--- In FailsafeNT@yahoogroups.com, "tarinya2" <tarinya2@...> wrote:

> > If you want to throw money at the problem, probably the single best
> > thing you can do is invest in some molybdenum supplements, some
> > flavour-free methylcobalamin (methyl-B12), if you can find such a
> > thing, and some milk thistle.
>
> OK...why? I know milk thistle is good for liver support (does it not
> contain salicylates?), but what about the rest? I have just started
> taking a folic acid/B12 supplement (just regular B12 not the methyl
> version) since we want to try to get pregnant soon, but I don't know
> if I'm actually B12 deficient (B6 deficient for sure, though).


Molybdenum:
The enzyme that converts various forms of sulphur and sulphites
(sulphite oxidase AKA SUOX) requires molybdenum in order to work, so
you can speed up your detox with it and shorten your reactions -
though it won't *stop* the inflammatory reaction, which seems to
happen independent of SUOX. SUOX genetic mutations seem to be common
in autistic/PDD families, who we know respond to food chemicals.

Methyl-B12:
Apparently M-B12 is not really found in nature, apart from in milk,
which implies that it could be semi-essential for infants. It is
produced in the body when folic acid methylates B12. It seems to help
you both produce and destroy neurotransmitters. The main enzyme
involved in this is MTHFR. There is an entire pathway of genes/enzymes
that are part of this process, and further down the chain is SUOX, and
glutathione, which is essential for detoxing a wide range of
chemicals, including food chemicals. Glutathione is known to be low in
autistic/PDD. MTHFR and a number of other genes in this pathway have
been found to be associated with autism/PDD, and I think ADHD. M-B12
seems to help most with back pain and brain fog. Salicylates seem to
interfere with folic acid, and thus neurotransmitter production,
whilst amines are excess neurotransmitters that need metabolising.
Again, M-B12 is not a cure, but it can help when you are reacting. It
has a strong stimulant effect. It is easy to overdose on it and you
can end up with insomnia and other unpleasant effects. Because of this
I do not recommend people take it every day, only when they are
reacting with brain-related symptoms. B12 per se also helps you to
detox sulphites.

Folic acid: a word of caution. Though it methylates B12, it also does
other jobs in the body, some very good, some not so good. If you have
methylation pathway mutations, it can disproportionately be used for
other tasks in the body. It helps your body produce histamine. I'm not
suggesting that you stop taking it at all as it is pretty important
for gene methylation in pregnancy. My own personal experience is that
I can tolerate 200mcg per day. Above that and I start to feel amined.
A few days of taking it and I get brain fog withdrawal if I don't take
it, and feel amined if I do take it. I just want you to be prepared
for that. Choline, found in eggs, is also a very important for gene
methylation. It's only semi-conditional, but you need to eat four eggs
per day to get your RDA.

Milk thistle: it has two effects. Firstly protecting the liver,
increasing glutathion production and thereby aiding detox of
chemicals. Secondly, the inflammation associated with food chemicals
comes from excess leukotriene production. Milk thistle actually helps
to inhibit leukotriene production. Many herbal remedies have
salicylate-like polyphenols in them, and I cannot attest to the purity
of any particular milk thistle supplement. However, 150mg of silymarin
per day has a positive effect on me. More than that has a negative effect.

There are a number of other potential leukotriene inhibitors and
detoxers, but as I haven't tested them or researched them thoroughly I
can't recommend them.


> I don't know
> if I'm actually B12 deficient (B6 deficient for sure, though).

Have you had a blood test or are you just going on your diet? Or some
symptoms you have? B6 is also involved in the methylation pathway. If
taking a normal dose of B6 hasn't helped, it is more likely to be a
genetic "deficiency" caused by an enzyme mutation. If it pans out,
this could help you to figure out where that mutation is.