Any word on the supply situation?

I still have eight (8) bottles "on-loan" to Third Day Resources.

As soon as I go to my MD for my periodic check-up, I am going to try
some other alternative herbal therapies to augment the Combetic.

I'll let you know how that works out.

Between a brutally Spartan and strict diet, skimping on the Combetic,
and the other alternatives, I can keep my blood glucose at acceptable
levels. I wish there were ways which we could "grow our own" herbal
ingredients that are contained in Combetic to get away from having to
import everything from an unreliable trading "partner" like China.

Thanks for all you do.

Jim

-----Original Message-----
From: CombeticFamily@yahoogroups.com
[mailto:CombeticFamily@yahoogroups.com] On Behalf Of Rob Roberts
Sent: Monday, August 03, 2009 12:00 PM
To: CombeticFamily@yahoogroups.com
Subject: [CombeticFamily] Diabetic Drugs May Be Harmful to Your Health



Combetic Family:

By God's good grace, we are still in business selling Combetic. It has
been a long hard stressful business to endure as most of you know. We
thank you for your understanding and support.

I just received a phone call from a customer that complained about the
price of Combetic compared to his monthly cost for his insured drugs for
his diabetes. He actually said he will stop buying Combetic because of
the price!

Hey look, we will never be able to compete with the health insurance
system but we can help provide the only all natural formula that works
without the possibilities of having your health challenged with more
complications such as your eyes. How important is healthy eyesight? Is
saving a little extra money per month with oral anti-diabetic drugs
worth the chance? Here is a good article to inform us of possible eye
complications when relying on drugs:

http://www.naturaleyecare.com/geninfo.asp?g_num=15
<http://www.naturaleyecare.com/geninfo.asp?g_num=15>

To your good health,

Rob

Combetic Family:

By God's good grace, we are still in business selling Combetic. It has been a
long hard stressful business to endure as most of you know. We thank you for
your understanding and support.

I just received a phone call from a customer that complained about the price of
Combetic compared to his monthly cost for his insured drugs for his diabetes. He
actually said he will stop buying Combetic because of the price!

Hey look, we will never be able to compete with the health insurance system but
we can help provide the only all natural formula that works without the
possibilities of having your health challenged with more complications such as
your eyes. How important is healthy eyesight? Is saving a little extra money per
month with oral anti-diabetic drugs worth the chance? Here is a good article to
inform us of possible eye complications when relying on drugs:

http://www.naturaleyecare.com/geninfo.asp?g_num=15

To your good health,

Rob

Combetic Family:

As you know, Third Day Resources trusts in our Heavenly Father as our C.E.O. and
we are always open to help and minister to as many people we possibly can. Our
supply of Combetic has been a challenge as we just have enough financially for
each shipment.

These days, I am in the process of helping a good brother in sincere need of
financial help, alternative products and therapy because he has throat cancer.
His name is Stephen Finch, and he had to go through legal problems because of a
contract while developing a functional food product. His loose dentures caused
throat cancer and he is now struggling financially to afford chemo medication.
Steve needs our prayers and anything we can give to him at this time. Steve's
website is http://www.vafaf.com and his e-mail address is manosteen@...

If Father touches your heart to respond, please contact us.

Thank You,

God Bless,

Rob

March 13, 2009

TO ALL OF OUR VALUED CUSTOMERS:

We have been informed that Customs and the FDA has cleared and released our
Combetic shipment. Our shipment should arrive on Monday, March 16th. We will get
all back-orders promptly mailed soon. Thank you for your patience.

Due to the cost of business expenditures continuing to rise, we have found it
necessary to increase the cost of Combetic from the current $37.00 per bottle to
$40.00 per bottle effective on orders received as of April 1, 2009. Also, the
shipping and handling charge must increase to $10.00 per order. This is due to
the increased cost of postal shipping. This is the first time we have increased
this cost, even with 3 postal rate increases. We continue to strive to bring you
this product and you are aware of how difficult this has become lately and we
want you to know how much we appreciate your continued support and patience
until a more secure supply line is manifested.

With best regards,

Rob and Lois Roberts

Third Day Resources, Inc.

I started using Combetic in early 2006. I was pleased with the results.

Recently, I managed to run out during the "supply crisis" and went for
about a month without any. Not a good idea.

I resumed use after I received a care package from the new limited
supply. Here are the last few days of my fasting glucose numbers,
starting with the first day after having no Combetic:

166
155
131
160
136 << very little food the previous day
193
191
172
202
159
170
179 << resumed this day; this reading is from the previous day w/o Combetic
114
117

My meals every day include a very controlled diet with no "white
menace" food (and low glycemic food otherwise) and as much
exercise as I am able to do. I also eat bitter melon every day and
drink guava and Jiaogulan tea most days.

Life with diabetes is a struggle:
thank God, Rob and Lois, and Dr. Kooh for Combetic!

Combetic Family:

Here is some very exciting news:

Breakthrough diabetes research may be the closest thing to a cure! [VIDEO]

To view it, click on:

http://www.israel21c.org/link.jsp?enDispWho=Articles^l2383&enZone=Health

Be blessed,

Rob

Combetic Family:

The delayed shipment of Combetic arrived on Wednesday. We are filling
partial orders because of the long wait with high demand and limited
supply. We will get another shipment in hopefully soon. We appreciate
everyone's patience and prayers.

Be blessed and have safe holidays.

Rob and Lois

THIRD DAY RESOURCES

Do you get any information on the status of the Combetic shipment delay?

