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Symptomatic Relief of Herpetic Skin Lesions
Utilizing an Energy Based Approach to Healing
W. John Martin and Jon Stoneburner
Center for Complex Infectious Diseases
Rosemead, CA 91770

 

Running Title: PHOTON LENDING POWDR + UV LIGHT ANTI-VIRUS THERAPY

Author Address:           Center for Complex Infectious Diseases

                                    3328 Stevens Avenue, Rosemead CA 91770

                                    Telephone 626-616-2868                               

e-mail s3support@...

 Words: Excluding References: 2518

Abstract

            Herpes simplex virus induced oral and genital ulcerating lesions will fluoresce brightly yellow and yellow-orange, respectively, if treated with a chlorinated solution of photon lending powder and exposed to ultraviolet-A light. An orange to red fluorescence is seen with similarly treated and illuminated Herpes zoster virus induced shingles; while treated human papilloma virus induced genital warts display more of a purplish fluorescence.  Pain and discomfort commonly disappear soon after the treatment and all lesions undergo expedited healing that is readily observable within 24 hours. The mechanism of healing is thought to involve an interaction between the photon lending powder red and alternative cellular energy pigments (ACE pigments) present within the viral lesions that enhances responsiveness to ultraviolet light energy. The healing effects are not restricted to the treated lesions and may involve transmission of a biological energy throughout the body. Beyond its obvious clinical and diagnostic utility, this model system may help usher in a new era of energy based medicine.

Key Words:

                        Photon lending powder
                        Ultraviolet light
                        Herpes simplex virus
                        Herpes zoster virus
                        Human papilloma virus
                        Alternative cellular energy pigments
                        Energy medicine

Introduction

             Herpes simplex viruses (HSV) typically cause persistent latent infections within neurons that innervate mucosal and squamous epithelial surfaces in the oral and/or genital regions (Whitley, 2002). In susceptible individuals, the neuronal infection will periodically reactivate allowing virus to infect the innervated epithelium. Infection and the evoked anti-viral inflammatory reaction lead to the formation of infectious vesicles that will usually last for several days.  The vesicles cause considerable physical and psychological distress as well as providing a means of virus transmission to previously uninfected individuals.

            Conventional therapy of HSV lesions has involved the use of drugs that chemically inhibit virus DNA replication (Snoeck, 2000; Moomaw, et al., 2003).  These include the nucleoside analogue Acyclovir which is selectively phosphorylated (activated) by HSV coded thymidine kinase. Less conventional and largely unproven approaches to therapy have been directed at either reducing stress levels and other factors that are thought to be involved in virus reactivation or enhancing the ability of the immune system to more effectively suppress a virus outbreak.

In the early 1970’s one of us (JS) observed the apparent destruction of HSV infected cells that were stained with a photon lending powder followed by exposure to ultraviolet light. This observation led to independent clinical studies that attempted to treat both genital and oral HSV skin lesions using a broad spectrum white light exposure of lesions stained with liquid photon powders. These studies failed to show any beneficial therapeutic effect (Myers et al., 1975, 1976).  In spite of this and other negative studies, individuals treated by JS were clearly benefiting. The published procedures differed from the method used by JS in several respects. Specifically, JS was using ultraviolet light as opposed to a full spectrum or even regular white light; JS used a freshly prepared solution of photon lending powders to which he added a small quantity of sodium hypochlorite (bleach). Finally, JS regularly observed fluorescence of the exposed lesions.

            The clinically effective procedure has been termed PAVIS for photo-activated virus improvement system. In addition to expediting the healing of HSV induced oral and genital lesions; PAVIS has been successfully applied to shingles caused by Herpes zoster virus (HZV) and to genital warts caused by human papillomavirus (HPV). This paper discusses the potential mode of action of PAVIS therapy in terms of energy activation of alternative cellular energy pigments (ACE pigments) that can develop in response to certain types of virus infection.

