From: ClinicalPearl@...
Date: April 8, 2009 10:50:33 AM EDT
To: glennskow@...
Subject: EMedHome Clinical Pearl

The New EMedHome Clinical Pearl is: The Safety of Metronidazole in Pregnancy

The Safety of Metronidazole in Pregnancy

The issue of the safety of metronidazole in pregnancy regularly comes up in EM practice.  This has been the subject of some controversy in past years.  In fact, there currently is no evidence to suggest that metronidazole places a pregnancy at risk at any stage. For some conditions, metronidazole is the only drug of choice and it is especially important to treat vaginal infections during pregnancy. Untreated infections such as bacterial vaginosis and trichomonas have been associated with miscarriages and preterm labor.

Below are two references to keep handy should this debate arise again in your ED.

References:
(1) Organization of Teratology Information Specialists
(2) Sorensen HT, et al.  Safety of metronidazole during pregnancy: a cohort study of risk of congenital abnormalities, preterm delivery and low birth weight in 124 women J Antimicrob Chemother 1999; 44: 854-855.

 

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