Combetic Family:

Thank you for your prayers and patience! Today we received official
notification from U.S. Customs that Combetic has been cleared for
release to us. We hope to have the next shipment by Monday of next
week due to the Thanksgiving holiday. Orders will be sent the same day
of arrival of the shipment. We have been assured that future shipments
will not be delayed because Combetic was tested and found to be safe
for human consumption.

If you have any questions about your order, please call Lois at
865-681-1596.

Combetic Family:

Customs still has not released our last shipment of Combetic. They do
not want to be contacted as we are waiting for the good report about
the Combetic analysis. Now is the time to pray. By the authority of
the blood of Jesus (Yeshua) we have the right to ask our Heavenly
Father to help us get Combetic distributed again. Our hearts go out to
every customer of Combetic as we pray together for a move of God to
help us in this difficult time.

We thank you for your patience and prayers,
Rob and Lois
Third Day Resources

PLEASE LET ME KNOW WHEN IT COMES IN. I NEED AT LEAST 3 BOTTLES. MY
PHONE NO# IS 352-835-8849 OR 352-683-0031. I WILL PAY WITH A CREDIT
CARD.
                                 THANK YOU
                                 ROSE HAMILTON

Combetic Family:

Fed Ex has informed us that our Combetic shipments should arrive to us
this Monday 8/11/08. We will have your Combetic orders in the mail when
it arrives. Thank you for your prayers and patience during this
difficult time. We will always do our best to assure an abundant supply
of Combetic in the future.

Best regards,

Rob and Lois Roberts

THIRD DAY RESOURCES

Combetic Family Members:

Due to the tight security at the Chinese Olympics, our supplier of
Combetic was required to only use Fed Ex in order to get Combetic out
of China. For the last three days, our 2 shipments have been held in
Anchorage, Alaska waiting for FDA clearance. We can only wait and
provide any information that Fed Ex asks of us. We have no contact
directly from the FDA. This is a very stressful and desperate situation
for all of us and we apologize for any inconvenience this has caused
any of our customers. Please pray about this situation as we wait for
Combetic. Thank you for your caring concern,

Rob Roberts
THIRD DAY RESOURCES

Your profile has been added to my personal space! Check my space here:
http://gsegese.zoomshare.com/files/myspace.htm

I think you will find that we are all different. I took metformin
(Glucophage) for a very short period of time, and then absolutely
refused to take it any more, as it does do liver damage, regardless
of what they tell you. You have to weigh the risks for yourself. The
MD's have tried to get me onto other oral meds but I am
"uncooperative". I am now using only Combetic and and a twice daily
injection of slow-acting Lantus insulin (25 ml). I also take a number
of supplements, but not like I did before I started with Combetic. My
h1Ac readings over the past year since starting Combetic have been
from a low of 6.0 to as high as 7  (during a period of time I had a
long term sinus infection and pneumonia), and most recently back to
6.4, so both my doctor (I had to change doctors) and I are happy. I
also have fibromyalgia, which does affect my blood sugar levels
significantly.

Elaine

On Mar 29, 2008, at 9:36 AM, dalenealiehubbard wrote:
> I take  blood sugar formula now for my type 2 diabetes of which has a
> very large number of herbs in it of which I think may be doing some
> good.  I would like to know when I start taking Cometic do I stop all
> other for this one of course I do take oral medicine Glucophage 1000
> twice a day and Glipized 10 MG once aday.
> I have been taking these medicines for a number of years.
>
> Do I also need to start a special diet with Combetic?  I would like to
> know what others are doing to keep their Diabetes under control
> without
> oral medicines.
> Thanks Dale
>

I take  blood sugar formula now for my type 2 diabetes of which has a
very large number of herbs in it of which I think may be doing some
good.  I would like to know when I start taking Cometic do I stop all
other for this one of course I do take oral medicine Glucophage 1000
twice a day and Glipized 10 MG once aday.
I have been taking these medicines for a number of years.

Do I also need to start a special diet with Combetic?  I would like to
know what others are doing to keep their Diabetes under control without
oral medicines.
Thanks Dale

Here is some Jiaogulan research:

Jiaogulan (Gynostemma pentaphyllum) "the immortality herb" Extract in
The Chinese Formula Combetic

In the 1970's the Chinese government sponsored a study focused on the
large number of people living to over 100 years old in certain
provinces in Southern China. They discovered the centenarians drank a
tea brewed from a local herb called Jiaogulan, "the immortality herb"
for it's beneficial effects of vitality and longevity.

Jiaogulan enhances endurance, lowers cholesterol and blood pressure,
inhibits tumors and help protect the cellular immunity as well as
providing many other health benefits.

Jiaogulan improves the metabolism of the heart directly as well as
enhancing the release of nitric oxide in the body, which helps to
relax the coronary blood vessels.

What makes Jiaogulan unique is the wide variety of therapeutic
effects that scientists have demonstrated through their research;
i.e., antioxidant protection, enhancing cardiovascular function,
blood pressure and cholesterol regulation, positive influence on
blood elements, strengthening immunity, etc.

In other words, getting these benefits by taking Jiaogulan might
eliminate the need for taking an array of other supplements.

An herb for all reasons. Rothacker, Jordan.
Vegetarian Times (August 2001): 14(2).

Jiaogulan contains amino acids, proteins, vitamins and an abundance
of trace minerals. It's also high in saponins, a natural "detergent"
that can improve liver function, increase good cholesterol (HDL) and
lower the bad (LDL). Additionally, the herb has also been heralded as
an adaptogenic, meaning that it can enhance the body's ability to
keep itself healthy by controlling blood pressure and regulating the
digestive and immune systems. Studies indicate that jiaogulan aids in
white blood cell formation, acts as an anti-inflammatory and reduces
tumor size.

