And I received an email to my private addy requesting a "$$ donation" to their
endeavor...  It came into my spam folder, and I deleted it..

I can't beleive they're still around.. I wonder if Meg and Pippin, etc are still
there..

Barb

--- In InfectionAndInflammation2@yahoogroups.com, Penny Houle <pennyhoule@...>
wrote:
>
>
> What was the bad news again?
>  
> I can't help but laugh and ask, how ironic is the following sentence?
>
> "We should be trying to work in collaboration, not in isolation."
> Or this?
>
> "Nothing can be achieved by ignoring the science, which is growing more
sophisticated month by month, or by ignoring the experience of the past eight
years.
> And if anyone finds the following statement surprising or unexpected, they
haven't been around very long, or they haven't been paying attention.
>
>  I have not been consulted about any of the changes your AAF Executive has
instituted this year. I therefore have no choice but to resign from, and
censure, the current Australian organization."
> Oh my god, I'm sorry, but I can't help but laugh. On a more serious level, how
is it that "the science" can keep changing month by month, but patients and
their doctors are not allowed to modify the protocol for their individual
needs? I guess, in the name of science, guinea pigs don't get a vote.
Apparently, neither do "collaborators"...until they mutiny. 
>  
> I don't know who or what this Australian organization is, but I hope
they adopt a much more objective and broader view in their study of "Chronic
Inflammatory and Autoimmune Diseases" than we've seen to date.
>  
> Perhaps something good can come out of this debaucle after all.
>  
>  
>
>
>
> --- On Fri, 12/11/09, Richard Windsor <rwindsor@...> wrote:
>
>
> From: Richard Windsor <rwindsor@...>
> Subject: [InfectionAndInflammation2] Fw: Aussie MP news - Both good and bad
> To: infectionandinflammation2@yahoogroups.com
> Date: Friday, December 11, 2009, 6:23 PM
>
>
>  
>
>
>
> FYI
> R
> ----- Original Message -----
> From: "Trevor Marshall" <Foundation@Autoimmu nityResearch. org>
> To: <rwindsor@alphalink. com.au>
> Sent: Saturday, December 12, 2009 10:04 AM
> Subject: Aussie MP news - Both good and bad
>
> >I am writing this letter to my Australian friends and colleagues bearing
> >both good and bad news. This past year our International network of
> >collaborators made major progress in moving the "Marshall Protocol" towards
> >acceptability to "mainstream medicine," with the goal that your local
> >physician will feel comfortable prescribing the MP, confident in the
> >knowledge of how it 'works its magic.' We have published five papers, have
> >spoken at numerous conferences, our new YouTube channel and wonderful new
> >MP Knowledge Base are both up and running:
> >
> > http://www.youtube. com/user/ DrTrevorMarshall
> >
> > http://MPKB. org
> >
> > For some time our FAQs have been slipping more and more out of date, as
> > the science underpinning the MP has become more advanced, and more solid.
> > The MPKB is designed as a Wiki, so that our community will be able to more
> > easily keep it up-to-date.
> >
> > The bad news is that I have been left no choice but to withdraw all
> > support from the organization which calls itself the "Australian
> > Autoimmunity Foundation" or its new name, the "Australian Chronic
> > Inflammatory and Autoimmune Diseases Foundation, Inc." The AAF executive
> > feels that I need to stand aside and perhaps fade into a university
> > somewhere, handing over responsibility for refining and improving the
> > protocol to physicians. Their expectation seems to be that a few busy
> > physicians, who may or may not have an adequate grasp of the current MP
> > science, will more quickly be able to devise improvements than the 598
> > members of our Professionals' Forum at the study site.
> >
> > At this critical moment in history we need absolute unity of purpose,
> > worldwide, if we are to successfully transition to mainstream. We should
> > be trying to work in collaboration, not in isolation. Nothing can be
> > achieved by ignoring the science, which is growing more sophisticated
> > month by month, or by ignoring the experience of the past eight years. I
> > have not been consulted about any of the changes your AAF Executive has
> > instituted this year. I therefore have no choice but to resign from, and
> > censure, the current Australian organization.
> >
> > My hope at this time is that our Australian members will be able to help
> > the AAF grow into an organization which understands that only with
> > worldwide collaboration can we stay on track to our own recoveries, and
> > best help others who are yet to commence that journey.
> >
> > We are about to start opening up the main MP site to new members again.
> > CureMy members who don't have access to the MarshallProtocol. com study
> > site will be able to join during a special 24 hour open-enrollment session
> > next Saturday, 19 December, from 12am to 12pm US Pacific time (7pm Sydney
> > time on the 19th to 7pm on 20th). Tell your family, and your friends.
> >
> > In May we will be mounting a big effort at the the Ljubjana International
> > Autoimmunity Congress, a special session themed on how to quickly
> > transition laboratory discoveries into the doctor's office - called
> > "Translating from Bench to Bedside." As we move into 2010, our focus must
> > be on 'collaboration, not isolation.'
> >
> > A very merry Christmas to you and yours,
> > Sincerely,
> > Trevor
> >
> > (Prof. Trevor G Marshall),
> > President, Autoimmunity Research Foundation.
> > This message was sent by: Autoimmunity Research Foundation, 3423 Hill
> > Canyon Ave, Thousand Oaks, CA 91360
> >
> > Email Marketing by iContact: http://freetrial. icontact. com
> >
> > Manage your subscription:
> > http://app.icontact .com/icp/ mmail-mprofile. pl?r=11754180& l=11228&s=
KYFB&m=132819& c=597929
> >
> >
> >
> >
> >
>

----- Original Message -----

From: Penny Houle

To: InfectionAndInflammation2@yahoogroups.com

Sent: Saturday, December 12, 2009 3:33 PM

Subject: Re: [InfectionAndInflammation2] Fw: Aussie MP news - Both good and bad

What was the bad news again?   I can't help but laugh and ask, how ironic is the following sentence? "We should be trying to work in collaboration, not in isolation." Or this? "Nothing can be achieved by ignoring the science, which is growing more sophisticated month by month, or by ignoring the experience of the past eight years. And if anyone finds the following statement surprising or unexpected, they haven't been around very long, or they haven't been paying attention.  I have not been consulted about any of the changes your AAF Executive has instituted this year. I therefore have no choice but to resign from, and censure, the current Australian organization." Oh my god, I'm sorry, but I can't help but laugh. On a more serious level, how is it that "the science" can keep changing month by month, but patients and their doctors are not allowed to modify the protocol for their individual needs? I guess, in the name of science, guinea pigs don't get a vote. Apparently, neither do "collaborators"...until they mutiny.    I don't know who or what this Australian organization is, but I hope they adopt a much more objective and broader view in their study of "Chronic Inflammatory and Autoimmune Diseases" than we've seen to date.   Perhaps something good can come out of this debaucle after all.     --- On Fri, 12/11/09, Richard Windsor <rwindsor@...> wrote: From: Richard Windsor <rwindsor@...> Subject: [InfectionAndInflammation2] Fw: Aussie MP news - Both good and bad To: infectionandinflammation2@yahoogroups.com Date: Friday, December 11, 2009, 6:23 PM   FYI R ----- Original Message ----- From: "Trevor Marshall" <Foundation@Autoimmu nityResearch. org> To: <rwindsor@alphalink. com.au> Sent: Saturday, December 12, 2009 10:04 AM Subject: Aussie MP news - Both good and bad >I am writing this letter to my Australian friends and colleagues bearing >both good and bad news. This past year our International network of >collaborators made major progress in moving the "Marshall Protocol" towards >acceptability to "mainstream medicine," with the goal that your local >physician will feel comfortable prescribing the MP, confident in the >knowledge of how it 'works its magic.' We have published five papers, have >spoken at numerous conferences, our new YouTube channel and wonderful new >MP Knowledge Base are both up and running: > > http://www.youtube. com/user/ DrTrevorMarshall > > http://MPKB. org > > For some time our FAQs have been slipping more and more out of date, as > the science underpinning the MP has become more advanced, and more solid. > The MPKB is designed as a Wiki, so that our community will be able to more > easily keep it up-to-date. > > The bad news is that I have been left no choice but to withdraw all > support from the organization which calls itself the "Australian > Autoimmunity Foundation" or its new name, the "Australian Chronic > Inflammatory and Autoimmune Diseases Foundation, Inc." The AAF executive > feels that I need to stand aside and perhaps fade into a university > somewhere, handing over responsibility for refining and improving the > protocol to physicians. Their expectation seems to be that a few busy > physicians, who may or may not have an adequate grasp of the current MP > science, will more quickly be able to devise improvements than the 598 > members of our Professionals' Forum at the study site. > > At this critical moment in history we need absolute unity of purpose, > worldwide, if we are to successfully transition to mainstream. We should > be trying to work in collaboration, not in isolation. Nothing can be > achieved by ignoring the science, which is growing more sophisticated > month by month, or by ignoring the experience of the past eight years. I > have not been consulted about any of the changes your AAF Executive has > instituted this year. I therefore have no choice but to resign from, and > censure, the current Australian organization. > > My hope at this time is that our Australian members will be able to help > the AAF grow into an organization which understands that only with > worldwide collaboration can we stay on track to our own recoveries, and > best help others who are yet to commence that journey. > > We are about to start opening up the main MP site to new members again. > CureMy members who don't have access to the MarshallProtocol. com study > site will be able to join during a special 24 hour open-enrollment session > next Saturday, 19 December, from 12am to 12pm US Pacific time (7pm Sydney > time on the 19th to 7pm on 20th). Tell your family, and your friends. > > In May we will be mounting a big effort at the the Ljubjana International > Autoimmunity Congress, a special session themed on how to quickly > transition laboratory discoveries into the doctor's office - called > "Translating from Bench to Bedside." As we move into 2010, our focus must > be on 'collaboration, not isolation.' > > A very merry Christmas to you and yours, > Sincerely, > Trevor > > (Prof. Trevor G Marshall), > President, Autoimmunity Research Foundation. > This message was sent by: Autoimmunity Research Foundation, 3423 Hill > Canyon Ave, Thousand Oaks, CA 91360 > > Email Marketing by iContact: http://freetrial. icontact. com > > Manage your subscription: > http://app.icontact .com/icp/ mmail-mprofile. pl?r=11754180& l=11228&s= KYFB&m=132819& c=597929 > > > > >

