[Non-text portions of this message have been removed]

YOU SHOULDN,T BELIEVE EVERYTHING YOU HERE.

Relax ......and take a laxative! It will all be ok.

Most scientists don,t see the danger that you do.






--- Sama <samasama@...> wrote:
>
>     ----- Original Message -----
>     From: Iman Badawi
>     To: A7fad_Mo7amed@yahoogroups.com ;
> ahmad_islam@yahoogroups.com ;
> Al-3eraq@yahoogroups.com ;
> Al-Awda-Egypt@yahoogroups.com ;
>     Sent: Friday, February 27, 2004 3:01 PM
>     Subject: [agamy] A Must Read on Depleted
> Uranium/خطير جدا عن اليورانيوم المستنفذ اقرأ ووزع
>
>
>     English Text Follows. Please, circulate Widley.
> Thanks.
>
>     السلام عليكم
>     رسالة غاية فى الاهمية ارسلها احد الاميركان
> للمجموعة وفيها وصلات بمواضيع  خطيرة عن اليورانيوم
> المستنفذ التى استخدمه التحالف فى العراق  و الاميركان
> فى افغانستان و اضرارة البالغة الممتدة الاثر لعشرات
> السنين على الحياة و الانسان  فى العراق  و افغانستان،
>
>     من فضلك ارسلها لكل من تعرف خاصة فى الدول
> الاجنبية لكى يعلموا من هم الارهابيين بحق، و من هم
> اعداء الحياة ،و الذين يرتكبون جرائم ضد الانسانية
>     وهذا ليس فقط ضد اخوتنا المدنيين فى العراق و
> افغانستان فقط و لكن ايضا ضد جنودهم المتواجدين فى هذة
> المناطق، و لكى يعرفوا اخبار حكوماتهم الكاذبة
> الارهابية المنحطة
>     ايمان بدوى
>
>
>     May Bush and his neo-con backers all burn in
> Hell for their lies and despicable deceit.
>
>     Amen
>
>     Please, everyone send this message to all your
> friends, let them know what the US govt., Bush and
> his gang is doing to others and to your sons there
>     in Iraq. Ask them to let Bush and his gang  send
> their kids as well there in Iraq to smell and
> absorbe some Uranium too.
>
>
>     Here are a few really powerful links to what the
> US and coalition forces are doing in order to win in
> Iraq, and win at all cost. May Bush and his neo-con
> backers all burn in Hell for their lies and
> despicable deceit. If these are not war crimes I for
> one have no idea what could constitute a war crime.
> May we one day wake up and see ourselves for what we
> really are. God forgive us for we allow our
> government to make war on lies an deceit.
>
>     Burnie.
>      ***
>
>     WHO 'suppressed' scientific study into depleted
> uranium cancer fears in Iraq :
>
>     Radiation experts warn in unpublished report
> that DU weapons used by Allies in Gulf war pose
> long-term health risk
>
>
http://www.informationclearinghouse.info/article5749.htm
>
>     ===
>
>     Effects Of War And The Use Of Depleted Uranium
> On Iraq:
>
>     According to a report from the Guardian
> newspaper 1000-2000 tons were delivered on 51 local
> areas in different Iraqi cities. I witnessed the
> A-10 planes for three days delivering the depleted
> uranium rounds against the tanks and armor vehicles
> near Basrah airport and at the southern parts of
> Basrah city.
>
> http://www.traprockpeace.org/jawad_al-ali_iraq.html
>
>     ===
>
>     Depleted Uranium: The War Crime That Has No End:
>
>
>     "Depleted uranium is a crime against God and
> humanity." Dr. Doug Rokke, U.S. Army health
> physicist
>
> http://www.unobserver.com/layout5.php?id=1462&blz=1
>
>
>     *****************************************
>
>     Depleted Uranium
>     http://www.bringthemhomenow.org/stand/du.html
>
>
>
>
>     نرجو منك أخي أن تنشر هذه الرسالة إلى كل من تعرف،
> حتى تكسب الثواب من الله تعالى.. ونرجو منك أن تدعو كل
> من تعرف للانضمام لمجموعتنا وذلك بأن يرسلوا رسالة
> فارغة إلى هذا العنوان:
>     agamy-subscribe@yahoogroups.com
>     ويجب التنبيه على أن من سيرسل هذه الرسالة سيصله
> تأكيد، عليه أن يعيده كما هو فيصبح بإذن الله عضوا في
> مجموعتنا..
>     وأخيرا جزاكم الله خيرا.. وشكرا..
>     أخوكم:
>     ط. أحمد رشدي العجمي
>
>
>
>
----------------------------------------------------------------------------
>     Yahoo! Groups Links
>
>       a.. To visit your group on the web, go to:
>       http://groups.yahoo.com/group/agamy/
>
>       b.. To unsubscribe from this group, send an
> email to:
>       agamy-unsubscribe@yahoogroups.com
>
>       c.. Your use of Yahoo! Groups is subject to
> the Yahoo! Terms of Service.
>
>
>
>
>
>
> [Non-text portions of this message have been
> removed]
>
>
>
>
> Yahoo! Groups Links
>
>
>      LIMU_MOUI-unsubscribe@yahoogroups.com
>
>
>


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Sharing What Physicians Are Saying

Dr. Kyosuke Owa on Fucoidan
In research studies, the main health enhancing
ingredient in
ROYAL TONGAN LIMUT, Fucoidan, has been shown to
have many
healthful benefits.

According to prominent Japanese researcher Dr.
Kyosuke Owa,
Fucoidan is said to
"Contain the same healing antibodies as mother's
milk,
providing essential amino acids and a balanced diet
of
minerals necessary to boost the immune system."
"Encourage the regeneration of new cells,
increasing cellular
immunity and giving the body additional 'firepower'
against
diseases."
"Not only aids in the development of new cells, but
it
encourages the regeneration of what are called
Natural Killer
Cells. These cells are found on the front lines
defending our
bodies from disease."

For centuries, the people of Tonga have benefited
from the
amazing health properties of Limu Moui. Now, thanks
to Dr.
Owa's extensive research on Fucoidan, it becomes
clear why it
is our mission to share ROYAL TONGAN LIMUT with the
world.

Dr. Derrick M. DeSilva, Jr., M.D.
Nationally recognized as an expert in the vital
area of
nutrition as it relates to health, Dr. DeSilva
maintains that
disease is caused by nutrient deficiency brought on
by such
factors as poor diets, depleted nutrients in food,
dieting,
medications, oxidation and stress.
Because Limu Moui, the key ingredient in ROYAL
TONGAN LIMUT,
absorbs a rich bounty of 77+ nutrients from
pristine ocean
waters, Dr. DeSilva truly believes that it's
the "PERFECT
FOOD."

Dr. DeSilva believes ROYAL TONGAN LIMUT works
because:
Its main ingredient Limu Moui is the "perfect
food" because
it absorbs a rich bounty of some 77 + nutrients
from
pristine ocean waters.


Limu Moui replaces nutrients lost from all the
different
causes of deficiency.


Oxidation, which is like rusting, is a cause of
disease.
Think about the last time you cut an apple. It
starts to
turn brown from oxidation...but if you pour ROYAL
TONGAN
LIMUT on it, it will NOT turn brown!


INTESTINES: 60% of our immune system resides in
our
intestine and 80% to 90% of those who suffer from
intestinal
problems also have allergies. So, if you "fix"
your
digestive system, you help "fix" your immune
system. Limu
Moui is very beneficial to the digestive system.


CHOLESTEROL: Cholesterol is made in the liver, so
if you can
keep the liver clean it will help with
cholesterol. Limu
Moui helps the liver.


CANCER: Limu Moui may make cancer cells pop (self-
destruct)
and stop cell division. Harvard School of Public
health
says: "Fucoidan in Limu Moui reduces plasmal
cholesterol and
the building of dangerous steroids to breast
tissue." Also,
chlorine in water has been attributed to breast
cancer. Limu
Moui contains substances like Magnesium and
Calcium, which
help dispel effects of chlorine.


BLOOD SUGAR: Fucoidan coats the GI system to
prevent
problems.


ARTHRITIS: Limu Moui lubricates joints to make
them more
flexible and thereby eliminating pain of
arthritis, etc.


MOOD DISORDERS: Mood disorders are affected by
essential
fatty acid deficiency, which is replenished by
Limu Moui.
Dr. DeSilva recommends for ADD/ADHD kids to take
them off
carbohydrates, sugar, processed foods and Ritelin
and put
them on ROYAL TONGAN LIMUT!


BLOOD PRESSURE: Limu Moui addresses all three
areas that
affect blood pressure, for which people normally
have to
take different medications.


HEADACHES: No one should suffer from headaches
and ROYAL
TONGAN LIMUT has the properties to address them,
along with
an increased intake of water.




According to Dr. DeSilva, the people who should
use ROYAL
TONGAN LIMUT include:
Every one of us


Anyone on Medication


Anyone who eats poorly


Anyone under stress


Anyone who wants to feel better


ANYONE WHO IS BREATHING!

For more information call:
Bill Sullivan 501-690-2948
             or visit
http://www.royaltonganlimu.com/  TODAY

USE MY ID PLEASE, 45788301

Ann Plast Surg 2001 Nov;47(5):540-6 Related Articles, Books, LinkOut


Protective effect of fucoidin (a neutrophil rolling inhibitor) on ischemia
reperfusion injury: experimental study in rat epigastric island flaps.

Cetin C, Kose AA, Aral E, Colak O, Ercel C, Karabagli Y, Alatas O, Eker A.

Department of Plastic & Reconstructive Surgery, Osmangazi University Medical
Faculty, Eskisehir, Turkey.

The objective of this study was to examine whether a decrease in
neutrophil-mediated tissue injury using Fucoidin, a nontoxic neutrophil rolling
inhibitor, would improve flap survival in an island flap model after
ischemia-reperfusion. Myeloperoxidase activity (an indirect index of tissue
neutrophil count) and malondialdehyde (an indicator of lipid peroxidation), the
degree of neutrophil infiltration by direct counting, and macroscopic flap
survival were assessed in the flap after arterial ischemia-reperfusion.
Epigastric island skin flaps were elevated in 56 rats. The first group of 21
rats was subjected to 6 hours of arterial ischemia. The second group of 21 rats
was subjected to 10 hours of arterial ischemia, and the rest of the rats were
used as nonischemic controls (sham flaps). For inhibiting neutrophil rolling, a
nontoxic polysaccharide agent-Fucoidin-was used. Each ischemic group was divided
further into three subgroups: Subgroup I (control rats) received saline,
subgroup II received 10 mg per kilogram Fucoidin, and subgroup III received 25
mg per kilogram Fucoidin before reperfusion. The results were evaluated as
tissue neutrophil counts, tissue malondialdehyde content, tissue myeloperoxidase
activity, and flap survival. Neutrophil counts and tissue myeloperoxidase
activity were decreased significantly (p <0.001) in subgroup III, but lipid
peroxidation by means of tissue malondialdehyde content was not affected by
Fucoidin administration. The authors conclude that administration of Fucoidin
before reperfusion can limit tissue injury apparently by inhibiting neutrophil
rolling in a dose-dependent manner.

