74 studies funded by industry all (100%) attested to aspartame's
safety, whereas of the 92 non-industry funded studies, 84 (91%)
identified a problem. Six of the seven non-industry funded studies
that were favorable to aspartame safety were from the FDA, which
has a public record that shows a strong pro-industry bias.
Ralph G. Walton, MD, Prof. of Clinical Psychology, Northeastern Ohio
Universities, College of Medicine, Dept. of Psychiatry, Youngstown,
OH 44501, Chairman, The Center for Behavioral Medicine,
Northside Medical Center, 500 Gypsy Lane, P.O. Box 240
Youngstown, OH 44501 330-740-3621 rwalton193@...
http://www.neoucom.edu/DEPTS/Psychiatry/walton.htm
*******************************************************


http://groups.yahoo.com/group/aspartameNM/message/1316
PubMed abstract: aspartame (methanol becoming formaldehyde) causes
many cancers in rats, Ramazzini Foundation, M Soffritti et al:
Murray 2006.03.06

http://www.ehponline.org/members/2005/8711/8711.html free full text

Environ Health Perspect. 2006 Mar; 114(3): 379-85.
First experimental demonstration of the multipotential carcinogenic
effects of aspartame administered in the feed to sprague-dawley rats.
Soffritti M, Belpoggi F, Esposti DD,
Lambertini L, Tibaldi E, Rigano A.
Cesare Maltoni Cancer Research Center, European Ramazzini
Foundation of Oncology and Environmental Sciences, Bologna, Italy.

The Cesare Maltoni Cancer Research Center of the European Ramazzini
Foundation has conducted a long-term bioassay on aspartame (APM),
a widely used artificial sweetener.

APM was administered with feed to 8-week-old Sprague-Dawley rats
(100-150/sex/group), at concentrations of
100,000, 50,000, 10,000, 2,000, 400, 80, or 0 ppm.

The treatment lasted until natural death, at which time
all deceased animals underwent complete necropsy.

Histopathologic evaluation of all pathologic lesions and of all organs
and tissues collected was routinely performed
on each animal of all experimental groups.

The results of the study show for the first time that APM,
in our experimental conditions, causes
a) an increased incidence of malignant-tumor-bearing animals
with a positive significant trend in males (p </= 0.05)
and in females (p </= 0.01),
in particular those females treated at 50,000 ppm (p </= 0.01);

b) an increase in lymphomas and leukemias
with a positive significant trend in both males (p </= 0.05)
and females (p </= 0.01),
in particular in females treated at doses of
100,000 (p </= 0.01), 50,000 (p </= 0.01), 10,000 (p </= 0.05),
2,000 (p </= 0.05), or 400 ppm (p </= 0.01);

c) a statistically significant increased incidence,
with a positive significant trend (p </= 0.01),
of transitional cell carcinomas of the renal pelvis and ureter and their
precursors (dysplasias) in females treated at
100,000 (p </= 0.01), 50,000 (p </= 0.01), 10,000 (p </= 0.01),
2,000 (p </= 0.05), or 400 ppm (p </= 0.05);

and d) an increased incidence of malignant schwannomas
of peripheral nerves with a positive trend (p </= 0.05) in males.

The results of this mega-experiment indicate that APM
is a multipotential carcinogenic agent,
even at a daily dose of 20 mg/kg body weight,
much less than the current acceptable daily intake. [ 50 mg/kg bw ]

On the basis of these results,
a reevaluation of the present guidelines
on the use and consumption of APM is urgent
and cannot be delayed.

Key words: artificial sweetener, aspartame, carcinogenicity,
lymphomas, malignant schwannomas, rats, renal pelvis carcinomas.
PMID: 16507461 Feb 24 2006 04:49:50

Address correspondence to M. Soffritti, Cesare Maltoni Cancer
Research Center, European Ramazzini Foundation of Oncology and
Environmental Sciences, Castello di Bentivoglio, Via Saliceto, 3,
40010 Bentivoglio, Bologna, Italy. 39-051-6640460
Fax: 39-051-6640223 crcfr@...
We thank the U.S. National Toxicology Program for convening a group
of pathologists at the National Institute of Environmental Health Sciences
to provide a second opinion for a set of malignant lesions and their
precursors related to aspartame treatment, and for their help in statistical
analysis.
We also thank all of the staff involved in the project.
This research was supported by the European Ramazzini Foundation of
Oncology and Environmental Sciences.
The authors declare they have no competing financial interests.
Received 3 October 2005; accepted 16 November 2005.


http://www.ehponline.org/members/2005/8711/tab1.jpg
[ transcribed to plain text ]
Table 1. Beverages and diet products studied at the CMCRC/ERF:
status of studies.