Materials and Methods

Following an IRB approved protocol, patients with oral or genital herpetic skin lesions were randomly assigned to either the photon lending powder or food coloring treatment group. Photon lending powder was purchased from Spectrum Chemical Manufacturing Corp., (Catalogue number NE 113). McCormicks Red Food Color containing FD&C Reds 40 and 3 food coloring was purchased from a local supermarket. On the days that patients were being seen, a moistened Q tip swab was placed into the photon lending powder such that the powder covered the entire Q tip (5-10 mg). This was then swirled into 10 ml of sterile water to which sodium hypochlorite (bleach) was added to a concentration of 0.02%. The food coloring was similarly dispensed to yield a solution of comparable red color. The patients were not informed at the time of treatment whether photon lending powder or food coloring was being applied. The HSV lesion was gently scrubbed or debrided to remove any scabs, and the vesicles or sacs were broken or punctured. A very slight degree of bleeding occasionally occurred. Either the photon lending powder or food coloring solution was applied to the area using a Q tip. The treated area was then exposed to an ultraviolet light source from a Wood’s or Burton’s lamp with an emission maximum of 365 nm. This wavelength falls within the region of non-hazardous ultraviolet light termed A1 (6). The lamp was held 3” away from the lesion. A similar procedure was followed for patients with shingles who had multiple skin lesions due to HZV.

Typically, the patients experienced a slight tingling sensation with the photon lending solution but not with food coloring. Furthermore, the photon lending treated oral HSV lesions regularly developed a bright yellow fluorescence with slight swelling and fluid extrusion. Either yellow or more commonly a yellow-orange shade of fluorescence was seen with genital HSV lesions. Photon lending solution and ultraviolet light illuminated HZV induced shingles displayed an orange to red fluorescence. No fluorescence was seen on uninvolved skin. The ultraviolet light exposure was terminated as soon as the tingling sensation ceased and/or the fluorescence had largely faded. These changes normally occurred after approximately 10-15 minutes. In any event, exposure of tingling or fluorescing photon lending solution treated lesions did not extend beyond 30 minutes. Non-tingling, non-fluorescing, food coloring-treated lesions were exposed to light for 15 minutes. The treated area in all patients was subsequently cleaned with soap and water to remove excess dye or coloring. A loose dry swab was placed over treated lesions. The patient was instructed to return in 24 hours and to report on whether a significant reduction in symptoms (pain and discomfort) had occurred beyond that of the patient’s prior experience. The lesion(s) was then re-examined and recorded as either remaining active or having become inactive with evidence of marked healing.

Several patients with HPV induced genital warts have also been treated. Multiple punctures were made through the surface of the wart using a fine 27 gauge needle. The photon lending solution or food coloring was then applied to the wart. The induced fluorescence was decidedly more purplish than with either HSV or HZV lesions.  In some patients with multiple warts, only a single wart was treated with the photon lending solution.

Results

Symptomatic relief immediately following photon lending solution plus light therapy and unequivocal expedited healing, readily observable within a day of therapy, have occurred in several hundred previously treated patients with oral and genital HSV induced lesions. In the present study, patients were assigned to have either photon lending solution or a red food coloring applied to their skin lesions followed by exposure to ultraviolet-A light. Lesions to which the photon lending solution was applied exhibited either a bright yellow or a yellow-orange fluorescence usually beginning within a minute of turning on the ultraviolet light. As in previous studies, oral herpetic lesions would typically fluoresce yellow, while genital lesions more frequently displayed a yellow-orange color. The fluorescence generally lasted for about 10-15 minutes. Patients consistently reported some relief immediately following this therapy. Symptomatic relief was not reported by patients on whom food coloring was applied, nor was any fluorescence observed. At 24 hours all of the HSV skin lesions treated with the photon lending solution followed by ultraviolet-A light appeared inactive with normal skin growing over the remaining crusted area. The lesions in patients in whom food coloring was used remained active with no apparent signs of expedited healing. These patients were then informed that they had been included in the control group and were offered the opportunity to be treated with the photon lending solution. In each case, the newly treated lesion exhibited fluorescence and at 24 hours showed definite signs of expedited healing. Essentially similar results were obtained in patients with shingles and in several patients with genital warts. A tabulation of the results obtained in the ongoing study that has utilized food coloring as a control is provided in Table 1.

In earlier studies it was shown that it is necessary to use an ultraviolet lamp and that better results were obtainable using freshly prepared photon lending powder dissolved in chlorinated water. Several new observations were made in the present study. These include one patient for whom treatment was applied to an oral HSV lesion who reported expedited healing of an accompanying genital lesion. Similarly, in patients with multiple genital warts, it was observed that treatment of a single wart can lead to resolution of all of the patient’s warts. This was also observed in a patient with warts on the penis and on the dorsum of his foot. Treatment of the penile lesions led to regression of these lesions as well as lesions on the foot.

