Way to go,Mike!!!!!!
Freeda





Message: 1
Date: Sat, 22 Jan 2005 15:09:20 -0000
From: "Michael"
Subject: Dr.Appointment Notice


Hello everyone, I just got my notice to make my appointment with my
hemtologist Dr. in March.
I can't beleive it will my 3 year aniversary with C.M.L.
I'am a single 400(gleevec) pill per day since diag. 3/02
I've been in remission since my 6 month(9/02) check up by F.I.S.H.
Test. I have my CBC'S checked 1 x month.
My last two 6 month check ups(3/04)& (9/04) have been by RT-PCR TEST.
I'am currently in Molecular Remission by RT-PCR TEST.
Age 46 w/m law enforcment.
Again, for those you are considering a bone marrow
transplant..consider gleevec first.Mike







Freeda

---------------------------------
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  Yahoo! Search presents - Jib Jab's 'Second Term'

[Non-text portions of this message have been removed]

My onc says, if he had to consider bone marrow transplant for me, that would be
his and my last resort. He says since Gleevec works so good for me, he will not
give up on me.
I am doing well so far. One never knows how the body will accept the new imune
system, I would rather not do it. Sounds very harsh, but thats how I feel.
Silvia, CML

__________________________________________________
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[Non-text portions of this message have been removed]

Hi Mike that's awesome news! I am so happy for you that you have done so
well on Gleevec.  I hope you continue to show excellent response....keep up  the
good work! - Lynne a.


[Non-text portions of this message have been removed]

Hello everyone, I just got my notice to make my appointment with my
hemtologist Dr. in March.
I can't beleive it will my 3 year aniversary with C.M.L.
I'am a single 400(gleevec) pill per day since diag. 3/02
I've been in remission since my 6 month(9/02) check up by F.I.S.H.
Test. I have my CBC'S checked 1 x month.
My last two 6 month check ups(3/04)& (9/04) have been by RT-PCR TEST.
I'am currently in Molecular Remission by RT-PCR TEST.
Age 46 w/m law enforcment.
Again, for those you are considering a bone marrow
transplant..consider gleevec first.Mike

Hi Kim,

I've been on Gleevec, 400mg, for almost 4 years, and I also get
cramps and sometimes feel 'achy' all over.  It helps me to drink a
lot of water, eat a banana and/or orange for breakfast in the morning
(for potassium) and I take a calcium/magnesium pill in the afternoon.
It's best to take the calcium/magnesium combination, because calcium
needs magnesium to work and absorb properly.

Some moderate exericise helps too, like a 20 minute daily walk.
Hope this helps your mom!

Regards,
Gale Bacon
dx'd 3/00, interferon until 5/01
currently on Gleevec 400mg, molecular remission

There is now a new central Meetup Message Board for all of the local
CML support groups around the world. There are now 132 local support
groups that have been created. Local support group meetings can be
created in any city in over 60 countries worldwide. These are a free
service that is provided by CMLHope.Com and Meetup.

For any of you new to the list who have not joined your local CML support
group meeting we encourage you to do so. Volunteers are also needed to
become the local organizers in their community as well.

To Join CML Local Meetings
http://cml.meetup.com

Central CML Meetup Message Board
http://cml.meetup.com/boards/

Rob


New! Sign up for local CML support group meetings in your local community at
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---------------------------------
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[Non-text portions of this message have been removed]

List Of BMS-354825 Trial Locations Worldwide

I posted information on the 3 upcoming BMS-354825 clinical trials
to the CMLHope.Com groups CML, CMLAsiaPacific, CMLCanada,
CMLIndia, CMLUK. and LMCLatino. The clinicaltrials database now
has the list of cities in each country where the trials will open. In the
U.S. there will be trials in many states and in a lot of different countries
in various regions of the world. For those who may be considering the
BMS-354825 trial you can review the list of cities to see what trial
centers will be close to you.

http://health.groups.yahoo.com/group/CML/message/91453

[Non-text portions of this message have been removed]

Linden.
I also have foot cramps which at times are nearly unbearable.No one seems to
know what causes them.My endocrinologist prescribed potassiun for me but the
drugist said I shouldn't take them with gleevec.I used magnesium for a while til
that stopped working.I have been at my wits end because I don't seem to be able
to get rid of the cramps which have recently started in my legs and hips.
Whether it's gleevec related I don't know.
Good luck to your Mother.
Freeda




Kim,
My mom has been on gleevec for just about a year for GIST (a rare form of gastro
cancer). She is on 800 mg and suffered from severe leg cramps. With the help of
a potassium pill and orange the cramps have gotten a lot better. Magnesium and
Calcium was also recommended to her to help with the leg cramps, but potassium
seems to do the job for her.

