Dear Robert

 

 

I am so sorry that you are going through all of this and that you turned out to be dual tropic in the tropism test for Maraviroc

 

I would suggest that you make sure that you have sensitivity to TMC 125 (that is the NNRT that I am assuming you are about to get on). Combining it with Raltegravir (Isentress or MK 518)  would probably do wonders with you with a background of nukes like Truvada (provided that your kidneys are OK)

 

Just make extra sure that you have full sensitivity to TMC 125.

 

I am getting emails from all over from people who have turned undetectable for the first time in years with raltegravir plus Prezista or TMC 125.  Make sure you talk to your doctor about how you guys would manage immune reconstitution syndrome when you start the new drugs and your immune system starts getting better. Most people feel like crap during the first weeks and it is key that you do not stop your meds. You can read more about IRIS here

http://www.thebody.com/content/treat/art2525.html

 

TNX 355 may be dead since Genetech bought TANOX and they may not have any interest in HIV.  Few activists seem to be trying to convince Genentech to not drop the drug.

 

I am giving a lecture on all this in Houston on July 11th and will video tape it to post it on the internet for all to see.

 

let me know if you need anything else. It is very stressful to try to make the right choice now and not screw up your future options.

 

Regards,

Nelson Vergel
powerusa dot org

PoWeRTX@... wrote:

In a message dated 7/3/2007 3:08:35 P.M. Central Daylight Time, mntwister@... writes:

Dear Nelson:

 

I am writing hoping I am not bothering you, this is my 2nd letter to you.I am writing because I know you and I are basically in the same position as far as our HIV. Drugs I have taken before are everything except Abacivir (got a skin rash so after 2 weeks they took me off of it) and never took

Tipranavir. My t cells have been under 25 for 8 years now. I tried Fuzeon unfortunately there were no other new drugs at the time and within a month, I became resistant and my t cells fell from 75 back to the current level.

 

I signed up to start a trial of the new TMC prot.Inhibitor, The new CCR5 blocker and the new Integrase inhibitor. My results came back yesterday that I cannot get on the CCR5 trial because I have dual-virus (which I kind of figured after 18 years), so the doctor is recommending both TMC drugs and MK0518. I read several months ago a post that you placed in the group about taking I think 2 of these and turning resistant. Since I have been without a good combo for 8 years now, I am very concerned about the same thing.

 

Are there any things you might recommend? Anything would be helpful before I make the decision. I see there are 2 new drugs entering Phase 2 trials, TNX 355 and .new NrTI's...Elvucitabine (ACH-126), Achillion, Apricitabine (AVX754), Racivir (PSI 5004). There is also Bevirimat (PA-457), Budding inhibitor and

Valproic acid, [Depakoteā„¢, Abbott].

 

How do you feel about all of this, the combo of the 2 new TMC drugs with

MK-0518, or waiting for one of the other I listed. Unfortunately I have had an illness for the first time in years, starting in November, where I lost 45 pounds so far asnd have diahrrea almost every day so that's been horrible, so a time element is important as well. I would really be interested in your opinions on all of this.

 

Most sincerelyu

 

Robert Siegel