FYI
R
----- Original Message -----
From: "Trevor Marshall" <Foundation@...>
To: <rwindsor@...>
Sent: Saturday, December 12, 2009 10:04 AM
Subject: Aussie MP news - Both good and bad


>I am writing this letter to my Australian friends and colleagues bearing
>both good and bad news. This past year our International network of
>collaborators made major progress in moving the "Marshall Protocol" towards
>acceptability to "mainstream medicine," with the goal that your local
>physician will feel comfortable prescribing the MP, confident in the
>knowledge of how it 'works its magic.' We have published five papers, have
>spoken at numerous conferences, our new YouTube channel and wonderful new
>MP Knowledge Base are both up and running:
>
> http://www.youtube.com/user/DrTrevorMarshall
>
> http://MPKB.org
>
> For some time our FAQs have been slipping more and more out of date, as
> the science underpinning the MP has become more advanced, and more solid.
> The MPKB is designed as a Wiki, so that our community will be able to more
> easily keep it up-to-date.
>
> The bad news is that I have been left no choice but to withdraw all
> support from the organization which calls itself the "Australian
> Autoimmunity Foundation" or its new name, the "Australian Chronic
> Inflammatory and Autoimmune Diseases Foundation, Inc." The AAF executive
> feels that I need to stand aside and perhaps fade into a university
> somewhere, handing over responsibility for refining and improving the
> protocol to physicians. Their expectation seems to be that a few busy
> physicians, who may or may not have an adequate grasp of the current MP
> science, will more quickly be able to devise improvements than the 598
> members of our Professionals' Forum at the study site.
>
> At this critical moment in history we need absolute unity of purpose,
> worldwide, if we are to successfully transition to mainstream. We should
> be trying to work in collaboration, not in isolation. Nothing can be
> achieved by ignoring the science, which is growing more sophisticated
> month by month, or by ignoring the experience of the past eight years. I
> have not been consulted about any of the changes your AAF Executive has
> instituted this year. I therefore have no choice but to resign from, and
> censure, the current Australian organization.
>
> My hope at this time is that our Australian members will be able to help
> the AAF grow into an organization which understands that only with
> worldwide collaboration can we stay on track to our own recoveries, and
> best help others who are yet to commence that journey.
>
> We are about to start opening up the main MP site to new members again.
> CureMy members who don't have access to the MarshallProtocol.com study
> site will be able to join during a special 24 hour open-enrollment session
> next Saturday, 19 December, from 12am to 12pm US Pacific time (7pm Sydney
> time on the 19th to 7pm on 20th). Tell your family, and your friends.
>
> In May we will be mounting a big effort at the the Ljubjana International
> Autoimmunity Congress, a special session themed on how to quickly
> transition laboratory discoveries into the doctor's office - called
> "Translating from Bench to Bedside." As we move into 2010, our focus must
> be on 'collaboration, not isolation.'
>
> A very merry Christmas to you and yours,
> Sincerely,
> Trevor
>
> (Prof. Trevor G Marshall),
> President, Autoimmunity Research Foundation.
> This message was sent by: Autoimmunity Research Foundation, 3423 Hill
> Canyon Ave, Thousand Oaks, CA 91360
>
> Email Marketing by iContact: http://freetrial.icontact.com
>
> Manage your subscription:
>
http://app.icontact.com/icp/mmail-mprofile.pl?r=11754180&l=11228&s=KYFB&m=132819\
&c=597929
>
>
>
>
>

File        : NOTICE IN CASE OF LIST CLOSURE.doc
Description : In the Event of List Closure go to: InfectionAndInflammation3

Hi! I suffered from chronic sinus infections for 3.5 years until about a year
ago. I tried lots of things and even had surgery, but it didn't help for more
than 6 months. Finally I saw a doctor who, amongst other things, advised me to
cut cow dairy products out of my diet. Since then I have been relatively free
from infections.

I've created a one page blog detailing my experiences, the things I tried and
the advice the doctor gave me. I hope it can help other people with this
problem. http://sinus-wars.blogspot.com/

All the best, Trinithebean

Just for giggles
R
----- Original Message -----
From: "Trevor Marshall" <Foundation@...>
To: <rwindsor@...>
Sent: Tuesday, November 17, 2009 11:39 AM
Subject: Exciting news from the Autoimmunity Research Foundation


> To all our members,
>
> We are at an exciting and crucial point in the execution of our
> Foundation's mission.
>
> During the last year we published five peer-reviewed papers and presented
> at six international conferences. Check out these new resources:
>  -  ARF's new YouTube channel at
> http://www.youtube.com/user/DrTrevorMarshall
>  -  Our Marshall Protocol Knowledge Base at http://www.MPKB.org
>
> And if you've been away for a while, please come back and chat with our
> wonderful volunteer staff at both CureMyTh1.org and MarshallProtocol.com
>
> As you know, I was asked to present a Keynote paper at the World Gene
> Congress. Our ideas were very well-received, and the reviews were
> positive:
>  http://www.futuremedicine.com/doi/pdf/10.2217/17410541.6.2.143
>
> Amy Proal has just finished writing a chapter for a textbook on the
> relationship between the metagenome and autoimmune disease. The book is
> scheduled for publication in July 2010. This represents a big step towards
> international acceptance of the science behind our etiology and treatment
> protocol. We will share it with you as soon as we can.
>
> In a few months, the next International  Congress on Autoimmunity will be
> held in Ljubljana, Slovenia. Dr. Greg Blaney will be presenting a paper.
> We will also be organizing one of the sessions at the congress. I will be
> chairing it and presenting our ongoing research.
>
> The big challenge at this point is to fully understand immunopathology
> (IP).  Next year we plan to investigate the biochemistry of IP, take a
> closer look at the other nuclear receptors and further investigate the
> biochemistry of chronic disease. We will continue to support our
> collaborators in China, and we are also looking to extend our reach both
> in the US and in other countries.
>
> Frankly, in order for this to happen we need your help. It has been a long
> time since we asked for financial help, but your help right now is
> critical. We must continue to get the word out, and build on the
> foundations we have already put in place.
>
> We have never been this close to changing the way the world looks at
> chronic disease and helping to change the lives of the chronically ill.
>
> We now know that chronic disease is a preventable tragedy.  Let's put an
> end to the suffering.
>
> Please visit our 'Donations' page at:
>  http://AutoimmunityResearch.org/donate.html
>
> Sincerely,
>
> ..Trevor..
> .
> This message was sent by: Autoimmunity Research Foundation, 3423 Hill
> Canyon Ave, Thousand Oaks, CA 91360
>
> Email Marketing by iContact: http://freetrial.icontact.com
>
> Manage your subscription:
>
http://app.icontact.com/icp/mmail-mprofile.pl?r=11754180&l=11228&s=KYFB&m=72129&\
c=597929
>
>
>
>
>

File        : NOTICE IN CASE OF LIST CLOSURE.doc
Description : In the Event of List Closure go to: InfectionAndInflammation3

This is not a legitimate post and I don't know what might happen if the link is
opened. It's probably just spam, but it's still an unknown and could be
malevolent.

Unfortunately, yahoo groups doesn't always catch these bad posts. I delete them
and ban the authors as soon as I become aware of them, but that doesn't prevent
them from going through.

Anyway, ignore these kinds of messages posted at I&I, and definitely don't open
any links they may have inside.

penny


--- In InfectionAndInflammation2@yahoogroups.com, "newbjnfriends"
<newbjnfriends@...> wrote:
>
> You have 9 unviewed new emails! Check them here:

>

Hello all....Yes and diabetes is caused by an escaped virus from the stomach. Read my revamped site for an explanation on why and how ..Catch the antibiotics and animals insects ..looks like ive found the cause of the honey bee problem ..My MP has lobbied the British Research Council to give me an audience ..I'll keep you posted 

 

--- On Fri, 10/9/09, ESME European Society for ME <post@esme-eu.com> wrote: From: ESME European Society for ME <post@esme-eu.com> Subject: Landmark study finds retrovirus in 95% of ME/CFS patients To: "ESME European Community of ME" <post@esme-eu.com> Date: Friday, October 9, 2009, 11:31 AM Scientists at the Whittemore Peterson Institute (WPI) in Nevada have found a retrovirus, XMRV, in 95% of ME/CFS patients tested. The virus was originally discovered in cancer tissue of men with a specific genetic immune system defect.  “This is the breakthrough that we have been hoping for. Now we have scientific proof that this infectious agent is a significant factor in ME/CFS,” said Annette Whittemore, founder and president of WPI and mother of a ME/CFS patient. “Patients and their doctors will soon have a blood test to verify their diagnosis and provide the answers that they’ve been seeking.”   Read the press release here: http://www.wpinstitute.org/xmrv/docs/wpi_pressrel_100809.pdf   ESME

Internal Virus Database is out of date.
Checked by AVG - www.avg.com Version: 8.5.238 / Virus Database: 270.14.3/2409 - Release Date: 10/02/09 06:46:00

What a moron.  I think the biggest issue in health care reform is dealing with
physician's ego's.  They don't like it when we don't bow down and
unquestioningly accept their 5 minute assessment of our decades long issues. 
Thank God they are not all that way, but unfortunately it is a common theme in
their professional "syndrome" which clearly keeps innovation out of their
community and inadvertantly causes the alternative health care profession to
thrive.  If they can't find compassion for their patients perhaps they can drum
up a little compassion and concern for their checkbook.