Hope this helps!
Linden





Freeda

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[Non-text portions of this message have been removed]

A tribute to Sandra Landels has been added to the CML blog. The site will
provide a permanent place  to remember Sandra. Her nephew Roy Smith has provided
a photograph of Sandra which has also been added. He gave some details of the
memorial service for Sandra that was held yesterday. There is a comments section
for those of you who would like to add your own memories and thoughts about
Sandra.

http://cmlsupport.blogspot.com/2005/01/tribute-to-sandra-landels.html

[Non-text portions of this message have been removed]

Harold wrote:

>Jennifer Sikes wrote:
>
>
>
>>Do you take Gleevec capsules or tablets?  When I took the capsules I got
heartburn very bad, but with the tablets I have not had the heartburn.
>>
>>
>>
>>  I take tablets.
>>
>>
>>
>
>  Harold
>
>
>
>>
>>---------------------------------
>>Do you Yahoo!?
>>Dress up your holiday email, Hollywood style. Learn more.
>>
>>[Non-text portions of this message have been removed]
>>
>>
>>
>>
>>Thank you for being a Gleevec Discussion Group Member!
>>Yahoo! Groups Links
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>
>
>
>[Non-text portions of this message have been removed]
>
>
>
>
>Thank you for being a Gleevec Discussion Group Member!
>Yahoo! Groups Links
>
>
>
>
>
>
>     I take tablets
>

     Harold

>
>
>
>
>



[Non-text portions of this message have been removed]

Jennifer Sikes wrote:

>Do you take Gleevec capsules or tablets?  When I took the capsules I got
heartburn very bad, but with the tablets I have not had the heartburn.
>
>
>
>   I take tablets.
>

   Harold

>
>---------------------------------
>Do you Yahoo!?
> Dress up your holiday email, Hollywood style. Learn more.
>
>[Non-text portions of this message have been removed]
>
>
>
>
>Thank you for being a Gleevec Discussion Group Member!
>Yahoo! Groups Links
>
>
>
>
>
>
>
>
>
>



[Non-text portions of this message have been removed]

Do you take Gleevec capsules or tablets?  When I took the capsules I got
heartburn very bad, but with the tablets I have not had the heartburn.


---------------------------------
Do you Yahoo!?
  Dress up your holiday email, Hollywood style. Learn more.

[Non-text portions of this message have been removed]

Sent mail in large print.  Do noi know why it was noi rwceived sam way


   hsimon@...




[Non-text portions of this message have been removed]

I take Cleevec as soon as I finish dinner, with a glass of water.
     An hour or two later, I get heartburn. Ant suggestions.


   Excuse large print.  bad eyes.


     hsimon@...




[Non-text portions of this message have been removed]

FDA Clears First of Kind Genetic Lab Test
The Food and Drug Administration (FDA) today cleared for marketing
the first laboratory test system that will allow physicians to
consider unique genetic information from patients in selecting
medications and doses of medications for a wide variety of common
conditions such as cardiac disease, psychiatric disease, and cancer.

"Physicians can use the genetic information from this test to prevent
harmful drug interactions and to assure drugs are used optimally,
which in some cases will enable patients to avoid less effective or
potentially harmful treatment choices," said Dr. Lester M. Crawford,
Acting FDA Commissioner.

The new test is the AmpliChip Cytochrome P450 Genotyping Test made by
Roche Molecular Systems, Inc., of Pleasanton, Calif. It was cleared
for use with the Affymetrix GeneChip Microarray Instrumentation
System, manufactured by Affymetrix, Inc., of Santa Clara, Calif.

The new test is the first DNA microarray test to be cleared by the
FDA and its clearance paves the way for similar microarray-based
diagnostic tests to be developed in the future. A microarray is
similar to a computer microchip, but instead of tiny circuits, the
chip contains millions of tiny DNA molecules. The test is performed
using DNA that is extracted from a patient's blood. A person's DNA
sequence is determined based on the sequence of the probe molecule to
which the DNA is most similar.

