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Nelson, I live in northern Minnesota, north of Duluth, and I go to Dr. Keith Henry in Minneapolis, who I have high regard for. I am sure you have heard of him, maybe even met him. Nelson, you said "There is a study that recently showed that those who have activity to Aptivus (Tipranavir) and Prezista can take Aptivus first and will still be sensitive to Prezista if the Aptivus fails. " I am concerned about how this works...If the Aptivus fails if I take that one first, then won't that leave room for the others to fail before we find out it has failed? As you know, I am very concerned with doing this right this time.
What would you think if I took TMC 114 AND TMC125 plus MK518, plus Truvada...wouldn't that be a pretty strong combo all together (if the doctor feels it would be safe)? Maybe I am just too scared of failure these days.
I want to personally thank you. I have emailed
you previously and always get an informative response and I want you to know I appreciate this very much. You really deserve an award for your work.
Robert
PoWeRTX@... wrote:
In a message dated 7/3/2007 6:31:29 P.M. Central Daylight Time, mntwister@... writes:Nelson, thank you so much for such a fast response. It seems a shame to me that when they went into production and research on the CCr5 med, that they didn't make sure to include both receptor blockers 4 and 5 in the drug. This seems like it was foolish since the virus can convert to the other receptor. I have not taken an NRTI like Viramune or that catagory for over 13 years, does that matter with resistance to the class? I have had wild virus three times after that.You didn't mention my going on TMC114 at the same time as TMC125 and Raltegravir. I am resistant to all other prot.inhibitors, except I have never taken Tipranivir, would that be better than the TMC prot.Inhibitor?Also, you didn't mention the new nukes I mentioned....some are in phase 1/to phase 2 trials now, and I would assume there will be studies soon, but I am scared to wait any longer. (see the list in the 3rd paragraph of my letter below). RobertDear RobertAt your current CD4 of 25, I would definitely do something nowIf you have full sensitivity to Prezista, then take it for sure. There is a study that recently showed that those who have activity to Aptivus (Tipranavir) and Prezista can take Aptivus first and will still be sensitive to Prezista if the Aptivus fails. Talk to your doctor about this sequencing conversation.If you have taken non nukes in the past and have developed resistance to them ,be very careful to assume that you have sensitivity to them now that your pheno shows wild type for them. Resistance to non nukes can be archived and re appear once you start them again. I am concerned that many people who took Sustiva and /or Viramune in the past and developed resistance to them will not respond well to the new non nuke TMC 125.I would not wait for the new nukes...they are too far away and may not be effective for long termers like you and I.So, in summary:You can take Aptivus (or Prezista)+ MK 518 + Truvada+ or - TMC 125Who is your doctor and where do you live?
Regards,
Nelson Vergel
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