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Thursday, May 13, 2004 - 11:45 AM
5034
Reproducible Prolonged Myalgia Syndrome (RPMS) Following Multiple
Anthrax Vaccinations: Draft of A New Rare Adverse Event Case
Definition Developed by The Vaccine Healthcare Centers (VHC) Network
Renata Engler1, Jeanette Williams2, Limone C. Collins2, and Michael
R. Nelson2. (1) Allergy-Immunology Department, Walter Reed Army
MEdical Center - US Army, 6900 Georgia Ave, NW, Washington, DC, USA,
(2) Walter Reed Vaccine Healthcare Center, US government, 6900
Georgia Ave, NW, Washington, DC, USA
BACKGROUND:
The Vaccine Healthcare Centers Network is a Department of Defense
(DoD) new medical advance developed in response to increasing
concerns about rare adverse events temporally linked with mandatory
vaccines and the need to provide clinical support services for
persistent or more severe adverse events. Myalgias and body aches
with varying features of fatigue and arthralgias (without any
evidence of joint inflammation or stiffness) are a common side
effects reported following routine vaccination. The symptoms are
generally of short duration resolving in a few days and responding to
over-the-counter analgesics. A small percent of vaccinees develop
more severe or prolonged symptoms raising concerns about the safety
of continued vaccination in a series.
OBJECTIVE:
To present a draft vaccine adverse event case definition from a
vaccine safety clinical case review program focusing on a subset of
patients who experienced reproducible prolonged myalgia syndrome
following multiple doses of anthrax vaccination.
METHOD:
The VHC Network provides clinical expert consultations and case
management services for DoD beneficiaries who experience adverse
events that are more severe and/or prolonged than expected side
effects. A systematic review process to identify patients with
adverse events identified the cluster of patients described.
RESULT:
Five cases (male, age range 29 to 52 years, 3 Caucasian, 2 African
Americans) who had received 19 doses of anthrax vaccine are described
to include details of an informed consent re-challenge that resulted
in symptoms lasting more than 4 months and responding to
corticosteroid therapy.
CONCLUSION:
Prolonged and more severe myalgias, arthralgias and fatigue,
particularly when recurring and worsening with each subsequent dose
of a vaccine, results in fear of long term disability. Further
studies are needed to improve understanding of this syndrome with a
focus on prevention and treatment.
LEARNING OBJECTIVES:
To understand the post anthrax vaccine clinical presentation of
prolonged and more severe myalgias.
* Recorded presentation
See more of The Military Experience with Vaccine Safety
See more of The 38th National Immunization Conference
[Non-text portions of this message have been removed]
Our Anthrax information web site: http://www.dallasnw.quik.com/cyberella/
http://groups.yahoo.com/group/Anthrax-no/files/VAERS.pdf
DESTROY QUARANTINED VACCINE:
http://www.PetitionOnline.com/mod_perl/signed.cgi?robi2662&1
PETITION TO OVERTURN/REPEAL FERES DOCTRINE
http://www.petitiononline.com/fd1950/petition.html
To visit Dr. Meryl Nass's web site, go to: http://www.anthraxvaccine.org
Also visit: Anthrax Vaccine Benefit vs Risk: http://www.avip2001.net AND
http://www.MajorBates.com/
Anthrax Vaccine Network http://www.ngwrc.org/anthrax/default.asp
Sgt. Sandra Larson's story:
http://www.ngwrc.org/anthrax/heroes/sandralarson.htm
http://www.avip2001.net/CongressionalTestimony.htm
Tom Heemstra's new book -
http://www.anthraxadeadlyshotinthedark.com/index.html
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