Look out, echinacea and ginkgo: with such a range of potential health
benefits, jiaogulan is poised to be the next big thing.

Jiaogulan. Block, Betsy.
Natural Health v.29 no.9 (Nov-Dec 1999), p.41

According to Dr. Jialiu Liu, more than 20 studies of the Chinese
herb, "jiaogulan as a treatment for high cholesterol have been
published in China. In a meta-analysis of this research, Liu found
that jiaogulan lowered LDL (bad cholesterol) and raised HDL (good
cholesterol) in 67 to 93 percent of the 980 people studied. A 1996
study of more than 200 people with hypertension found that jiaogulan
was almost as effective as Indapamide, a prescription drug used to
treat high blood pressure (jiaogulan was 82 percent effective, while
the drug was 93 percent effective)." (p41)

Jiaogulan. Jule Klotter.
Townsend Letter for Doctors and Patients 247-248 (Feb-March 2004): p25
(1).
The botanical Gynostemma pentaphyllum, known as Jiaogulan (pronounced
jee-ow-goo-lahn), is a powerful adaptogen and antioxidant… Jiaogulan
encourages body functions to normalize, strengthens the immune
system, and supports the adrenal glands…Its leaves contain active
components that are used in Chinese folk medicine to treat lung
ailments.

…Researchers have found that jiaogulan contains active saponins
(gypenosides) that boost cardiac output, increasing blood supply and
nourishment to body organs. These gypenosides also maintain blood
pressure within a normal range.

Jiaogulan's gypenosides have an equally modulating effect on the
central nervous system, calming irritated nerves and stimulating
underactive nerves. The herb also modulates lymphocyte
transformation, enhances lymphocyte activity, and inhibits tumor
growth. Two clinical studies found that gypenosides encourage the
body to produce superoxide dismutase (SOD), an antioxidant enzyme
that scavenges free radicals.

Department of Medical Biochemistry and Biophysics, Karolinska
Institutet, SE-171 77 Stockholm, Sweden.

Extracts from Gynostemma pentaphyllum Makino (Cucurbitaceae), a
Southeast Asian herb, has been reported to affect numerous activities
resulting in antitumor, cholesterol-lowering, immunopotentiating,
antioxidant, and hypoglycemic effects. We have isolated one active
compound by ethanol extraction, distribution in n-butyl
alcohol/water, solid phase extraction/separation, and several rounds
of reverse phase high pressure liquid chromatography. We have shown
by NMR and mass spectrometry that this active compound is a novel
saponin, a gypenoside, which we have named phanoside (21-,23-epoxy-
,3beta-,20-,21-trihydroxydammar-24-ene-3-O-([alpha-d-rhamnopyranosyl
(1-->2)]-[beta-d-glycopyranosyl(1-->3)]-beta-d-lyxopyranoside)), with
a molecular mass of 914.5 Da. Phanoside is a dammarane-type saponin,
and four stereoisomers differing in configurations at positions 21
and 23 were identified, each of which were found to stimulate insulin
release from isolated rat pancreatic islets. We have also found that
the stereoisomers are interconvertible. Dose-dependent insulin-
releasing activities at 3.3 and 16.7 mM glucose levels were
determined for the racemic mixture containing all four stereoisomers.
Phanoside at 500 microM stimulates insulin release in vitro 10-fold
at 3.3 mM glucose and potentiates the release almost 4-fold at 16.7
mM glucose. At these glucose levels, 2 microm glibenclamide
stimulates insulin release only 2-fold. Interestingly, beta-cell
sensitivity to phanoside is higher at 16.7 mM than at 3.3 mM glucose,
although insulin responses were significantly increased by phanoside
below 125 microM only at high glucose levels. Also when given orally
to rats, phanoside (40 and 80 mg/ml) improved glucose tolerance and
enhanced plasma insulin levels at hyperglycemia.

Anti-hyperlipidemic and hypoglycemic effects of Gynostemma
pentaphyllum in the Zucker fatty rat.Megalli S, Davies NM, Roufogalis
BD.
Faculty of Pharmacy and Herbal Medicines Research and Education
Centre University of Sydney, Building Al5, Sydney NSW 2006.
smegalli@...

Gynostemma pentaphyllum is a traditional Chinese medicine used for a
variety of conditions, including elevated cholesterol. We have
examined the pharmacological anti-hyperlipidemic and hypoglycemic
effectiveness of Gynostemma pentaphyllum in the obese Zucker fatty
diabetic rat model. After treatment for 4 days Gynostemma
pentaphyllum 250 mg/kg reduced triglyceride (33%), total cholesterol,
(13%) and low density lipoprotein cholesterol levels (33%). These
effects were dose-dependent and maintained for at least 5 weeks.
Chronic treatment for 3-5 weeks also reduced post-prandial
hypertriglyceridemia induced by olive oil 10 mg/kg in the Zucker
fatty rats but had no significant effect in lowering sucrose-induced
hyperglycemia in Sprague-Dawley rats. A novel regulation by
Gynostemma of glucose levels was also observed in the Zucker fatty
rat model. In a glucose tolerance test in obese and lean Zucker rats
pretreatment with Gynostemma pentaphyllum 250 mg/kg demonstrated
glucose levels were significantly less 2 hours post challenge (20%)
in the Gynostemma pentaphyllum obese rats compared to the control
group. Gynostemma pentaphyllum did not significantly reduce glucose
levels at 120 min in the lean strain, in contrast to the 20% decrease
seen in the obese rat. In vitro, Gynostemma pentaphyllum inhibited
alpha-glucosidase activity (50% inhibition at 42.8), which compared
to acarbose (50% at 53.9 microg/mL). The improvement in glucose
tolerance at 120 min by Gynostemma pentaphyllum in obese Zucker fatty
rats but not lean rats suggests that it may improve insulin receptor
sensitivity and together with the significant reduction of
hypertriglyceridemia, cholesterol and low density lipoprotein
cholesterol suggests that Gynostemma should be examined further by
oral hypoglycemic/anti-hyperlipidemic therapy.

