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NHE hypothesis confirmed by new findings   Message List  
Reply | Forward Message #283 of 426 |
Re: [HormonalFitness] Re: NHE hypothesis confirmed by new findings

Hi Keith and Joel,

Since you mentioned calorie restriction and life extension, you may be interested in an article I came across recently. It discusses glyceroneogenesis in skeletal muscle and ehanced physical performance in transgenic mice that overexpress the gluconeogenic enzyme PEPCK. I find this extremely interesting, as it counters the argument that calorie restriction is a key to longevity. It also suggests that the role of fatty acids in intensive physical activity is underrated.
 
Hakimi et al (2007) Over-expression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J. Biol. Chem., Aug 2007; doi:10.1074 /jbc.M706127200

Cheers!

Simon

On Dec 8, 2007 9:39 PM, Joel Rosart <joel.rosart@...> wrote:

Hi Keith,
 
Rob talks about epidemiological studies on page 54 of NHE. As he points out, numerous studies have correlated fat intake with cardiovascular disease. But if any of us thought that these studies were true, then we wouldn't be following NHE! The problem of course is that all of these populations also have high sugar intakes, so its impossible to find the real culprit based on these studies.
 
So an epidemiological study is pretty useless on its own, especially when a researcher's bias can determine what conclusions are made.
 
You did make a very good point in your original post saying that "...they incorrectly assume that all food is equal." I couldn't agree more. I suspect that a lot of the mice studies that claim to support calorie restriction as a form of life extension are massively flawed in that the type of food fed is not considered. Do you think a human would be healthier eating 3000 calories of white flour per day, or 2000 calories? I think we all know the answer to that! And it certainly proves nothing about calorie restriction except to restrict crap calories!
 
Cheers,
 
Joel

 
On Dec 9, 2007 4:45 AM, Keith Thomas <keith@...> wrote:

"Joel Rosart" <joel.rosart@...> wrote:
>
> Uh oh, epidemiological study alert!
>
Hi, Joel

Could you elaborate on the reason for your wariness about epidemiological studies,
please? Is it a general skepticism of epidemiology, is it about the narrow focus of some
epidemiological research, or is it more about popular media oversimplification of research
reports?

Keith





Sun Dec 9, 2007 10:34 am

simon_dankel
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Message #283 of 426 |
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Hi, Simon, Joel and others. The following article from New Scientist is directly relevant to NHE, although the scientists whi reported their research seem to...
Keith Thomas
keiththomasau
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Nov 14, 2007
8:13 pm

Uh oh, epidemiological study alert! I agree that fasting is probably healthy every now and again (just not during intense recovery periods!!!) That said, I...
Joel Rosart
jrosart295
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Nov 14, 2007
10:14 pm

... Hi, Joel Could you elaborate on the reason for your wariness about epidemiological studies, please? Is it a general skepticism of epidemiology, is it about...
Keith Thomas
keiththomasau
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Dec 8, 2007
6:15 pm

Hi Keith, Rob talks about epidemiological studies on page 54 of NHE. As he points out, numerous studies have correlated fat intake with cardiovascular disease....
Joel Rosart
jrosart295
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Dec 8, 2007
8:39 pm

Hi Keith and Joel, Since you mentioned calorie restriction and life extension, you may be interested in an article I came across recently. It discusses ...
Simon Dankel
simon_dankel
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Dec 9, 2007
10:34 am

... Joel, sorry for my tardy reply. As I read it, you are not criticizing epidemiological studies as such, just the poor methodology employed by some...
Keith Thomas
keiththomasau
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Dec 21, 2007
8:06 pm
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