Study---------------------------No. of bioassays
---Products-------------------------Species---------No. Study status

1 Water in
polyvinyl chloride bottles------2 rat a--------------2,200 P b

2 Coca-Cola---------------------4 rat a------------1,999 RP

3 Pepsi Cola--------------------1 rat----------------400 E

4 Ethyl alcohol-----------------4 rat, mouse a-----1,458 P c

5 Sucrose-----------------------1 rat----------------400 E

6 Aspartame (APM)---------------6 rat, mouse a-----4,460 BO, PP d

7 Sucralose (Splenda)-----------1 mouse *------------760 BO

8 Caffeine----------------------1 rat----------------800 E

9 Vitamin A---------------------5 rat--------------5,100 E

10 Vitamin C--------------------5 rat--------------3,680 E

11 Vitamin E--------------------5 rat--------------3,680 E

12 Feed sterilized by-----------1 rat a------------2,000 E
gamma radiation

Total--------------------------36-----------------26,937

Abbreviations:
BO, biophase ongoing
E, in elaboration
P, published
PP, partially published
RP, ready for publication
a, treatment started from embryonic life
b, data from Maltoni et al. (1997)
c, data from Soffritti et al. (2002a)
d, data from Soffritti et al. (2005).
*, data from Soffritti et al. (1992)


Investigations into the metabolism of APM have shown that,
in rodents, nonhuman primates, and humans,
it is metabolized in the gastrointestinal tract into three constituents --
aspartic acid, phenylalanine, and methanol --
which are absorbed into the systemic circulation (Ranney et al. 1976).

For each molecule of APM,
one molecule of each constituent is produced.

After absorption, they are then used, metabolized, and/or excreted by
the body following the same metabolic pathways
as when consumed through the ordinary diet:

aspartate is transformed into alanine plus oxaloacetate (Stegink 1984);

phenylalanine is transformed mainly into tyrosine and, to a smaller extent,
phenylethylamine and phenylpyruvate (Harper 1984);

and methanol is transformed into formaldehyde and then to formic acid
(Opperman 1984).
*******************************************************

Morando Soffritti 1, Fiorella Belpoggi 1, Davide Degli Esposti 1, Luca
Lambertini 1, Eva Tibaldi 1,
and Anna Rigano 1
1 Cesare Maltoni Cancer Research Center,
European Ramazzini Foundation of Oncology and
Environmental Sciences, Bologna, Italy
Address of the institution:
Cesare Maltoni Cancer Research Center,
European Ramazzini Foundation of Oncology and Environmental Sciences.
Castello di Bentivoglio, Via Saliceto, 3, 40010 Bentivoglio, Bologna, Italy
+39/051/6640460 Fax +39/051/6640223 crcfr@...

Address correspondence to
Dr. M. Soffritti, M.D., Scientific Director of the Cesare Maltoni
Cancer Research Center,
European Ramazzini Foundation of Oncology and Environmental
Sciences.
Castello di Bentivoglio, Via Saliceto, 3, 40010 Bentivoglio, Bologna, Italy
+39/051/6640460 Fax +39/051/6640223 crcfr@...

