Metformin does NOT stimultate insulin secretion, is not
a sugar, and does not turn into a sugar. It is a hydrochloride.

Metformin improves glucose tolerance in patients with
type 2 diabetes, lowering basal and postprandial plasma
glucose. It works in a way different from other oral
antihyperglycemic meds. Metformin decreases hepatic
glucose production, decreases intestinal absorption of
glucose, and improves insulin sensitivity by increasing
peripheral glucose uptake and utilization.

Unlike sulfonylureas, metformin does not produce
hypoglycemia in either patients with type 2 diabetes or
normal subjects and does not cause hyperinsulinemia.

With metformin therapy, insulin secretion remains unchanged
while fasting insulin levels and day-long plasma insulin
response may actually decrease. I think Metformin is one
of the better and safer drugs out there.

Ellis wrote: In any case, it would be rather Machiavellic,
wouldn't it, to give diabetics SUGAR to stimulate a release
of insulin?

Ellis, you must be aware that your statement above is the
norm, not the exception in the pharmaceutical business.

Pharmacy companies are extremely Machiavellian. That is,
the pharmaceutical industry will trade harm for profits
in a heartbeat, and have for decades with eyes wide open.

It's all a matter of how far they can push that formula before
there is a sufficient backlash to take a drug off the market
or change research transparency so that people know what is
going on (ie: Vioxx, Celebrex, etc, etc).

Drug companies do not see you as their friend, they see you as
a consumer, pure and simple. No different in any aspect than
a tobacco company.

I'm a former employee who worked in the research labs and
clinical studies units at the Eli Lilly world headquarters
in Indianapolis. The last thing one wants to do is be
'Pollyannish' about drug companies. That is, if you want a
realistic viewpoint.

ltkpn wrote:

Ellis, Metformin is definitely not sugar! I don't know where
you got that information.

There's not even 6 carbon atoms in one molecule of metformin,
while glucose has a 6 carbon cycle.

See, metformin's chemical formula here:

http://www.rxlist.com/cgi/generic/metformi.htm

= ltkpn

[Hello ltkpn... well... as I said... I was guessing... but I
will tell you why this occurred to me... As I wrote, I bought a
1985 edition of "Joslin: Diabetes Mellitus"... There is a
chart of the "best" secretagogues for insulin release...
I was surprised to find the word "secretagogue" used for insulin
release, as until now I had only found it used to refer to HGH
release... but here it is in a 1985 diabetes textbook for doctors.

It says at the top of the chart: "Metabolism and Insulin Release
with combinations of Glucose and Fructose" and then it has
different combinations of Glucose and Fructose "stimulus
combination" and then the results. The "combination" that
worked the "best" was 8 parts glucose, 27.5 parts fructose
which is why I decided I would even bet metformin is two parts
glucose to seven parts fructose.

In any case, it would be rather Machiavellic, wouldn't it, to
give diabetics SUGAR to stimulate a release of insulin? I
thought to myself that would be just like an unscrupulous
person or company, to sell diabetics a little poison and claim
it is good for them. It would definitely stimulate the release
of insulin, so I thought to myself: why didn't I think of this
before?

So, ltkpn, if metformin isn't sugar then what IS metformin?
And how and why does it cause release of insulin? Is it possible
that once it combines with water in the intestines it forms
sugar? Because "sugar" or glucose is definitely what stimulates
the pancreas to release insulin.

In any case, I am against stimulating the pancreas to release
insulin, since I don't think that is very wise. I am trying to
prevent my pancreas from overworking on the theory that I might
be extending its life by keeping it still if I can inject the
right amount of insulin at the proper time.

It would really be extra-cruel to give diabetics "Glucophage" if
it is or becomes a type of sugar, wouldn't it? Please set my mind
at ease and tell me how you would describe metformin, does it even
look like a type of sugar or carbohydrate minus water to you?

(I can read that chemical structure in the link you give us, but I
don't know enough about the structure of sugar or carbohydrates, or
what becomes when you add water to metformin... I know that
carbohydrates means: "carbon plus water..." Would "metformin
hydrochloride plus water" give you "carbon plus water"?

- Ellis ]



Ellis wrote:

> Do you know what metformin IS??? Surprise! Read my next post,
> coming soon. Again, I am guessing, but: metformin is SUGAR!!!
>
> Pure, unadulterated GLUCOSE + FRUCTOSE, which is 100%
> SUGAR in my book... I will even bet it is two parts Glucose
> to seven parts Fructose! (I'll tell you soon how I reached
> this conclusion, in a different post....)