PMID: 11716267 [PubMed - indexed for MEDLINE]

Hear Powerful Testimonies
Like These Every Monday Evening 8:30PM CST TOLL FREE 212-990-8000   6688#


Since my pregnancy, 2 years ago, I suffered from daily migraines. My doctors
thought these were due to hormonal changes and could only recommend pain
medication. Of course, I could not risk harm to my unborn baby by taking it. But
16 months after my son, Zachary's birth, the headaches were no better. It was
hard for Zachary to understand why mommy didn't want to do anything but lay on
the couch some days. After taking Limu Moui for 1 day, my headache was gone!
Zachary and I have so much more fun now. I will even take it during my next
pregnancy. I want to tell everyone I come into contact with about Limu Moui
because it has changed my life!
Chastity T., Cordova, TN

I am 42 years old and was diagnosed with Multiple Sclerosis in 1998. I
experienced episodes of weakness and progression of the disease. I went through
physical therapy and medications, feeling better at times and then another
episode would leave me feeling weak and numb. The last episode was so fast and
progressive that I became wheelchair bound, weak and with no feeling from the
waist down. I could not even hold my grandbaby. I was never this debilitated
before and was convinced I would die. On May 8th, I started taking about 2
tablespoons of Limu Moui, twice a day, and within one month, I was out of the
wheelchair and walking without a brace or cane. I even resumed my housework and
cooking supper. Next week, I intend to start driving again. I feel generally
good and have an increase in energy. My physical therapist commented that he'd
never seen anyone progress so quickly from how debilitated I was. I will never
be without Limu Moui!
Theresa C., Dequincy, LA

My husband, who is in construction, is exposed to the elements 8 to 10 hours a
day and suffered from constant sinus headaches. After taking Limu Moui, he
rarely suffers at all now! In addition, my pain from carpal tunnel syndrome in
my right arm and a bulging disc in my back are gone. I no longer need the brace
for my arm and I can sleep so much better at night. Limu Moui is a blessing to
the entire world!
LeJoyce A., Arcadia, LA

I have had severe fever blisters, caused by Herpes virus, on my lower lip for as
long as I can remember. These typically begin with a tingling sensation in a
small area and progress until 1/4 to 1/2 of my lower lip is swollen, red, and
bleeding. Ultimately, the lesion becomes painful throughout the typical 3 to
5-week duration and is quite unsightly and embarrassing. Upon feeling the
familiar sensation begin, I immediately applied Limu Moui directly onto the
emerging blister to see what would happen. After 4 days of applying it twice a
day, the blister was going away and never surfaced! I was amazed, as I have
never experienced this quick of a recovery from this repulsive ailment.
Mark K. Springfield, MO

I am 39 and have had asthma most of my life, starting as a small child and
becoming worse in my early 20's. Though detrimental to my internal organs, I've
used 3 different steroid based medications twice a day to keep this disease
under control and have visited the emergency room 3 times over the last 15
years. Since the day I started taking Limu Moui, I have not used any
prescription medication and I can breathe! I can now have a normal life. This is
a gift from above and it is now my duty to share my blessing!
Gary R., Sedro Woolley, WA

I have had ulcers since I was 15 years old and inflammation of the stomach
lining most of my adult life. Because of extreme heartburn, I had to take Zantac
with every meal and sometimes even between meals. Since I started taking Limu
Moui, I have not had to take Zantac. In additional, my energy level and general
well being have dramatically improved.
Nileen B., Sedro Wooley, WA

I have been on Avapro and Toprol, blood pressure medication since my open heart
surgery a year ago. My blood pressure still remained at around 179/100 or
179/120. The lowest it had ever reached was 158/90. With my doctor's approval, I
started taking 2 tablespoons per day of Limu Moui. After the second day on the
product, my blood pressure dropped to 116/66 and my doctor cut my medication
dosage in half. Three days later, he took me off Avapro completely and reduced
my dosage of Toprol even more and will take me off it completely in 2 more days.
My blood pressure has stayed consistently between 116/66 and 118/66. I am no
longer sleepy, have more energy, feel calmer, my head is clearer and my heart no
longer pounds. I will never stop taking Limu Moui and it's just a matter of time
before my doctor is in the business!
Phil R., Minden, LA

I've had rheumatoid arthritis since 1980 and in spite of having tried every kind
of medication imaginable--from Gold injections and steroids, to Methotrexate and
Remicade -- I still had to live with many physical limitations. These included
being unable to turn the car keys, raise my arms over my head, get up and down
from a sitting position, morning stiffness, low energy and little to no strength
in my hands and wrists. I began to see results after 1 week on Limu Moui and it
has continued ever since. Recently I spent 3 days, rolling paint up to the
ceiling and wallpapering. I also mowed an acre of land for 2-1/2 hours with a
tractor that has no power steering. Not only was I not sore the next day, I
drove into the city and took a CPR and First Aid Class. I'm doing things I have
not done in 15 years.
Nancy O'C., Pleasant Hill, MO

Our 6-year old daughter, Christina, has had breathing problems since the day she
was born. Ever since a near death experience when she was 6 weeks old, she has
had to use a Breathalyzer on many occasions. Recently, we had to cut a weekend
trip short and return home due to the breathing problems Christina was having
from the high spring time pollen content. We decided to try Limu Moui because
the traditional medications she was taking were not clearing her up completely.
After 4 days, all signs of Christina's pneumonia were gone and all her other
symptoms cleared up, as well. Our whole family is now on the product and we have
noticed many other benefits, after approximately 4 days of use.
David L., Shreveport, LA

I suffered from fibromyalgia and chronic fatigue syndrome, both causing constant
pain, especially after any kind of strenuous exertion, or when the weather
changed. I was taking at least 6 Ibuprofen a day and 2 or 3 Tylenol PM for pain
and to sleep at night. After 2 weeks on Limu Moui, I am not taking either one of
those medications, and my pain during the day has all but disappeared, my energy
level is "out the roof" and I am sleeping very well at night.
Rebecca S., Oak Ridge, LA

My father-in-law has diabetes, which was out of control. He had been taking oral
medication, but when his blood sugar level reached between 200 and 350, the
doctor had put him on insulin shots. His first week on Limu Moui, he took 2
tablespoons, 2 times a day. The second week, he increased it to 2 tablespoons, 3
times a day. After checking his blood sugar level, he found it had dropped to
140 and remains between 150 and 160.
Jeff B., Liberty, TX

I have had chronic sleep problems for the past 20 years and have spent many
hours tossing and turning and staring at the ceiling till daybreak. I chose to
get off the prescription medication my doctor prescribed years ago and no over
the counter aids helped. After hearing friends and family say they were sleeping
better at night because of Limu Moui I began taking it. After 3 nights, I
noticed a total change in my sleeping. What a joy it is to wake up and find it's
morning! I feel rested during the day and feel a sense of well being and
happiness from the product. Limu Moui is a real blessing!
Sally H., Heflin, LA

My health issues included allergy and sinus problems for which I had to take
medication, including a 12-hour nasal spray, every 3 to 4 hours. In addition, I
was taking Prilosec for a severe problem with indigestion and heartburn, which I
experienced with even one bit of any kind of food. After just 3 days on Limu
Moui, my allergies and sinus problems were gone and I was able to get a good
night's sleep, without any medication. I am also completely off the Prilosec and
have no more indigestion symptoms. I have not felt better in a long time!
Alton W., Oake Grove, LA

For 13 years, my daughter has been suffering from asthma and a chronic cough
every night. After 5 days on Limu Moui, I noticed she was not coughing at night.
For the last 46 days, she has not coughed, wheezed, or had to use the inhaler!
The product has been a blessing to her and she will take it for the rest of her
life!
Bonita W., Sugarland, TX

I am legally blind due to diabetes and I suffer from congestive heart failure. I
have had several heart attacks and 4 angioplasty surgeries. I also have
shortness of breath, poor circulation, bad lungs, poor kidney control and sleep
apnea, to name a few of my ailments. My blood sugar ranged from 200-450,
sometimes even higher. I was about to start kidney dialysis because of the
kidney failure. After taking Limu Moui for 3 days, I felt noticeably improved.
My blood sugar has dropped to between 130 and 170, I am able to get up without
aid, and am much more active. Before, I could barely walk 50 feet, from the
house to the mailbox, and now, I have been walking 7 blocks at a time. In
addition, I have more energy, less shortness of breath and control of my
kidneys. I have done nothing different from before, except take Limu Moui.
Edward W., Cullman, AL

I was in extreme pain following knee replacement surgery in January and physical
therapy was an excruciating experience. Twice a day, I had to take 200-500 mg of
Extra Strength Tylenol, 250 mg of Ultram and 50 mg of Percoset, totaling 2300 mg
of pain medication, daily. I began taking Limu Moui on March 31, 2001 and 4
weeks later, the last week in April, I began to notice that my pain was almost
gone. Consequently, I stopped taking all pain medication, except one 50 mg
tablet of Ultram at bedtime. Even though physical therapy is still painful, I
find that my pain subsides about 30 minutes after taking Limu Moui.
Robert W., Springfield, MO

I was plagued with year round sinus related problems, including infection,
bronchitis and laryngitis, especially in the spring and fall. This would deplete
my energy and wellness and cause me to miss work as a sign language interpreter,
causing hardship on my colleagues and deaf students, who depended on me. For
years, I tried medications, nasal sprays and herbal remedies. Within 3 days of
using Limu Moui, I was able to breathe freely and now take no medication.
Vicki W., Springfield, MO

Experientia 1989 Oct 15;45(10):996-8 Related Articles, Books, LinkOut


Further characterization of sulfated homopolysaccharides as anti-HIV agents.

Sugawara I, Itoh W, Kimura S, Mori S, Shimada K.

Department of Pathology, University of Tokyo, Japan.

Fucoidan and dextran sulfate showed anti-HIV activities against mononuclear
cells from AIDS patients, and they abrogated HIV reverse transcriptase (RT)
activity by interacting with the HIV envelope in the membranes of target cells.
Furthermore, they showed a synergistic effect with azidothymidine (AZT).

PMID: 2478388 [PubMed - indexed for MEDLINE




Phytomedicine 1999 Nov;6(5):335-40 Related Articles, Books, LinkOut


Antiviral properties of fucoidan fractions from Leathesia difformis.

Feldman SC, Reynaldi S, Stortz CA, Cerezo AS, Damont EB.

Departamento de Quimica Organica-CIHIDECAR, Facultad de Ciencias Exactas y
Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Argentina.

Three fractions of fucoidans isolated from the brown seaweed Leathesia difformis
(Ee, Ec and Ea) were found to be selective antiviral agents against herpes
simplex virus (HSV) types 1 and 2 and human cytomegalovirus. Fraction Ea was the
most active, with IC50 values in the range 0.5-1.9 microg/ml without affecting
cell viability at concentrations up to 400 microg/ml. The antiherpetic activity
of Ea was assessed by three different methods, plaque reduction, inhibition of
virus yield and prevention of HSV-2 induced shut-off of cell protein synthesis,
demonstrating that the inhibitory effect was independent of the antiviral assay
and the multiplicity of infection. The mode of action of Ea could be ascribed to
an inhibitory action on virus adsorption. The fucoidans did not inhibit the
blood coagulation process even at concentrations exceeding more than 100 times
the IC50 value.

