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Marsha has a new HDL article online covering the exciting press release this past weekend on Novel targets for HD. It's a pretty detailed study and article. I don't know what most of us would do without the HDL to help translate the majority of the research published on HD. THANK YOU Marsha!!
Approved drugs found to induce autophagy
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=559&test=1
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=559&test=1
UK researchers have found that several existing drugs which are already approved for other purposes induce autophagy, an alternate way to clear away the HD protein.
Editor's Comment:
Inducing autophagy as an alternate way to enhance the clearance of the HD protein is a very promising strategy for preventing or delaying the onset of Huntington's Disease. A new study by Professor David C. Rubinsztein and colleagues suggests new drugs that induce autophagy for the research pipeline. Understanding how these drugs work has also provided some new insights about Huntington's Disease.
Press release March 2008
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Promising new drug targets identified for Huntington's disease
Research funded by the Wellcome Trust has provided a number of promising new drug targets for Huntington's disease, a neurodegenerative disease. Scientists at the University of Cambridge have identified a number of candidate drugs to investigate further which encourage cells to "eat" the malformed proteins that lead to the disease.
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