Acknowledgements: A special thanks to the
US National Toxicology Program (NTP)
for convening a group of pathologists at NIEHS
in order to provide a second opinion
for a set of lesions of malignancies and their precursors
related to the APM treatment, and for the help in statistical analysis.

http://groups.yahoo.com/group/aspartameNM/message/1250
aspartame causes cancer in rats at levels approved for humans,
Morando Soffritti et al, Ramazzini Foundation, Italy &
National Toxicology Program of National Institute of Environmental
Health Sciences 2005.11.17 Env. Health Pers. 35 pages: Murray

http://groups.yahoo.com/group/aspartameNM/message/1226
USA National Institutes of Health National Toxicology
Program aids eminent Ramazzini Foundation, Bologna, Italy,
in more results on cancers in rats from lifetime low levels
of aspartame (methanol, formaldehyde), Felicity Lawrence,
www.guardian.co.uk: Murray 2005.09.30

http://groups.yahoo.com/group/aspartameNM/message/1186
aspartame induces lymphomas and leukaemias in rats, full plain text,
M Soffritti, F Belpoggi, DD Esposti, L Lambertini: Ramazzini
Foundation study 2005.07.14: main results agree with their previous
methanol and formaldehyde studies: Murray 2005.09.03

http://groups.yahoo.com/group/aspartameNM/message/1189
Michael F Jacobson of CSPI now and in 1985 re aspartame
toxicity, letter to FDA Commissioner Lester Crawford;
California OEHHA aspartame critique 2004.03.12; Center for
Consumer Freedom denounces CSPI: Murray 2005.07.27

http://groups.yahoo.com/group/aspartameNM/message/1016
President Bush & formaldehyde (aspartame) toxicity:
Ramazzini Foundation carcinogenicity results Dec 2002:
Soffritti: Murray 2003.08.03 rmforall

p. 88 "The sweetening agent aspartame hydrolyzes in the gastrointestinal
tract to become free methyl alcohol, which is metabolized in the liver
to formaldehyde, formic acid, and CO2. (11)"
Medinsky MA & Dorman DC. 1994; Assessing risks of low-level
methanol exposure. CIIT Act. 14: 1-7.

Ann N Y Acad Sci. 2002 Dec; 982: 87-105.
Results of long-term experimental studies on the carcinogenicity of
formaldehyde and acetaldehyde in rats.
Soffritti M, Belpoggi F, Lambertin L,
Lauriola M, Padovani M, Maltoni C.
Cancer Research Center, European Ramazzini Foundation for Oncology
and Environmental Sciences, Bologna, Italy. crcfr@...
Formaldehyde was administered for 104 weeks in drinking water
supplied ad libitum at concentrations of
1500, 1000, 500, 100, 50, 10, or 0 mg/L
to groups of 50 male and 50 female Sprague-Dawley rats beginning at
seven weeks of age.
Control animals (100 males and 100 females) received tap water only.
Acetaldehyde was administered to 50 male and 50 female
Sprague-Dawley rats beginning at six weeks of age at concentrations of
2,500, 1,500, 500, 250, 50, or 0 mg/L.
Animals were kept under observation until spontaneous death.
Formaldehyde and acetaldehyde were found to produce an increase
in total malignant tumors in the treated groups
and showed specific carcinogenic effects on various organs and tissues.
PMID: 12562630

Ann N Y Acad Sci. 2002 Dec; 982: 46-69.

Results of long-term experimental studies on the carcinogenicity of
methyl alcohol and ethyl alcohol in rats.
Soffritti M, Belpoggi F, Cevolani D,
Guarino M, Padovani M, Maltoni C.
Cancer Research Center, European Ramazzini Foundation for Oncology
and Environmental Sciences, Bologna, Italy. crcfr@...
Methyl alcohol was administered in drinking water
supplied ad libitum at doses of
20,000, 5,000, 500, or 0 ppm to groups of male and female
Sprague-Dawley rats 8 weeks old at the start of the experiment.
Animals were kept under observation until spontaneous death.
Ethyl alcohol was administered by ingestion in drinking water at a
concentration of 10% or 0% supplied ad libitum to groups of male and
female Sprague-Dawley rats; breeders and offspring were included in
the experiment.
Treatment started at 39 weeks of age (breeders), 7 days before mating,
or from embryo life (offspring) and lasted until their spontaneous death.
Under tested experimental conditions, methyl alcohol and ethyl alcohol
were demonstrated to be carcinogenic for various organs and tissues.
They must also be considered multipotential carcinogenic agents.
In addition to causing other tumors, ethyl alcohol induced malignant
tumors of the oral cavity, tongue, and lips.
These sites have been shown to be target organs in man by
epidemiologic studies.
Publication Types: Review Review, Tutorial PMID: 12562628
*******************************************************

http://groups.yahoo.com/group/aspartameNM/message/1307
formaldehyde from 11% methanol part of aspartame or from red wine
causes same toxicity (hangover) harm: Murray 2006.03.07

"Of course, everyone chooses, as a natural priority,
to actively find, quickly share, and act upon the facts
about healthy and safe food, drink, and environment."