The new test analyzes one of the genes from a family of genes called
cytochrome P450 genes, which are active in the liver to break down
certain drugs and other compounds. Variations in this gene can cause
a patient to metabolize certain drugs more quickly or more slowly
than average, or, in some cases, not at all. The specific enzyme from
this family that is analyzed by this test, called cytochrome P4502D6,
plays an important role in the body's ability to metabolize some
commonly prescribed drugs including antidepressants, anti-psychotics,
beta-blockers, and some chemotherapy drugs.

The test is not intended to be a stand-alone tool to determine
optimum drug dosage, but should be used along with clinical
evaluation and other tools to determine the best treatment options
for patients.

FDA cleared the test and the scanner based on results of a study
conducted by the manufacturers of hundreds of DNA samples as well as
on a broad range of supporting peer-reviewed literature.

AG-858 personalized cancer vaccine
An investigational product in clinical trials
What is AG-858?
AG-858 (HSPPC-70) is an investigational personalized vaccine designed
to treat cancer while minimizing side effects that are often
associated with other treatment options. AG-858 is currently being
investigated as a cancer treatment and is only administered to
patients in research studies.

How does AG-858 work?

AG-858 is a vaccine made from individual patients' cancerous cells.
Patients undergo a blood filtering process called leukapheresis,
during which white blood cells are collected. The white blood cells
are sent to Antigenics so that the personalized vaccines can be made.

Vaccines provoke the body's natural disease-fighting response. A
vaccine that is made from the patient's own cancerous cells is
designed to contain the particular cancer's `fingerprint.' Injection
of the AG-858 vaccine may cause the body to attack any cells bearing
this cancer fingerprint.

How is AG-858 different from Oncophage and other treatments?
AG-858 is based on a different heat shock protein than the one used
in Oncophage. AG-858 is a vaccine based on heat shock protein 70
(HSP70), whereas Oncophage is based on a heat shock protein called
gp96.

  Learn more about heat shock proteins.

Both AG-858 and Oncophage are different from other treatments because
they're:

Vaccines that may help your immune system fight your cancer
Personalized — they're created from cells from your own body
Well-tolerated — they're designed to leave your healthy cells alone
so the side effects of most conventional cancer treatments are
minimized

What indications for AG-858 are being tested?
AG-858 is currently being evaluated in combination treatment for
chronic myelogenous leukemia (CML). Based on findings from an ongoing
pilot study being conducted at the University of Connecticut of an
earlier HSP70-based vaccine in combination with the FDA-approved
therapy Gleevec® (imatinib mesylate, Novartis), Antigenics is
conducting an exploratory Phase 2 study of AG-858 in combination with
Gleevec for the treatment of chronic phase CML.

  Learn more about the Phase 2 exploratory study of AG-858 in CML.

How is AG-858 administered?
In the trial of AG-858 in chronic myelogenous leukemia, white blood
cells from the patient are sent to Antigenics, where the personalized
vaccines are made. Using a standardized quality-controlled process,
heat shock proteins and their associated peptides are isolated from
the cells and made into an injectable vaccine. To minimize disruption
to the patient's everyday life, AG-858 treatment is administered on
an outpatient basis over the course of several weeks.

Is Antigenics enrolling patients for an AG-858 clinical trial?
Yes, Antigenics is enrolling patients for a Phase 2 exploratory
research study of AG-858 in combination treatment for chronic
myelogenous leukemia.

  Learn more about the Phase 2 exploratory study of AG-858 in CML.

How does HSP technology work?
What is the immune system?

The information provided on this site is intended to support, not
replace, the relationship that exists between a patient/site visitor
and his/her physician.

Kim,
My mom has been on gleevec for just about a year for GIST (a rare form of gastro
cancer). She is on 800 mg and suffered from severe leg cramps. With the help of
a potassium pill and orange the cramps have gotten a lot better. Magnesium and
Calcium was also recommended to her to help with the leg cramps, but potassium
seems to do the job for her.

Hope this helps!
Linden



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[Non-text portions of this message have been removed]

Hi, I am writing on behalf of my mother who has been on Gleevec for a few
years. She has always had on again/off again leg cramps on the drug, but
recently they have become significantly worse.

She says that after she sits or lays down, when she tries to stand up every
bone in her body hurts. She's a very active 58 year old who suddenly feels
like a 90 year old.

We are trying to figure out whether this might be Gleevec related. Has
anyone else had comparable experiences?

Thanks,
Kim Duty
kduty@...


