Sorry for the throwback to original limu info, but what a great study
AND yes I still use the best nitrition out there.



1: Eur J Pharmacol. 2009 Jun 19. [Epub ahead of print]
Fucoidan protects against dopaminergic neuron death in vivo and in
vitro. Luo D
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Pubmed_RVAbstractPlus> , Zhang Q
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l.Pubmed_RVAbstractPlus> , Wang H
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.Pubmed_RVAbstractPlus> , Cui Y
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Pubmed_RVAbstractPlus> , Sun Z
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Pubmed_RVAbstractPlus> , Yang J
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.Pubmed_RVAbstractPlus> , Zheng Y
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l.Pubmed_RVAbstractPlus> , Jia J
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Pubmed_RVAbstractPlus> , Yu F
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ubmed_RVAbstractPlus> , Wang X
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.Pubmed_RVAbstractPlus> , Wang X
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.Pubmed_RVAbstractPlus> .
Key laboratory of Neurodegenerative Diseases of the Ministry of
Education, Capital Medical University, Beijing 100069, PR China.

Parkinson's disease is a neurodegenerative disorder of uncertain
pathogenesis characterized by a loss of dopaminergic neurons in
substantia nigra pars compacta, and can be modeled by the neurotoxin
1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Oxidative stress
may contribute to MPTP- and Parkinson's disease-related
neurodegeneration. Fucoidan is a sulfated polysaccharide extracted from
brown seaweeds which possesses a wide variety of biological activities
including potent antioxidative effects. Here we investigated the effect
of fucoidan treatment on locomoter activities of animals, striatal
dopamine and its metabolites and survival of nigral dopaminergic neurons
in MPTP-induced animal model of Parkinsonism in C57/BL mice in vivo and
on the neuronal damage induced by 1-methyl-4-phenylpyridinium (MPP(+))
in vitro, and to study the possible mechanisms. When administered prior
to MPTP, fucoidan reduced behavioral deficits, increased striatal
dopamine and dopamine metabolite levels, reduced cell death, and led to
a marked increase in tyrosine hydroxylase expression relative to mice
treated with MPTP alone. Furthermore, we found that fucoidan inhibited
MPTP-induced lipid peroxidation and reduction of antioxidant enzyme
activity. In addition, pre-treatment with fucoidan significantly
protected against MPP(+)-induced damage in MN9D cells. Taken together,
these findings suggest that fucoidan has protective effect in
MPTP-induced neurotoxicity in this model of Parkinson's disease via its
antioxidative activity.



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