Rich Murray, MA Room For All rmforall@...
505-501-2298 1943 Otowi Road Santa Fe, New Mexico 87505

http://groups.yahoo.com/group/aspartameNM/messages
group with 151 members, 1,317 posts in a public, searchable archive
http://RMForAll.blogspot.com http://AspartameNM.blogspot.com

Dark wines and liquors, as well as aspartame, provide
similar levels of methanol, above 120 mg daily, for
long-term heavy users, 2 L daily, about 6 cans.

Within hours, methanol is inevitably largely turned into formaldehyde,
and thence largely into formic acid -- the major causes of the dreaded
symptoms of "next morning" hangover.

Fully 11% of aspartame is methanol -- 1,120 mg aspartame
in 2 L diet soda, almost six 12-oz cans, gives 123 mg
methanol (wood alcohol). If 30% of the methanol is turned
into formaldehyde, the amount of formaldehyde, 37 mg,
is 18.5 times the USA EPA limit for daily formaldehyde in
drinking water, 2.0 mg in 2 L average daily drinking water.

http://groups.yahoo.com/group/aspartameNM/message/1143
methanol (formaldehyde, formic acid) disposition: Bouchard M
et al, full plain text, 2001: substantial sources are
degradation of fruit pectins, liquors, aspartame, smoke:
Murray 2005.04.02

Any unsuspected source of methanol, which the body always quickly
and largely turns into formaldehyde and then formic acid, must be
monitored, especially for high responsibility occupations, often with
night shifts, such as pilots and nuclear reactor operators.

http://groups.yahoo.com/group/aspartameNM/message/1291
European Food Safety Authority to decide aspartame safety by May:
caffeine diet drinks cause female hypertension, WC Winkelmayer et al,
JAMA 2005.11.09: PubMed lists 50 items for "diet soft drinks" since
2004 Oct.: Murray 2006.01.24

http://groups.yahoo.com/group/aspartameNM/message/1279
all three aspartame metabolites harm human erythrocyte [red blood cell]
membrane enzyme activity, KH Schulpis et al, two studies in 2005,
Athens, Greece, 2005.12.14: 2004 research review, RL Blaylock:
Murray 2006.01.14

http://groups.yahoo.com/group/aspartameNM/message/939
aspartame (aspartic acid, phenylalanine) binding to DNA:
Karikas July 1998: Murray 2003.01.05 rmforall
Karikas GA, Schulpis KH, Reclos GJ, Kokotos G
Measurement of molecular interaction of aspartame and
its metabolites with DNA. Clin Biochem 1998 Jul; 31(5): 405-7.
Dept. of Chemistry, University of Athens, Greece
http://www.chem.uoa.gr gkokotos@...;
K.H. Schulpis inchildh@...; G.J. Reclos reklos@...;

http://groups.yahoo.com/group/aspartameNM/message/1271
combining aspartame and quinoline yellow, or MSG and brilliant blue,
harms nerve cells, eminent C. Vyvyan Howard et al, 2005
education.guardian.co.uk, Felicity Lawrence: Murray 2005.12.21

http://groups.yahoo.com/group/aspartameNM/message/925
aspartame puts formaldehyde adducts into tissues, Part 1/2
full text Trocho & Alemany 1998.06.26
Universitat Autònoma de Barcelona : Murray 2002.12.22

http://groups.yahoo.com/group/aspartameNM/message/1250
aspartame causes cancer in rats at levels approved for humans,
Morando Soffritti et al, Ramazzini Foundation, Italy &
National Toxicology Program
of National Institute of Environmental Health Sciences
2005.11.17 Env. Health Pers. 35 pages: Murray

http://groups.yahoo.com/group/aspartameNM/message/1106
hangover research relevant to toxicity of 11% methanol in aspartame
(formaldehyde, formic acid): Calder I (full text): Jones AW:
Murray 2004.08.05 rmforall

Since no adaquate data has ever been published on the exact disposition
of toxic metabolites in specific tissues in humans of the 11% methanol
component of aspartame, the many studies on morning-after hangover
from the methanol impurity in alcohol drinks are the main available
resource to date.