[Non-text portions of this message have been removed]

) -
- Next-generation leukemia pills, designed to help patients not cured
by the successful drug Gleevec®, work even better than doctors had
hoped, researchers said on Sunday.

One new drug, made by Bristol-Myers Squibb, put 86 percent of
patients who tried it into remission - meaning signs of their cancer
disappeared, the researchers said.

Although they were only Phase I trials, meant to show the drug was
safe, the effects were dramatic, the doctors told a meeting in San
Diego of the American Society of Hematology.

"Certainly it is wonderful. It will save lives," said Alan
Kinniburgh, Ph.D., senior vice president, Research Administration,
The Leukemia & Lymphoma Society.

Oncologists hope the approach may work in many other cancers, too.
Dr. Kinniburgh said it is likely that the new pills will be used in
combination, like old-fashioned chemotherapy.

"I know of no cancer where one single drug has ever cured the
cancer," he said.

The new drugs are being tested in patients with chronic myeloid
leukemia (CML), which affects about 4,400 Americans a year and 10,000
people around the world.

High Remission Rate
The Bristol drug is known by its experimental name BMS-354825. During
the trial, also financed by Bristol-Myers, 31 of 36 patients with
advanced CML, who had not been helped by Gleevec, had a complete
hematologic response, meaning their bodies stopped producing leukemia
cells.

This translates to an 86 percent remission rate, said Dr. Charles
Sawyers, a Howard Hughes Medical Institute investigator at the
University of California Los Angeles, who is helping test the drug.

Gleevec, made by Swiss drug company Novartis and marketed as Glivec
in Europe, targets an enzyme, called BCR-ABL, that leukemia cells use
to proliferate. The drug attaches to the cancerous cells and stops
them from growing and spreading. It was the first "targeted" cancer
drug and made headlines when it was approved in 2001 because never
before had a simple pill shown such dramatic effects in cancer.

Gleevec, or imatinib, is Novartis's second-biggest product, with
sales in the first nine months of this year of $1.1 billion. But in a
few patients, perhaps 12 percent, the cancer cells mutate just enough
to slip out of Gleevec's grip. The cancer comes back.

New Pill Seems Safe
So some of the researchers who worked on Gleevec teamed with Bristol-
Myers Squibb to develop the new pill, which is less picky about how
it grabs onto a cancer cell to deactivate it. The Bristol-Myers drug
affects a different enzyme called SRC, pronounced "sark."

Sawyers said he and colleagues worried that there could be unforeseen
side effects in patients, as no one had ever tested a SRC inhibitor
in people. But so far it seems safe, he said.

Meanwhile, Novartis also designed its own new compound, AMN107,
dubbed "super Glivec," to overcome the weaknesses in Gleevec. It is
in Phase I safety tests in 76 patients with advanced leukemia and has
shown a strong response in half of them, said Dr. Francis Giles of
the M. D. Anderson Cancer Center in Houston.

"The response rates were dramatic," Giles said in a telephone
interview after presenting his findings to the hematology meeting.
Giles and colleagues started patients on very low doses of AMN107,
but he believes higher doses will show even better responses.

AMN107 is up to 30 times more potent than Gleevec because it was
designed to more efficiently bind to the BCR-ABL enzyme, Giles
said. "Clearly, we have a decent shot at a cure," he said.