Evaluation of possible toxicity of Gynostemma pentaphyllum. Attawish
A, Chivapat S, Phadungpat S, Bansiddhi J, Techadamrongsin Y, Mitrijit
O, Chaorai B, Chavalittumrong P. Medicinal Plant Research Institute,
Department of Medical Sciences, Ministry of Public Health, 88/7
Tiwanont road, Muang, Nonthaburi 11000, Thailand.

The effect of water extract of Gynostemma pentaphyllum was evaluated
on 6-month chronic toxicity in Wistar rats. Control group received
orally 10 ml kg(-1) day(-1). The extract was orally given to the five
treatment groups at the doses of 6, 30, 150, 750 and 750 mg kg(-1) day
(-1) for 24 weeks. The last group served as the recovery group. The
results showed that the extract did not produce any significant dose-
related changes. Therefore, it is concluded that the extract of G.
pentaphyllum at the given doses did not produce any significant toxic
effect in rats during 6-month period of the treatment.

JIAOGULAN OR GINSENG?

According to Subhuti Dharmanda, Ph.D., Portland Oregon, January 1999:

As a result of my investigations, jiaogulan became part of the
clinical treatment programs at our organization's clinics,
particularly for the treatment of persons undergoing cancer
therapies. Jiaogulan is a tonic adaptogen herb that can help protect
the body from the stresses of the cancer therapies.

Jiaogulan has been a relatively obscure folk remedy in China, mainly
used for treating lung diseases. It was recently discovered to
contain the same kind of active constituents as ginseng. In fact, a
few of its ingredients were shown to be identical to those found in
ginseng.

Ginseng became famous because of the root's shape, which is sometimes
like a human figure. To be an effective health-care product, the root
has to be grown for many years (6 years is the standard for most
cultivated ginseng ), which contributes to the rarity and high cost
of ginseng. Jiaogulan grows wild over a large region, and provides
low cost supplies of the active constituent from its leaves that can
be harvested each year. For this reason, jiaogulan is a very
appealing ginseng substitute.

Various Chinese clinical trails have shown that jiaogulan is safe and
has both chemical constituents and herbal properties comparable to
that of ginseng. Proponents of the herb suggest that it might even be
superior to ginseng, having a broder range of the active constituents
( more variety of saponin glycosides, Jiaogulan having 82, ginseng
having 28 ), and producing less of a stimulatory action in persons
who are sensitive to ginseng in that way. The body of research
supporting the use of jiaogulan is extensive and expanding, so much
so that jiaogulan has become a permanent addition to the valuable
collection of Chinese herbal tonics used as adaptogens.

Jiaogulan the Rejuvenating Elixir

According to the book, Jiaogulan China's "Immortality" Herb by
Michael Blumert and Dr. Jialiu Liu:

Jiaogulan has been used by the people in the mountainous regions of
Southern China as an energizing agent. They take it as a tea before
work to increase endurance and strength, and after work to relieve
fatigue. It is taken for general health and as a rejuvenating elixir.
The local Chinese called Jiaogulan xiancao the "Immortality Herb,"
and described it, "Like ginseng but better."

Jiaogulan contains saponins, flavones, polysaccharides, amino acids,
vitamins and minerals, including many essential trace elements. Among
these, the saponins are the most important of the effective
components. The type of saponins of both Jiaogulan and Panax ginseng
are classified as belonging to the dammarane diol family, hence both
herbs exert similar effects on the human body. There is a similarity
between the chemical structure of gypenosides and our own body's own
steroids which explains the secret of the energizing, balancing and
therapeutic effects.

Out of the 82 saponins or gypenosides of jiaogulan, 4 are exactly the
same as ginseng in chemical structure and function. 17 other
gypenosides, when hydrolyzed, have been found to be similar to those
found in ginseng. Jiaogulan differs from Panax ginseng in that most
herbalists offer a caution to persons with high blood pressure to
avoid higher doses of Panax ginseng. There are no such cautions with
jiaogulan.

It seems timely now for researchers, natural health practitioners,
and the health industry to look more seriously at the use of
jiaogulan and jiaogulan based products as a beneficial addition to
their range of health care supplements.

Jiaogulan is one of the 11 herbal extracts in the Chinese diabetic
formula Combetic that helps normalize blood sugar levels. Combetic
has the right combination of synergestic herbs that contributes to
optimum health of the immune system, circulatory system, cholesterol,
triglyceride levels and helping in the recovery of complications,
illness and fatigue. For more information and research about
Jiaogulan and Combetic, visit: http://www.thirddayresources.com

Thank you,
Health and Happiness,
Rob

Combetic Family Forum:

Third Day Resources now has a secure reliable source of Combetic.
Please go to our new website to order. The price increased to $37
because of the devalued American dollar. You can now tell your
friends about Combetic.

Here is the latest news about Stem Cell Therapy:

An international team of researchers has finally managed to locate
stem cells in the pancreas -- in mice, at least and could pave the
way for dramatic new therapies for diabetes, namely the regeneration
of beta cells so the body could once again produce its own insulin.

If confirmed in humans, it could mean new therapies. Until now,
scientists had all but abandoned hopes that the pancreas made its own
stem cells because they had failed to find evidence to support the
theory.

