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Hi
Nelson / Robert
Thanks Nelson for the discussion and
Robert for sharing a very similar story.
My viral load is off the chart and my CD4
below 20. I take Aptivus, Norvir
and Truvada. I have been taking this failing regimen
and waiting for new meds combo for at least 18 months. (FYI -I have been tested
for Maravaroc and I am waiting for the results). Due
to my genotype responses I have little or no options. Truvada
is still partially effective.
My doctor tells me that Mk 518 and Prezista
are available to me now but not TMC125. She is running a GRACE study on TMC125 whose
protocol states that only FDA approved meds can be taken in conjunction with
it. Since MK518 is waiting final approval (not till Oct) it is ruled noncompliant
for the study.
Nelson, are you aware of another way to
get these three drugs together in combination?
Thanks to all who participate in this
life-line of information. I could not do this alone.
Brent
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Nelson, I live in northern
, north of Minnesota , and I go to Dr. Keith Henry in Duluth , who I have high regard for. I am sure you have heard of him, maybe even met him. Nelson, you said "There is a study that recently showed that those who have activity to Aptivus (Tipranavir) and Prezista can take Aptivus first and will still be sensitive to Prezista if the Aptivus fails. " I am concerned about how this works...If the Aptivus fails if I take that one first, then won't that leave room for the others to fail before we find out it has failed? As you know, I am very concerned with doing this right this time. Minneapolis
What would you think if I took TMC 114 AND TMC125 plus MK518, plus Truvada...wouldn'
t that be a pretty strong combo all together (if the doctor feels it would be safe)? Maybe I am just too scared of failure these days.
I want to personally thank you. I have emailed you previously and always get an informative response and I want you to know I appreciate this very much. You really deserve an award for your work.
Robert
Dear
Robert
I
believe in trying to save options for the future while trying your best to
attain undetectable viral load now with at least two active agents plus
nukes. Three active agents would probably be best but no one is sure.
There are no data on the TMC 125 + Prezista+ MK 518 combo, but we know that
there are no bad interactions between those three that could lower medication
blood levels that can cause virologic failure.
Trying
Aptivus before Prezista may preserve Prezista for later use in case that you
need another combo in the future. The drug pipeline will dry up in the
next two years again. I feel we should hope for the best now but prepare
for failure in case. The disadvantages of Aptivus, however, is that you cannot
take it with TMC 125 since it lowers TMC 125's blood levels. Aptivus also
requires more pills and two Norvir a day. I am sure Dr Henry is aware of the
recently presented data in
I think
you would have a great change at having undetectable viral load with MK
518+Prezista+ TMC 125. We are hoping it is a sustainable response long term,
though.
Thanks for the compliment. I am just a guy trying to survive
HIV resistance and have put all my obsessive compulsive behavior to use in
learning all I can about new treatments by going to many conferences and
reading emails that are sent by many sources. I will be going to the largest
HIV research conference in the world
Regards,
Nelson Vergel
powerusa dot org
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