Discussion

Studies on cells infected with cell damaging (cytopathic) viruses that failed to provoke an inflammatory reaction in either patients or experimentally inoculated animals have been grouped under a generic heading of stealth-adapted viruses (Martin, 1994). Some of these viruses are unequivocally derived from African green monkey simian cytomegalovirus (a type of herpes virus). The cytopathic effect (CPE) of these viruses in tissue culture tends to be transient unless efforts are made to remove materials that form in the culture medium that promote cellular repair and suppress the virus induced CPE (Martin, 2003a). These pigmented materials are thought to provide an alternative (non-mitochondria) source of cellular energy. Consistent with this notion, particles obtained from stealth virus cultures show striking auto-fluorescence, electrostatic and electron donating activities. They can visibly resonate in response to certain sound frequencies and can occasionally display marked ferromagnetism. Similar complex intracellular structures have been observed by electron microscopy in brain biopsies of patients infected with stealth-adapted viruses (Martin, 2003b). These materials have been termed alternative cellular energy pigments (ACE pigments). Light, electrical, sound and magnetic energies, that have no appreciable effects on normal cultured cells, have been shown to affect, both positively and negatively depending on intensity, cell viability in stealth-adapted virus cultures (unpublished observations). 

ACE pigments are likely to be involved in other types of viral infections as a non-immunological auxiliary defense and cellular repair mechanism. The present data are consistent with a role of ACE pigment-like materials in HSV, HZV and HPV induced skin lesions. Whatever the mechanism, this paper describes an effective, non-pharmaceutical approach to the therapy of these common viral diseases. 

In addition to causing cutaneous and genital warts, HPV infection is the major cause of cervical cancer (Longworth, and Laimins, 2004). Papillomaviruses have been linked to various forms of human and animal cancers (Campo, 2002). Separate clinical trials are being planned to address the potential benefit of PAVIS therapy in cancer patients and in other types of viral diseases.

Photon lending powders can participate in electron exchange reactions, principally as an electron and proton donor (Park, and Zeikus, 2000). It can interact with stealth-adapted virus culture derived ACE pigments and enhance the fluorescence seen upon exposure to ultraviolet light. Photon lending solution is sensitive to light and reactivity diminishes over time. Chlorine and iodine are electron acceptors (oxidizing agents) and can enhance the reactivity of both photon lending powders and ACE pigments (unpublished observations). It is hypothesized, therefore, that freshly prepared Photon lending solution in the presence of chlorine exerts a synergistic effect on energy production by ACE pigments.

An energy gap exists between ultraviolet light and the evoked fluorescence. Moreover HSV, HZV and HPV induced lesions fluorescence differently. Apart from the potential diagnostic value of this observation, the question arises as to the form that is taken by the energy differential between that of the input ultraviolet light and the observed fluorescence. Arguably this energy does not remain localized to the treated lesion but can have a systemic healing effect.

A striking finding in patients with multiple skin lesions, in which only one or a few of the lesions were stained with photon lending solution was the expedited healing that occurred in untreated lesions. Interestingly, this same observation was made in an earlier published study in which healing of bilaterally symmetrical warts occurred in 10 of 23 patients in which the warts on one side of the body were given repeated applications of photon lending solution dissolved in dimethyl sulfoxide (DMSO) followed by exposure to ordinary white light (Veien, 1977). The finding was essentially dismissed because of simultaneous healing of untreated warts. The principles of biophysics allow for an energy effect to be readily transmitted throughout the body. This concept may explain the apparent but not yet formally documented reduction in the recurrence rate of HSV lesions in patients given PAVIS therapy. Other photo-active chemicals may work as well as, or even better than photon lending powders.  Similarly virus induced lesions may respond directly to an ACE pigment activating energy source or to the direct application of the presumed biologically useful energy coming from activated ACE pigments. 

