Brent, sound like we are in the exact same position. It's been hard,
as I am sure you know, waiting for these meds. When my t count is
under 20 (been that way for 6 years), every day you wonder about
tomorrow. The drugs my doctor wants to start (I talked to him this
afternoon are Truvada (which I have taken for some time, but went off
of it 3 months ago, so no aids meds for 3 months and TMC125 and
Prezista and MK518 (with the truvada). Boy, alot of drugs there, but
at the same time maybe all the mouth pain will go away and the runs
that I have had for over 7 months (yes, daily-lost 50 pounds, luckily
I was overweight then). Wow, now that I read results like that I am
very excited (for us both and everyone else). Congrads Brent, I know
how I am going to feel should this happen with me.

Brent you might want to check further.....My doctor has access to all
of these (through studies, ect), so somehow I would think you are too
in some way or plan.






--- In FuzeonSupport@yahoogroups.com, "CurtisHome" <curtishome@...>
wrote:
>
> Hi Nelson / Robert
>
> Thanks Nelson for the discussion and Robert for sharing a very
similar
> story.
>
> My viral load is off the chart and my CD4 below 20. I take Aptivus,
> Norvir and Truvada. I have been taking this failing regimen and
waiting
> for new meds combo for at least 18 months. (FYI -I have been tested
for
> Maravaroc and I am waiting for the results). Due to my genotype
> responses I have little or no options. Truvada is still partially
> effective.
>
> My doctor tells me that Mk 518 and Prezista are available to me now
but
> not TMC125. She is running a GRACE study on TMC125 whose protocol
states
> that only FDA approved meds can be taken in conjunction with it.
Since
> MK518 is waiting final approval (not till Oct) it is ruled
noncompliant
> for the study.
>
> Nelson, are you aware of another way to get these three drugs
together
> in combination?
>
> Thanks to all who participate in this life-line of information. I
could
> not do this alone.
>
> Brent
>
> -----Original Message-----
> From: FuzeonSupport@yahoogroups.com
> [mailto:FuzeonSupport@yahoogroups.com] On Behalf Of PoWeRTX@...
> Sent: Tuesday, July 03, 2007 10:53 PM
> To: FuzeonSupport@yahoogroups.com
> Subject: Re: [FuzeonSupport] Re: I need your knowledge #3
>
> In a message dated 7/3/2007 11:26:01 P.M. Central Daylight Time,
> mntwister@... writes:
> Nelson, I live in northern Minnesota, north of Duluth, and I go to
Dr.
> Keith Henry in Minneapolis, who I have high regard for. I am sure
you
> have heard of him, maybe even met him. Nelson, you said "There is a
> study that recently showed that those who have activity to Aptivus
> (Tipranavir) and Prezista can take Aptivus first and will still be
> sensitive to Prezista if the Aptivus fails. " I am concerned about
how
> this works...If the Aptivus fails if I take that one first, then
won't
> that leave room for the others to fail before we find out it has
failed?
> As you know, I am very concerned with doing this right this time.
>
> What would you think if I took TMC 114 AND TMC125 plus MK518, plus
> Truvada...wouldn't that be a pretty strong combo all together (if
the
> doctor feels it would be safe)? Maybe I am just too scared of
failure
> these days.
>
> I want to personally thank you. I have emailed you previously and
always
> get an informative response and I want you to know I appreciate this
> very much. You really deserve an award for your work.
>
> Robert
> Dear Robert
>
>
> I believe in trying to save options for the future while trying your
> best to attain undetectable viral load now with at least two active
> agents plus nukes. Three active agents would probably be best but
no
> one is sure. There are no data on the TMC 125 + Prezista+ MK 518
combo,
> but we know that there are no bad interactions between those three
that
> could lower medication blood levels that can cause virologic
failure.
>
> Trying Aptivus before Prezista may preserve Prezista for later use
in
> case that you need another combo in the future. The drug pipeline
will
> dry up in the next two years again. I feel we should hope for the
best
> now but prepare for failure in case. The disadvantages of Aptivus,
> however, is that you cannot take it with TMC 125 since it lowers TMC
> 125's blood levels. Aptivus also requires more pills and two Norvir
a
> day. I am sure Dr Henry is aware of the recently presented data in
> Barbados on Aptivus and he can discuss it with you.
>
> I think you would have a great change at having undetectable viral
load
> with MK 518+Prezista+ TMC 125. We are hoping it is a sustainable
> response long term, though.
>
> Thanks for the compliment. I am just a guy trying to survive HIV
> resistance and have put all my obsessive compulsive behavior to use
in
> learning all I can about new treatments by going to many
conferences and
> reading emails that are sent by many sources. I will be going to the
> largest HIV research conference in the world
> Regards,
>
> Nelson Vergel
> powerusa dot org
>
>
>
> _____
>
> See what's free at AOL.com
> <http://www.aol.com?ncid=AOLAOF00020000000503> .
>