>
> THANK YOU CINDY FOR SHARING YOUR STORY OF YOUR AMAZING
BROTHER WITH US

> Hello, friends,
>
> I'm Cindy Brown, Marque Lesuer's oldest sister in CO.  I'm
> sure most of you have heard by now that CML claimed the
> life of my baby brother on Nov. 27. Marque remained able
> to do almost everything during most of his 7 year battle
> with the disease. He had purchased a "fixer-upper" house
> on Oct. 22 and had been working on it for over a week with
> his sons.  He anticipated moving into the new house on
> Nov. 20, but around Nov. 1 he became very ill with what we
> assumed was the flu....coughing and a bad headache.
>
> DETAILS...if you want them.....
> When we found him the day after Thanksgiving he was
> extremely weak and had difficulty focusing his thoughts.
> We talked him into going into the hospital, where he was
> admitted with a blood oxygen percentage of 75. Oxygen
> helped and they immediately put him on IV antibiotics,
> feeling the pneumonia might be bacterial.  Unfortunately,
> it was a white blood cell related pneumonia, however, and
> he died less than 24 hours later.  He had refused all
> along to have a bone marrow transplant, chemo or a blood
> transfusion.  In the end he also refused to be placed on a
> ventilator since it would render him unable to speak.
>
> I tell you the details since you are all in Marque's CML
> distribution list. I'm sure you know a great deal more
> about CML than I do since you either suffer from the
> disease or love someone who does....  I am happy to
> communicate individually with any of you who need more
> details...or just want to visit.  Many of you have kindly
> sent cards...thanks for the cookies for Marque's boys,
> Gina!!!.....and we are all SO appreciative!
>
> If you have the time and the interest, I have posted a
> tribute to Marque on the web at :
>
> http://cindybeads.com/marque.htm Feel free to visit
> anytime...I hope it helps you get to know my brother a
> little better and learn what a truly remarkable man he
> was.  There is also a small red link to a obituary page
> that you may use to post memories or whatever.  Those
> comments will remain on that website until Dec. 31,
> 2004....perhaps it will be possible for me to also paste
> them on my tribute pages if that is permitted.
>
> Thanks to all of you who were friends, educators and
> supporters of Marque's. I know losing a fellow fighter is
> a blow to you all and I wish you strength and health. You
> all know what a proponent Marque was in natural remedies
> and diet.  Changing his lifestyle and taking charge of his
> disease, I am CONVINCED, along with his unparalleled
> bravery and positive attitude, kept Marque active and
> comparatively "healthy" for such a long period of time.
> The end was quick and he was spiritually calm and ready to
> continue his journey to God.  May this message as well as
> the Marque Page give you peace and joy this Holiday
> season....
>
> Sincerely,
> Cindy Brown
> cindy@...
> 303-423-1616
>
> 11734 W. 76 Lane
> Arvada, CO  80005-3364
>
>
>
> ------------------------ Yahoo! Groups Sponsor
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> Register anything.
> http://us.click.yahoo.com/Q7_YsB/neXJAA/yQLSAA/DxgolB/TM
> ----------------------------------------------------------
> ----------~->
>
> Thank you for being a Gleevec Discussion Group Member!
> Yahoo! Groups Links
>
>
>
>
>
>
>

That is a wonderful and moving tribute page to Marque.

Rob
   ----- Original Message -----
   From: Cindy Brown for Marque W. Lesuer
   To: Lucinda Loo Lesuer
   Sent: Saturday, December 18, 2004 4:07 PM
   Subject: [CML] Online Tribute to Marque Lesuer


   Hello, friends,

   I'm Cindy Brown, Marque Lesuer's oldest sister in CO.  I'm sure most of you
   have heard by now that CML claimed the life of my baby brother on Nov. 27.
   Marque remained able to do almost everything during most of his 7 year
   battle with the disease. He had purchased a "fixer-upper" house on Oct. 22
   and had been working on it for over a week with his sons.  He anticipated
   moving into the new house on Nov. 20, but around Nov. 1 he became very ill
   with what we assumed was the flu....coughing and a bad headache.

   DETAILS...if you want them.....
   When we found him the day after Thanksgiving he was extremely weak and had
   difficulty focusing his thoughts.  We talked him into going into the
   hospital, where he was admitted with a blood oxygen percentage of 75.
   Oxygen helped and they immediately put him on IV antibiotics, feeling the
   pneumonia might be bacterial.  Unfortunately, it was a white blood cell
   related pneumonia, however, and he died less than 24 hours later.  He had
   refused all along to have a bone marrow transplant, chemo or a blood
   transfusion.  In the end he also refused to be placed on a ventilator since
   it would render him unable to speak.

   I tell you the details since you are all in Marque's CML distribution list.
   I'm sure you know a great deal more about CML than I do since you either
   suffer from the disease or love someone who does....  I am happy to
   communicate individually with any of you who need more details...or just
   want to visit.  Many of you have kindly sent cards...thanks for the cookies
   for Marque's boys, Gina!!!.....and we are all SO appreciative!

   If you have the time and the interest, I have posted a tribute to Marque on
   the web at :
                                          http://cindybeads.com/marque.htm
   Feel free to visit anytime...I hope it helps you get to know my brother a
   little better and learn what a truly remarkable man he was.  There is also a
   small red link to a obituary page that you may use to post memories or
   whatever.  Those comments will remain on that website until Dec. 31,
   2004....perhaps it will be possible for me to also paste them on my tribute
   pages if that is permitted.

