A link between human exposure to some chemical
substances and neurotoxicity<br>has been firmly established
(Anger, 1986; OTA, 1990).
<br><br><a href=http://www.mcscfs.de/pdf/epa-neurotox99.pdf
target=new>http://www.mcscfs.de/pdf/epa-neurotox99.pdf</a><br><br><a
href=http://www.usdoj.gov/crt/foia/tal478a.txt
target=new>http://www.usdoj.gov/crt/foia/tal478a.txt</a>
<br><br><a href=http://www.wws.princeton.edu/~ota/disk2/1990/9031_n.html
target=new>http://www.wws.princeton.edu/~ota/disk2/1990/9031_n.html</a><br><br><\
a href=http://www.safer-world.org/e/topics/neurotox.htm
target=new>http://www.safer-world.org/e/topics/neurotox.htm</a><br><br>9/99:<br>\
Seventh International Symposium On Neurobehavioral
Methods and Effects in Occupational and Environmental
Health <br>Subcortical hypernetabolism and cortical
hypometabolism after neurotoxic exposure. Human PET Studies.
<br><br>Heuser G, Wu J. C. <br>Brain Imaging Center, University
of California, Irvine, CA, USA <br><br>Introduction
and objectives: Impairment of cortical function after
neurotoxic exposure has been documented by SPECT (decreased
perfusion) and also by PET (decreased glucose metabolism) in
several publications.<br>Detailed visualization of deap
subcortical structures (e.g. olifactory bulb, amygdala,
limbiohypothalamic pathways )has only recently become available.
<br>It was our goal to investigate these structures by
PET scanning aftere neurotoxic exposure, <br>Material
and Methods: Patients with a documented neurotoxic
exposure and with a diagnosis of toxic encephalopathy
under went PET studies. Approximately 30 healthy adults
served as controls. <br><br>Results: we found that a
significant numbrt of our patients show not only cortical
hypoperfusion (SPECT) and hypometabolism (PET) but - by
contrast - hypermetabolism (PET), with potential seizure
activity, in deep subcortical structures.<br>Dicussion and
Conclusions: These findings shed light on the possible
mechanism of neurotoxic injury and raise the question
whether hypermetabolism represents seizure activity in
some cases be the result of kindling (by toxic
chemicals). <br>------------<br>For those of you who are
trying to put together insurance claims or even just
learn more about neurological etiology of our assorted
illnesses,check this out: <a href=http://neurosomatic.cjb.net.
target=new>http://neurosomatic.cjb.net.</a> The young
many who put this together was doing research to help
himself understand the complicated terminology in
neuroscience. He was pre-med & realized that he had a
cross-referenced glossary, so decided to put it on-line for other
people.<br><br>**************<br><br><a
href=http://idaho-web.com/redhen/government.html
target=new>http://idaho-web.com/redhen/government.html</a><br><br><a
href=http://www.ota.nap.edu/pdf/data/1990/9031.PDF
target=new>http://www.ota.nap.edu/pdf/data/1990/9031.PDF</a><br><br>Neurotoxicit\
y: Identifying and Controlling Poisons of the
Nervous System April 1990 OTA-BA-436 NTIS order
#PB90-252511 original document: 362
pages<br><br><a href=http://www.neurotox.com
target=new>http://www.neurotox.com</a>