PMID: 11962540 [PubMed - indexed for MEDLINE]




Gen Pharmacol 1997 Oct;29(4):497-511 Related Articles, Books, LinkOut


Sulfated polysaccharides extracted from sea algae as potential antiviral drugs.

Witvrouw M, De Clercq E.

Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium.

The inhibitory effects of polyanionic substances on the replication of herpes
simplex virus (HSV) and other viruses were reported almost four decades ago.
However, these observations did not generate much interest, because the
antiviral action of the compounds was considered to be largely nonspecific.
Shortly after the identification of human immunodeficiency virus (HIV) as the
causative agent of the acquired immune deficiency syndrome (AIDS) in 1984,
heparin and other sulfated polysaccharides were found to be potent and selective
inhibitors of HIV-1 replication in cell culture. Since 1988, the activity
spectrum of the sulfated polysaccharides has been shown to extend to various
enveloped viruses, including viruses that emerge as opportunistic pathogens
(e.g., herpes simplex virus [HSV] and cytomegalovirus [CMV]) in immunosuppressed
(e.g., AIDS) patients. As potential anti-HIV drug candidates, sulfated
polysaccharides offer a number of promising features. They are able to block HIV
replication in cell culture at concentrations as low as 0.1 to 0.01 microgram
ml-1 without toxicity to the host cells at concentrations up to 2.5 mg ml-1. We
noted that some polysulfates show a differential inhibitory activity against
different HIV strains, suggesting that marked differences exist in the target
molecules with which polysulfates interact. They not only inhibit the cytopathic
effect of HIV, but also prevent HIV-induced syncytium (giant cell) formation.
Furthermore, experiments carried out with dextran sulfate samples of increasing
molecular weight and with sulfated cyclodextrins of different degrees of
sulfation have shown that antiviral activity increases with increasing molecular
weight and degree of sulfation. A sugar backbone is not strictly needed for the
anti-HIV activity of polysulfates because sulfated polymers composed of a
carbon-carbon backbone have also proved to be highly efficient anti-HIV agents
in vitro. Other, yet to be defined, structural features may also play an
important role. Sulfated polysaccharides may act synergistically with other
anti-HIV drugs (e.g., azidothymidine [AZT]). They are known to lead very slowly
to virus-drug resistance development and they show activity against HIV mutants
that have become resistant to reverse transcriptase inhibitors, such as AZT,
tetrahydro-imidazo [4,5,l-jk] [1,4]-benzodiazepin-2(1H)-thione (TIBO) and
others. From studies on their mechanism of action we concluded that polysulfates
exert their anti-HIV activity by shielding off the positively charged sites in
the V3 loop of the viral envelope glycoprotein (gp120). The V3 loop is necessary
for virus attachment to cell surface heparan sulfate, a primary binding site,
before more specific binding occurs to the CD4 receptor of CD4+ cells. This
general mechanism also explains the broad antiviral activity of polysulfates
against enveloped viruses. Variations in the viral envelope glycoprotein region
may result in differences in the susceptibility of different enveloped viruses
to compounds that interact with their envelope glycoproteins. The efficacy of
polysulfates in the therapy and/or prophylaxis of retroviral infections and
opportunistic infections remains to be demonstrated both in animal models and
humans. It is important to consider not only treatment of patients who are
already infected with HIV, but also prophylaxis and protection from HIV and/or
other virus infections. Because (i) sexual transmission is responsible for the
large majority of HIV infections worldwide; (ii) this transmission is mostly
mediated via mononuclear cells that infect epithelial cells of the genital
tract; and because (iii) polysulfates effectively inhibit cell-cell adhesion,
polysulfates may be considered as potentially effective in a vaginal formulation
to protect against HIV infection.

Publication Types:
Review
Review, Tutorial

PMID: 9352294 [PubMed - indexed for MEDLINE]




Biomed Pharmacother 1996;50(5):207-15 Related Articles, Books, LinkOut


Chemotherapy of human immunodeficiency virus (HIV) infection: anti-HIV agents
targeted at early stages in the virus replicative cycle.

De Clercq E.

Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.

Several compounds have been identified that inhibit an early stage in the
replicative cycle of the human immunodeficiency virus (HIV): i) virus
adsorption: polysulfates, polysulfonates, polycarboxylates, polyphosphates, and
polyoxometalates; or ii) virus-cell fusion: plant lectins, negatively charged
albumins and betulinic acid derivatives; iii) virus fusion/uncoating: bicyclam
derivatives; iv) reverse transcription: dideoxynucleoside analogues, acyclic
nucleoside phosphonates and non-nucleoside reverse transcriptase inhibitors. In
principle, HIV may develop resistance to any of these specific anti-HIV agents.
However, virus breakthrough can be completely prevented if these agents, alone
or in combination, are added to the HIV-infected cells from the beginning at
sufficiently high ('knock-out') concentrations.

Publication Types:
Review
Review, Tutorial

PMID: 8949401 [PubMed - indexed for MEDLINE

MAKE 200 DOLLARS (PLUS) 1ST DAY

I have a better one for you. With my
  company. The fastest
  growing
in referral marketing.

How money is made is presented below,
  BUT, All you have
to do is:
A. SIGN UP
B. SUPPLY email addresses or phone
numbers. (I'll do the
  selling.)
C. Collect checks of 235 to 260 dollars
  for each five I
sell in a 30 day period. (I sell 20
today, You MAKE 940
to 1040 dollars TODAY)
D.Those I sell provide you with residual
  income build-up.

Some are making 50 thousand plus after
  12 months.


       1.    You sign up ...........
I get 27 dollars

2. everyone you sign up...You get 27
  dollars each.
3.for everyone on your 2nd 3rd and
4th  levels you get
6 dollars.. so do I.
On your 5th level, you get 12 dollars.

4.For every 5 you sign up in a month,
  you get and extra
  120 to 150 dollars. example: sign up
  10 get and extra
240 to 300 dollars.

5. After the FIVE levels You also get
  a portion of 2
  precent of the total production of
all those on your
level in the company.
6. That not all. Your Upline will
sign up the first
five for you. You supply the names.
  We'll do it. And
  we will continue till you say uncle!

My ID 45788301
For more information call:
501-690-2948   or email
billts@...

P.S. Ask about my company, product
and timing.

Control the input, and you will master
  the output
www.freenetleads.com/free/4791980sul

http://www.trafficswarm.com/go.cgi?46941

Bill

Immunological analysis of inhibition of lung metastases by fucoidan (GIV-A)
prepared from brown seaweed Sargassum thunbergii.

Itoh H, Noda H, Amano H, Ito H.

Laboratory of Marine Biochemistry, Faculty of Bioresources, Mie University, Tsu,
Japan.

The antimetastatic effect of GIV-A (fucoidan) and/or 5-FU was examined in an
experimental model of lung metastases induced by Lewis lung carcinoma in mice.
Injection of GIV-A i.p. after removal of the implanted primary tumor inhibited
the development of lung metastases. Combination treatment with GIV-A and 5-FU
inhibited significantly the lung metastases. The number of peritoneal
macrophages, total cells and macrophages in the lung increased in mice treated
with GIV-A. Binding of the third component of complement (C3) cleavage products
(C3b) to the C3 receptor on peritoneal macrophages after i.v. injection of GIV-A
was enhanced, as shown by the fluorescent antibody technique. Lung metastases
were inhibited by i.v. injection of peritoneal macrophages activated with GIV-A.
GIV-A depressed aniline hydroxylase and aminopyrine demethylase activities of
the hepatic microsomal drug-metabolizing system in tumor-bearing mice. Moreover,
the concentration of 5-FU in the tissues (lung, liver, kidney, spleen and blood)
was increased significantly by coadministration of GIV-A. The picryl
chloride-induced delayed type hypersensitivity (PC-DTH) response in mice was
depressed after the implantation of tumor and treatment with 5-FU. GIV-A
restored the suppression of PC-DTH by 5-FU, but did not increase the PC-DTH of
normal mice. GIV-A not only enhanced the degree of spleen cell-mediated sheep
red blood cell (SRBC) hemolysis (quantitative hemolysis of SRBC), the indexes of
the spleen and thymus and the number of spleen cells, but also restored the
suppressive effect of 5-FU. In the group receiving GIV-A, the percentages of
splenic Thy1.2-, L3T4- and asialo GM1-positive cells were significantly
increased as compared with the tumor-bearing mice treated with saline.
Furthermore, the L3T4+/Lyt2+ ratio showed a tendency to increase, and the
Lyt2+/Thy1.2+ ratio was decreased. These results suggest that the antitumor
effect of GIV-A may be correlated with the changing pattern of the Thy1.2-,
L3T4- and asialo GM1-positive cells, C3 activation, macrophage activation and
depression of the hepatic microsomal drug-metabolizing system. These findings
raise the possibility that GIV-A may have clinical value in the prevention of
cancer metastasis.

PMID: 8572581 [PubMed - indexed for MEDLINE]


  Anticancer Res 1996 May-Jun;16(3A):1213-8 Related Articles, Books, LinkOut


Antitumor and antiproliferative effects of a fucan extracted from ascophyllum
nodosum against a non-small-cell bronchopulmonary carcinoma line.

Riou D, Colliec-Jouault S, Pinczon du Sel D, Bosch S, Siavoshian S, Le Bert V,
Tomasoni C, Sinquin C, Durand P, Roussakis C.

ISOMer (Institut des Substances et Organismes de la Mer), SMAB, Laboratoire de
Pharmacologie Marine, Faculte de Pharmacie, Nantes, France.

Fucans, sulfated polysaccharides extracted from brown seaweeds, have been shown
to be endowed with inhibitory effects cell growth in various experimental
models. We studied both the antiproliferative and antitumor properties of a
fucoidan extract (HF) obtained from the brown seaweed Ascophyllum nodosum on a
cell line derived from a non-small-cell human bronchopulmonary carcinoma
(NSCLC-N6), this type of carcinoma is particularly chemo-resistant. HF exerts in
vitro a reversible antiproliferative activity with a block observed in the G1
phase the cell cycle. Studies performed with the NSCLC-bearing nude mice show
antitumor activity at subtoxic doses. These preliminary results indicate that HF
exhibits inhibitory effect both in vitro and in vivo and is very potent
antitumor agent in cancer therapy.

PMID: 8702239 [PubMed - indexed for MEDLINE]

J Cosmet Sci 2002 Jan-Feb;53(1):1-9 Related Articles, Books, LinkOut


Treatment of human skin with an extract of Fucus vesiculosus changes its
thickness and mechanical properties.

Fujimura T, Tsukahara K, Moriwaki S, Kitahara T, Sano T, Takema Y.

Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi,
Haga-gun, Tochigi 321-3497, Japan.

Recently the researchers found that an extract of Fucus vesiculosus, which is a
type of seaweed, promotes the contraction of fibroblast-populated collagen gels
through increased expression of integrin molecules. In this study, they
investigated the effects of topical application of an aqueous extract of this
alga on the thickness and the mechanical properties of human skin. A gel
formulation that included 1% of the extract was applied topically to human cheek
skin twice daily for five weeks. A significant decrease in skin thickness
measured by B-mode ultrasound was elicited, as was a significant improvement in
elasticity measured with a Cutometer as compared with controls. In cheek skin,
the thickness normally increases and the elasticity usually decreases with age.
These results suggest that the Fucus vesiculosus extract possesses anti-aging
activities and should be useful for a variety of cosmetics.

Publication Types:
Clinical Trial
Controlled Clinical Trial

PMID: 11917251 [PubMed - indexed for MEDLINE]



1: Biol Pharm Bull 2000 Oct;23(10):1180-4 Related Articles, Books, LinkOut


Fucoidan is the active component of fucus vesiculosus that promotes contraction
of fibroblast-populated collagen gels.

Fujimura T, Shibuya Y, Moriwaki S, Tsukahara K, Kitahara T, Sano T, Nishizawa Y,
Takema Y.

Biological Science Laboratories, Kao Corporation, Haga, Tochigi, Japan.
301620@...

The fibroblast-populated collagen gel culture method has been evaluated as a
dermal model of wound contraction and granulation in tissues during the wound
healing process and as an in vitro model of dermal tissue. We previously
reported that an extract of Fucus vesiculosus promoted fibroblast-populated
collagen gel contraction and that the promotion of the gel contraction was due
to the increased expression of integrin alpha2beta1 on the surface of the
fibroblasts. In this study, we investigated the active component of the extract
of this alga using extraction and fractionation techniques. Water extraction of
the alga was followed by precipitation with excess ethanol and then gel
filtration with the boundary molecular weight of 30,000. The high molecular
weight fraction obtained from gel filtration was fractionated by ion exchange
chromatography on diethylaminoethyl cellulose column to give active fractions
that have more polar properties. These polar, high molecular weight fractions
which contained molecules with fucose and sulfate groups showed significant gel
contraction-promoting activity and integrin expression-enhancing activity, and
were estimated to be the sulfated-polysaccharide fucoidan. Commercially
available fucoidan showed similar activities to the above-described fraction of
this alga. Although it remains necessary to precisely identify the specific
active component, the above results indicate that fucoidan is the active
component which promotes collagen gel contraction, and also indicate the
possibility that it dose so by enhancing the integrin alpha2beta1 expression.

PMID: 11041247 [PubMed - indexed for MEDLINE]

J Nutr Sci Vitaminol (Tokyo) 1999 Jun;45(3):325-36 Related Articles, Books,
LinkOut


Inhibitory effect of Cladosiphon fucoidan on the adhesion of Helicobacter pylori
to human gastric cells.

Shibata H, KimuraTakagi I, Nagaoka M, Hashimoto S, Sawada H, Ueyama S, Yokokura
T.

Yakult Central Institute for Microbiological Research, Tokyo, Japan.

We studied the inhibitory effect of Cladosiphon fucoidan on the attachment of
Helicobacter pylori (H. pylori), a gastroduodenal pathogen, to human gastric
cell lines. The bacterial binding in these cell lines was inhibited more by
Cladosiphon fucoidan (IC50 = 16-30 mg/mL), than by the fucoidan from Fucus (IC50
> 30 mg/mL). Dextran sulfate, another sulfated polysaccharide, did not inhibit
the binding at all. Pre-incubating the bacterial suspension with fucoidans
reinforced the inhibitory ability of these components, and reduced the IC50
value of Cladosiphon fucoidan to approximately 1 mg/mL. However, the binding was
not inhibited by pre-treatment of gastric cells with these components. It was
also shown that this fucoidan blocks both Leb- and sulfatide-mediated attachment
of H. pylori to gastric cells. Furthermore, fucoidan-binding proteins were found
on the H. pylori cell surface by Western blot analysis. Thus, the inhibitory
effect exerted by Cladosiphon fucoidan on binding between H. pylori and gastric
cells might result from the coating with this component of the bacterial
surface.

PMID: 10524351 [PubMed - indexed for MEDLINE]



Biomed Mater Eng 2001;11(1):55-61 Related Articles, Books, LinkOut


Effect of oligofucose derivatives on acetic acid-induced gastric ulcer in rats.

Shibata H, Nagaoka M, Takagi IK, Hashimoto S, Aiyama R, Yokokura T.

Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan.
hideyuki-shibata@...

This study attempted to enhance the anti-ulcer activity of fucoidan from
Cladosiphon okamuranus TOKIDA by chemical modification with a hydrophobic group.
The suitable number of fucose residues in the effective compound was also
clarified to obtain a compound of constant quality. Degraded fucoidans were
coupled with several hydrophobic groups via Schiff bases, and their anti-ulcer
activities were determined by acetic acid-induced ulcer models in rats.
Size-fractionated oligofucose was also modified and assayed for anti-ulcer
activity. Among the modified oligofucoses, only the oligofucose-dodecylaniline
combination (OFDA) significantly promoted ulcer healing. The effective dose was
0.2 mg/kg/d. The most suitable number of fucose residues in the compound for the
anti-ulcer activity was determined to be around 12. We succeeded in enhancing
the anti-ulcer activity of Cladosiphon fucoidan by modification with
dodecylaniline. The activity of this compound was comparable or greater than
that of typical anti-ulcer agents. By determination of the optimal OF chain
length for the anti-ulcer activity of OFDA, it became possible to obtain OFDA of
constant quality.

PMID: 11281579 [PubMed - indexed for MEDLINE]

----- Original Message -----
     From: Iman Badawi
     To: A7fad_Mo7amed@yahoogroups.com ; ahmad_islam@yahoogroups.com ;
Al-3eraq@yahoogroups.com ; Al-Awda-Egypt@yahoogroups.com ;
     Sent: Friday, February 27, 2004 3:01 PM
     Subject: [agamy] A Must Read on Depleted Uranium/خطير جدا عن اليورانيوم
المستنفذ اقرأ ووزع


     English Text Follows. Please, circulate Widley. Thanks.

     السلام عليكم
     رسالة غاية فى الاهمية ارسلها احد الاميركان للمجموعة وفيها وصلات بمواضيع 
خطيرة عن اليورانيوم المستنفذ التى استخدمه التحالف فى العراق  و الاميركان فى
افغانستان و اضرارة البالغة الممتدة الاثر لعشرات السنين على الحياة و الانسان  فى
العراق  و افغانستان،
     من فضلك ارسلها لكل من تعرف خاصة فى الدول الاجنبية لكى يعلموا من هم
الارهابيين بحق، و من هم اعداء الحياة ،و الذين يرتكبون جرائم ضد الانسانية
     وهذا ليس فقط ضد اخوتنا المدنيين فى العراق و افغانستان فقط و لكن ايضا ضد
جنودهم المتواجدين فى هذة المناطق، و لكى يعرفوا اخبار حكوماتهم الكاذبة الارهابية
المنحطة
     ايمان بدوى


     May Bush and his neo-con backers all burn in Hell for their lies and
despicable deceit.

     Amen

     Please, everyone send this message to all your friends, let them know what
the US govt., Bush and his gang is doing to others and to your sons there
     in Iraq. Ask them to let Bush and his gang  send their kids as well there in
Iraq to smell and absorbe some Uranium too.


     Here are a few really powerful links to what the US and coalition forces are
doing in order to win in Iraq, and win at all cost. May Bush and his neo-con
backers all burn in Hell for their lies and despicable deceit. If these are not
war crimes I for one have no idea what could constitute a war crime. May we one
day wake up and see ourselves for what we really are. God forgive us for we
allow our government to make war on lies an deceit.

     Burnie.
      ***

     WHO 'suppressed' scientific study into depleted uranium cancer fears in Iraq
:

     Radiation experts warn in unpublished report that DU weapons used by Allies
in Gulf war pose long-term health risk
     http://www.informationclearinghouse.info/article5749.htm

     ===

     Effects Of War And The Use Of Depleted Uranium On Iraq:

     According to a report from the Guardian newspaper 1000-2000 tons were
delivered on 51 local areas in different Iraqi cities. I witnessed the A-10
planes for three days delivering the depleted uranium rounds against the tanks
and armor vehicles near Basrah airport and at the southern parts of Basrah city.
     http://www.traprockpeace.org/jawad_al-ali_iraq.html

     ===

     Depleted Uranium: The War Crime That Has No End:

     "Depleted uranium is a crime against God and humanity." Dr. Doug Rokke, U.S.
Army health physicist
     http://www.unobserver.com/layout5.php?id=1462&blz=1


     *****************************************

     Depleted Uranium
     http://www.bringthemhomenow.org/stand/du.html




     نرجو منك أخي أن تنشر هذه الرسالة إلى كل من تعرف، حتى تكسب الثواب من الله
تعالى.. ونرجو منك أن تدعو كل من تعرف للانضمام لمجموعتنا وذلك بأن يرسلوا رسالة
فارغة إلى هذا العنوان:
     agamy-subscribe@yahoogroups.com
     ويجب التنبيه على أن من سيرسل هذه الرسالة سيصله تأكيد، عليه أن يعيده كما هو
فيصبح بإذن الله عضوا في مجموعتنا..
     وأخيرا جزاكم الله خيرا.. وشكرا..
     أخوكم:
     ط. أحمد رشدي العجمي



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[Non-text portions of this message have been removed]

Hi Group,
     The more I hear about the product and the company, it increases
my gut feeling that I've made a great decision for my future health &
wealth.  The product is working and after several days I can see the
differance in how fare I can walk with my walker.  Usally it takes
months to see the differance, but I already notice several little
things.  Hear more on the Web Conference, I'll sign-in under RICH.
Hope to see ya there, and I hope you start feeling better like me.

   Just go to www.nqiusa.com and Click on Conference Buttom on the
buttom right, then Click THE WEB CONFERENCE button, add your name and
you are in the conference.  For the phone connection dial 212-990-
8000 Pin# 2150# ...
  Don't forget the $50,000 Challenge if you find a better product....
http://www.50kcgallenge.com/users/healthwealth2004/

Richard A Smith

rasmith4me@...

This wouldn't happen if the Bombers stopped, would it .......!!!!!

SO who is really to blame .........!!!!!!!!!!!!!!!!

Now send your mail to the real fucking bombers and killers who cause this
problem........the Palestinians who dont give a shit about you or anyone
else.......wankers..........


Sama <samasama@...> wrote:


Sameh Kassem Tel : +49-3816602781Mobil : +49-1794867339Email: 
kassemsameh@...