   Thanks to all of you who were friends, educators and supporters of Marque's.
   I know losing a fellow fighter is a blow to you all and I wish you strength
   and health. You all know what a proponent Marque was in natural remedies and
   diet.  Changing his lifestyle and taking charge of his disease, I am
   CONVINCED, along with his unparalleled bravery and positive attitude, kept
   Marque active and comparatively "healthy" for such a long period of time.
   The end was quick and he was spiritually calm and ready to continue his
   journey to God.  May this message as well as the Marque Page give you peace
   and joy this Holiday season....

   Sincerely,
   Cindy Brown
   cindy@...
   303-423-1616

   11734 W. 76 Lane
   Arvada, CO  80005-3364



   New! Sign up for local CML support group meetings in your local community at
http://cml.meetup.com

   Apply for Commercial Real Estate loans online and submit your deal to dozens
of hungry lenders in just minutes. Loan programs for all types of business and
commercial real estate. Apply anytime at http://realestatezoo.com

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[Non-text portions of this message have been removed]

----- Original Message -----
From: Rob
To: CMLAsiaPacific@yahoogroups.com ; LMCLatino@yahoogroups.com ;
CMLIndia@...
Sent: Saturday, December 18, 2004 6:32 PM
Subject: [CMLIndia] In search of the sugar-coating


       In search of the sugar-coating

       The new product patents regime will decide the future of hundreds of
leukemia patients


''I'VE lost everything trying to battle this illness,'' shudders P Sundaram
(name changed), resting in his cramped two-room home in Bhandup, a Mumbai
suburb. The 59-year-old was devastated when he was diagnosed with Chronic
Myeloid Leukemia (CML), a cancer of the white blood cells, back in 2002. His
condition has improved, he says, after a year's treatment with a locally
manufactured drug"

http://cmlsupport.blogspot.com/2004/12/in-search-of-sugar-coating.html


CMLIndia
--------
Part Of CMLHope.Com
An International Community Of CML Patients

For more information: http://cmlhope.com
Post message: CMLIndia@...
Subscribe: CMLIndia-subscribe@...
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   b.. To unsubscribe from this group, send an email to:
   CMLIndia-unsubscribe@...

   c..



[Non-text portions of this message have been removed]

Hello, friends,

I'm Cindy Brown, Marque Lesuer's oldest sister in CO.  I'm sure most of you
have heard by now that CML claimed the life of my baby brother on Nov. 27.
Marque remained able to do almost everything during most of his 7 year
battle with the disease. He had purchased a "fixer-upper" house on Oct. 22
and had been working on it for over a week with his sons.  He anticipated
moving into the new house on Nov. 20, but around Nov. 1 he became very ill
with what we assumed was the flu....coughing and a bad headache.

DETAILS...if you want them.....
When we found him the day after Thanksgiving he was extremely weak and had
difficulty focusing his thoughts.  We talked him into going into the
hospital, where he was admitted with a blood oxygen percentage of 75.
Oxygen helped and they immediately put him on IV antibiotics, feeling the
pneumonia might be bacterial.  Unfortunately, it was a white blood cell
related pneumonia, however, and he died less than 24 hours later.  He had
refused all along to have a bone marrow transplant, chemo or a blood
transfusion.  In the end he also refused to be placed on a ventilator since
it would render him unable to speak.

I tell you the details since you are all in Marque's CML distribution list.
I'm sure you know a great deal more about CML than I do since you either
suffer from the disease or love someone who does....  I am happy to
communicate individually with any of you who need more details...or just
want to visit.  Many of you have kindly sent cards...thanks for the cookies
for Marque's boys, Gina!!!.....and we are all SO appreciative!

If you have the time and the interest, I have posted a tribute to Marque on
the web at :
                                        http://cindybeads.com/marque.htm
Feel free to visit anytime...I hope it helps you get to know my brother a
little better and learn what a truly remarkable man he was.  There is also a
small red link to a obituary page that you may use to post memories or
whatever.  Those comments will remain on that website until Dec. 31,
2004....perhaps it will be possible for me to also paste them on my tribute
pages if that is permitted.

Thanks to all of you who were friends, educators and supporters of Marque's.
I know losing a fellow fighter is a blow to you all and I wish you strength
and health. You all know what a proponent Marque was in natural remedies and
diet.  Changing his lifestyle and taking charge of his disease, I am
CONVINCED, along with his unparalleled bravery and positive attitude, kept
Marque active and comparatively "healthy" for such a long period of time.
The end was quick and he was spiritually calm and ready to continue his
journey to God.  May this message as well as the Marque Page give you peace
and joy this Holiday season....