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Message: 2
Date: Tue, 31 May 2005 12:29:48 -0800
From: Stuart Cracraft
Subject: Meter?

Is there a workable blood glucose monitoring meter that does not
require blood or urine collection, keeps a record, and can handle
both very high and very low levels?

[Man, you want everything, don't you? You forgot to say, cheap
too.

Let me see... keeps a record, no problem... very high and very
low levels, I suppose that's possible... but that does not
require blood or urine collection... that's more difficult...

The only way to get the reading would have to be through the skin,
since what you want is to know how much sugar is in the blood,
but you don't want to know it by measuring the blood... There
might be some way to tell if there is sugar in the blood by
measuring electrical resistance through the skin, but I can only
imagine it would be less accurate than by testing a tiny drop of
blood directly.

Another problem is that the results might not be similar to what
I and most other people are getting, which is with a Roche Accucheck
meter or a Johnson and Johnson meter, and even these don't give the
same results... so you would have a really hard time interpreting
your results.

There are some sensors, like a watch that is strapped tightly
to the wrist, and it senses when a diabetic is hypoglycemic and
sounds an alarm. These are a lot more expensive than a glucose
meter, and I understand they have to be really tight so that the
plate makes contact with the skin, and it irritates some people.

But they just sense really low blood glucose and then they sound
an alarm. I don"t think that they are to the point where they
can give you an accurate reading, nor is that the intention...
they are meant to prevent death from hypoglycemia, especially at
night when the person is sleeping and you can"t tell that he is
actually unconscious and going through a crisis.

Does anybody know if there is a blood glucose monitoring meter
that is accurate and does not require blood or urine?

Thanks for writing... Why do you want a meter that doesn"t
work with blood?
- Ellis]





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Message: 3
Date: Tue, 31 May 2005 20:11:32 -0000
From: "gfosmo"
Subject: Re: How to counter the 'HGH is asking for diabetes' argument?

I was thinking the same thing, that he was in a very controlled
environment. He thought that the theory was that it makes you more
sensitive to insulin. He was more in it for the money at that
time.

I'm trying to talk him into trying HGH again and see if he gets
the same results outside of a controlled experiment.

[O.K... let us know what happens, if he tries it. - Ellis]


--- In Rejuvenation@yahoogroups.com, "gfosmo" wrote:
> My brother is diabetic and was enrolled in a clinical trial about
> a year ago to test whether HGH would reduce insulin needs.
> He told me they attached an automatic pump to him that would
> inject a certain amount of HGH everytime his bloodsugar started
> rising.
>
> This was the Phase One part of the trial where he had to stay at
> the facility for two weeks so they could monitor everything
> constantly and he got paid.
>
> He said it lowered his insulin usage down to almost nothing.
>
> Other then that he said he has never heard anything else about
> it.
>
> [Thatīs very interesting... I donīt see that lowering insulin
> needs is very important, I see that lowering blood glucose levels
> is more important, and I suppose that the way to lower insulin
> needs is to lower blood glucose... but it is interesting anyways,
> to see that by injecting HGH his insulin usage was lowered to
> "almost nothing".
>
> I wonder why that happened? It shouldnīt be related... Maybe it
> happened in part because he was forced to stay in the facility for
> two weeks so they could monitor everything constantly, thus he
> didnīt eat the bad food that he otherwise might have eaten?
>
> Whatever, I suppose their report will be that HGH helped to bring
> down the need for insulin, which I think might be a mistake...
>
> But the message of their report will be the right message: that
> GH does not cause an increase in the need for insulin.
>
> As we say in Mexico, the Lord works in mysterious ways. I donīt
> think HGH lowers the need for insulin, but if that is what they
> will say in their report, I will agree with them.
>
> Thanks for sending us this. - Ellis]
>
>





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Message: 4
Date: Tue, 31 May 2005 16:27:10 -0700 (PDT)
From: "cathy.digitalfashion"
Subject: Can anyone recommend a compounding Pharmacy for Testosterone Gel/cream?

My doctor wrote my husband a prescription for Androgel
5% but it costs $225 for a months supply, I heard it
is much less expensive from compounding pharmacist,
can anyone recommend one?

Thanks,



Cathy Smith


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