All the best,

Shelley

--- In InfectionAndInflammation2@yahoogroups.com, Penny Houle <pennyhoule@...>
wrote:
>
> Yeah, I'm so over it as well.
>  
> I recently posted here about a San Diego immunologist for whom I had very high
hopes. Turns out Dr Jeckyll became Mr. Hyde when in the exam room alone with me.
Most humiliating and frustrating doctor's visit I've ever had, and I've had some
pretty bad ones.
>  
> He basically said I needed treatment for depression, not a physical illness
(despite a huge folder of evidence to the contrary and dxs of
chronic infection). He even told me there was no such thing as "chronic
infection" (although on the previous visit he said he suspected a chronic
underlying infection). I was so shocked and angry at what he was saying that my
eyes teared up, which he used as conclusive proof that the root of all my health
problems was mental. (clearly he has no understanding of common female anger
reactions.) His rationalle was that everything I was dealing with health-wise
would only naturally cause depression. But, um...didn't you just say that I'm
sick because I'm depressed? Or is it I'm depressed because I'm sick? When I told
him I knew the difference between depression and normal frustration because I'd
been depressed many years ago, he told me that confirmed his dx because I "had a
history of depression"!!! Omigod!!! This
>  after talking to him for all of 30 seconds. GRRRRR!!!   Basically, he was
angry that I didn't obediently agree to the sinus surgery he referred me for. I
guess he felt the need to belittle me rather than calmly discuss the pros and
cons of more sinus surgery.  
>  
> I'd love to air-drop a ton of these articles all over his smug self as he
walks out to his mercedes at the end of the day.
>  
> Please, if any of you thought about making an appointment with this San Diego
immunologist, talk to me first and save yourself a huge disappointment.
>  
> penny
>  
>  
>
>
> --- On Fri, 10/9/09, sreed57 <sreedp@...> wrote:
>
>
> From: sreed57 <sreedp@...>
> Subject: [InfectionAndInflammation2] Re: Discovery of XMRV retrovirus in
chronic fatigue syndrome
> To: InfectionAndInflammation2@yahoogroups.com
> Date: Friday, October 9, 2009, 12:08 PM
>
>
>  
>
>
>
> This is so exciting, Penny. It cracks me up that the CDC is so concerned about
it being in 4% of the healthy controls.... ..excuse me, I think the real problem
is in our camp! I too am tired of being treated like an hysterical middle aged
female in response to my devastating illness. It seems the only available
treatment from traditional medical offices is condescension. I'm over it.
>
> --- In InfectionAndInflamm ation2@yahoogrou ps.com, Penny Houle <pennyhoule@
...> wrote:
> >
> > Here's the NY Times article on the subject:
> >  
> > http://www.nytimes. com/2009/ 10/09/health/ research/ 09virus.html? _r=1
> >  
> > And a whole list of major publications reporting the story:
> >
> > http://news. google.com/ news/more? pz=1&cf=all& ncl=dANLiI0J4tW0
VZMDD9ozWdRfBN_ MM&topic= m
> >  
> > The good news, the study is getting lots of attention. It's a significant
finding.
> >  
> > The bad news, it's hard to treat viruses. But then, as we've learned, it's
hard to treat entrenched bacterial infections and their biofilms as well.
> >  
> > Viruses and bacterial infections both cause the same kinds of immune
response and inflammatory symptoms. I hope science starts to realize the
obvious link between chronic illness and infections of all sorts sooner than
later.
> >  
> > Mostly, I hope that what appears to be a big step in acknowledging CFS as a
real illness is sustained, and research continues, after the attention to this
new finding dies down.
> >  
> > It would be nice to walk into a doctor's office and have your illness
acknowledged, rather than ridiculed, which happens too frequently and
happened to me recently.
> >  
> > penny
> >  
> >  
> >  
> >  
> >  
> >  
> >
>

This is so exciting, Penny.  It cracks me up that the CDC is so concerned about
it being in 4% of the healthy controls......excuse me, I think the real problem
is in our camp!  I too am tired of being treated like an hysterical middle aged
female in response to my devastating illness.  It seems the only available
treatment from traditional medical offices is condescension.  I'm over it.

--- In InfectionAndInflammation2@yahoogroups.com, Penny Houle <pennyhoule@...>
wrote:
>
> Here's the NY Times article on the subject:
>  
> http://www.nytimes.com/2009/10/09/health/research/09virus.html?_r=1
>  
> And a whole list of major publications reporting the story:
>
>
http://news.google.com/news/more?pz=1&cf=all&ncl=dANLiI0J4tW0VZMDD9ozWdRfBN_MM&t\
opic=m
>  
> The good news, the study is getting lots of attention. It's a significant
finding.
>  
> The bad news, it's hard to treat viruses. But then, as we've learned, it's
hard to treat entrenched bacterial infections and their biofilms as well.
>  
> Viruses and bacterial infections both cause the same kinds of immune response
and inflammatory symptoms. I hope science starts to realize the
obvious link between chronic illness and infections of all sorts sooner than
later.
>  
> Mostly, I hope that what appears to be a big step in acknowledging CFS as a
real illness is sustained, and research continues, after the attention to this
new finding dies down.
>  
> It would be nice to walk into a doctor's office and have your illness
acknowledged, rather than ridiculed, which happens too frequently and
happened to me recently.
>  
> penny
>  
>  
>  
>  
>  
>  
>

Published Online October 8, 2009
Science DOI: 10.1126/science.1179052 Science Express Index

Reports

Submitted on July 14, 2009
Accepted on August 31, 2009

Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with
Chronic Fatigue Syndrome

Vincent C. Lombardi 1 , Francis W. Ruscetti 2 , Jaydip Das Gupta 3, Max A. Pfost
1, Kathryn S. Hagen 1, Daniel L. Peterson 1, Sandra K. Ruscetti 4, Rachel K.
Bagni 5, Cari Petrow-Sadowski 6, Bert Gold 2, Michael Dean 2, Robert H.
Silverman 3, Judy A. Mikovits 1*
1 Whittemore Peterson Institute, Reno, NV 89557, USA.
2 Laboratory of Experimental Immunology, National Cancer Institute-Frederick,
Frederick, MD 21701, USA.
3 Department of Cancer Biology, The Lerner Research Institute, The Cleveland
Clinic Foundation, Cleveland, OH 44106, USA.
4 Laboratory of Cancer Prevention, National Cancer Institute-Frederick,
Frederick, MD 21701, USA.
5 Advanced Technology Program, National Cancer Institute-Frederick, Frederick,
MD 21701, USA.
6 Basic Research Program, Scientific Applications International Corporation,
National Cancer Institute-Frederick, Frederick, MD 21701, USA.

* To whom correspondence should be addressed.
Judy A. Mikovits , E-mail: judym@...

  These authors contributed equally to this work.

Chronic fatigue syndrome (CFS) is a debilitating disease of unknown etiology
that is estimated to affect 17 million people worldwide. Studying peripheral
blood mononuclear cells (PBMCs) from CFS patients, we identified DNA from a
human gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), in
68 of 101 patients (67%) compared to 8 of 218 (3.7%) healthy controls. Cell
culture experiments revealed that patient-derived XMRV is infectious and that
both cell-associated and cell-free transmission of the virus are possible.
Secondary viral infections were established in uninfected primary lymphocytes
and indicator cell lines following exposure to activated PBMCs, B cells, T
cells, or plasma derived from CFS patients. These findings raise the possibility
that XMRV may be a contributing factor in the pathogene