From: "Ihsan hotmail" To: "Fawaz Soufi" ,"Rami" ,"the prince Eyad" ,"Taha Ahmed"
,"sameh kassem" ,"ousama" ,,"Muhammad Sabi" ,"mudar" ,"Mokayyes (E-Mail)"
,"Mohamed Ismael" ,"Moawia Al-Hamid" ,"khaled hamzeh" ,,,,"Al-Khwlani Khaled"
,"Ahmed" ,"AbdulRahman khames" Subject: Fw: Fwd: Date: Mon, 19 Jan 2004 12:23:55
+0100 ----- Original Message ----- From: ousama wazan Sent: Saturday, January
17, 2004 3:25 PM Subject: FW: Fwd:
--------------------------------------------------------------------------------






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---------------------------------
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> ATTACHMENT part 2 image/jpeg name=the dignity of human rights.jpg


---------------------------------
   Yahoo! Messenger - Communicate instantly..."Ping" your friends today! Download
Messenger Now

[Non-text portions of this message have been removed]

you are bad


[Non-text portions of this message have been removed]

Sameh Kassem
Tel : +49-3816602781
Mobil : +49-1794867339
Email:  kassemsameh@...

From: "Ihsan hotmail" To: "Fawaz Soufi" ,"Rami" ,"the prince Eyad" ,"Taha Ahmed"
,"sameh kassem" ,"ousama" ,,"Muhammad Sabi" ,"mudar" ,"Mokayyes (E-Mail)"
,"Mohamed Ismael" ,"Moawia Al-Hamid" ,"khaled hamzeh" ,,,,"Al-Khwlani Khaled"
,"Ahmed" ,"AbdulRahman khames" Subject: Fw: Fwd: Date: Mon, 19 Jan 2004 12:23:55
+0100 ----- Original Message ----- From: ousama wazan Sent: Saturday, January
17, 2004 3:25 PM Subject: FW: Fwd:
--------------------------------------------------------------------------------


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[Non-text portions of this message have been removed]

Yea John, I invited Rich to the group.

Any limu is probably better than none.

I haven,t changed my mind though. All the new
Companies are there because of US. We began it all.
There will be more new companies that will seek to
take a share of our market.

Right now we control more than 99% percent of the
market. Our product is RESULTS DRIVEN. We have no
fear. Thats why I invite all.

KNOW THIS the KEY is in the extraction process! It
took 15 years for this process to be researched and
developed. NO ONE ELSE HAS IT!

SEE it,s not enough to get some of the nutrition out
ESPECIALLY FUCOIDAN, you MUST do it without changing
the MOLECULAR STRUCTURE. We can do it.

So I ask you, If some entity looks at us, our growth
etc. Determine that there is a GREAT MARKET THERE.
Decides to get in next week. WHAT IS THE ODDS  that
they developed an extraction process that even comes
close to doing what is needed, THAT  HAS MADE OUR
PRODUCT SO EFFECTIVE.

Hey, if you make it to Shreeveport March the 5th, You
can get to see the Man that discovered Our proprietary
extraction Process. He is from New Zealand.

SEE ya there!

Bill




--- "John Philip: Souza" <pilipohale@...> wrote:
>   Bill, Do you know what Limu nei is all about?
>   Pilipo
>     ----- Original Message -----
>     From: Ask
>     To: LIMU_MOUI@yahoogroups.com
>     Sent: Wednesday, February 18, 2004 2:57 PM
>     Subject: [LIMU_MOUI] You are invited to the
> OFFICIAL LAUNCH of the limu company.
>
>
>     You are invited to the OFFICIAL LAUNCH of the
> limu company.
>
>     The Launch will be held in Shreeveport Louisiana
> at the lovely
>     HARRAHS
>     casino. .Besides meeting all the GREAT people
> and hearing their
>     WONDERFUL testimonies of Limu Health benefits,
> You will  get
>
>     NEW AT THIS LAUNCH
>
>     1. How to work 5 to 7 hours a month and make  an
> extra
>     $100 dollars a hour.
>
>     2. Demonstrates how to become  Gold in 30 days.
>
>     3. How to become a Ruby in 90 days.
>
>     4. How to be making $5,000 extra dollars a month
>     in 180 days.
>
>
>     2 MORE REASONS TO ATTEND
>     TLC'S OFFICIAL LAUNCH EVENT ...
>
>     REASON #1
>     ALAN SMITH ... SPECIAL GUEST SPEAKER!
>     Mr. Smith is coming all the way from New Zealand
> just to
>     meet the TLC family. Here is your chance to hear
> from the
>     KEY INDIVIDUAL responsible for the secret behind
> Original
>     Limu ... the FOUNDER & GENIUS behind the unique
>     EXTRACTION PROCESS that tookover 15 YEARS to
> perfect
>     & is EXCLUSIVE to The Limu Company! You may
> never have
>     this chance again!
>
>     REASON #2 ...
>     MR. ROBERT BREEN ... SENIOR ADVISOR
>     Few individuals in the entire industry have
> reached the level of
>     success or command the level of respect Bob
> Breen has earned.
>     With a 35 year background that includes roles as
> President and
>     CEO of major companies like Avon, MCI,
> Starlight,& FundAmerica,
>     Bob's name is synonymous with success. Meet Bob
> & find out for
>     yourself why he was awarded this prestigious
> position with TLC &
>     his part in making it a huge sucees!
>
>     MEET THESE 2 ELITE INDIVIDUALS & EXPERIENCE THE
>     MOST EXCITING COMPANY LAUNCH OF THE DECADE!
>
>     MARCH 5 & 6  at HARRAHS  CASINO,  SHREVEPORT,
> LOUISIANA
>     Leaders meeting 3 to 7pm march  5th.
>     the BIG day starts SAT. March 6th 9am.
>
>     For TICKETS  call Jane at: 501-413-1948 or go
> to:
>     http://thelimuman.originallimu.com
>     $50 dollars per ticket if ordered before FEB.
> 29TH.
>     $75 DOLLARS AT THE DOOR.
>
>     SEE YOU THERE!
>
>     Hey guys take a post card with you and leave it
> with the receptionist.
>     Put Bill Sullivan on the card. Your name, phone
> number and email
>     I would love to meet and greet all of you.
>
>     thanks,
>
>     Bill
>
>
>
>
>
>
>           Yahoo! Groups Sponsor
>                 ADVERTISEMENT
>
>
>
>
>
>
----------------------------------------------------------------------------
>     Yahoo! Groups Links
>
>       a.. To visit your group on the web, go to:
>       http://groups.yahoo.com/group/LIMU_MOUI/
>
>       b.. To unsubscribe from this group, send an
> email to:
>       LIMU_MOUI-unsubscribe@yahoogroups.com
>
>       c.. Your use of Yahoo! Groups is subject to
> the Yahoo! Terms of Service.
>
>
>
>
> [Non-text portions of this message have been
> removed]
>
>
>
> ------------------------ Yahoo! Groups Sponsor
>
>
> Yahoo! Groups Links
>
>
>      LIMU_MOUI-unsubscribe@yahoogroups.com
>
>
>


__________________________________
Do you Yahoo!?
Yahoo! Mail SpamGuard - Read only the mail you want.
http://antispam.yahoo.com/tools

Bill, Do you know what Limu nei is all about?
   Pilipo
     ----- Original Message -----
     From: Ask
     To: LIMU_MOUI@yahoogroups.com
     Sent: Wednesday, February 18, 2004 2:57 PM
     Subject: [LIMU_MOUI] You are invited to the OFFICIAL LAUNCH of the limu
company.


     You are invited to the OFFICIAL LAUNCH of the limu company.

     The Launch will be held in Shreeveport Louisiana at the lovely
     HARRAHS
     casino. .Besides meeting all the GREAT people and hearing their
     WONDERFUL testimonies of Limu Health benefits, You will  get

     NEW AT THIS LAUNCH

     1. How to work 5 to 7 hours a month and make  an extra
     $100 dollars a hour.

     2. Demonstrates how to become  Gold in 30 days.

     3. How to become a Ruby in 90 days.

     4. How to be making $5,000 extra dollars a month
     in 180 days.


     2 MORE REASONS TO ATTEND
     TLC'S OFFICIAL LAUNCH EVENT ...

     REASON #1
     ALAN SMITH ... SPECIAL GUEST SPEAKER!
     Mr. Smith is coming all the way from New Zealand just to
     meet the TLC family. Here is your chance to hear from the
     KEY INDIVIDUAL responsible for the secret behind Original
     Limu ... the FOUNDER & GENIUS behind the unique
     EXTRACTION PROCESS that tookover 15 YEARS to perfect
     & is EXCLUSIVE to The Limu Company! You may never have
     this chance again!

     REASON #2 ...
     MR. ROBERT BREEN ... SENIOR ADVISOR
     Few individuals in the entire industry have reached the level of
     success or command the level of respect Bob Breen has earned.
     With a 35 year background that includes roles as President and
     CEO of major companies like Avon, MCI, Starlight,& FundAmerica,
     Bob's name is synonymous with success. Meet Bob & find out for
     yourself why he was awarded this prestigious position with TLC &
     his part in making it a huge sucees!

     MEET THESE 2 ELITE INDIVIDUALS & EXPERIENCE THE
     MOST EXCITING COMPANY LAUNCH OF THE DECADE!

     MARCH 5 & 6  at HARRAHS  CASINO,  SHREVEPORT, LOUISIANA
     Leaders meeting 3 to 7pm march  5th.
     the BIG day starts SAT. March 6th 9am.

     For TICKETS  call Jane at: 501-413-1948 or go to:
     http://thelimuman.originallimu.com
     $50 dollars per ticket if ordered before FEB. 29TH.
     $75 DOLLARS AT THE DOOR.

     SEE YOU THERE!

     Hey guys take a post card with you and leave it with the receptionist.
     Put Bill Sullivan on the card. Your name, phone number and email
     I would love to meet and greet all of you.

     thanks,

     Bill






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[Non-text portions of this message have been removed]

You are invited to the OFFICIAL LAUNCH of the limu company.

The Launch will be held in Shreeveport Louisiana at the lovely
HARRAHS
casino. .Besides meeting all the GREAT people and hearing their
WONDERFUL testimonies of Limu Health benefits, You will  get

NEW AT THIS LAUNCH

1. How to work 5 to 7 hours a month and make  an extra
$100 dollars a hour.

2. Demonstrates how to become  Gold in 30 days.

3. How to become a Ruby in 90 days.

4. How to be making $5,000 extra dollars a month
in 180 days.


2 MORE REASONS TO ATTEND
TLC'S OFFICIAL LAUNCH EVENT ...

REASON #1
ALAN SMITH ... SPECIAL GUEST SPEAKER!
Mr. Smith is coming all the way from New Zealand just to
meet the TLC family. Here is your chance to hear from the
KEY INDIVIDUAL responsible for the secret behind Original
Limu ... the FOUNDER & GENIUS behind the unique
EXTRACTION PROCESS that tookover 15 YEARS to perfect
& is EXCLUSIVE to The Limu Company! You may never have
this chance again!

