Oettiki Mikrob we semizlik
Insanlarning oetidiki Mikroblarning semizlik bilen
munasiwiti bolidiken.
Milyonlighan mikroblar insanlarning oetide yashap,
insanlar hezim qilalmaydighan yemeklerni parchilashqa
yardem beridu. Toewendiki tetqiqatta, insanlar
oetidiki muhim microbning semiz kishilerde oruq
kishilerge selishturghanda azlap ketkenliki
bayqalghan.

Nature 444, 1022-1023 (21 December 2006) |
doi:10.1038/4441022a; Received 8 October 2006;
Accepted 10 November 2006; Published online 21
December 2006

Microbial ecology: Human gut microbes associated with
obesity

Ruth E. Ley1, Peter J. Turnbaugh1, Samuel Klein1 and
Jeffrey I. Gordon1

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Abstract
Two groups of beneficial bacteria are dominant in the
human gut, the Bacteroidetes and the Firmicutes. Here
we show that the relative proportion of Bacteroidetes
is decreased in obese people by comparison with lean
people, and that this proportion increases with weight
loss on two types of low-calorie diet. Our findings
indicate that obesity has a microbial component, which
might have potential therapeutic implications.

Trillions of microbes live in the human gut, helping
to break down otherwise indigestible foods1.
Transplanting the gut microbiota from normal mice into
germ-free recipients increases their body fat without
any increase in food consumption2, raising the
possibility that the composition of the microbial
community in the gut affects the amount of energy
extracted from the diet2.

The relative abundance of the two predominant
bacterial divisions (deep evolutionary lineages or
superkingdoms) in mice differs between lean and obese
animals: mice that are genetically obese (ob/ob) have
50% fewer Bacteroidetes, and correspondingly more
Firmicutes, than their lean (+/+) siblings3. In an
accompanying Article4, we show that the gut microbiota
in these ob/ob mice are more effective at releasing
calories from food during digestion than are the +/+
microbiota: this trait is transmissible to germ-free
recipients, resulting in greater adiposity.

To investigate the relation between gut microbial
ecology and body fat in humans, we studied 12 obese
people, who were randomly assigned to either a
fat-restricted (FAT-R) or to a carbohydrate-restricted
(CARB-R) low-calorie diet. The composition of their
gut microbiota was monitored over the course of 1 year
by sequencing 16S ribosomal RNA genes from stool
samples (for details, see supplementary information).
more.....
http://www.nature.com/nature/journal/v444/n7122/full/4441022a.html

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Dr. Ahmad Abliz
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School of Math, Physics, and Informatics

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