WALL STREET JOURNAL
OCTOBER 8, 2009, 3:12 P.M. ET

Retrovirus Linked to Chronic-Fatigue Syndrome

By AMY DOCKSER MARCUS

Researchers have linked an infectious virus known to cause cancer in animals to
chronic-fatigue syndrome, a major discovery for sufferers of the condition and
one that concerned scientists for its potential public-health implications.
An estimated 17 million people world-wide suffer from chronic-fatigue syndrome,
a devastating condition about which there is little medical consensus. CFS is
characterized by debilitating fatigue and chronic pain, among other symptoms,
but diagnosis is generally made by ruling out other diseases, and there are no
specific treatments.
Many patients say they are told by doctors that their problems are
psychological, so a study showing a strong association between a virus and CFS
is likely to change the field.
But the significance of the finding, published Thursday in Science, extends far
beyond the community of people living with CFS. Researchers are just as
concerned about the finding that nearly 4% of healthy people used as controls in
the study were also infected with the virus, called XMRV. If larger studies
confirm these numbers, it could mean that as many as 10 million people in the
U.S. and hundreds of millions of people around the world are infected with a
virus that is already strongly associated with at least two diseases.
The study was done by researchers at the Whittemore Peterson Institute for
Neuro-Immune Disease in Reno, Nev., the National Cancer Institute and the
Cleveland Clinic.
In September, researchers at the University of Utah and Columbia University
Medical Center found XMRV in 27% of the prostate-cancer samples they examined.
That study also showed that 6% of the benign prostate samples had XMRV. The
chronic-fatigue study is the first to find live XMRV virus in humans.
Neither study conclusively shows that XMRV causes chronic-fatigue syndrome or
prostate cancer. But the National Cancer Institute was sufficiently concerned to
convene a closed-door workshop in July to discuss the public-health implications
of XMRV infection. "NCI is responding like it did in the early days of HIV,"
says Stuart Le Grice, head of the Center of Excellence in HIV/AIDS and cancer
virology at NCI and one of the organizers of the July workshop.
Like HIV, XMRV is a retrovirus, meaning once someone is infected, the virus
permanently remains in the body; either a person's immune system keeps it under
control or drugs are needed to treat it. The virus creates an underlying immune
deficiency, which might make people vulnerable to a range of diseases, said Judy
Mikovits of the Whittemore Peterson Institute and one of the lead authors on the
paper.
So far, XMRV, known fully as xenotropic murine leukemia virus-related virus,
doesn't appear to replicate as quickly as HIV does. Scientists also don't know
how XMRV is transmitted, but the infection was found in patients' blood samples,
raising the possibility that it could be transmitted through blood or bodily
fluids.
Dr. Le Grice of the NCI said the highest priority now was to quickly develop a
validated blood test or other assay that could be used in doctors' offices to
determine who has XMRV. At the workshop, participants also raised the issue of
protecting the nation's blood supply. Dr. Le Grice said there isn't enough
evidence yet to suggest that people with XMRV shouldn't be blood donors but that
determining how XMRV is transmitted was a critical issue. "A large effort is
under way to answer all these questions," he said. "I do not want this to be
cause for panic."
Although Thursday's scientific paper doesn't demonstrate conclusively that XMRV
is a cause of CFS, additional unpublished data make it a very strong
possibility. Dr. Mikovits said that using additional tests, the scientists
determined that more than 95% of the patients in the study are either infected
with live virus or are making antibodies that show their immune systems mounted
an attack against XMRV and now had the virus under control. "Just like you
cannot have AIDS without HIV, I believe you won't be able to find a case of
chronic-fatigue syndrome without XMRV," Dr. Mikovits said.
At the July workshop, Dr. Mikovits also presented preliminary data showing that
20 patients of the 101 in the study have lymphoma, a rare form of cancer. The
link between XMRV and lymphoma is still being investigated, but it raised the
possibility that XMRV may be associated with other cancers in addition to
prostate cancer. NCI's Dr. Le Grice said studies will be launched to determine
whether XMRV is associated with other diseases. At the Whittemore Peterson
Institute, Dr. Mikovits said they also found XMRV in people with autism,
atypical multiple sclerosis and fibromyalgia.
The Science study was based on blood samples from a national repository at the
Whittemore Peterson Institute collected from doctors in cities where outbreaks
of chronic-fatigue syndrome occurred during the 1980s and '90s. One of the key
questions that the NCI's Dr. Le Grice says must now be answered is whether XMRV
shows up in large numbers of CFS patients all over the country.
Robert Silverman, a professor at the Cleveland Clinic Lerner Research Institute
who is one of the co-authors of the study and one of the discoverers of the XMRV
virus, said he believes the virus began in mice and then spread to humans, and
that "in most cases, people's immune systems are probably able to control the
virus." Researchers are already starting to test antiretroviral therapies
developed for AIDS to see if they are effective against XMRV.
The work on XMRV in chronic-fatigue patients initially was funded by Annette and
Harvey Whittemore and the University of Nevada, Reno. The Whittemores set up the
institute in 2006 after watching their daughter Andrea suffer from
chronic-fatigue syndrome for most of her life. They spent millions of their own
money to pay for administrative services, office space, lab equipment and
research operations. They were frustrated by the lack of government funding for
scientific research into the disease.
At their home in Reno, the Whittemores' daughter, Andrea Whittemore-Goad, 31
years old, used oxygen before speaking about the devastating toll CFS has taken
on her.
Ms. Whittemore-Goad says she was a regular school girl, playing sports and
involved in school activities, until the age of 10, when she became ill with a
monolike virus that she couldn't shake. She said doctors first told her parents
that the illness was psychological, that she had school phobia and was under
stress from her parents. "We kept searching for an answer," says Ms.
Whittemore-Goad, who says lymph nodes in her groin were so painful that her
brothers and sisters used to have to carry her upstairs. She was diagnosed at
age 12 with chronic-fatigue syndrome.
Over the years, doctors have treated her symptoms, like intense headaches and
severe pain, but the illness persists. She has had her gallbladder, spleen, and
appendix removed because they became infected. She tried an experimental drug
that she says gave her relief for years, but she then started experiencing side
effects and had to stop taking it. Recently the illness has become worse; she
began suffering seizures and can no longer drive.
Sitting on the couch next to her husband, whom she married six months ago after
meeting, Ms. Whittemore-Goad says the news that she is infected with XMRV "made
everything that has happened to me make sense." Brian Goad, her husband, said he
felt relieved knowing "now we can find a way to treat and hopefully cure it."
For both of them, the discovery of the virus is life-changing. There are more
than 10 families in the group where family members also tested positive for
XMRV. Members of the Whittemore family are now being tested.
Write to Amy Dockser Marcus at amy.marcus@...

REUTERS

Study isolates virus in chronic fatigue sufferers
Thu Oct 8, 2009 2:00pm EDT

* Virus found in 67 percent of chronic fatigue patients

* Findings show link to CSF, not proof of causation

* Discovery a major step toward treatment options

By David Morgan

WASHINGTON, Oct 8 (Reuters) - A virus linked to prostate cancer also appears to
play a role in chronic fatigue syndrome, according to research that could lead
to the first drug treatments for a mysterious disorder that affects 17 million
people worldwide.

Researchers found the virus, known as XMRV, in the blood of 68 out of 101
chronic fatigue syndrome patients. The same virus showed up in only 8 of 218
healthy people, they reported on Thursday in the journal Science.

Judy Mikovits of the Whittemore Peterson Institute in Nevada and colleagues at
the National Cancer Institute and the Cleveland Clinic emphasized that the
finding only shows a link between the virus and chronic fatigue syndrome, or
CFS, and does not prove that the pathogen causes the disorder.

Much more study would be necessary to show a direct link, but Mikovits said the
study offers hope that CFS sufferers might gain relief from a cocktail of drugs
designed to fight AIDS, cancer and inflammation.

"You can imagine a number of combination therapies that could be quite effective
and could at least be used in clinical trials right away," Mikovits said in a
telephone interview.

She said AIDS drugs such as non-nucleoside reverse transcriptase inhibitors and
integrase inhibitors as well as nonsteroidal anti-inflammatory drugs and
cancer-fighting proteasome inhibitors could be tested as potential treatments
for CFS.

Takeda Pharmaceutical Co Ltd (4502.T: Quote, Profile, Research, Stock Buzz)
makes a cancer drug called Velcade that is a proteasome inhibitor, although
there are no reports that it has been tested against XMRV.

INCAPACITATING FATIGUE

CFS impairs the immune system and causes incapacitating fatigue, according to
the U.S. Centers for Disease Control and Prevention. Sufferers can also
experience memory loss, problems with concentration, joint and muscle pain,
headaches, tender lymph nodes and sore throats.

Symptoms last at least six months and can be as disabling as multiple sclerosis
or rheumatoid arthritis, the CDC said.

But Mikovits said there is currently no treatment for CFS aside from cognitive
behavioral therapy to help patients cope with the disorder's crippling effects.

The XMRV virus is a retrovirus, like the HIV virus that causes AIDS. As with all
viruses, a retrovirus copies its genetic code into the DNA of its host but uses
RNA -- a working form of DNA -- instead of using DNA to do so.

Known formally as xenotropic murine leukemia virus-related virus, XMRV has also
been found in some prostate tumors and is also known to cause leukemia and
tumors in animals. [ID:nN07209255]

Mikovits' team said further research must now determine whether XMRV directly
causes CFS, is just a passenger virus in the suppressed immune systems of
sufferers or a pathogen that acts in concert with other viruses that have been
implicated in the disorder by previous research.

"Conceivably these viruses could be co-factors in pathogenesis, as is the case
for HIV-mediated disease, where co-infecting pathogens play an important role,"
the report said.

Because 3.7 percent of the healthy test population tested positive for XMRV, the
researchers said several million otherwise healthy people in the United States
could be infected with it. (Editing by Maggie Fox and Vicki Allen)


THE WASHINGTON POST

Virus Associated With Chronic Fatigue Syndrome

Scientists have found evidence that a virus may play a role in chronic fatigue
syndrome.