REASON #2 ...
MR. ROBERT BREEN ... SENIOR ADVISOR
Few individuals in the entire industry have reached the level of
success or command the level of respect Bob Breen has earned.
With a 35 year background that includes roles as President and
CEO of major companies like Avon, MCI, Starlight,& FundAmerica,
Bob's name is synonymous with success. Meet Bob & find out for
yourself why he was awarded this prestigious position with TLC &
his part in making it a huge sucees!

MEET THESE 2 ELITE INDIVIDUALS & EXPERIENCE THE
MOST EXCITING COMPANY LAUNCH OF THE DECADE!

MARCH 5 & 6  at HARRAHS  CASINO,  SHREVEPORT, LOUISIANA
Leaders meeting 3 to 7pm march  5th.
the BIG day starts SAT. March 6th 9am.

For TICKETS  call Jane at: 501-413-1948 or go to:
http://thelimuman.originallimu.com
$50 dollars per ticket if ordered before FEB. 29TH.
$75 DOLLARS AT THE DOOR.

SEE YOU THERE!

Hey guys take a post card with you and leave it with the receptionist.
Put Bill Sullivan on the card. Your name, phone number and email
I would love to meet and greet all of you.

  thanks,

Bill

Hi Group,
     The more I hear about the company and the product, it increases
my gut feelings that I've made a good decision  for my future health
& wealth.  Since I've had M.S. for over 20 years now I've tried
everything out there.  So when this product starts working I'll know
and I'll let you know to.   Hear more on the web/tele- conference,
I'll sign in under RICH.  I see you on there!!!

Just go to http//www.nqiusa.com Click the CONFERENCE button on the
buttom right, then CLICK THE WEB CONFERENCE BUTTON, add your name and
you are in the conference.  For the phone connection dial 212-990-
8000 pin # 2150#  Hope to see you on the conference...

Don't forget the $50,000 Challenge if you find a better product....
http://www.50kchallenge.com/users/healthwealth2004/

Richard A. Smith,

rasmith4me@...

That's right Limu NEI has the highest concentration of Fucoidan, Anti-
Aging Colostrum at 40:1 and with an Isotonic delivery system for
rapid absorption !!! You feel the difference.

I know, everybody claims to have the best product out there...
but NQI puts its money where its mouth is!  After independent lab
test against those other produts...NQI is so confident, they have the
best Immune boosting, Immune modulating, inch loss, age reversing
natural product on the planet, they have put up a $50,000 Challenge
to anyone who can prove them wrong !!!1

http://www.50kchallenge.com/users/healthwealth2004/

This spectacular immune boosting power of Limu + Colostrum "The 6
Hour Miracle."

This dynamic blend provides simultanous support for the Nervous
System, Endocrine System and Immune Systems.  This complete
nuttritional product builds the immune system and gives the body all
the nutrients it needs to HEAL itself!
    95+ Immune Factors
    All 87 Natural Anti-aging Growth Factors
    All essential Amino-acids
    All essential glyconutrients + essential fatty acids

A storehouse of vitamins, minerals and nutrients that provide your
body what it needs to help heal and balance itself naturally.

Sign up for your own FREE $50k Challenge website and start making
money now!  Unprecedented Marketing program...Company paid Ad
campaign with leads coming back to particpating Distributors!  You
can have a positive impact on peoples health and wealth .  There's
still room at the top!
1-800-253-7650 (4 min. msg.)  Company website http://www.nqiusa.com
e-mail rasmith4me@...,  719-473-0242

Richard A. Smith'

Sorry group,
   http://www.50kchallenge.com/users/healthwealth2004/

Richard A. Smith  rasmith4me@...

New Limu NEI, Higher contration of Fucoidan, Anti-Aging Colostrum!!!

I know, everybody claims to have the best product out there...but NQI
puts its money wgere its mouth is!  After independent lab test
against other products...NQI is so confident, they have the best
immune boosting, immune modulating, inch loss, age reversing natural
product on the planet, they have put up a $50,000 Challenge to anyone
who can prove them wrong.

http://wwww.50kchallenge.com/users/healthwealth2004

The spectacular immune boosting power of Limu + Colostrum"The 6Hour
Miracle."

This dynamic blend provides support for the Nervous System, Enocrine
System and Immune System.  This complete nutritional product will
build the immune system and gives the body all the nutrients it needs
to heal itself!
    95+ Immune Factors
    All 87 Natural Anti-Aging Growth Factor
    All Essential Amino-Acids
    All Essential Glyconutrients + Essential Fatty Acids

A storehouse of vitamins, minerals and nutrients that provide your
body what it needs to heal and balance itself naturally.

100% Natural with no artificial preservatives Fucoidan concentration
extract = 40:1 Isotonic delivery system for rapid absorption.

Sign-up for your own FREE $50k Challenge Website and start Making
Money NOW!  Unprecedented Martketing Program...Company paid Ad
Campaign with Leads coming back to participating distributors!  You
can have a positive impact on peoples health and wealth.  There's
still room at top!
1-800-253-7650  ( 4 min. msg.)
1-866-327-2855  (info. line)  both 24 hours


Richard A. Smith   rasmith4me@...

New Limu NEI,Higher concentration of fucoidan, Anti-Aging Colostrum!!!

I  know, everybody claims to have the best product out there....but
NQI puts it's money where it's mouth is!  After independent lab tests
against those other products...NQI is so confindent, they have The
Best immune boosting, immune modulating, inch loss, age reversing
natural product on the planet, they have put up a $50,000 Challenge
to anyone who can prove them wrong.

http://www.50kchallenge.com/users/dreamteam/

The spectacular immune boosting power of Limu + Colostrum "The 6 Hour
Miracle."

This dynamic blend provides simultaneous support for the Nervous
System, Endocrine System  and Immune Systems. This complete
nutritional product build the immune system and gives the body all
the nutrients it needs to heal itself!
    95+ Immune Factors
    All 87 Natural Anti-aging Growth Factor
    All essential amino-acids,
    All essential glyconutrients + essential fatty acids

A storehouse of vitamins, minerals and nutrients that provide your
body what it needs to help it heal and balance itself naturally

100% Natural with no artificial preservatives
Fucoidan concentration extract = 40:1
Isontonic delivery system for rapid absorption

Sign up for your own free $50K Challenge Website and Start Making
Money now! Unprecedented Marketing program...Company paid Ad Campaign
with leads coming back to participating distributors! You can have a
positive impact on people's health and wealth. There's still room at
the top!
  1-800-253-7650 (4 min msg.)

Lydia Baugh,

http://www.radiantgoodhealth.com

dreamteambonuses@...

OH PLEASE! SHOW SOME SCIENTIFIC STUDIES!
www.pubmed.gov the Government site for scientific
study summaries may be a good place to SEARCH.






--- *As Seen On TV* <iearn2@...> wrote:
>
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>
> ** AS SEEN ON TV ** The ORIGINAL RAYMA Balance
> Bracelet
>
> * This *Jewel* Of Health will have you feeling
> Better in No Time!
> * GUARANTEED! Amazing Benefits will astound you!
> * Natural relief for all types of Aches and Pains,
> such as...
> * Bad backs, arthritis, insomnia, fibromyalgia,
> migraines, etc.
> * Don't be fooled by copies! Only OUR
> * Original Rayma Balance Bracelet  comes with a
> * 60 Day Money Back Guarantee!
> * All sizes in Stock!
> * Electronic Gift Certificates also  INSTANTLY
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>
> http://www.balancebraceletexpress.com
> ¤§¤==========¤§¤=========¤§¤=========¤§¤========¤§¤
>
>
> This email is not Spam. We are both Members of
> LIMU_MOUI@yahoogroups.com
> If you wish to be removed from these mailings, you
> must
> remove yourself from the Group. Thank you for your
> kind consideration.
>
>
>
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__________________________________
Do you Yahoo!?
Yahoo! Finance: Get your refund fast by filing online.
http://taxes.yahoo.com/filing.html

¤§¤==========¤§¤=========¤§¤==========¤§¤=========¤§¤

** AS SEEN ON TV ** The ORIGINAL RAYMA Balance Bracelet

* This *Jewel* Of Health will have you feeling Better in No Time!
* GUARANTEED! Amazing Benefits will astound you!
* Natural relief for all types of Aches and Pains, such as...
* Bad backs, arthritis, insomnia, fibromyalgia, migraines, etc.
* Don't be fooled by copies! Only OUR
* Original Rayma Balance Bracelet  comes with a
* 60 Day Money Back Guarantee!
* All sizes in Stock!
* Electronic Gift Certificates also  INSTANTLY available!
* ORDER YOURS TODAY!

!! SPECIAL !!  FREE SHIPPING WITHIN NORTH AMERICA

http://www.balancebraceletexpress.com
¤§¤==========¤§¤=========¤§¤=========¤§¤========¤§¤


This email is not Spam. We are both Members of LIMU_MOUI@yahoogroups.com
If you wish to be removed from these mailings, you must
remove yourself from the Group. Thank you for your
kind consideration.

Hear Powerful Testimonies
Like These Every Monday Evening 8:30PM CST TOLL FREE 212-990-8000   6688#


Since my pregnancy, 2 years ago, I suffered from daily migraines. My doctors
thought these were due to hormonal changes and could only recommend pain
medication. Of course, I could not risk harm to my unborn baby by taking it. But
16 months after my son, Zachary's birth, the headaches were no better. It was
hard for Zachary to understand why mommy didn't want to do anything but lay on
the couch some days. After taking Limu Moui for 1 day, my headache was gone!
Zachary and I have so much more fun now. I will even take it during my next
pregnancy. I want to tell everyone I come into contact with about Limu Moui
because it has changed my life!
Chastity T., Cordova, TN

I am 42 years old and was diagnosed with Multiple Sclerosis in 1998. I
experienced episodes of weakness and progression of the disease. I went through
physical therapy and medications, feeling better at times and then another
episode would leave me feeling weak and numb. The last episode was so fast and
progressive that I became wheelchair bound, weak and with no feeling from the
waist down. I could not even hold my grandbaby. I was never this debilitated
before and was convinced I would die. On May 8th, I started taking about 2
tablespoons of Limu Moui, twice a day, and within one month, I was out of the
wheelchair and walking without a brace or cane. I even resumed my housework and
cooking supper. Next week, I intend to start driving again. I feel generally
good and have an increase in energy. My physical therapist commented that he'd
never seen anyone progress so quickly from how debilitated I was. I will never
be without Limu Moui!
Theresa C., Dequincy, LA

My husband, who is in construction, is exposed to the elements 8 to 10 hours a
day and suffered from constant sinus headaches. After taking Limu Moui, he
rarely suffers at all now! In addition, my pain from carpal tunnel syndrome in
my right arm and a bulging disc in my back are gone. I no longer need the brace
for my arm and I can sleep so much better at night. Limu Moui is a blessing to
the entire world!
LeJoyce A., Arcadia, LA

