Contacts: Mike Nelson
Roche
973-562-2409
mike.nelson@...
Walter Capone
Trimeris
919-949-3998
wcapone@...
Robyn Meyer
Manning Selvage & Lee
212-468-3376
robyn.meyer@...

 

NUTLEY, N.J. and MORRISVILLE, N.C. (Nov. 23, 2005) – Roche and Trimeris (Nasdaq: TRMS)
announced that today the companies have received an approvable letter from the U.S. Food and Drug
Administration (FDA), in response to their request for inclusion of information about the Biojector®
2000 (B2000) needle-free injection device in the FUZEON® (enfuvirtide) labeling. In the approvable
letter, FDA has requested additional information from the ongoing ENF-404 or WAND (With A
Needle-Free Device) study, a randomized, open-label, two-way, cross-over study assessing the
tolerability of the B2000 device for administration of FUZEON.
- more -
- 2 -
The B2000, made by Bioject Medical Technologies Inc., is a needle-free, CO2-powered injector
that disperses liquid medication beneath the skin. FUZEON is the first and only entry inhibitor
available for the treatment of HIV and is currently approved for administration with a needle and
syringe.
Roche and Trimeris filed a supplemental New Drug Application (sNDA) in May 2005 based on
data from the T20-405 study, a single-dose pharmacokinetic study of FUZEON administered by a
nurse via the B2000 needle-free device, compared to standard needle-syringe administration. In
August 2005, Roche and Trimeris announced the initiation of the FUZEON WAND (With A Needle-
Free Device, or ENF-404) study, an eight-week trial designed to assess patient acceptance and
experience of FUZEON administration via the B2000 needle-free device compared to the standard
needle and syringe. The primary endpoints of this study are tolerability and injection site reactions.
This trial is currently enrolling and final data are expected in the second half of 2006.
Healthcare providers and patients can call Roche/Trimeris at 877-4FUZEON (877-438-9366)
or visit www.clinicaltrials.gov for details regarding participation in the FUZEON WAND study.
Facts About FUZEON
FUZEON is the first and only fusion inhibitor for the treatment of HIV. Unlike other HIV drugs that
work after HIV has entered the human immune cell, FUZEON works outside the CD4 cell, blocking
HIV from entering the cell. For this reason, FUZEON is effective in treatment-experienced patients
who have developed resistance to other anti-HIV drugs, though patients may still develop resistance to
FUZEON. FUZEON was granted accelerated approval by the U.S. Food and Drug Administration
(FDA) in March 2003 on the basis of 24-week data, and was granted traditional (full) approval on Oct.
15, 2004 on the basis of long-term 48-week data.
- more -
- 3 -
Injection Site Reactions (ISRs): ISRs are the most common adverse events associated with FUZEON.
ISRs occurred in 98% of patients studied and 4% discontinued FUZEON due to ISRs. Signs/symptoms
may include pain and discomfort, hardened skin, redness, bumps, itching and swelling. Eleven percent
of patients had local reactions that required analgesics or limited usual activities.
Pneumonia: An increased rate of bacterial pneumonia was observed in subjects treated with FUZEON
in the Phase III clinical trials compared to the control arm. It is unclear if the increased incidence of
pneumonia is related to FUZEON use. Patients with HIV infection should be carefully monitored for
signs and symptoms of pneumonia. Risk factors for pneumonia included low initial CD4 cell count,
high initial viral load, intravenous drug use, smoking and a prior history of lung disease.
Hypersensitivity Reactions: Systemic hypersensitivity reactions have been associated with FUZEON
therapy and may recur on rechallenge. Hypersensitivity reactions have included individually and in
combination: rash, fever, nausea and vomiting, chills, rigors, hypotension and elevated serum liver
transaminases. Other adverse events that may be immune mediated and have been reported in subjects
receiving FUZEON include primary immune complex reaction, respiratory distress,
glomerulonephritis and Guillain-Barre syndrome.
Other Adverse Events: The events most frequently reported in patients receiving FUZEON plus an
optimized background regimen were diarrhea (32%), nausea (23%) and fatigue (20%). These events
were seen at a lower incidence in patients taking a FUZEON-based regimen compared to those
receiving an optimized background regimen without FUZEON when taking into account the uneven
number of patients in each arm and the length of time they are in that arm. As measured in number per
100 patient years, the incidence was: diarrhea (38 per 100 patient-years in subjects receiving
FUZEON-based regimens vs. 73 per 100 patient-years in patients who did not receive FUZEON),
nausea (27 vs. 50, respectively) and fatigue (24 vs. 38, respectively).