"This is the first conclusive evidence that there are stem cells in
the pancreas, but any potential benefit is a very long way away,"
said Juan Dominguez-Bendala, director of Stem Cell Development for
Translational Research at the Diabetes Research Institute of the
University of Miami Miller School of Medicine.

"If this kind of cell and their progenitors with a capacity to divide
exist in the pancreas of man, and if we can identify the factors that
are responsible to induce their proliferation and differentiation,
then these latter processes might be stimulated in vitro but also, by
noninvasive means, in vivo," said senior study author Harry Heimberg,
an associate professor at the Diabetes Research Center of Vrije
Universiteit Brussel in Belgium.

Diabetes is primarily a failing of the pancreatic beta cells to
produce insulin. Beta cells are one of several types of cells making
up clusters of cells called the islets of Langerhans. Insulin is a
hormone that moves blood sugar from the bloodstream to the cells,
where it is used as energy.

Islet-cell transplantation, in which islets are transferred from one
person to another, is performed today but is limited in scope because
of a shortage of donors, according to the study.

The very existence of pancreatic stem cells is controversial. A
recent study out of Harvard found that the major source of new beta
cells in adult mice was preexisting beta cells, not stem cells. The
finding reduced the urgency to track down pancreatic stem cells.

"If stem cells didn't contribute, what was the point," said Dominguez-
Bendala.

For this study, Heimberg and his colleagues cut off the duct that
drains digestive enzymes from the pancreas in mice. Within two weeks,
the number of beta cells in the pancreas doubled. Not only did the
number of beta cells increase, the mice started producing more
insulin.

"When damaged a specific way, it triggered stem cells" production,
Dominguez-Bendala said.

The newly identified stem cells were almost identical to embryonic
beta cell progenitors. In fact, the gene Neurogenin 3 (Ngn3), which
plays a role in embryonic development of the pancreas, is also
involved in the formation of these new beta cells, the researchers
said.

"This is a model of regeneration no one has tested before," Dominguez-
Bendala said. "From a basic science point of view, it's very
exciting. It opens the door to potential therapies. If we could
trigger regeneration, that would be fantastic."

"This demonstrates a stem cell repair mechanism in the pancreas that,
if we understand it more, then we can help develop more cures with
either transplantation or with drugs that can increase the body's own
stem cells and beta cells," said Paul Sanberg, director of the
University of South Florida Center for Aging and Brain Repair in
Tampa.

The findings are published in the Jan. 25 issue of the journal Cell.
Juan Dominguez-Bendala, Ph.D., director, Stem Cell Development for
Translational Research, Diabetes Research Institute, and assistant
professor, surgery, University of Miami Miller School of Medicine,
Miami.

=========================================

To Your Health and Happiness,
Rob

Combetic Family:

Here is a new interesting therapy:

