----- Original Message -----

From: CurtisHome

To: FuzeonSupport@yahoogroups.com

Sent: Wednesday, July 04, 2007 1:01 PM

Subject: RE: [FuzeonSupport] Re: I need your knowledge #3 - new question

Hi Nelson / Robert

Thanks Nelson for the discussion and Robert for sharing a very similar story.

My viral load is off the chart and my CD4 below 20. I take Aptivus, Norvir and Truvada. I have been taking this failing regimen and waiting for new meds combo for at least 18 months. (FYI -I have been tested for Maravaroc and I am waiting for the results). Due to my genotype responses I have little or no options. Truvada is still partially effective.

My doctor tells me that Mk 518 and Prezista are available to me now but not TMC125. She is running a GRACE study on TMC125 whose protocol states that only FDA approved meds can be taken in conjunction with it. Since MK518 is waiting final approval (not till Oct) it is ruled noncompliant for the study.

Nelson, are you aware of another way to get these three drugs together in combination?

Thanks to all who participate in this life-line of information. I could not do this alone.

Brent

-----Original Message-----
From: FuzeonSupport@yahoogroups.com [mailto:FuzeonSupport@yahoogroups.com] On Behalf Of PoWeRTX@aol.com
Sent: Tuesday, July 03, 2007 10:53 PM
To: FuzeonSupport@yahoogroups.com
Subject: Re: [FuzeonSupport] Re: I need your knowledge #3

In a message dated 7/3/2007 11:26:01 P.M. Central Daylight Time, mntwister@yahoo.com writes:

Nelson, I live in northern Minnesota, north of Duluth, and I go to Dr. Keith Henry in Minneapolis, who I have high regard for.  I am sure you have heard of him, maybe even met him.  Nelson, you said "There is a study that recently showed that those who have activity to Aptivus (Tipranavir) and Prezista can take Aptivus first and will still be sensitive to Prezista if the Aptivus fails. "  I am concerned about how this works...If the Aptivus fails if I take that one first, then won't that leave room for the others to fail before we find out it has failed? As you know, I am very concerned with doing this right this time.

What would you think if I took TMC 114 AND TMC125 plus MK518, plus Truvada...wouldn't that be a pretty strong combo all together (if the doctor feels it would be safe)?  Maybe I am just too scared of failure these days.

I want to personally thank you. I have emailed you previously and always get an informative response and I want you to know I appreciate this very much.  You really deserve an award for your work.

Robert

Dear Robert

I believe in trying to save options for the future while trying your best to attain undetectable viral load now with at least two active agents plus nukes.  Three active agents would probably be best but no one is sure. There are no data on the TMC 125 + Prezista+ MK 518 combo, but we know that there are no bad interactions between those three that could lower medication blood levels that can cause virologic failure.

Trying Aptivus before Prezista may preserve Prezista for later use in case that you need another combo in the future.  The drug pipeline will dry up in the next two years again.  I feel we should hope for the best now but prepare for failure in case. The disadvantages of Aptivus, however, is that you cannot take it with TMC 125 since it lowers TMC 125's blood levels. Aptivus also requires more pills and two Norvir a day. I am sure Dr Henry is aware of the recently presented data in Barbados on Aptivus and he can discuss it with you.

I think you would have a great change at having undetectable viral load with MK 518+Prezista+ TMC 125. We are hoping it is a sustainable response long term, though.

Thanks for the compliment. I am just a guy trying to survive HIV resistance and have put all my obsessive compulsive behavior to use in learning all I can about new treatments by going to many conferences and reading emails that are sent by many sources. I will be going to the largest HIV research conference in the world
Regards,

Nelson Vergel
powerusa dot org

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