Sincerely,
Cindy Brown
cindy@...
303-423-1616

11734 W. 76 Lane
Arvada, CO  80005-3364

Freeda:

I am getting Procrit shots once a month for my anemia.  I have had
lots of problems with fatigue.  It is okay to take Procrit for
anemia if you have CML and are on Gleevec.  Lots of people do.  I
know there was a study done on this but I can't remember where I
read about it.


My oncologist also suggested that I take Flintstones vitamins with
iron.

I still sometimes have to take a nap in the afternoon even with the
Procrit shots.  Also if I do too much I pay for it later.

Mary K


> I was surprised to read that procrit may not be good for all
cml'ers.I had some hope when I read telephonics reply and had
hopes.Thanks,though,telephonics!!! So maybe the iron is the answer.I
will check on that too.ANYTHING!!! I get reasured when I read that I
am not alone.Some times I feel all alone in this thing.Then I think
maybe it's a small price to be able to enjoy my family and
friends.Without Gleevec I may not be here to have that opportunity.
> Thank you all for being there when I have a complaint and need to
whine a little.I am just used to doing SO much and get so
discouraged when I don't have the strength.
> Freeda
>
>
>
>
>
>
> Message: 3
> Date: Tue, 9 Nov 2004 00:17:10 EST
> From: cfhdbhhuff@a...
> Subject: Re: Digest Number 1061
>
>
> Freeda, I am so sorry u are so very tired--I to get very tired--
but am
> taking high dosage of iron and that seems to be helping some- My
onc. Phys.
> assistant gave me one injection of procrit and I began a search on
the internet
> and got the impression that it was not for CML patients. I
contacted md
> anderson hospital in Texas and their response was, it was an
individual oncologist
> decision to use it. A long story short-my oncologist stopped it
and said
> that he would try other measures first. please let us know what
happens when u
> visit your oncologist! We are concerned and hope you get to
feeling better.
> Sometimes I hate to complain about being so tired, but when you
don't even
> feel like bathing or getting up off of the couch, you can't help
but be
> concerned. In Christ Love--hang in there-Dorothy
>
>
>
>
>
> Freeda
>
> ---------------------------------
> Do you Yahoo!?
>  Check out the new Yahoo! Front Page. www.yahoo.com
>
> [Non-text portions of this message have been removed]

----- Original Message -----
From: Rob
To: CMLHope@googlegroups.com ; CML@yahoogroups.com
Sent: Wednesday, December 15, 2004 1:02 PM
Subject: [CML] Some Photos Of Chelsea


Lori wanted to post some photos of Chelsea. Since the photo storage area
is full I have posted them on the blog so all of you can see them.

Rob

http://cmlsupport.blogspot.com/2004/12/some-photos-of-chelsea.html


New! Sign up for local CML support group meetings in your local community at
http://cml.meetup.com

Apply for Commercial Real Estate loans online and submit your deal to dozens of
hungry lenders in just minutes. Loan programs for all types of business and
commercial real estate. Apply anytime at http://realestatezoo.com

CML (Chronic Myelogenous Leukemia Support List)
---------------------------------
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[Non-text portions of this message have been removed]

Mark's Report From ASH

Mark Petersen's three part report from ASH for the CML group is a must read.
He gives a great overview of the ASH conference and the excitement that
surrounds the new drugs that are on the way.

Rob
http://cmlhope.com


"...this rare disease that we all share (CML) is truly leading the way.  CML has
become the rosetta stone for cancer research.  Dr. Sawyers recently phrased it
best in an interview when he said that, "this is the blueprint for treating
other cancers". In my career I've had firsthand opportunities to see two other
technological revolutions unfold.  The first was the development of the personal
computer in the early 1980's and more recently the explosion in cellular
telecommunications.  ASH reminds me of the early days of these other fields. 
Optimism is everywhere.  People know that they are onto something big."

Parts 1 - 3
http://health.groups.yahoo.com/group/CML/message/90176
http://health.groups.yahoo.com/group/CML/message/90177
http://health.groups.yahoo.com/group/CML/message/90178

[Non-text portions of this message have been removed]

complete text copyright Reuters sorry! from CNN.com 5 december 2004 SANTA
...