Israeli 'guided missiles' induce cancer cells to commit suicide By Nicky Blackburn   November 21, 2007
Target-In CEO Dr. Shai Yarkoni: We take the small molecule, fuse to it a protein that causes cell suicide and get a molecule that preserves the specificity of the target while making the killing very effective. Target-In http://www.target-in.com		For a moment, Dr. Shai Yarkoni, president and CEO of biotechnology start-up Target-In, appears to veer off on a tangent. "There's something very interesting in the terms we take from the military to the medical world and vice versa," he says contemplatively. "Surgical strike, magic bullets, these are all phrases that pass from one industry to the other." People call what Target-In is doing 'guided missiles', and in a way that's exactly what the company's technology is: a guided missile that can recognize and kill inflamed cells from tumors and other diseases. But Target-In's technology is more sophisticated than that. The technology doesn't just shoot diseased cells down, it makes them commit suicide. Target-in was founded in 2002 and stems from over 10 years of academic research by Prof. Hiya Galski, a leading academic in the field of immunotoxins at Hebrew University, and Yarkoni, who was her PhD student. The pair had been looking for a human toxin that could be used to kill off diseased human cells. The problem was, however, that no creature on the planet will create a toxin for itself because basically it's suicide to do so. Instead doctors were using alternative man-made toxic compounds like radioactivity, chemotherapy and antibodies to treat diseased cells. Then the researchers had a bright idea. Cell apotosis (programmed cell death) is one of the pivotal mechanisms through which an organism can control its cells. It enables an animal or human to induce suicide in cells that no longer serve appropriately and is a physiological, rather than pathological response. It is also used actively in the development of a fetus. Yarkoni holds out his arm as an example. "As long as it the shaft of the arm that is developing, everything is fine. But what happens when you get to the fingers?" He touches the creases of skin between his fingers. "In the fingers the cells have to keep on growing, but where the creases are it has to stop. The way it does this is through the cells committing suicide. "The whole idea of modern medicine is to imitate the processes that happen naturally in the body. In one bright moment we realized that the cell suicide mechanism is the toxic compound we were looking for," Yarkoni told ISRAEL21c. Targeted cell death is only possible because of advances that have taken place in targeted therapies over the last few years. Antibodies, hormones and growth factors, are already being used to treat diseases by targeting the specific cells that cause the illness. The only problem with these therapies, however, is that they don't kill the cells and have little biological effect. Target-In aims to change that. The company has so far created eight molecules that can be combined with the molecules of proven targeted therapies to create a single small protein with two functional domains. "This protein acts through using the targeting molecule to get to the right cells, and then once there, initiates the physiological effects of cell suicide," explains Yarkoni. "Think of it like a key in a keyhole," he adds. "Antibodies match certain receptors of the cell the way a key matches a key hole. But getting a key into a hole doesn't always open the door. We have to add something to make it more effective and kill the cells. We take the small molecule or key, fuse to it a protein that causes cell suicide and get a molecule that preserves the specificity of the target while making the killing very effective. And it does this with little, if any, side effects and no effect on safety." The apotosis protein will not destroy healthy cells, for example, because outside the cell it cannot have any impact. The only way for it to enter the cell is through the targeting molecule. In addition only small amounts of the protein are needed. "We imitate the physiological process and the cell doesn't know that the process is artificial," says Yarkoni. "There's no collateral damage." This all sounds very innovative, but the company's goal is not to waste time pioneering anything that doesn't need to be pioneered. As a result, the company plans to only use antibody targets that have already been proven by other companies - treatments like Herceptin, an antibody used to treat breast carcinoma cells. This treatment sells for more than $2 billion, according to Yarkoni, but doesn't cure the patients. "It merely prolongs the remission time," he said. "The market of targeted therapies has to be upgraded and we are bringing the solution." The company has now taken five prototypes through successful animal studies which indicate that the treatment is a generic solution. The company's lead compound, the IL2-Caspase3, now has full proof of concept. In studies this receptor proved to have a clear beneficial effect on animal models of Crohn's disease and Diabetes Type 1. This receptor is currently used in three products on the market - two antibody treatments, Simulict and Zenapax, and one immunotoxin, Ontak, which are used to treat cancer and transplantation rejection. "The existing treatments suffer major drawbacks," says Yarkoni. "The antibodies have low efficacy and the immunotoxin has high toxicity inducing many side effects." The company now plans to add its protein to these three compounds and test them in a clinical setting. Trials will begin in one year. The goal, to show that the new drug is safer than Ontak, and more efficacious than the antibodies. To do this as quickly and efficiently as possible, Target-In has signed two licensing agreements with an Indian active pharmaceutical ingredient (API) company, Century Pharmaceutical, which develops anti-allergens and asthma therapies; and a US company based in Palo Alto in San Francisco, which is developing a product for leukemia. Target-In will co-develop its treatment with Century Pharmaceuticals. Yarkoni, who worked as CTO at Collguard before joining Target-In, is expecting to receive fast-track status from the FDA to develop the new treatments at a faster rate than normal. This will enable the company to carry out Phase I clinical trials and then pass directly to a pivotal study with fewer patient numbers than normal Phase II and III trials. Once the first treatments have gone through clinical trials and proved safe, the company intends to expand the indications to address other diseases. Target-In is a small company employing six; most of the work is sub-contracted out. It received $200,000 in seed money from the Hebrew University of Jerusalem. "This was very unusual," says Yarkoni. "It was the first time that the university had invested money directly into a company. The head of Yissum Technology Transfer company (the commercial arm of the Hebrew University), strongly believed in us." Since then the company has raised more than $4 million from private investors, and is now gearing up for its second round. The aim is to raise $10 million. Already Century Pharmaceutical has pledged $1 million, and Yarkoni says the company has also received a firm commitment for a further $3 million from a Japanese company. Further negotiations are taking place with US and Japanese venture capital companies. This money will get the company through two clinical trials and proof of concept. "For me this is déjà vu," says Yarkoni. "I remember the antibodies industry in the late '80s. No one believed in it. In 1997 the whole worldwide market of antibodies was $250 million. In 2007, it's worth $20 billion. I think this is going to happen once again. We expect to revolutionize the whole concept of targeting therapy." Be Blessed, Rob

Combetic Family:

Here is some interesting research about the Chaga Mushroom:

In 1958, scientific studies in Finland and Russia found the Chaga mushroom provided an epochal (significant change) effect in uterine, liver, breast, and gastric cancer, hypertension and diabetes.

The Gandodelan A-B in Chaga is responsible for blood sugar maintenance. Chaga activates the immunity system and arrests the excess production of allergen. Gandodelan A-B  lowers blood sugar content quickly in white mice clinical studies by 60-89% in seven hours.

The post-antibiotic world of Western Medicine is now beginning to study, evaluate, and test Chaga for the active compounds underlying its historically understood homeopathic benefits. As with many other natural medicinal foods and herbs, the modern medical and scientific community is coming to understand that whole supplements like Chaga, offer a complex balance of active compounds, delivery mineral structures, and co-agents, more effective to sustaining a healthy immune balance than isolated compounds synthesized from these natural products.

Scientists worldwide are now discovering the healing abilities of this ancient and noble remedy. In this century, there are over 1400 clinical and scientific research publications, and in vitro controlled studies devoted to Chaga and its effects, supporting medicinal mushrooms as an alternative to over-the-counter drugs and prescription medications.

Wild Siberian Chaga:

• Contains 215 Phytonutrients
• Contains Ergo sterol (Vitamin D2) not found in vegetables
• Contains complex immune activating compounds
• Contains Beta Glucans (Complex Carbohydrates or Polysaccides)
• Contains 29 Beta functions
• Contains Saponins, Sterols, Triterpenes, Butilinic Acid, SOD (super oxide) and Protein
• Contains Amino Acid Complexes and other trace minerals
• Contains compound Melanin, which restores a youthful appearance
• Has the highest antioxidant value ever recorded for a food or product
• Has been shown to increase human Natural Killer (NK) Cell activity by up to 300%

Arguably, the most well known western research conducted on the use of Chaga has been performed by Dr. Kirsti Kahlos and her team at School of Pharmacology, at the University of Helsinki, Finland. Dr. Kahlos' team conducted studies validating the immuno-modulating impact of Lanosterol-linked triterpenes effective as a flu-vaccination and for anti-tumor applications. Institutional studies at the University of Tokyo, Japan have determined effectiveness of Inotodials in the destruction of certain cancerous carcinosarcomas and mammary adenocarcinomas. The Melanin complex produced by the Chaga mushroom demonstrates high antioxidant and genoprotective effects ( Melanin Complex from Medicinal Mushroom Inonotus Obliquus, Journal of Medical Mushrooms, 2002, vol. 4) . The polysaccharide beta-glucan, also present in Chaga, is proven to be effective at inhibiting mutagenic and immuno-modulating effects of cancerous tumors by triggering immune system response ( SP Wasser, 2002,InstituteofEvolution,UniversityofHaifa,Israel).

