From: DailyQuestion@...

Date: November 27, 2008 6:05:38 AM EST

To: glennskow@...

Subject: EMedHome Question of the Day

The EMedHome Question of the Day is:

The diagnosis of herpes zoster is based on clinical presentation. The primary differential diagnosis is zosteriform herpes simplex virus infection.  How does the clinician differentiate the two?

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The Answer is:

Herpes simplex infection tends to produce a shorter and milder prodrome, followed by skin vesicles that are more uniform, smaller, and closely clustered. Herpes simplex is also more likely to be recurrent (Mayo Clin Proc, Vo. 79, pg. 1057).


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