I have had severe fever blisters, caused by Herpes virus, on my lower lip for as
long as I can remember. These typically begin with a tingling sensation in a
small area and progress until 1/4 to 1/2 of my lower lip is swollen, red, and
bleeding. Ultimately, the lesion becomes painful throughout the typical 3 to
5-week duration and is quite unsightly and embarrassing. Upon feeling the
familiar sensation begin, I immediately applied Limu Moui directly onto the
emerging blister to see what would happen. After 4 days of applying it twice a
day, the blister was going away and never surfaced! I was amazed, as I have
never experienced this quick of a recovery from this repulsive ailment.
Mark K. Springfield, MO

I am 39 and have had asthma most of my life, starting as a small child and
becoming worse in my early 20's. Though detrimental to my internal organs, I've
used 3 different steroid based medications twice a day to keep this disease
under control and have visited the emergency room 3 times over the last 15
years. Since the day I started taking Limu Moui, I have not used any
prescription medication and I can breathe! I can now have a normal life. This is
a gift from above and it is now my duty to share my blessing!
Gary R., Sedro Woolley, WA

I have had ulcers since I was 15 years old and inflammation of the stomach
lining most of my adult life. Because of extreme heartburn, I had to take Zantac
with every meal and sometimes even between meals. Since I started taking Limu
Moui, I have not had to take Zantac. In additional, my energy level and general
well being have dramatically improved.
Nileen B., Sedro Wooley, WA

I have been on Avapro and Toprol, blood pressure medication since my open heart
surgery a year ago. My blood pressure still remained at around 179/100 or
179/120. The lowest it had ever reached was 158/90. With my doctor's approval, I
started taking 2 tablespoons per day of Limu Moui. After the second day on the
product, my blood pressure dropped to 116/66 and my doctor cut my medication
dosage in half. Three days later, he took me off Avapro completely and reduced
my dosage of Toprol even more and will take me off it completely in 2 more days.
My blood pressure has stayed consistently between 116/66 and 118/66. I am no
longer sleepy, have more energy, feel calmer, my head is clearer and my heart no
longer pounds. I will never stop taking Limu Moui and it's just a matter of time
before my doctor is in the business!
Phil R., Minden, LA

I've had rheumatoid arthritis since 1980 and in spite of having tried every kind
of medication imaginable--from Gold injections and steroids, to Methotrexate and
Remicade -- I still had to live with many physical limitations. These included
being unable to turn the car keys, raise my arms over my head, get up and down
from a sitting position, morning stiffness, low energy and little to no strength
in my hands and wrists. I began to see results after 1 week on Limu Moui and it
has continued ever since. Recently I spent 3 days, rolling paint up to the
ceiling and wallpapering. I also mowed an acre of land for 2-1/2 hours with a
tractor that has no power steering. Not only was I not sore the next day, I
drove into the city and took a CPR and First Aid Class. I'm doing things I have
not done in 15 years.
Nancy O'C., Pleasant Hill, MO

Our 6-year old daughter, Christina, has had breathing problems since the day she
was born. Ever since a near death experience when she was 6 weeks old, she has
had to use a Breathalyzer on many occasions. Recently, we had to cut a weekend
trip short and return home due to the breathing problems Christina was having
from the high spring time pollen content. We decided to try Limu Moui because
the traditional medications she was taking were not clearing her up completely.
After 4 days, all signs of Christina's pneumonia were gone and all her other
symptoms cleared up, as well. Our whole family is now on the product and we have
noticed many other benefits, after approximately 4 days of use.
David L., Shreveport, LA

I suffered from fibromyalgia and chronic fatigue syndrome, both causing constant
pain, especially after any kind of strenuous exertion, or when the weather
changed. I was taking at least 6 Ibuprofen a day and 2 or 3 Tylenol PM for pain
and to sleep at night. After 2 weeks on Limu Moui, I am not taking either one of
those medications, and my pain during the day has all but disappeared, my energy
level is "out the roof" and I am sleeping very well at night.
Rebecca S., Oak Ridge, LA

My father-in-law has diabetes, which was out of control. He had been taking oral
medication, but when his blood sugar level reached between 200 and 350, the
doctor had put him on insulin shots. His first week on Limu Moui, he took 2
tablespoons, 2 times a day. The second week, he increased it to 2 tablespoons, 3
times a day. After checking his blood sugar level, he found it had dropped to
140 and remains between 150 and 160.
Jeff B., Liberty, TX

I have had chronic sleep problems for the past 20 years and have spent many
hours tossing and turning and staring at the ceiling till daybreak. I chose to
get off the prescription medication my doctor prescribed years ago and no over
the counter aids helped. After hearing friends and family say they were sleeping
better at night because of Limu Moui I began taking it. After 3 nights, I
noticed a total change in my sleeping. What a joy it is to wake up and find it's
morning! I feel rested during the day and feel a sense of well being and
happiness from the product. Limu Moui is a real blessing!
Sally H., Heflin, LA

My health issues included allergy and sinus problems for which I had to take
medication, including a 12-hour nasal spray, every 3 to 4 hours. In addition, I
was taking Prilosec for a severe problem with indigestion and heartburn, which I
experienced with even one bit of any kind of food. After just 3 days on Limu
Moui, my allergies and sinus problems were gone and I was able to get a good
night's sleep, without any medication. I am also completely off the Prilosec and
have no more indigestion symptoms. I have not felt better in a long time!
Alton W., Oake Grove, LA

For 13 years, my daughter has been suffering from asthma and a chronic cough
every night. After 5 days on Limu Moui, I noticed she was not coughing at night.
For the last 46 days, she has not coughed, wheezed, or had to use the inhaler!
The product has been a blessing to her and she will take it for the rest of her
life!
Bonita W., Sugarland, TX

I am legally blind due to diabetes and I suffer from congestive heart failure. I
have had several heart attacks and 4 angioplasty surgeries. I also have
shortness of breath, poor circulation, bad lungs, poor kidney control and sleep
apnea, to name a few of my ailments. My blood sugar ranged from 200-450,
sometimes even higher. I was about to start kidney dialysis because of the
kidney failure. After taking Limu Moui for 3 days, I felt noticeably improved.
My blood sugar has dropped to between 130 and 170, I am able to get up without
aid, and am much more active. Before, I could barely walk 50 feet, from the
house to the mailbox, and now, I have been walking 7 blocks at a time. In
addition, I have more energy, less shortness of breath and control of my
kidneys. I have done nothing different from before, except take Limu Moui.
Edward W., Cullman, AL

I was in extreme pain following knee replacement surgery in January and physical
therapy was an excruciating experience. Twice a day, I had to take 200-500 mg of
Extra Strength Tylenol, 250 mg of Ultram and 50 mg of Percoset, totaling 2300 mg
of pain medication, daily. I began taking Limu Moui on March 31, 2001 and 4
weeks later, the last week in April, I began to notice that my pain was almost
gone. Consequently, I stopped taking all pain medication, except one 50 mg
tablet of Ultram at bedtime. Even though physical therapy is still painful, I
find that my pain subsides about 30 minutes after taking Limu Moui.
Robert W., Springfield, MO

I was plagued with year round sinus related problems, including infection,
bronchitis and laryngitis, especially in the spring and fall. This would deplete
my energy and wellness and cause me to miss work as a sign language interpreter,
causing hardship on my colleagues and deaf students, who depended on me. For
years, I tried medications, nasal sprays and herbal remedies. Within 3 days of
using Limu Moui, I was able to breathe freely and now take no medication.
Vicki W., Springfield, MO

J Cosmet Sci 2002 Jan-Feb;53(1):1-9 Related Articles, Books, LinkOut


Treatment of human skin with an extract of Fucus vesiculosus changes its
thickness and mechanical properties.

Fujimura T, Tsukahara K, Moriwaki S, Kitahara T, Sano T, Takema Y.

Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi,
Haga-gun, Tochigi 321-3497, Japan.

Recently the researchers found that an extract of Fucus vesiculosus, which is a
type of seaweed, promotes the contraction of fibroblast-populated collagen gels
through increased expression of integrin molecules. In this study, they
investigated the effects of topical application of an aqueous extract of this
alga on the thickness and the mechanical properties of human skin. A gel
formulation that included 1% of the extract was applied topically to human cheek
skin twice daily for five weeks. A significant decrease in skin thickness
measured by B-mode ultrasound was elicited, as was a significant improvement in
elasticity measured with a Cutometer as compared with controls. In cheek skin,
the thickness normally increases and the elasticity usually decreases with age.
These results suggest that the Fucus vesiculosus extract possesses anti-aging
activities and should be useful for a variety of cosmetics.

Publication Types:
Clinical Trial
Controlled Clinical Trial

PMID: 11917251 [PubMed - indexed for MEDLINE]



1: Biol Pharm Bull 2000 Oct;23(10):1180-4 Related Articles, Books, LinkOut


Fucoidan is the active component of fucus vesiculosus that promotes contraction
of fibroblast-populated collagen gels.

Fujimura T, Shibuya Y, Moriwaki S, Tsukahara K, Kitahara T, Sano T, Nishizawa Y,
Takema Y.

Biological Science Laboratories, Kao Corporation, Haga, Tochigi, Japan.
301620@...

The fibroblast-populated collagen gel culture method has been evaluated as a
dermal model of wound contraction and granulation in tissues during the wound
healing process and as an in vitro model of dermal tissue. We previously
reported that an extract of Fucus vesiculosus promoted fibroblast-populated
collagen gel contraction and that the promotion of the gel contraction was due
to the increased expression of integrin alpha2beta1 on the surface of the
fibroblasts. In this study, we investigated the active component of the extract
of this alga using extraction and fractionation techniques. Water extraction of
the alga was followed by precipitation with excess ethanol and then gel
filtration with the boundary molecular weight of 30,000. The high molecular
weight fraction obtained from gel filtration was fractionated by ion exchange
chromatography on diethylaminoethyl cellulose column to give active fractions
that have more polar properties. These polar, high molecular weight fractions
which contained molecules with fucose and sulfate groups showed significant gel
contraction-promoting activity and integrin expression-enhancing activity, and
were estimated to be the sulfated-polysaccharide fucoidan. Commercially
available fucoidan showed similar activities to the above-described fraction of
this alga. Although it remains necessary to precisely identify the specific
active component, the above results indicate that fucoidan is the active
component which promotes collagen gel contraction, and also indicate the
possibility that it dose so by enhancing the integrin alpha2beta1 expression.

PMID: 11041247 [PubMed - indexed for MEDLINE]

J Nutr Sci Vitaminol (Tokyo) 1999 Jun;45(3):325-36 Related Articles, Books,
LinkOut


Inhibitory effect of Cladosiphon fucoidan on the adhesion of Helicobacter pylori
to human gastric cells.

Shibata H, KimuraTakagi I, Nagaoka M, Hashimoto S, Sawada H, Ueyama S, Yokokura
T.

Yakult Central Institute for Microbiological Research, Tokyo, Japan.