Roche in HIV
Roche is at the forefront of efforts to combat HIV infection and AIDS, committed for 15 years to
groundbreaking research and development of new drugs and diagnostic technology. The objective is
to provide tailored treatment solutions and an improved standard of care worldwide for those people
living with HIV. Roche and Trimeris are working together to discover, develop and commercialize the
next generation of HIV fusion inhibitors.
About Roche – More Than a Century in the U.S. and the World
Founded in 1896 and headquartered in Basel, Switzerland, Roche is one of the world’s leading
innovation-driven healthcare groups. Its core businesses are pharmaceuticals and diagnostics. Roche is
one of the world’s leaders in diagnostics, the leading supplier of pharmaceuticals for cancer, as well as
a leader in virology and transplantation. As a supplier of products and services for the prevention,
diagnosis and treatment of disease, the Group contributes on many fronts to improve people’s health
and quality of life. Roche employs roughly 65,000 people in 150 countries, including approximately
15,000 in the United States.
- more -
- 4 -
Roche’s U.S. operations celebrate their American Centennial in 2005. In another milestone this year,
Roche was named in January to Fortune magazine’s list of Best Companies to Work for in America.
One of an increasingly rare breed of major healthcare companies that still bear their original name,
Roche today has more than a dozen U.S. sites located in California, Colorado, Indiana, New Jersey and
South Carolina, as well as in Puerto Rico. Roche has alliances and research and development
agreements with numerous partners, including majority ownership interests in Genentech and Chugai.
Roche’s Pharmaceuticals Division offers a portfolio of leading medicines in therapeutic areas
including cancer, HIV/AIDS, hepatitis C, transplantation, dermatology and influenza. Roche’s
Diagnostics Division supplies a wide array of innovative testing products and services to researchers,
physicians, patients, hospitals and laboratories world-wide. For further information, please visit our
worldwide and U.S. Web sites (Global: http://www.roche.com and U.S.: http://www.roche.us). For
more information on the Roche pharmaceuticals business in the United States, visit the company’s
Web site at: http://www.rocheusa.com.
About Trimeris, Inc.
Trimeris, Inc. (Nasdaq: TRMS) is a biopharmaceutical company engaged in the discovery,
development and commercialization of novel therapeutic agents for the treatment of viral disease. The
core technology platform of fusion inhibition is based on blocking viral entry into host cells.
FUZEON, approved in the U.S., Canada and European Union, is the first in a new class of anti-HIV
drugs called fusion inhibitors. Trimeris is developing FUZEON and future generations of peptide
fusion inhibitors in collaboration with F. Hoffmann-La Roche Ltd. For more information about
Trimeris, please visit the company's Web site at http://www.trimeris.com.
Trimeris Safe Harbor Statement
This document and any attachments may contain forward-looking information about the Company's
financial results and business prospects that involve substantial risks and uncertainties. These
statements can be identified by the fact that they use words such as "expect," "project," "intend,"
"plan," "believe" and other words and terms of similar meaning. Among the factors that could cause
actual results to differ materially are the following: there is uncertainty regarding the success of
research and development activities, regulatory authorizations and product commercializations; the
results of our previous clinical trials are not necessarily indicative of future clinical trials; and our drug
candidates are based upon novel technology, are difficult and expensive to manufacture and may cause
unexpected side effects. For a detailed description of these factors, see Trimeris' Form 10-K filed with
the Securities and Exchange Commission on March 11, 2005 and its periodic reports filed with the
SEC.
About Bioject Medical Technologies Inc.
Bioject Medical Technologies Inc., based in Bedminster, New Jersey, and Portland, Oregon, is an
innovative developer and manufacturer of needle-free drug delivery systems. Needle-free injection
works by forcing medication at high speed through a tiny orifice held against the skin. This creates a
fine stream of high-pressure fluid penetrating the skin and depositing medication in the tissue beneath.
The Company is focused on developing mutually beneficial agreements with leading pharmaceutical,
biotechnology, and veterinary companies.
# # #