DNA repair polymorphisms associated with cytogenetic subgroups in B-cell chronic
lymphocytic leukemia.
Christina Ganster, Jurgen Neesen, Sonja Zehetmayer, Ulrich Jager, Harald
Esterbauer, Christine Mannhalter, Britta Kluge, and Christa Fonatsch
Genes Chromosomes Cancer, May 29, 2009;

Department of Medical Genetics, Medical University of Vienna, Vienna, Austria.

Genetic polymorphisms in DNA repair genes can affect the risk of developing
different forms of cancer. Therefore, we have studied the putative association
of seven single nucleotide polymorphisms (SNPs) in five DNA repair genes with
the incidence of chronic lymphocytic leukemia (CLL). We included 461 CLL
patients and the same number of age- and sex-matched controls. As chromosomal
aberrations are important prognostic markers in CLL, we additionally correlated
the SNPs with the occurrence of favorable and unfavorable cytogenetic
aberrations in CLL patients. Patients with del(13q) as a sole aberration were
allocated to the favorable cytogenetic risk group, and patients with del(17p)
and/or del(11q) to the unfavorable cytogenetic risk group. All investigated SNPs
were equally distributed between patients with the favorable cytogenetic
aberration and controls. However, differences were observed in the distribution
of rs13181 in ERCC2 between all CLL patients and controls. Moreover, the
clearest differences were found for rs13181 in ERCC2 and rs25487 in XRCC1
between CLL patients with unfavorable cytogenetic aberrations and controls.
These data suggest that inborn genetic polymorphisms may predict the outcome of
CLL. (c) 2009 Wiley-Liss, Inc.
PMID: 19484764

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