Mushrooms are a flavorful and nutritious food group. Good sources of B-Vitamins Thiamine, Riboflavin and Niacin. They contain all the essential amino acids. Chaga is rich in minerals such as: Vitamin B1, B2 and B3 as well as Amino Acids. It contains Ergosterol (Vitamin D2), which is not found in vegetables and has low Caloric Value and High in Dietary Fibers.

Mushrooms have also been used for thousands of years as some of the most effective, yet benign, of many plants that formed the Oriental herbal tradition.

Combetic Family:

Here is another good link all about Jiaogulan, 75 ml. of the Combetic
formula:

http://www.jiaogulan.net

*****Also,  Cucurbitacin is used for diabetes by Dr. S.Dharmananda,
Institute for Traditional Medicine, Portland, Oregon. (Cucurbitacin is
found in Trichosanthis, 60 mg. of the Combetic formula.


Be Blessed,
Rob

Profile of Plansulin Formulator:

      Dr. Yang Yuzhong was born in 1951. His family has a long history
in Traditional Chinese Medicine. Because of his family influence, Dr.
Yang was introduced to TCM as a child. He has learned the essence of
Dr. Yang Jizhou---a doctor especially for emperor in the Qing
Dynasty.
      Dr. Yang joined the army in 1968. He continued medical work in
the Donghai Fleet logistics. From 1969 to 1972, he studied Clinical
Medicine Science in 412 hospitals, affiliated to Donghai Fleet.
      After delving into ancient medicine formulas, he has accumulated
considerable medical experience, and achieved many patents and glory,
especially in Human immunity and Health Application of TCM. He has
been awarded the Gold Award of Hebei Province Scientific Achievement,
Silver Award of Tangshan City Scientific Achievement and Labor Model
of Hebei Province.
       In 1996, Dr.Yang developed many valuable herbal medicines such
as Babao Huisheng Liquid and Kidney Recovery Capsule.
       As energetic as before and making new progress after two years
in commerce, he felt that the busy commercial life affected his focus
in research. He left the company as general manager and rededicated
himself to medical science.
       From 1998, Dr. Yang learned from other experts and innovates
ingeniously. For the patients coming because of his reputation, he
takes them as his family member. For people coming to learn, he
teaches what he knows without reserve.
       In the past five years, the team of Dr. Yang has grown. Dr.
Yang and his students have visited many famous doctors and continue
to study enormous amounts of medical books. They have developed many
good formulas against many intractable diseases. Some of his formulas
include:
      Stomach Benefiting Capsule, which is made of eight herbs
including fleece flower root, is used against many stomach and
intestine disease, such as gastritis, gastric ulcer, duodenum ulcer,
etc. It takes about 7 days to cure them. It is approved by Heibei
Province medical department in 1996. It is a popular product in
Southeast Asia.
       Musk Wind Tablet, which is used for rheumatism and arthritis,
etc. Pains could disappear in 12 hours. Swell could disappear in 24
hours. Languor, sorrow in the waist, legs and muscle could be fully
dispersed.
        In April,2003, SARS was widespread in China. Dr. Yang was very
keen to do something to improve the grave situation. Based on his
knowledge of ancient formulas, he developed Qing Re Detoxification
Liquid. It was initially used to improve immunity and prevent SARS.
The medicine was submitted and approved by the National SARS
Prevention and Treating Direction Team. It is put out in the
Traditional Chinese Medicine Website and allowed to be used
nationally.
       In 1995 The Special Effect Medical Technology Research Society
of China was founded. In 2004, Dr. Yang was designated as a famous
doctor for Special Medical Effect, and Vice Secretary of the society.

From: Robin Roberts

To: CombeticFamily@yahoogroups.com

Sent: Wednesday, July 18, 2007 3:22 PM

Subject: Re: [CombeticFamily] PLANSULIN

Combetic Family:

 

I e-mailed information about Plansulin to Rose. If anyone else needs information about Plansulin, please e-mail me.

 

Third Day Resources is not discontinuing coated Combetic and replacing it with Plansulin. We are offering Plansulin to those customers for the following reasons:

 

1)  The uncoated Combetic has not worked for them or has lost it's effectiveness.

2) Started on the coated Combetic, switched to the uncoated Combetic because of the  lack of supply and then went back on the coated and the coated did not work.

3) Their supply of coated Combetic has run out and want something else to help maintain their blood sugars.

4) The coated Combetic has lost it's effectiveness which means their pancreas produces little natural insulin and may or may not be a type I diabetic.   !

 5) Being a type I diabetic ( such as Myself ) and need blood sugar control.

 

Third Day Resources will soon only carry the best formulas that work. We will assure that coated Combetic or Plansulin will never be in short supply because of the severity of the disease. It is our number one priority to offer only the formulas that work for each individual with your confidence in us that we will never have a shortage of life sustaining formulas. Thank you for your patience and your willingness to allow us to help each of you on your road to recovery.

 

Be Blessed,

 

Rob

    

kittykat <kittykat60@FoxValley.net> wrote:

Rose, did you ge! t an answer to your question? 