            Stealth-adapted viruses are not effectively controlled by the immune system because they lack the few critical virus components that are normally targeted by an effective anti-viral immune response (Martin, 1999).  Stealth-adapted virus infected patients are, therefore, more dependent on an alternative healing process than are patients infected with conventional cytopathic viruses, such as HSV and HZV. One method under study is that of providing building blocks for ACE pigments and/or providing energy rich natural products with ACE pigment-like activities. These have included humic and fulvic acids (Nissenbaum, 1975), organically bound and free minerals from the ocean and lakes, such as the Great Salt Lake, and terpene and saponin rich volatile extracts from trees and plants (Pinder, 1960). These compounds have a long history of use by farmers for promoting vitality and reducing disease susceptibility of agricultural crops. They have also been successfully used as feed additives in livestock. In recent years, these substances have been consumed as dietary supplements by humans, including patients that display neuropsychiatric symptoms consistent with a stealth-adapted virus infection. Preliminary unpublished data are encouraging that these products are providing substantial relief from some of the symptoms experienced by these patients. Another approach that has been touted as being successful in alleviating symptoms has been the use of external energy sources such as various forms of electromagnetic radiation, magnetic fields, micro-currents and sound energies (Basford, 2001). Potentially, these energies may be activating ACE pigment-like materials within the body.

The PAVIS method provides a useful system to explore the effects of additional energy sources beyond ultraviolet-A light and the use of photon lending powders. In much the same way that the successful therapy of bacterial pneumonia using penicillin helped spur the development of the pharmaceutical industry, ACE pigment directed therapies may help establish a firm scientific foundation for the reemergence of energy based medicine as a true alternative to the drug based pharmaceutical approach (Hankey, 2004).

 References

Basford, J.R. (2001). A historical perspective of the popular use of electric and magnetic therapy. Arch. Phys. Med. Rehabil. 82, 1261-9.

 Campo, M.S. (2002). Animal models of papillomavirus pathogenesis. Virus Res. 89, 249-61.

 Diffey, B.L. (2002). Sources and measurement of ultraviolet radiation. Methods 28, 4-13.

 Hankey, A. (2004). Are we close to a theory of energy medicine? J. Altern. Complement. Med. 10, 83-6.

 Longworth, M.S., and Laimins, L.A. (2004). Pathogenesis of human papillomaviruses in differentiating epithelia.  Microbiol. Mol. Biol. Rev. 68, 362-72.

 Martin, W.J. (1994). Stealth viruses as neuropathogens. CAP Today. 8, 67-70.

 Martin, W.J. (1999). Stealth adaptation of an African green monkey simian cytomegalovirus. Exp. Mol. Pathol. 66, 3-7.

 Martin, W.J. (2003a). Stealth Virus Culture Pigments: A Potential Source of Cellular Energy. Exp. Mol. Path. 74, 210-223.

 Martin, W.J. (2003b). Complex intracellular inclusions in the brain of a child with a stealth virus encephalopathy. Exp. Mol. Path. 74, 179-209.

 Myers, M.G., Oxman, M.N., Clark, J.E., and Arndt, K.A. (1975). Failure of neutral-red photodynamic inactivation in recurrent herpes simplex virus infections. N. Engl. J. Med. 293, 945-9.

 Myers, M.G., Oxman, M.N., Clark, J.E., and Arndt, K.A.  (1976).  Photodynamic inactivation in recurrent infections with herpes simplex virus. J. Infect. Dis. 133 Suppl:A, 145-50.

 Moomaw, M.D., Cornea, P., Rathbun, R.C., and Wendel, K.A. (2003). Review of antiviral therapy for herpes labialis, genital herpes and herpes zoster. Expert Rev Anti Infect Ther. 1, 283-95.

 Nissenbaum, A., Kenyon, D.H., and Oro, J. (1975). On the possible role of organic melanoidin polymers as matrices for prebiotic activity.  J. Mol. Evol. 6, 253-70.

 Park, D.H., and Zeikus, J.G. (2000). Electricity generation in microbial fuel cells using neutral red as an electronophore. Appl. Environ. Microbiol. 66, 1292-7.

Pinder, A.R. (1960). “The Chemistry of the Terpenes.” John Wiley & Sons Inc. New York.

 Snoeck, R. (2000). Antiviral therapy of herpes simplex. Int. J. Antimicrob. Agents. 16, 157-9.