WASHINGTON (Reuters) -- A next-generation leukemia pill designed to help
patients not cured by the successful drug Gleevec works even better than
doctors had hoped, researchers said Sunday.

The new drug, made by Bristol-Myers Squibb put 86 percent of patients who
tried it into remission -- meaning signs of their cancer disappeared, the
researchers said.

Although this was only a Phase I trial meant to show the drug was safe, the
effects were dramatic, the doctors told a meeting in San Diego of the
American Society of Hematology.

"Certainly it is wonderful. It will save lives," said Dr. Alan Kinniburgh,
senior vice president of research for The Leukemia and Lymphoma Society,
which helped sponsor the study.

Rumors of the new drug's success have been leaking for months because cancer
experts are so excited by the results. Oncologists hope the approach may
work in many other cancers, too.

The new drug is being tested in patients with chronic myeloid leukemia,
which affects about 4,400 Americans a year and 10,000 people around the
world.

The drug is known by its experimental name BMS-354825. During the trial,
also financed by Bristol-Myers, 31 of 36 patients with advanced CML who had
not been helped by Gleevec had a complete hematologic response, meaning
their bodies stopped producing leukemia cells.

This translates to an 86 percent remission rate, said Dr. Charles Sawyers, a
Howard Hughes Medical Institute investigator at the University of California
Los Angeles who is helping test the drug.

Gleevec, made by Swiss drug company Novartis, targets an enzyme called
BCR-ABL that leukemia cells use to proliferate. It attaches to the cancerous
cells and stops them from growing and spreading.

Targeted cancer pill
Sold in Europe under the name Glivec, it was the first "targeted" cancer
drug. It made headlines when it was approved in 2001 because never before
had a simple pill shown such dramatic effects in cancer.

Later Sunday Novartis will report on its new compound AMN107, dubbed "super
Glivec", also designed to overcome the weaknesses in Gleevec.

Gleevec, or imatinib, is Novartis's second-biggest product, with sales in
the first nine months of this year of $1.1 billion.

But in a few patients, perhaps 12 percent, the cancer cells mutate just
enough to slip out of Gleevec's grip. The cancer comes back.

So some of the researchers who worked on Gleevec teamed with Bristol-Myers
Squibb to develop the new pill, which is less picky about how it grabs onto
a cancer cell to deactivate it.

The Bristol-Myers drug affects a different enzyme called SRC, pronounced
"sark".

"It is definitely not Gleevec," Sawyers said in a telephone interview. "It's
not Gleevec 2. It has a completely different chemical structure."

Sawyers said he and colleagues worried that there could be unforeseen
side-effects in patients, as no one had ever tested a SRC inhibitor in
people. But so far it seems safe, he said.

There are more than 17 known mutations in leukemia cells that allow the
cancer to evade Gleevec's effects, but most of them seem to be susceptible
to BMS-354825, Sawyers said.

One mutation, known as T315I, resists both Gleevec and the Bristol drug.
"That mutation will likely require a different drug, and researchers are
working on that now," said Sawyers.

Kinniburgh said it is likely that the new pills will be used in combination,
like old-fashioned chemotherapy.

"I know of no cancer where one single drug has ever cured the cancer," he
said.


   http://www.cnn.com/2004/HEALTH/12/05/leukemia.pill.reut/index.html

   ------------FLASH -------READ THIS

   Greetings to ALL and CML


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   Thank you for being a Gleevec Discussion Group Member!


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[Non-text portions of this message have been removed]

http://www.cnn.com/2004/HEALTH/12/05/leukemia.pill.reut/index.html

------------FLASH -------READ THIS

Greetings to ALL and CML


----------------------------------------------------------------------------
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[Non-text portions of this message have been removed]

For those who may be interested in the latest developments on CML, I wanted to
mention that Cheryl-Anne and Mark are providing extensive coverage of the CML
presentations from the ASH conference in San Diego. They are filing daily
reports for the CML Group at http://health.groups.yahoo.com/group/CML They are
doing an excellent job of reporting on the results of the latest clinical trials
on new drugs for CML, other ASH presentations on CML, and news on other new
drugs that may be in the pipeline for the future. Their reports are a must read
for those interested in these important developments for CML patients.

http://cmlsupport.blogspot.com/2004/12/ash-coverage-from-cheryl-anne-and-mark.ht\
ml

[Non-text portions of this message have been removed]

60093


[Non-text portions of this message have been removed]