Ok, I found this in my 'drafts' section...  Thought I had sent it.. but
seems I didn't..  Sorry it's so OLD... LOL  But, think it's still important
for those of us with CMT to know about this...

Ernie



Sal, you are correct that RLS does affect the 'normal' population, but it is
also a known fact that those of us with CMT are at a higher risk for it.

http://www.ncbi.nlm.nih.gov/pubmed/19038854?ordinalpos=1&itool=EntrezSystem2.PEn\
trez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Is there a higher risk of restless legs syndrome in peripheral neuropathy?

Hattan E, Chalk C, Postuma RB.
Department of Neurology & Neurosurgery, McGill University, Montreal General
Hospital, Montreal, Quebec, Canada.

OBJECTIVE: Associations between peripheral neuropathy and restless legs
syndrome (RLS) have been described, but have not been consistently
reproduced. If RLS prevalence is truly increased by neuropathy, this has
important implications for RLS pathophysiology.

METHODS: In a case-control design, 245 patients with peripheral neuropathy
and 245 age- and sex-matched controls were screened for RLS using a
standardized phone questionnaire based on international RLS diagnostic
criteria. All persons who answered yes to three of four criteria were
considered screen-positive. All screen-positive patients underwent a
confirmatory diagnostic evaluation by a movement disorders specialist
blinded to the neuropathy status of the patient. RLS prevalence was
calculated and compared using Fisher exact test.

RESULTS: A total of 65 (26.5%) patients with neuropathy screened positive
compared to 25 (10.2%) controls (p < 0.0001). However, the diagnosis was
confirmed in only 46% of screen-positive patients with neuropathy, vs 80% of
controls (p = 0.005). Cramps and paresthesia without true diurnal variation
or rest exacerbation were the commonest causes of false-positive screens.
After diagnostic confirmation, the overall prevalence of RLS did not differ
between neuropathy patients and controls (12.2% vs 8.2%, p = 0.14). However,
when classified by etiology, RLS was found in 14/72 (19.4%) patients with
hereditary neuropathy, a prevalence higher than found in controls (p =
0.016) and acquired neuropathy (9.2%, p = 0.033). Among patients with
neuropathy, those with RLS more commonly had a family history of RLS (37% vs
15%, p = 0.007) and were younger (49.9 vs 61.4, p = 0.0003).

CONCLUSIONS: Restless legs syndrome is more prevalent among patients with
hereditary neuropathy, but not in those with acquired neuropathies.



PMID: 19038854 [PubMed - indexed for MEDLINE







----- Original Message -----
From: "sal2491" <gbsb2002@...>
To: <CMT-Support@yahoogroups.com>
Sent: Wednesday, June 03, 2009 2:04 PM
Subject: [CMT-Support] Re: i am in pain tonight/Restless Legs Syndrome





http://www.ninds.nih.gov/disorders/restless_legs/detail_restless_legs.htm

The general population has it has well.

Sal


In CMT-Support@yahoogroups.com, Angela <agraham2k@...> wrote:
>
> Hi Lana,
>
> I believe my issue is CMT related. The neurologist hasn't called it RLS.
>
> As I understand it, the Restless Leg Syndrome is associated with a strong,
> sometimes uncontrollable, urge to move the legs. That's different than
> what I experience.
>
> I do hear many people with CMT talk about having RLS and I wonder if it's
> really a separate disease state or just a result of the CMT nerve
> deterioration.
>
> Angela
>
>



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