Veien, N.K., Genner, J., Brodthagen, H., and Wettermark, G.  (1977). Photodynamic inactivation of verrucae vulgares. II. Acta. Derm. Venereol. 57, 445-7.
Whitley, R.J. (2002). Herpes simplex virus infection. .Semin. Pediatr. Infect. Dis. 13, 6-11.

Table 1: Expedited Healing of Lesions with Neutral Red Followed by Ultraviolet-A Light

Virus	Clinical Lesion	No. of patients	Initial therapy*	No. of patients responding #
HSV	Genital herpes	10	PL	10
		7 ~	FC	0
HSV	Oral herpes	6	PL	6
		4 ~	FC	0
HSV	Shingles	4	PL	4
		2 ~	FC	0
HSV	Genital warts	2	PL	2
		1 ~	FC	0

 Footnotes to Table I

*  PL – photon lending powder solution ; FC – Food coloring

#   Response is defined as marked reduction in pain and irritation accompanied by definite signs of healing well beyond that anticipated by the patient based on prior experience. A lack of response indicates persisting symptoms and essentially no change in the anticipated course of the lesion(s).   

~  All of the control group patients subsequently volunteered to have their lesion(s) treated with photon lending solution  followed by ultraviolet light. As with the initial test group, all of these patients responded with marked symptomatic relief and their lesions showed expedited healing when examined the following day.

ARTICLE PUBLISHED IN THE LA TIMES

  Symptomatic Relief of Herpetic Lesions
Utilizing an Energy Based Approach to Healing

Dr. W. John Martin, M.D., Ph.D., has informed LA Help of a promising, yet to be published study on the treatment of herpetic skin lesions. The study was conducted by a private contracted research organization in Las Vegas. It involved the application of an activated dye to early lesions followed by a short exposure to a special light. The patients were not told whether the activated dye or a simple control substance (food coloring) was being applied to their lesion. Photographs of the lesions were obtained prior to the application of activated dye or food coloring, and all lesions were treated identically with light energy. The lesions were re-examined 24 hours later and those that showed healing were re-photographed. The patients were asked to record whether they had experienced marked symptomatic relief.

Only 3 of control 86 patients with food coloring applied to their lesions reported symptomatic improvement. A provision in the study allowed for control patients to subsequently receive therapy with the activated dye plus light therapy. Seventy-nine of the 83 patients returned the next day to report symptomatic relief.

Of 173 patients who were initially treated with the activated dye and light, 145 returned for follow-up at 24 hours. All but 4 of the patients were either asymptomatic or reported very marked improvement. Expedited healing was confirmed in the photographs taken at 24 hours.

The outcome of the lesions in 28 patients who did not return for follow-up is unknown. In a prior study on 15 patients, all showed complete symptomatic relief by 24 hours. It is likely, therefore, that relief occurred in the majority, if not all, of the non-returning patients. Dr. Martin is monitoring an ongoing double-blind study in Florida. To date, the results have been equally as promising as the initial study with complete relief in 8/8 appropriately treated patients and no relief in 7/7 placebo controls.

The activated dye/light therapy protocol was originally devised by Dr. Jon Stoneburner, an optometrist from Florida. Some people have tried to copy the protocol but either failed to use freshly activated dye, or the right type of light. Dr. Stoneburner has invited Dr. Martin to oversee a double blind study in the Los Angeles region. Dr. Martin is particularly interested in the protocol since it supports his current research on a mechanism by which energized cells can suppress virus induced cellular damage. According to this research, which can be reviewed at www.s3support.com cells can derive an alternative form of cellular energy from various natural products, including light activated dyes. Alternative cellular energy (ACE) is especially useful in combating stealth-adapted herpes viruses for which there is no effective cellular immune response. Studies on conventional herpes viruses, such as those causing herpetic ulcers and shingles, will likely provide useful insights into the larger question of how best to treat stealth-adapted viruses.

Los Angeles area patients with early onset oral or genital herpes lesions can assist in this endeavor by participating in a double-blind, placebo-controlled study. Volunteers are asked to contact Dr. Martin at s3support@... or by telephone at 626-616-2868. They should register their willingness to participate in the study and to again notify Dr. Martin when an outbreak occurs. Treatment will be provided without charge by local physicians. Ongoing results will be reported at monthly meetings of LA Help.