Very interesating! New resesrch is always welcome.
The trials bring back 45 years of memories for me.I was a subject for study at
UCLA in 1960 for rh neg mothers.They were learning to give blood transfusions to
pre birth babies.I was treated like royalty.So if all is the same there any one
of you who takes part in this research will be well treated.
Freeda
complete remission
400 mg gleevec daily for three years



Dear Listmembers:

Some good news for CML'ers who do not live close enough to NYC to participate in
the CML vaccine trial at Sloan-Kettering (www.mskcc.org)
.

Around or about the end of 2005, the Phase 2 trial will be expanded to MD
Anderson, UCLA, and Oregon, according to MSKCC sources. It appears that Dr.
Cortes at MDACC and Dr. Druker at OHSU will be involved with the trial.
Presumably, Dr. Sawyers will be involved at the UCLA trial, but I have not
confirmed this.

I survived the intial trial screening process at MSKCC on Wednesday, having
surrendered 14 vials of blood to establish the base-line data to measure my
immune response to the vaccine as well as some extra aspirate taken during the
bone marrow aspiration. I was told that Dr. David Scheinburg, inventor of the
vaccine, will personally receive a sample of the aspirate samples from trial
participants.

Present at the screening were my doctor, Dr. Gupta, head of the trial, and
Suzanne Chanel, the brilliant clinical trial nurse, who handles the
nuts-and-bolts of clinical trials at the hospital.

The official title of the trial, according to the patient informed consent
documents I signed is: "PIlot Trial of a Synthetic Tumor Specific Breakpoint
Peptide Vaccine in Patients with Chronic Myelogenous Leukemia and Minimal
Residual Disease."

You must show Philadelphia Chromosome positive on the RT-PCR to qualify, so if I
hit ZERO PCR, I won't qualify. (PCR in February was .00015% on 600 mg. of IM.)

If the PCR results shows positive, I return to MSKCC on Aug. 3 for the first
inoculation.

If the PCR result shows negative, I'll jump for joy. Talk about a win-win
situation!

I'll provide addtional information about the trial in future posts. Meanwhile,
if you are interested in further information on the vaccine there is an article
on Jennifer's excellent website detailing the results of an earlier MSKCC trial:

Just go this link and download the article :

"A multivalent bcr-abl fusion peptide vaccination trial in patients with chronic
myeloid leukemia

You may also contact Dr. Gupta, the trial head, at: (212) 639-2327
email: guptas@....

Best regards,
Carl Davies










Freeda

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