Vincent C. Lombardi of the Whittemore Peterson Institute in Reno, Nev., and
scientists elsewhere studied 101 patients with chronic fatigue syndrome, a
baffling, debilitating and controversial condition that affects an estimated 17
million people worldwide. They discovered that 68 of the patients -- 67 percent
-- had a virus in their blood known as the xenotropic murine leukemia
virus-related virus or XMRV. Only eight of 218 similar subjects who did not have
chronic fatigue syndrome -- 3.7 percent -- had the virus in their blood, the
researchers report in a paper published online Thursday by the journal Science.
Further studies showed that the virus is indeed infectious, and can "provoke"
the immune system to respond.
The researchers cautioned that the findings far from prove that the virus causes
chronic fatigue. It may be just part of the picture. But they suggest that the
virus may at least contribute to the development of the disorder. This isn't the
first time a virus has been associated with the condition. Previous research has
suggested that some herpes viruses and other viruses may also play a role.
In an article accompanying the research, John Coffin of Tufts University in
Boston and Jonathan Stoye of the National Institute for Medical Research in
London agreed. They noted that there are many unanswered questions about the
virus, including how it is transmitted. But if the findings are representative
of what's going on in the general public, perhaps 10 million Americans and
hundreds of millions of people worldwide might be infected with the virus, which
could turn out to be playing a role in a variety of diseases. The virus
previously was found in some patients with prostate cancer.
By Rob Stein |  October 8, 2009; 2:00 PM ET  |


NPR

Virus Linked To Chronic Fatigue Syndrome

by Jon Hamilton
October 8, 2009

Scientists have uncovered a strong link between an unusual virus and chronic
fatigue syndrome, which affects more than 1 million people in the United States.
Researchers found that two-thirds of people with chronic fatigue are infected
with a retrovirus called XMRV, according to a new study in the journal Science
Express. XMRV has also been found in the tumors of some prostate cancer
patients.
Scientists say it's too soon to say whether XMRV actually causes chronic
fatigue.
People with the syndrome feel tired even after a good night's sleep. Many also
have debilitating pain in their muscles or joints, trouble concentrating and
immune problems.
The new study compared blood samples from 101 chronic fatigue patients with
samples from 218 healthy people. About 67 percent of the sick people had XMRV,
compared with fewer than 4 percent of healthy people.
Understanding The Retrovirus
XMRV and other retroviruses are known to infect immune cells. XMRV has been
found in some prostate tumors. It's also related to a retrovirus that causes
cancer in animals.
The best-known retrovirus is HIV. But scientists say XMRV is simpler, and not a
close relative.
In people, XMRV could explain "the entire spectrum of symptoms that have come to
be known as chronic fatigue syndrome," says Judy Mikovits, one of the study's
authors and research director of the Whittemore Peterson Institute at the
University of Nevada, Reno.
But scientists have pointed to viruses as a cause of chronic fatigue before and
been wrong.
"This is a very striking initial finding, but it is only an initial finding,"
says John Coffin, a molecular biologist from Tufts University who was not
involved in the study. He co-authored a companion piece about the finding in
Science Express.
Researchers have suspected for a long time that chronic fatigue might be caused
by a virus.
One reason for that suspicion is that many people get the condition after a
flu-like illness, says Mikovits. "They get very bad flu-like symptoms and
essentially never recover," she says.
Most viruses don't survive long in the body. But retroviruses are one type that
lingers. HIV, for example, is a retrovirus that infects people for a lifetime.
So when scientists found XMRV in people a couple of years ago, Mikovits thought
there might be a connection to chronic fatigue, which also tends to last a
lifetime.
She was in a position to find out. After many years at the National Institutes
of Health, she'd come to the Whittemore Peterson Institute, a place founded to
help people with chronic fatigue.
Mikovits worked with a team that began checking patients' blood for XMRV.
"We simply did a screen of the sickest of the sick of our patients because we
figured that would be where we would find the most virus," she says. "And, lo
and behold, there it was."
Tests also showed the virus was infectious and was provoking an immune response
in people with chronic fatigue.
Isolating The Cause
The finding is "the best news ever" for people with chronic fatigue, says
Annette Whittemore, one of the founders of the Whittemore Peterson Institute.
"We've always known there was something out there. Now we see its face," she
says.
Whittemore has an adult daughter who has had chronic fatigue since she was 12.
She created the institute with Dr. Daniel Peterson, one of the first doctors to
identify people with the condition that later became known as chronic fatigue
syndrome.
Even though XMRV has not yet been shown to cause chronic fatigue syndrome, it
has characteristics that make it a likely suspect, experts say.
For one thing, it's a retrovirus.
"Retroviruses in general give rise to infections that persist indefinitely,"
says Coffin. Most other viruses are eliminated from the body.
Coffin says he's concerned by the finding that nearly 4 percent of healthy
people carried XMRV. That would mean 10 million people in the U.S. are infected.
Coffin says scientists need to find out whether the virus is causing health
problems other than chronic fatigue in any of these people.
For people who have chronic fatigue, the XMRV finding could lead to the first
treatments.
Antiviral drugs developed for people with HIV may also work against XMRV,
Mikovits says. The institute plans to begin testing that idea soon.


NATURENEWS
Published online 8 October 2009 | Nature | doi:10.1038/news.2009.983
Virus linked to chronic fatigue syndrome
Prostate cancer pathogen may be behind the disease once dubbed 'yuppie flu'.
Lizzie Buchen
A study on chronic fatigue syndrome (CFS) has linked the mysterious and
controversial disease to a recently discovered retrovirus. Just last month
researchers found the same virus to be associated with aggressive prostate
tumours.
CFS is marked by debilitating exhaustion and often an array of other symptoms,
including memory and concentration problems and painful muscles and joints. The
underlying cause of the disease is unknown; it is diagnosed only when other
physical and psychiatric diseases have been excluded. Though the disease's
nebulous nature originally drew scepticism from both doctors and the general
public, most of the medical community now perceives it as a serious — if poorly
defined — disease.
Now Judy Mikovits of the Whittemore Peterson Institute for Neuro-Immune Disease
in Reno, Nevada, and her colleagues think they have discovered a potential
pathogenic link to CFS. In patients with the disease from different parts of the
United States, 67% were infected with a retrovirus known as XMRV. Less than 4%
of controls carried the virus.
"I can't wait to be able to tell my patients," says Mikovits, who is also the
vice president of drug development for Genyous Biomed in Henderson, Nevada.
"It's going to knock their socks off. They've had such a stigma. People have
just assumed they were just complainers who didn't handle stress well."
Prostate puzzle
CFS researchers have long had their eyes on retroviruses. A number of the
symptoms, including fatigue and cognitive dysfunction, can occur when the immune
system is dealing with a viral infection, and the disease is often preceded by a
flu-like illness. Although a number of retroviruses have been hypothesized to
play a role in CFS, none has ever been confirmed.
About three years ago Robert Silverman, a biologist at the Cleveland Clinic
Foundation in Ohio and a coauthor of the new study, discovered a previously
unknown retrovirus, XMRV, while searching for a pathogen that might contribute
to prostate cancer. The retrovirus was very similar to MLV, a group of viruses
that can cause cancer and neurological and immunological diseases in mice.
Silverman found XMRV in a subset of prostate tumours, and more recent research
found a stronger correlation between XMRV and aggressive prostate tumours1,2.
Mikovits asked Silverman to analyze the blood samples of 101 CFS patients and
218 healthy controls. The authors detected XMRV DNA in the immune cells of 67%
of the CFS patients but in only 3.7% of healthy controls. The authors also
showed that the virus was able to spread from infected immune cells to cultured
prostate cancer cells and that the virus's DNA sequence was more than 99%
similar to the sequence of the virus associated with prostate cancer. The
findings were published in Science3.
"It's scary," says Mikovits. "But it's cool. Hopefully this will finally make
people change their attitudes to this disease."
Mikovits believes the association may be even stronger than the present work
indicates. DNA sequencing only picks up active infections, she says, so she
wants to study CFS exposure to the virus more broadly. In an unpublished
investigation, she and her colleagues analyzed blood cells in about 330 CFS
patients and found that more than 95% expressed antibodies to XMRV, whereas
about 4% of healthy controls did.
Controversial connection
Although Mikovits acknowledges that it's premature to suggest a causal link
between XMRV and CFS, she thinks it makes sense. Chronic XMRV infection in
immune cells could cause them to churn out inflammatory cytokines, which are
observed in some CFS patients, she says. Mikovits also points out that the MLV
coat protein can disrupt red blood cells in mice, leading to low blood oxygen
levels.
William Reeves, principal investigator for the Centers for Disease Control and
Prevention (CDC)'s CFS public health research programme, says the findings are
"unexpected and surprising" and that it is "almost unheard of to find an
association of this magnitude between an infectious agent and a well-defined
chronic disease, much less an illness like CFS".
But Reeves is cautious. "Until the work is independently verified, the report
represents a single pilot study," he says. According to Reeves, the CDC is
already trying to replicate these findings. He also notes that CFS is a
heterogeneous disease and likely arises from a combination of many factors.
XMRV presents its own puzzle. John Coffin, a virologist at Tufts University in
Boston who has studied MLV, points out that the virus's prevalence in healthy
controls "is, in some ways, an equally striking result".
"It's highly preliminary, but if it's in fact representative, then there are 10
million Americans with this infection, which is very similar to MLV and is now
linked to two important diseases," says Coffin. "There's a lot we don't know,
including whether XMRV causes disease, but that's always the case when the first
paper, like this one, comes out."
• References
1. Schlaberg, R. et al. Proc. Natl Acad. Sci. USA 106, 16351– 16356 (2009).
2. Urisman, A. et al. PLoS Pathogens 2, e25 (2006).
3. Lombardi, V. C. et al. Science doi:10.1126/science.117052 (2009).

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Hi everyone,

Summary of talk presented by Dr. Chitra Bhakta on "Adrenal Fatigue, Correction
of Genetic Methylation Pathways, and Protocol for Decreasing Inflammation in
Lyme, Autism and Chronic Illness"

by

Rich Van Konynenburg


Dr. Chitra Bhakta, M.D., Director of Orange County Integrative Medical Center in
Tustin, California, presented a talk on the above topics on Saturday afternoon,
September 12, 2009, in Conference Room F in the lower level of the Presbyterian
Intercommunity Hospital in Whittier, CA.