We studied the inhibitory effect of Cladosiphon fucoidan on the attachment of
Helicobacter pylori (H. pylori), a gastroduodenal pathogen, to human gastric
cell lines. The bacterial binding in these cell lines was inhibited more by
Cladosiphon fucoidan (IC50 = 16-30 mg/mL), than by the fucoidan from Fucus (IC50
> 30 mg/mL). Dextran sulfate, another sulfated polysaccharide, did not inhibit
the binding at all. Pre-incubating the bacterial suspension with fucoidans
reinforced the inhibitory ability of these components, and reduced the IC50
value of Cladosiphon fucoidan to approximately 1 mg/mL. However, the binding was
not inhibited by pre-treatment of gastric cells with these components. It was
also shown that this fucoidan blocks both Leb- and sulfatide-mediated attachment
of H. pylori to gastric cells. Furthermore, fucoidan-binding proteins were found
on the H. pylori cell surface by Western blot analysis. Thus, the inhibitory
effect exerted by Cladosiphon fucoidan on binding between H. pylori and gastric
cells might result from the coating with this component of the bacterial
surface.

PMID: 10524351 [PubMed - indexed for MEDLINE]



Biomed Mater Eng 2001;11(1):55-61 Related Articles, Books, LinkOut


Effect of oligofucose derivatives on acetic acid-induced gastric ulcer in rats.

Shibata H, Nagaoka M, Takagi IK, Hashimoto S, Aiyama R, Yokokura T.

Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan.
hideyuki-shibata@...

This study attempted to enhance the anti-ulcer activity of fucoidan from
Cladosiphon okamuranus TOKIDA by chemical modification with a hydrophobic group.
The suitable number of fucose residues in the effective compound was also
clarified to obtain a compound of constant quality. Degraded fucoidans were
coupled with several hydrophobic groups via Schiff bases, and their anti-ulcer
activities were determined by acetic acid-induced ulcer models in rats.
Size-fractionated oligofucose was also modified and assayed for anti-ulcer
activity. Among the modified oligofucoses, only the oligofucose-dodecylaniline
combination (OFDA) significantly promoted ulcer healing. The effective dose was
0.2 mg/kg/d. The most suitable number of fucose residues in the compound for the
anti-ulcer activity was determined to be around 12. We succeeded in enhancing
the anti-ulcer activity of Cladosiphon fucoidan by modification with
dodecylaniline. The activity of this compound was comparable or greater than
that of typical anti-ulcer agents. By determination of the optimal OF chain
length for the anti-ulcer activity of OFDA, it became possible to obtain OFDA of
constant quality.

PMID: 11281579 [PubMed - indexed for MEDLINE]

Experientia 1989 Oct 15;45(10):996-8 Related Articles, Books, LinkOut


Further characterization of sulfated homopolysaccharides as anti-HIV agents.

Sugawara I, Itoh W, Kimura S, Mori S, Shimada K.

Department of Pathology, University of Tokyo, Japan.

Fucoidan and dextran sulfate showed anti-HIV activities against mononuclear
cells from AIDS patients, and they abrogated HIV reverse transcriptase (RT)
activity by interacting with the HIV envelope in the membranes of target cells.
Furthermore, they showed a synergistic effect with azidothymidine (AZT).

PMID: 2478388 [PubMed - indexed for MEDLINE




Phytomedicine 1999 Nov;6(5):335-40 Related Articles, Books, LinkOut


Antiviral properties of fucoidan fractions from Leathesia difformis.

Feldman SC, Reynaldi S, Stortz CA, Cerezo AS, Damont EB.

Departamento de Quimica Organica-CIHIDECAR, Facultad de Ciencias Exactas y
Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Argentina.

Three fractions of fucoidans isolated from the brown seaweed Leathesia difformis
(Ee, Ec and Ea) were found to be selective antiviral agents against herpes
simplex virus (HSV) types 1 and 2 and human cytomegalovirus. Fraction Ea was the
most active, with IC50 values in the range 0.5-1.9 microg/ml without affecting
cell viability at concentrations up to 400 microg/ml. The antiherpetic activity
of Ea was assessed by three different methods, plaque reduction, inhibition of
virus yield and prevention of HSV-2 induced shut-off of cell protein synthesis,
demonstrating that the inhibitory effect was independent of the antiviral assay
and the multiplicity of infection. The mode of action of Ea could be ascribed to
an inhibitory action on virus adsorption. The fucoidans did not inhibit the
blood coagulation process even at concentrations exceeding more than 100 times
the IC50 value.

PMID: 11962540 [PubMed - indexed for MEDLINE]




Gen Pharmacol 1997 Oct;29(4):497-511 Related Articles, Books, LinkOut


Sulfated polysaccharides extracted from sea algae as potential antiviral drugs.

Witvrouw M, De Clercq E.

Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium.

The inhibitory effects of polyanionic substances on the replication of herpes
simplex virus (HSV) and other viruses were reported almost four decades ago.
However, these observations did not generate much interest, because the
antiviral action of the compounds was considered to be largely nonspecific.
Shortly after the identification of human immunodeficiency virus (HIV) as the
causative agent of the acquired immune deficiency syndrome (AIDS) in 1984,
heparin and other sulfated polysaccharides were found to be potent and selective
inhibitors of HIV-1 replication in cell culture. Since 1988, the activity
spectrum of the sulfated polysaccharides has been shown to extend to various
enveloped viruses, including viruses that emerge as opportunistic pathogens
(e.g., herpes simplex virus [HSV] and cytomegalovirus [CMV]) in immunosuppressed
(e.g., AIDS) patients. As potential anti-HIV drug candidates, sulfated
polysaccharides offer a number of promising features. They are able to block HIV
replication in cell culture at concentrations as low as 0.1 to 0.01 microgram
ml-1 without toxicity to the host cells at concentrations up to 2.5 mg ml-1. We
noted that some polysulfates show a differential inhibitory activity against
different HIV strains, suggesting that marked differences exist in the target
molecules with which polysulfates interact. They not only inhibit the cytopathic
effect of HIV, but also prevent HIV-induced syncytium (giant cell) formation.
Furthermore, experiments carried out with dextran sulfate samples of increasing
molecular weight and with sulfated cyclodextrins of different degrees of
sulfation have shown that antiviral activity increases with increasing molecular
weight and degree of sulfation. A sugar backbone is not strictly needed for the
anti-HIV activity of polysulfates because sulfated polymers composed of a
carbon-carbon backbone have also proved to be highly efficient anti-HIV agents
in vitro. Other, yet to be defined, structural features may also play an
important role. Sulfated polysaccharides may act synergistically with other
anti-HIV drugs (e.g., azidothymidine [AZT]). They are known to lead very slowly
to virus-drug resistance development and they show activity against HIV mutants
that have become resistant to reverse transcriptase inhibitors, such as AZT,
tetrahydro-imidazo [4,5,l-jk] [1,4]-benzodiazepin-2(1H)-thione (TIBO) and
others. From studies on their mechanism of action we concluded that polysulfates
exert their anti-HIV activity by shielding off the positively charged sites in
the V3 loop of the viral envelope glycoprotein (gp120). The V3 loop is necessary
for virus attachment to cell surface heparan sulfate, a primary binding site,
before more specific binding occurs to the CD4 receptor of CD4+ cells. This
general mechanism also explains the broad antiviral activity of polysulfates
against enveloped viruses. Variations in the viral envelope glycoprotein region
may result in differences in the susceptibility of different enveloped viruses
to compounds that interact with their envelope glycoproteins. The efficacy of
polysulfates in the therapy and/or prophylaxis of retroviral infections and
opportunistic infections remains to be demonstrated both in animal models and
humans. It is important to consider not only treatment of patients who are
already infected with HIV, but also prophylaxis and protection from HIV and/or
other virus infections. Because (i) sexual transmission is responsible for the
large majority of HIV infections worldwide; (ii) this transmission is mostly
mediated via mononuclear cells that infect epithelial cells of the genital
tract; and because (iii) polysulfates effectively inhibit cell-cell adhesion,
polysulfates may be considered as potentially effective in a vaginal formulation
to protect against HIV infection.

Publication Types:
Review
Review, Tutorial

PMID: 9352294 [PubMed - indexed for MEDLINE]




Biomed Pharmacother 1996;50(5):207-15 Related Articles, Books, LinkOut


Chemotherapy of human immunodeficiency virus (HIV) infection: anti-HIV agents
targeted at early stages in the virus replicative cycle.

De Clercq E.

Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.

Several compounds have been identified that inhibit an early stage in the
replicative cycle of the human immunodeficiency virus (HIV): i) virus
adsorption: polysulfates, polysulfonates, polycarboxylates, polyphosphates, and
polyoxometalates; or ii) virus-cell fusion: plant lectins, negatively charged
albumins and betulinic acid derivatives; iii) virus fusion/uncoating: bicyclam
derivatives; iv) reverse transcription: dideoxynucleoside analogues, acyclic
nucleoside phosphonates and non-nucleoside reverse transcriptase inhibitors. In
principle, HIV may develop resistance to any of these specific anti-HIV agents.
However, virus breakthrough can be completely prevented if these agents, alone
or in combination, are added to the HIV-infected cells from the beginning at
sufficiently high ('knock-out') concentrations.

Publication Types:
Review
Review, Tutorial

PMID: 8949401 [PubMed - indexed for MEDLINE

Ann Plast Surg 2001 Nov;47(5):540-6 Related Articles, Books, LinkOut


Protective effect of fucoidin (a neutrophil rolling inhibitor) on ischemia
reperfusion injury: experimental study in rat epigastric island flaps.

Cetin C, Kose AA, Aral E, Colak O, Ercel C, Karabagli Y, Alatas O, Eker A.

Department of Plastic & Reconstructive Surgery, Osmangazi University Medical
Faculty, Eskisehir, Turkey.

The objective of this study was to examine whether a decrease in
neutrophil-mediated tissue injury using Fucoidin, a nontoxic neutrophil rolling
inhibitor, would improve flap survival in an island flap model after
ischemia-reperfusion. Myeloperoxidase activity (an indirect index of tissue
neutrophil count) and malondialdehyde (an indicator of lipid peroxidation), the
degree of neutrophil infiltration by direct counting, and macroscopic flap
survival were assessed in the flap after arterial ischemia-reperfusion.
Epigastric island skin flaps were elevated in 56 rats. The first group of 21
rats was subjected to 6 hours of arterial ischemia. The second group of 21 rats
was subjected to 10 hours of arterial ischemia, and the rest of the rats were
used as nonischemic controls (sham flaps). For inhibiting neutrophil rolling, a
nontoxic polysaccharide agent-Fucoidin-was used. Each ischemic group was divided
further into three subgroups: Subgroup I (control rats) received saline,
subgroup II received 10 mg per kilogram Fucoidin, and subgroup III received 25
mg per kilogram Fucoidin before reperfusion. The results were evaluated as
tissue neutrophil counts, tissue malondialdehyde content, tissue myeloperoxidase
activity, and flap survival. Neutrophil counts and tissue myeloperoxidase
activity were decreased significantly (p <0.001) in subgroup III, but lipid
peroxidation by means of tissue malondialdehyde content was not affected by
Fucoidin administration. The authors conclude that administration of Fucoidin
before reperfusion can limit tissue injury apparently by inhibiting neutrophil
rolling in a dose-dependent manner.

PMID: 11716267 [PubMed - indexed for MEDLINE]