No, Tammy, I haven't tried it.  But, this article was so inspiring, wasn't it?!
lj

--- On Wed, 4/1/09, Tammy Trahan <hourglass37@...> wrote:


From: Tammy Trahan <hourglass37@...>
Subject: [CMT-Support] Re: Question about lab test called CRP ( C-reactive
protein)
To: CMT-Support@yahoogroups.com
Date: Wednesday, April 1, 2009, 2:33 PM







I have been taking Zonegram 100mg twice a day, which is a
anticonvulsant. . for my C.M.T. pain and it is working awesomely!!!

I tried Lyric and it did nothing for me but made me gain weight.... The
Zonegram is Great!!! Have you tried it...?

Tammy Trahan, Louisiana

--- In CMT-Support@ yahoogroups. com, Lana Jarvis <fyfer1949@. ..> wrote:
>
> hi. this artical is about a new anticonvulsant being tested for
neuropathic pain. The HNF sent a general email about it, but I'm
hoping it will print in it's entirety. Apparently, it's all here.
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> Monday, March 30th, 2009
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sh_menu_interior' ); //end AC code
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> Two Intriguing Studies: Axonal Loss & Pain Relief for Neuropathies
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> Issue date:Â 03/27/2009
> Protective Effects of the Myelin-Associated Glycoprotein
> Â
> Researchers at the Departments of Neurology, Neuroscience, and
Pathology, The Johns Hopkins University School of Medicine have made an
interesting discovery that could one day lead to treatments for people
with CMT.
> Â
> In the study, published January 21 in the Journal Neuroscience,
researchers found that a protein called MAG (see below) has protective
properties that may lead to therapeutic strategies for neurological
diseases characterized by axonal loss, such as CMT.
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> The report explained that progressive axonal degeneration follows
demyelination in many neurological diseases, including multiple
sclerosis and inherited demyelinating neuropathies, such as
Charcot-Marie- Tooth disease. One glial molecule, the myelin-associated
glycoprotein (MAG), located in the adaxonal plasmalemma of
myelin-producing cells, is known to signal to the axon and to modulate
axonal caliber through phosphorylation of axonal neurofilament proteins.
> Â
> This report establishes for the first time the key findingâ€"that
MAG also promotes resistance to axonal injury and prevents axonal
degeneration both in cell culture and in vivo. This effect on axonal
stability depends on the RGD domain around arginine 118 in the
extracellular portion of MAG, but it is independent of Nogo signaling in
the axon. Exploiting this pathway, the researchers believe, may lead to
therapeutic strategies for neurological diseases characterized by axonal
lossâ€"a characteristic of CMT.
> Â
> The authors of the study are Nguyen T, Mehta NR, Conant K, Kim KJ,
Jones M, Calabresi PA, Melli G,
> Hoke A, Schnaar RL, Ming GL, Song H, Keswani SC, Griffin JW.
> Â
> Anticonvulsants to Alleviate Painful Neuropathies
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> Now for some good news out of Pakistan: Researchers at the Department
of Anaesthesia, Aga Khan University Hospital, Karachi, Pakistan, have
discovered that use of anticonvulsant drugs may help alleviate the pain
associated with neuromuscular diseases, including CMT.
> Â
> Neuropathic pain, a form of chronic pain initiated and sustained by an
insult to the peripheral or central nervous system, is a challenge to
clinicians as it does not respond well to traditional pain therapies,
says Hussain AM, Afshan G, the study’s author. Anyone who has
severe pain as a result of CMT knows just how difficult it is to get
through the day with pain that does not abate, despite a host of
traditional and nontraditional therapies.
> Â
> The Pakistani researchers found the the use of anticonvulsants might
just be the ticket for people experiencing neuropathic pain. The exact
pathophysiology is not known, but considering similarities between
epilepsy models and in neuropathic pain models, the researchers justify
the rationale for use of anticonvulsant drugs in the symptomatic
management of neuropathic pain disorders.
> Â
> The role of anticonvulsant drugs in the treatment of neuropathic pain
is evolving and various clinical trials have used these anticonvulsants
and shown positive results in the treatment of trigeminal neuralgia,
painful diabetic neuropathy and postherpetic neuralgia. The availability
of newer anticonvulsants tested in higher quality clinical trials has
marked a new era in the treatment of neuropathic pain. The drugs have
not yet been tested on people with CMT.
> Â
> Gabapentin has the most clearly demonstrated analgesic effect for the
treatment of neuropathic pain, specifically for treatment of painful
diabetic neuropathy and postherpetic neuralgia. Pregablin is a newer
drug and will soon gain popularity in clinical practice. The researchers
say there is a need for further advances in our understanding of the
neuropathic pain syndromes to establish the role of anticonvulsants in
the treatment of neuropathic pain. In the interim, the drugs hold
promise for many who have acute pain resulting from neuropathies.
> Â
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> Author Name:Â Christy Casamassima
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