The talk was sponsored by the Southern California Lyme Support group,
coordinated by Earis Coram.  I heard about it from Al Melillo, who also
attended, together with about 30 other people.

Dr. Bhakta is from India, where she received her medical training.  She did her
residency at the Los Angeles County Hospital.  Her specialty is family medicine.

It was clear to me from her talk and discussions afterward that Dr. Bhakta puts
the best interests of her patients first, and that she continues to search for
new developments that will enhance their treatment.  The protocols she uses
today combine contributions from several front-line researchers.

A few years ago, she was treating a number of autism patients, and she had
become familiar with and used the Defeat Autism Now! (DAN!) approach for
treating autism.  This was effective for many of the cases, but some of the kids
she was treating never got better.  She attended the Lyme-Induced-Autism
conference and then tested these nonresponding patients for Lyme disease,
finding that they all had either Lyme disease or its coinfections.  This is how
she became involved in treating Lyme disease.  She then trained with Dr. Charles
Ray Jones (age 82!) in Connecticut.  He is the foremost pediatrician treating
Lyme disease.

She integrated the DAN! and ILADS (International Lyme and Associated Diseases
Society) approaches to treatment into her treatment protocols, but felt that
antibiotics were being used too much to treat Lyme disease.  She developed an
approach that treats several aspects first, and then uses antibiotics later, if
necessary.

She decided to start her treatment with the gut, as is done by others in autism.

She has been treating the methylation cycle for about ten years, based on the
research of Drs. S. Jill James and Richard Deth.

She became aware of the later work of Amy Yasko, Ph.D., N.D., who applied the
science of nutrigenomics, which had come from the University of California at
Davis, to the treatment of autism.  She believes that this approach has merit,
but she found Dr. Yasko's treatment to be very complicated.

She reported that she found my work (involving the Glutathione
Depletion—Methylation Cycle Block (GD-MCB) hypothesis for chronic fatigue
syndrome (CFS) and the Simplified Treatment Approach based on it) on the
internet.  She noted that I had applied the methylation cycle related
biochemistry to CFS and had been able to explain many of the features of CFS on
this basis.  She also noted that I had "streamlined" the Yasko treatment
approach, making it easier to use.

She displayed a large chart showing the methylation cycle and associated
pathways that had been developed by Dr. Yasko, and explained the relationships
between the methylation and folate cycles and the transsulfuration pathway,
including glutathione.

She explained that Dr. James and coworkers had found that genetic "weaknesses"
can block several sites in this part of the metabolism.  In addition,
environmental factors, such as thimerosol in vaccines, can contribute to this as
well.  A block in the methylation cycle will cause decreases in plasma
methionine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine
(SAMe/SAH). It will also lower the ratio of reduced to oxidized glutathione
(GSH/GSSG).

She went on to describe the GD-MCB hypothesis for CFS in detail.  A discussion
of this hypothesis can be found on the internet at

http://aboutmecfs.org/Rsrch/GSHMethylation.aspx

She noted that according to this hypothesis CFS is caused by a combination of
genetic predisposition and stressors, except in the epidemics or clusters, where
the genetic factor is less important because of the action of a virulent
pathogen.

She suggested that polymorphisms in the enzymes CYP2D6 and COMT may be
associated with fibromyalgia, and a polymorphism in NAT2 may be associated with
multiple chemical sensitivity.

She also reported that Borrelia burgdorferi bacteria have been found to deplete
glutathione in their host, and noted that I had suggested that this may provide
a link between Lyme disease and CFS.

She reviewed some of the polymorphisms to which Dr. Yasko has drawn attention,
including AHCY-1, BHMT-08, CBS C699T, COMT V158M, MTR A2756G, and MTRR A66G.

She discussed the work of Dr. Ritchie Shoemaker on Lyme and other biotoxin
diseases, noting his FACT test for visual contrast sensitivity, HLA DR DQ
typing, and other tests.

She said that she prefers using the K-PAX multivitamin.

She reported success in raising the glutathione levels in two autistic patients
using OSR#1 at a dosage of 300 mg per day, in whom it had not been possible to
raise glutathione levels before.

She discussed KPU or the "mauve factor" as originally discovered by the late Dr.
Abram Hoffer and coworkers.  This was originally found in the urine of
schizophrenia patients.  It results from an inborn genetic error in the pyrrole
metabolism, which is used to make hemoglobin.  Dr. Dietrich Klinghardt has found
that this is present in 80% of his Lyme patients, and it causes a depletion of
zinc and vitamin B6.  Dr. Bhakta recommended getting the $59 test for KPU from
www.kryptopyrrole.com.  She described Dr. Klinghardt's KPU treatment, which is
available on his website.  She also discussed his metal detox protocol.  Dr.
Bhakta said that she prefers to use the Metagenics formulas for detox, i.e. the
Ultraclear Renew for fibromyalgia, and the Ultraclear Plus pH for CFS.

Dr. Bhakta also discussed the Neuroscience approach to testing and treating the
neuroendocrineimmune issues.  She talked about the stages of adrenal fatigue and
noted that correction of this condition must be done centrally, because
neurotransmitters are involved.

She discussed inflammation and noted that there are many chronic inflammatory
conditions, which involve inflammatory cytokines.  She discussed new research
pertaining to the cholinergic anti-inflammatory pathway, and noted that
acetylcholine has been found to be important for lowering the levels of
inflammatory cytokines and stopping inflammation.  She discussed a new treatment
called Avipaxin, produced by Neuroscience.  Avipaxin contains both a
cholinesterase inhibitor to inhibit the breakdown of acetylcholine, as well as
supplements to feed the formation of new acetylcholine.

In starting her treatment with the gut, she recommends three tests:  food
allergies, stool analysis, and an organic acids test.

She emphasized that the human body is complex, and it is necessary to address
several aspects of these illnesses in order to treat it successfully.  She
pointed out the importance of eating organic food, locally grown and seasonal.
She recommended eating 5 or 6 small meals per day, like a diabetic diet.
For food allergies, she recommends a rotation diet, switching foods each week. 
She recommended taking Juice Plus to get the nutrients from vegetables and
fruits.  For omega-3 fatty acids, she recommended EPA-Select.  She emphasized
that it's important to raise the EPA intake, but not DHA.

She favors starting with one new supplement at a time, to see what the response
is, before adding others.

In response to a question, she recommended that vegetables be cooked at first,
until the gut is able to handle raw vegetables.  At that point, salads are very
beneficial.

For protein, she recommended Alaskan wild salmon and organic meats, such as
bison meat.

She favors removing amalgams, so that they do not continue to introduce mercury
into the body.

She emphasized that in treating these disorders, it is necessary to use a
synergistic approach.

I was of course gratified to learn that Dr. Bhakta had found the Glutathione
Depletion—Methylation Cycle Block hypothesis and the Simplified Treatment
Approach based on it to be helpful in treating her patients.  She has found
treatment of the methylation cycle issue to be an important part of her overall
treatment protocol, but it must be emphasized that it is not the whole thing.
Her treatment also includes several other aspects of these disorders as well.

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I have something VERY important to tell you! Check it here:
http://needextral.zoomshare.com/files/myfriends.htm

File        : NOTICE IN CASE OF LIST CLOSURE.doc
Description : In the Event of List Closure go to: InfectionAndInflammation3

Well- That's pretty thorough.  He just have a LIST of people he wants to sue..
I guess he's still out there beating the bushes for people to subscribe to his
theories.