Jones AW (1987) found next-morning hangover from red wine with
100 to 150 mg methanol
(9.5% w/v ethanol, 100 mg/l methanol, 0.01%,
one part in ten thousand).

http://groups.yahoo.com/group/aspartameNM/message/870
Aspartame: Methanol and the Public Interest 1984: Monte:
Murray 2002.09.23

Humans suffer "toxic syndrome" (54) at a minimum lethal dose
of <1 gm/kg, much less than that of monkeys, 3-6 g/kg (42, 59).

The minimum lethal dose of methanol
in the rat, rabbit, and dog is 9.5, 7.0 , and 8.0 g/kg, respectively (43);
ethyl alcohol is more toxic than methanol to these test animals (43)."

http://groups.yahoo.com/group/aspartameNM/message/1302
The Lowdown on Sweet? (Ramazzini Foundation, M Soffritti proof that
aspartame causes cancers), Melanie Warner, The New York Times:
Murray 2006.02.12

http://groups.yahoo.com/group/aspartameNM/message/1303
David L. Katz MD comments briefly with Diane Sawyer on ABC
Good Morning America re Ramazzini aspartame cancer study:
excellent opus at Yale U: mainstream research on aspartame
(methanol, formaldehyde, formic acid) toxicity: Murray 2006.02.14

http://groups.yahoo.com/group/aspartameNM/message/1304
to DL Katz MD, Yale U: M. Soffritti, Ramazzini F., did not mention that
humans are about 10X more vulnerable to aspartame than are rats:
found methanol and formaldehyde carcinogenicity 2002: human ADI
levels must be reduced hugely: Katz: Murray 2006.02.15

http://groups.yahoo.com/group/aspartameNM/message/1306
ban aspartame speech, Roger Williams MP, UK Parliament
2005.12.14: www.TheyWorkForYou.com: Murray 2006.02.20

As a medical layman, I suggest that evidence mandates immediate
exploration of the role of these ubiquitious, potent formaldehyde
sources as co-factors in epidemiology, research, diagnosis,
and treatment in a wide variety of disorders.

Folic acid, from fruits and vegetables, plays a role by powerfully
protecting against methanol (formaldehyde) toxicity.

Many common drugs, such as aspirin, interfere with folic acid,
as do some mutations in relevant enzymes.

The majority of aspartame reactors are female.

In mutual service, Rich Murray
*******************************************************

http://groups.yahoo.com/group/aspartameNM/message/1310
Aspartame and smoking give the same toxic metabolite as does benzene,
Lin YS et al, U N Carolina, Chapel Hill, 2006 Jan.,
Center for Environmental Health and Susceptibility: Murray 2006.03.01

http://groups.yahoo.com/group/aspartameNM/message/1309
History and origin of benzene in soft drinks, Ross E. Getman, Esq,
Wash DC and NY State Bars, http://argentina.indymedia.org:
Murray 2006.03.01

http://groups.yahoo.com/group/aspartameNM/message/1131
genotoxicity of aspartame in human lymphocytes 2004.07.29
full plain text, Rencuzogullari E et al, Cukurova University,
Adana, Turkey 2004 Aug: Murray 2004.11.06

http://groups.yahoo.com/group/aspartameNM/message/935
Comet assay finds DNA damage from sucralose, cyclamate, saccharin
in mice: Sasaki YF & Tsuda S Aug 2002: Murray 2003.01.01
[ Also borderline evidence, in this pilot study of 39 food additives,
using test groups of 4 mice, for DNA damage from for stomach, colon,
liver, bladder, and lung 3 hr after oral dose of 2000 mg/kg aspartame --
a very high dose. Methanol is the only component of aspartame that can
lead to DNA damage. ]
*******************************************************