 

----- Original Message -----

From: roseann hamilton

To: CombeticFamily@yahoogroups.com

Sent: Wednesday, July 18, 2007 1:43 PM

Subject: [CombeticFamily] PLANSULIN

HELLO THIS IS ROSE HAMILTON AND I WAS JUST WONDERING
ABOUT THE NEW DIABETIC MEDS THAT YOU ARE GETTING AND
HOW DOES IT COMPARE TO COMBETIC AND IS THE COST LOWER?
I HAVE STOPPED TAKING COMBETIC BECAUSE I JUST CANT
AFFORD THE COST. YOU DONT EVEN GET A MONTH SUPPLY IN
ONE BOTTLE AND IT DOES GET EXPENSIVE.

rose hamilton

__________________________________________________________
Need a vacation? Get great deals
to amazing places on Yahoo! Travel.
http://travel.yahoo.com/

---

No virus found in this incoming message.
Checked by AVG Free Edition.
Version: 7.5.476 / Virus Database: 269.10.8/906 - Release Date: 7/17/2007 6:30 PM

---

My mailbox is spam-free with ChoiceMail, the leader in personal and corporate anti-spam solutions. Download your free copy of ChoiceMail from www.digiportal.com.

---

Luggage? GPS? Comic books?
Check out fitting gifts for grads at Yahoo! Search.

Rose, did you get an answer to your question? 

 

----- Original Message -----

From: roseann hamilton

To: CombeticFamily@yahoogroups.com

Sent: Wednesday, July 18, 2007 1:43 PM

Subject: [CombeticFamily] PLANSULIN

HELLO THIS IS ROSE HAMILTON AND I WAS JUST WONDERING
ABOUT THE NEW DIABETIC MEDS THAT YOU ARE GETTING AND
HOW DOES IT COMPARE TO COMBETIC AND IS THE COST LOWER?
I HAVE STOPPED TAKING COMBETIC BECAUSE I JUST CANT
AFFORD THE COST. YOU DONT EVEN GET A MONTH SUPPLY IN
ONE BOTTLE AND IT DOES GET EXPENSIVE.

rose hamilton

__________________________________________________________
Need a vacation? Get great deals
to amazing places on Yahoo! Travel.
http://travel.yahoo.com/

---

No virus found in this incoming message.
Checked by AVG Free Edition.
Version: 7.5.476 / Virus Database: 269.10.8/906 - Release Date: 7/17/2007 6:30 PM

---

My mailbox is spam-free with ChoiceMail, the leader in personal and corporate anti-spam solutions. Download your free copy of ChoiceMail from www.digiportal.com.

----- Original Message -----

From: roseann hamilton

To: CombeticFamily@yahoogroups.com

Sent: Wednesday, July 18, 2007 1:43 PM

Subject: [CombeticFamily] PLANSULIN

HELLO THIS IS ROSE HAMILTON AND I WAS JUST WONDERING
ABOUT THE NEW DIABETIC MEDS THAT YOU ARE GETTING AND
HOW DOES IT COMPARE TO COMBETIC AND IS THE COST LOWER?
I HAVE STOPPED TAKING COMBETIC BECAUSE I JUST CANT
AFFORD THE COST. YOU DONT EVEN GET A MONTH SUPPLY IN
ONE BOTTLE AND IT DOES GET EXPENSIVE.

rose hamilton

__________________________________________________________
Need a vacation? Get great deals
to amazing places on Yahoo! Travel.
http://travel.yahoo.com/

---

No virus found in this incoming message.
Checked by AVG Free Edition.
Version: 7.5.476 / Virus Database: 269.10.8/906 - Release Date: 7/17/2007 6:30 PM

HELLO THIS IS ROSE HAMILTON AND I WAS JUST WONDERING
ABOUT THE NEW DIABETIC MEDS THAT YOU ARE GETTING AND
HOW DOES IT COMPARE TO COMBETIC AND IS THE COST LOWER?
I HAVE STOPPED TAKING COMBETIC BECAUSE I JUST CANT
AFFORD THE COST. YOU DONT EVEN GET A MONTH SUPPLY IN
ONE BOTTLE AND IT DOES GET EXPENSIVE.


rose hamilton






________________________________________________________________________________\
____
Need a vacation? Get great deals
to amazing places on Yahoo! Travel.
http://travel.yahoo.com/

--- rosalita3466 <rosalita3466@...> wrote:

> HELLO, THIS IS ROSE HAMILTON. I HAVE NEVER HEARD OF
> PLANSULIN. IS IT
> NEW. AND COULD I HAVE SOME INFORMATION ON IT. IS IT
> BETTER THAN
> COMBETIC AND CHEAPER?
>
>
>
>
>
>
>
>
>
>
>
> -- In CombeticFamily@yahoogroups.com, "Rob Roberts"
> <awonderwater@...> wrote:
> >
> > Combetic Family Members:
> >
> > Combetic Family Members:
> >
> > As you know, we have experienced an interruption
> with our source
> of
> > Combetic. We should be getting the coated Combetic
> in this week.
> We
> > apologize for any inconvenience this may have
> caused you.
> >
> > We are in the process of assuring a constant
> unlimited supply of
> > Combetic in the future. An effective reliable
> source of Combetic
> is
> > vital to us and our customers.
> >
> > We are also encouraged with another Chinese
> formula called
> Plansulin
> > that has effectiveness for type I and type II
> diabetes.
> >
> > Please keep us in your prayers as we pray for each
> of you.
> >
> > Be Blessed,
> >
> > Rob
> >
>
>
>



rose hamilton





      
________________________________________________________________________________\
____
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