Barb

--- In InfectionAndInflammation2@yahoogroups.com, Penny Houle <pennyhoule@...>
wrote:
>
> Someone sent me a link to the following post from the Pro Health site:
>  
> http://www.prohealth.com/me-cfs/blog/boardDetail.cfm?id=1354223&B1=EG070109
>  
> mayers
> 6/16/09 7:36 PM
>  
> Hidden Risks and Dangers of the Marshall Protocol
>  
> “The human body does not require sunlight, nor foods containing Vitamin D,
in order for it to function correctly. The human body can manufacture all the
Vitamin D it needs from its own 7-dehydrocholesterol. Clinical medicine is just
plain wrong on its understanding of the actions of Vitamin D.” Trevor Marshall
(1)
>
> The Marshall Protocol (MP) claims to cure CFS and FM, as as such, is a very
polarizing topic. People are either really for it, or really against it. Seduced
by the molecular modeling and hope of a cure, I was on the protocol for almost
two years. However, after almost landing in ER and experiencing a permanent
deterioration in all my CFS symptoms, I have learnt first-hand of the dangers
and risks of the MP, none of which I was warned. The MP worsened my existing CFS
symptoms such as fatigue, sleep dysfunction, muscle and joint pain and created
new symptoms such as neuropathy, parenthesisa, breathing difficulties, cardiac
pain and tinnitus which have persisted. Thus I feel that it is my duty to warn
others who may be considering the MP, which continues to attract many new
patients, of all the hidden risks so that they can make a fully informed
decision about whether to undertake this protocol.
>
> The Marshall Protocol claims to be a curative treatment for illnesses caused
by cell wall deficient bacteria. Given that various credible researchers such as
Nicholson and De Meirleir have found mycoplasma in between 50-68% of CFS and FM
patients, the MP seems to be a logical treatment option (2). (However it is
unclear whether mycoplasma are the causative agent for CFS or FM or a secondary
infection.) However, just because mycoplasma may be involved in your condition,
it does not necessarily follow that the Marshall Protocol is either a safe or
effective therapy.
>
> Invented by electrical engineer Trevor Marshall PhD, the Marshall Protocol was
initially designed for the treatment of sarcoidosis, a Th1 disease in which
granulomas form in the lungs and where vitamin D pathways appear to be
deregulated (this is generally not the case with CFS). The treatment is based on
the premise that 25 vitamin D is immunosuppressive, that the cell wall deficient
bacteria are converting excessive amounts of it into 1,25 vitamin D which
creates inflammation in the body and thus disease symptoms. Consequently the
Marshall Protocol advocates:
>
> 1 Eliminating exogenous sources of vitamin D including both dietary and
sunshine. (This is includes blocking windows and installing low watt globes).
> 2 The use of Benicar in high doses which partially blocks the vitamin D
receptor and inhibits certain inflammatory processes.
> 3 The use of different combinations of low pulsed antibiotics in order to
eliminate the bacteria. (Penny's note: I would add here that the minocyline
literature cites dangerous side effects that the MP dismiss as "herx".)
>
> The elimination of vitamin D in tandem with the use of Benicar is claimed to
switch on the innate immune system so that it ‘sees’ the bacteria. Marshall
claims that the antibiotics don't directly kill the bacteria, but merely latch
on to their RNA subunits, weakening them, and allowing the immune system to
eliminate them. This theory, none of the elements of which have ever been tested
in a lab, has since been rolled out to all autoimmune diseases as well as CFS
and FM all of which Marshall claims are Th1 conditions and thus have the same
pathogenesis and can all be cure by his protocol.
>
> Who is Trevor Marshall?
> Before I tackle the safety of the MP directly I think there is value in having
a look at who Trevor Marshall is as the protocol has been wholly created by him
and is not endorsed by any other researcher. While there has been some interest
in his theories lately, there is little support in the biomedical or molecular
modeling communities for the protocol to be applied to patients in its present
form.
>
> Trevor Marshall trained as an electrical engineer and did his PhD thesis with
the Department of Electrical Engineering on modeling insulin production and
flows in diabetic patients (using mathematical equations). Although he spent
some time in the early 1980s modeling reproductive hormones, he spent most of
his career working on electronic engineering and IT, including running YARC, a
printer technology company, from 1988 until its bankruptcy in 2000. During this
time YARC, headed by Marshall, was involved in over a dozen litigations at the
Superior Court of California, predominantly as the defendant. The most
interesting being Joseph La Bruna v. YARC Systems Corporation (2001) where the
court found that Marshall “made representations and promises and concealed and
omitted the true facts knowing such representations, promises and concealments
and omissions to be false. They were made with the intention of deceiving,
defrauding and misleading the
>  plaintiff, and to induce him to act in reliance thereon.” (3)
>
> After YARC went bankrupt, Marshall devoted himself to reading as much as he
could on sarcoidosis, from which he suffered, and devised the Marshall Protocol
in order to rid himself of the disease. After he and a small group of other
sarcoidosis patients began noting improvements in their condition, Trevor
Marshall decided to create a study site on the web for other sarcoidosis
patients in 2002 and then in 2004 decided that all autoimmune illnesses, as well
as CFS and FM, were Th1 illness and had the same pathogenesis as sarcoidosis and
opened the study site up to all these conditions.
>
> It is important to note that Trevor Marshall has little research experience in
chronic illnesses and no formal training or research experience in microbiology,
biochemistry or drug administration. While Trevor Marshall promotes himself as a
Biochemical Engineer his PhD was in electrical engineering and consists of many
equations modeling the effects of insulin in diabetic patients. His area of
expertise is computer modeling, rather than medicine. His understanding of
immunology is based on his own readings of various scientific literature.
>
> How was the Marshall Protocol devised?
> Trevor Marshall devised the protocol in order to treat his own sarcoidosis. He
read into the discipline as an outsider and created a theory from his own
research and personal experiences. He then wrote a computer model based on his
research. The current Marshall Protocol is an extrapolation of the sarcoidosis
theory to all autoimmune conditions which Marshall claims are all Th1 illness.
(CFS is not considered an autoimmune condition and is considered a Th2 dominate
illness not Th1 dominant illness). No objective lab work or animal testing was
performed in order to determine the safety or efficacy of the treatment. Trevor
and a few compatriots who were sarcoidosis patients simply experimented with
various drugs on themselves. While Marshall has presented his model at a number
of conferences now, he has not published any scientific papers on the full
protocol itself in any peer reviewed journals. There is no support for his work
in the biomedical community
>  as he has not presented any objective data to support his claims.
>
> Is it a cure?
> The protocol is promoted as a curative treatment yet there is no evidence of
this yet. The statement is made based solely on Marshall’s theoretical model
not patient outcomes. After 5 years, no CFS patients are permanently of all the
medications (including Benicar) and completely ‘cured’. While some patients
have improved on the antibiotics, many of them have relapsed when they have
stopped taking them and many still have just steadily deteriorated. A couple of
CFS patients who had improved on the protocol and were held up as 'success
stories' relapsed after stopping the antibiotics after 3-4 years on the
protocol. Other patients stopping the protocol have also developed urinary tract
infections, cancer and osteoporosis after extended periods on the MP. If you
read the Phase 2 and 3 web boards on the www.marshallprotocol.com (you need to
be a member in phase 2 or 3 to have access to these) you will see that the
health of many people deteriorated
>  while on the MP and they have had difficulty clawing it back (4). You will
not hear about this or any such dangers on the public access Marshall Protocol
site or www.curemyth1.org or www.bacteriality.com. There only the success
stories are advertised.
>
> The time promised for full remission on the Marshall Protocol was initially
12-18 months, then it became 2-3 years, then 3-5 years now 8-10 years is being
bandied about. These are all Marshall’s projections, none of these claims are
based on fact or outcomes. That’s an awfully long time to be on antibiotics
and out of the sun.
>
> Hidden Risks
> Marshall claims that his protocol is perfectly safe for use by adults and
children but does not provide any evidence to back this claim up. In fact the
protocol involves many risks none of which are disclosed on the Marshall
Protocol site, namely:
>
> 1. The risk of being out of the sun for extended periods of time will
invariably deregulate your hormones. Vitamin D is a hormone that is critical to
numerous of functions in the body. Long term vitamin D deprivation is associated
with an increased the risk of osteoporosis, rickets and cancer. Vitamin D plays
an important role in both the adaptive and innate the immune systems and has
been found to be responsible for the synthesis of antimicrobial peptides(5).
Marshall thinks that clinical medicine is completely wrong, that vitamin D is
always immunosuppressive and dismisses the health risks associated with vitamin
D deprivation because they do not fit in with his theories.
>
> 2. Modulating the immune system for prolonged periods in a way that has not
been tested in a lab or on animals can have all sorts of dangers. Marshall has
based his protocol on a computer simulation which is underpinned by his
assumptions, rather than lab tests. Medical science does not yet fully
understand what various receptors and components in the immune system do and
what happens if you shut some of them down. For example, if you block
Angiotensin II Receptor, which Benicar does, wound healing is impaired. Any
number of feedbacks or alternative pathways could result none of which are known
or can be predicted in a computer model. We simply don’t have enough
information to make definitive claims yet.
>
> 3. The risk of taking antibiotics over long periods of time can create
resistant strains of bacteria. This is especially a risk where patients are
exposed to concentrations of antibiotics which are below the minimum
concentration required for killing bacteria as on the Marshall Protocol.
Bacteria have a number of ways in which to avoid being detected or killed by
antibiotics particularly when they are exposed to them over a long period of
time. Indeed resistance to macrolides (which are used in the MP) is an
increasingly growing problem.(6) Marshall claims that it is the immune system,
not the antibiotics doing the killing, that the antibiotics simply weaken the
bacteria and make them more susceptible to being killed by the immune system,
but there is no evidence of this. You just have to trust his theory that vitamin
D is always immunosuppressive (which no one else agrees with) and its absence
activates the immune system. One must also consider damage
>  that long term impacts of antibiotic use can have on bacteria in the
gastrointestinal tract.
>
> 4. Side effects of the drugs themselves:
> o Benicar: The Marshall Protocol recommends the use of Benicar at four times
the recommended dose for extended periods.
