Hi Madhulika,

I'm sorry to hear about your mother. Why is she not in one of the
trials for Gleevec resistant patients? There are two very promising
new drugs being trialed right now (AMN107 and Dasatinib). Patients
who never responded to Gleevec in the past, have experienced
complete remissions with these new drugs.

These trials have been going on for some time now, they aren't new.
If your mother's doctor doesn't know about them by now and hasn't
tried to get her into one of them, I would seriously consider
getting another doctor.

Please don't waste any time getting her into one of these trials.
Time is of the essence.

Best wishes,
Tracey


--- In Gleevec@yahoogroups.com, "madhumathur" <madhumathur@...>
wrote:
>
> Hi All,
>
> Its good to see some activity on the group. I have a question for
you
> all. My mum's been CML patient for last 9 years. Started Gleevec
> nearly 4 years back. Since then she has stayed in chronic phase.
No
> remission. But steady reduction in the number of bone marrow cells
> carrying the Ph chromosome. But her recent test done last week
showed
> the her blast %age has gone up from 5% in Sept 2005 to 18%. We are
> very concerned. In last few months she has also become anaemic.
Does
> anyone have any idea how effective is Gleevec in accelerated
phase?
> Can u go back to Chronic phase if dosage is increased? What can we
> expect to happen now. Any information would be helpful.
>
> Thanks
>
> Madhulika
>