Thanks, Jennifer, for updating us on this important piece of
research. Rituximab, or Rituxan as it is known here in the U.S., has
had positive effect for Rheumatoid Arthritis treament as well as
several forms of cancer. I was wondering if anyone on this board has
had it prescribed for themselves or their children with APS 1 and if
the treatment helped.
I am delighted to hear that Julia is enjoying her pre-kindergarten
and you are able to enjoy this positive experience with her. Good
news is always the best news.
Best wishes,
Linda





--- In apeced@yahoogroups.com, "Orange, Jennifer" <jorange@...> wrote:
>
> Please see below.
> Jennifer Orange
> Torys LLP
>
> ----- Original Message -----
> From: Jennifer Orange <jenniferorange@...>
> To: Orange, Jennifer
> Sent: Wed Sep 17 11:53:15 2008
> Subject: FW: New research
>
>
>
>
>
> ________________________________
>
> From: Jennifer Orange [mailto:jenniferorange@...]
> Sent: September 17, 2008 10:58 AM
> To: 'apeced@yahoogroups.com'
> Subject: New research
>
>
>
> Hi Everyone,
>
> I am attaching an interesting article describing a new development
in APECED research. The authors confirm that B-cells are involved in
the onset of disease. My understanding of the science on this is
very limited, but to date no one has been sure if B cells are
involved. The study also reports that Rituximab, a drug commonly
used to treat lymphoma, was used on mice with APECED with success.
My understanding is that Rituximab has not yet been studied on people
with APECED, but was wondering if any of you had heard of anyone
trying it. Rituximab is an immunosuppressant, but works differently
than Imuran or Cellcept (MMF).
>
> This research is exciting, as it will likely lead to research on
how drugs that affect B cells, like Rituxamed, work on people with
APECED. You may want to share this article with your doctors to help
them understand the disease.
>
>
>
> On another bright note, my daughter Julia started junior
kindergarten last week. She is loving it and we are so pleased that
she has been able to take this wonderful step. Just a year ago Julia
was still in the ICU with grave lung problems. I hope that this
September has brought some new beginnings for all of you.
>
>
>
> Jennifer
>
>
>
>
> This email and any attachments are for the sole use of the intended
recipients and may be privileged or confidential. Any distribution,
printing or other use by anyone else is prohibited. If you are not an
intended recipient, please contact the sender immediately, and
permanently delete this email and attachments.
>