> - Benicar is a very effective antihypertensive agent and also decreases
aldosterone levels. CFS specialist Dr. Cheney states that this can be
problematic in CFS patients who already often have low blood volume and low
aldosterone levels.
> - The safety of Benicar has only been tested on humans for up to a year and
only at half of the dose recommended by the Marshall Protocol. It has only been
tested on rats for up to 2 years, yet the protocol requires patients to remain
on Benicar for several years. (7)
> o The antibiotic Minocycline can have a number of side effects especially when
used over the long term. Many of these are similar to the rise in symptoms that
patients are told to expect from bacterial die back(8). So it is impossible to
tell whether patients on the MP are experiencing bacteria die back or just a
drug side effect.
> o Other antibiotics used in the MP are not typically used over the long term
so little is known about their safety over extended periods.
>
> Patient Care
> Every symptom encountered on the site is attributed by the moderators to
toxins released due to bacterial die back or 'Jarisch Herxheimer Reaction' (or
'herx'). Symptoms can be acute and varied and can include cardiac symptoms,
breathing difficulties, vomiting, depression etc
Some of these may be
dangerous drug reactions others merely exacerbation of disease symptoms.
Moderators constantly assure patients on the internet web boards that these
symptoms are an indication of bacterial die back, that their medication dosage
should merely be adjusted and at best some palliation may be required. No other
alternative causes such as allergic reactions, drug toxicity, disease
exacerbation, vitamin D deficiency are ever suggested as these symptoms are
never contemplated as possibilities on the MP, despite the fact that vitamin D
deficiency is known to create depression, muscle and joint pain (9). Patients on
the MP are encouraged to drive their 25 vitamin D
>  levels to below 12ng/ml on Phase 2 and 3 of the protocol, which is severely
deficient, the recommended vitamin D levels being 32-65ng/ml.
>
> Interestingly the moderators who are advising patients on how to interpret
symptoms and how to adjust their medication are all themselves Marshall Protocol
patients. They have all yet to finished the protocol and are still ill (to
varying degrees) and see the protocol as their only way out of the disease. They
all cling to the protocol as it represents hope, the only road to health and
gives them a sense of control over their illness. As such, they are all very
devoted to the protocol which inevitably clouds their judgment when advising
patients on how to interpret symptoms and adjust their medications or whether
the patients ought to be on the protocol at all. The overriding goal of the MP
site is not to achieve the best possible outcome for the patient, but to push
the patient through the protocol, as it is automatically assumed that in the end
this will be in the patient’s best interest. Thus patients are encouraged to
‘hang in there’ even when
>  their symptoms are quite acute and dangerous and are assured that this is a
sign of bacterial die back and thus part of the healing process. This has
resulted in a number of patients ending up in emergency wards.
>
> Validity of Data
> While the Marshall Protocol site claims to be a study site, the evidence used
to support the MP on the site is not objective. Any positive post by a patient
on the Marshall Protocol.com site is put up in the success stories section even
though the improvement may be temporary and the patient has subsequently felt
worse. The only way to verify this is to read all of a patients posts in the
Phase 2/3 forum which are off limits to anyone not in phase 2 or 3. A handful of
people have improved on the MP but it is a much smaller number than the success
stories page would have you believe and improvement is based on self reporting.
There is no way of knowing what percentage of people who started the MP have
subsequently improved because anyone who stops the MP, due to an adverse
reaction to the protocol is discounted. No one is interested in why they dropped
out and none of this is followed up or documented. One only needs to scan the
membership list (which has
>  date of commencement and number and date of patient posts) to see how high
the dropout rate is. These patients are simply dismissed as not being tough or
dedicated enough, or not complying with the rules. Only those who stay on it for
over a year are eligible for inclusion in any ‘study’. So far the only study
conducted was a voluntary retrospective survey that was sent out to a random
selection of patients. Obviously those having more success with the protocol are
more likely to stay on it as well as respond to a survey. The patient feedback
was retrospective and based on self reporting so this study (which was conducted
by a patient as well) has more holes in it than Swiss cheese. This is the data
that Marshall cites at conferences in order to prove the efficacy of the MP.
>
> Interestingly no one is off all the MP medications and actually cured
themselves of anything except perhaps Trevor Marshall. The number of CFS
patients who have not relapsed going off the antibiotics is still in single
digits. Most patients are plugging away on 3 different types of antibiotics,
Benicar often with anti-inflammatories, pain killers, sleep meds etc
and
claiming they feel better or that they will 'turn the corner soon'. It is
difficult to know what is a drug effect and what is genuine improvement as
Benicar and Minocycline do have an anti-inflammatory effect which could be
mistake for genuine healing and, as state previously, most MP patients have
experienced a worsening of symptoms when discontinuing the antibiotics which is
ongoing (see patient comments on the following web boards) (10). This all
implies that at best the antibiotics were palliating their symptoms and at worse
suppressing their own immune systems allowing bacteria to
>  proliferate and possibly breeding new antibiotic resistant strains of
bacteria on the way.
>
> Patients often persist on the Marshall Protocol despite being in great pain as
cling to the hope of a cure and they are told by moderators that these symptom
exacerbations are a sign of healing. Thus often patients do not quit until their
symptoms become so intolerable that they are forced to stop. Interestingly, of
the 40 MP the patients at my doctor’s clinic who persisted into Phase 2 (most
dropped out in phase 1 due to acute symptoms), half them have experienced a
worsening of CFS symptoms as a result of the MP and they have often developed
new CFS symptoms including orthostatic intolerance, anxiety, neuropathy, muscle
and joint pain, light sensitivity, digestive problems and depression. The other
half managed to return to their pre-MP level of health after a couple of months
(these people usually have spent less time in Phase 2.) Interestingly, none of
the ex-MP patients from my clinic have experienced any symptoms improvement
after stopping the
>  MP. One would think that if bacteria were indeed being killed by the
protocol, that at least someone would feel better after all that herxing.
>
> Conclusion
> Perhaps the biggest folly of the Marshall Protocol is the belief that what
happens in a computer simulation will be directly replicated in the human body.
The human body is vastly complex system with multiple pathways and feedback
loops. The idea of calculating the drug affinity of a few receptors on a
computer, running a simulation, and then confidently claiming that this will be
replicated in the human body is naĂŻve and dangerous. Molecular modeling is a
starting point for research, it provides a general direction for lab work,
avoiding the needle in the haystack approach to research which wastes time. But
all of this needs to be validated step by step in the lab before being rolled
out to desperate patients as cure, especially when it contradicts many current
lab findings, as the Marshall Protocol does. Patients on the MP are expected to
trust the results of one computer model, however unfortunately theory does not
neatly translate into reality (11).
>  We don’t know enough about how bacteria and the immune system work to build
reliable models at this stage.
>
> So in summary the risks of going on the Marshall Protocol include:
> - Risks associated with having low vitamin D for extended periods of time
include immune suppression, risk of cancer, rickets and osteoporosis.
> - Risk of modulating the immune system in untested ways with unknown
consequences.
> - Risk of taking Benicar at four times the recommended doses for prolonged
periods of time with unknown consequences.
> - Risk of developing bacterial resistance and proliferation from being on
antibiotics for long periods of time and a worsening of your condition.
>
> These are substantial health risks to be taking in light of the lack of
evidence to support the claim of a cure for CFS and FM by the Marshall Protocol.
So if mycoplasma are found to be contributing to your condition, it may be best
to consider other treatment options.
>
> Footnotes:
> (1): http://www.marshallprotocol.com/view_topic.php?id=9023&forum_id=35
jump_to=178280#p178280
> (2): http://www.immed.org/illness/fatigue_illness_research.html,
http://www.neurotransmitter.net/mycoplasma.html
>
> (3) JOSEPH LA BRUNA VS YARC SYSTEMS CORP, Superior Court of California, County
of Ventura (2001) Case number: CIV201956 ; A summary of this and other cases can
be read at
http://www.sarkoidose.de/apboard/useraction.php?action=get_upload&id=23; The
list of court cases the YARC and Marshall were involved in can be found by
typing ‘YARC’ into the Case Enquiry search box (for Civil cases) at the
Superior Court of California, County of Ventura website found at:
http://www.ventura.courts.ca.gov/vent_frameset_puba.htm
> (4) See the patient comments on the following pages:
http://heartscanblog.blogspot.com/2008/03/marshall-protocol-and-other-fairy-tale\
s.html,http://articles.mercola.com/sites/articles/archive/2009/03/14/Clearing-Up\
-Confusion-on-Vitamin-D--Why-I-Dont-Recommend-the-Marshall-Protocol.aspx
>
> (5)
http://www.jimmunol.org/cgi/content/abstract/179/4/2060?maxtoshow=&HITS=10&hits=\
10&RESULTFORMAT=&searchid=1&FIRSTINDEX=0&minscore=5000&resourcetype=HWCIT,
http://www.sciencemag.org/cgi/content/abstract/1123933v1,
http://www.ncbi.nlm.nih.gov/pubmed/19285323?ordinalpos=6&itool=EntrezSystem2.PEn\
trez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum,
http://www.ncbi.nlm.nih.gov/pubmed/19086827?ordinalpos=17&itool=EntrezSystem2.PE\
ntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum,
http://www.ncbi.nlm.nih.gov/pubmed/19090451?ordinalpos=15&itool=EntrezSystem2.PE\
ntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum,
http://healthnewsdigest.com/news/Patient_230/Vitamin_D_Immune_Response_May_Reduc\
e_Fatal_Infections_in_Dialysis_Patients.shtml
>
> (6) http://aac.asm.org/cgi/content/abstract/50/11/3646,
http://www.ncbi.nlm.nih.gov/pubmed/14733843,
http://www.docguide.com/news/content.nsf/news/8525697700573E1885256AE800496803
> (7) http://www.fda.gov/medwatch/SAFETY/2004/nov_PI/Benicar_Tab_PI.pdf
> (8) http://www.drugs.com/minocycline.html,
http://www.drugs.com/pro/minocycline.html
> (9)
http://www.webmd.com/pain-management/news/20031210/lack-of-vitamin-d-linked-to-p\
ain,
http://www.nutraingredients-usa.com/Research/Vitamin-D-deficiency-linked-to-grea\
ter-pain
>
> (10) See the patient comments on the following pages:
http://heartscanblog.blogspot.com/2008/03/marshall-protocol-and-other-fairy-tale\
s.html,http://articles.mercola.com/sites/articles/archive/2009/03/14/Clearing-Up\
-Confusion-on-Vitamin-D--Why-I-Dont-Recommend-the-Marshall-Protocol.aspx
>
> (11) http://www.thisisms.com/ftopic-5628-0-days0-orderasc-.html,
> http://stuff.mit.edu/people/london/universe.htm
>  
>
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>  
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